PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between FYN and GRAP

The interaction score between FYN and GRAP is 1.58E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	FYN Orthologue		GRAP Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00029769	0.172	IPI00299763	0.071
human	IPI00016871	0.411	IPI00299763	0.071
human	IPI00013864	0.058	IPI00299763	0.071
human	IPI00298625	0.117	IPI00299763	0.071
human	IPI00479530	0.12	IPI00299763	0.071
human	IPI00396447	0.309	IPI00299763	0.071
human	IPI00013981	0.47	IPI00299763	0.071
human	IPI00328867	0.386	IPI00299763	0.071
human	IPI00306217	0.097	IPI00299763	0.071
human	IPI00029769	0.172	IPI00472451	0.077
human	IPI00016871	0.411	IPI00472451	0.077
human	IPI00013864	0.058	IPI00472451	0.077
human	IPI00298625	0.117	IPI00472451	0.077
human	IPI00479530	0.12	IPI00472451	0.077
human	IPI00396447	0.309	IPI00472451	0.077
human	IPI00013981	0.47	IPI00472451	0.077
human	IPI00328867	0.386	IPI00472451	0.077
human	IPI00306217	0.097	IPI00472451	0.077
human	IPI00029769	0.172	IPI00410080	0.074
human	IPI00016871	0.411	IPI00410080	0.074
human	IPI00013864	0.058	IPI00410080	0.074
human	IPI00298625	0.117	IPI00410080	0.074
human	IPI00479530	0.12	IPI00410080	0.074
human	IPI00396447	0.309	IPI00410080	0.074
human	IPI00013981	0.47	IPI00410080	0.074
human	IPI00328867	0.386	IPI00410080	0.074
human	IPI00306217	0.097	IPI00410080	0.074
human	IPI00029769	0.172	IPI00013981	0.053
human	IPI00016871	0.411	IPI00013981	0.053
human	IPI00013864	0.058	IPI00013981	0.053
human	IPI00298625	0.117	IPI00013981	0.053
human	IPI00479530	0.12	IPI00013981	0.053
human	IPI00396447	0.309	IPI00013981	0.053
human	IPI00013981	0.47	IPI00013981	0.053	InVitro InVivo Get References From PubMed
human	IPI00328867	0.386	IPI00013981	0.053
human	IPI00306217	0.097	IPI00013981	0.053
human	IPI00029769	0.172	IPI00328867	0.05
human	IPI00016871	0.411	IPI00328867	0.05
human	IPI00013864	0.058	IPI00328867	0.05
human	IPI00298625	0.117	IPI00328867	0.05
human	IPI00479530	0.12	IPI00328867	0.05
human	IPI00396447	0.309	IPI00328867	0.05
human	IPI00013981	0.47	IPI00328867	0.05
human	IPI00328867	0.386	IPI00328867	0.05
human	IPI00306217	0.097	IPI00328867	0.05
human	IPI00029769	0.172	IPI00399054	0.058
human	IPI00016871	0.411	IPI00399054	0.058
human	IPI00013864	0.058	IPI00399054	0.058
human	IPI00298625	0.117	IPI00399054	0.058
human	IPI00479530	0.12	IPI00399054	0.058
human	IPI00396447	0.309	IPI00399054	0.058
human	IPI00013981	0.47	IPI00399054	0.058
human	IPI00328867	0.386	IPI00399054	0.058
human	IPI00306217	0.097	IPI00399054	0.058
bakers yeast	YBL007C	0.058	YBL007C	1
worm	Q9BKW3	1	P29355	0.106

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07

Domains

Domains present in FYN and GRAP:

Domains in FYN

Domains in GRAP

IPR000719	Protein kinase
IPR001245	Tyrosine protein kinase
IPR008266	Tyrosine protein kinase, active site
IPR011009	Protein kinase-like
IPR001452	SH3
IPR000980	SH2 motif

IPR001452	SH3
IPR000108	Neutrophil cytosol factor 2
IPR000980	SH2 motif

The Chi square scores for co-occurrence of domains that are present in FYN and GRAP are listed below.

Domain 1		Domain 2		Chi Square
IPR008266	Tyrosine protein kinase, active site	IPR000980	SH2 motif	383.26
IPR001245	Tyrosine protein kinase	IPR000980	SH2 motif	238.73
IPR008266	Tyrosine protein kinase, active site	IPR001452	SH3	164.706
IPR001245	Tyrosine protein kinase	IPR001452	SH3	100.857
IPR000719	Protein kinase	IPR000980	SH2 motif	82.1364
IPR011009	Protein kinase-like	IPR000980	SH2 motif	59.6059
IPR001452	SH3	IPR000980	SH2 motif	59.5667
IPR008266	Tyrosine protein kinase, active site	IPR000108	Neutrophil cytosol factor 2	43.9279
IPR000980	SH2 motif	IPR000980	SH2 motif	36.445
IPR000719	Protein kinase	IPR001452	SH3	27.1334
IPR001245	Tyrosine protein kinase	IPR000108	Neutrophil cytosol factor 2	22.4767
IPR000980	SH2 motif	IPR000108	Neutrophil cytosol factor 2	21.5484
IPR011009	Protein kinase-like	IPR001452	SH3	20.4416
IPR001452	SH3	IPR000108	Neutrophil cytosol factor 2	10.5439
IPR000719	Protein kinase	IPR000108	Neutrophil cytosol factor 2	4.72045
IPR001452	SH3	IPR001452	SH3	3.15089
IPR011009	Protein kinase-like	IPR000108	Neutrophil cytosol factor 2	2.89179

The background colour of the table refers to:

Blue Domain is only present in FYN
Yellow Domain is only present in GRAP
Green Domain is present in both FYN and GRAP

0.265

Post-translational Modifications

Protein: FYN

PTM	Residue	Reference
Dephosphorylation	420	PubMed, HPRD
Dephosphorylation	531	PubMed, HPRD
Myristoylation	2	PubMed, HPRD
Palmitoylation	3	PubMed, HPRD
Phosphorylation	28	PubMed, HPRD
Phosphorylation	30	PubMed, HPRD
Phosphorylation	39	PubMed, HPRD
Phosphorylation	420	PubMed, HPRD
Phosphorylation	531	PubMed, HPRD
Phosphotyrosine	530	HPRD
Proteolytic Cleavage	19	PubMed, HPRD

Protein: GRAP

PTM	Residue	Reference

Localisation

Protein: FYN

Localisation	Reference
Plasma membrane	HPRD
Cytoplasm	HPRD

Protein: GRAP

Localisation	Reference
Cytoplasm	HPRD

Transitive Score

The common interactors between FYN and GRAP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FYN andGRAP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FYN has 1745 interactors and GRAP has 466 interactors of which there are 384 common interactors.

Common Interactor	Name of Common Interactor	Score for FYN-Interactor (?)	Score for GRAP-Interactor (?)
PDGFRB	PDGFRB: Beta-type platelet-derived growth factor receptor precursor	1.01E3	133.00
FLT1	FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor	1.01E3	147.00
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	563.00	31.80
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	563.00	0.274
PTK2	PTK2, FAK, FAK1: Focal adhesion kinase 1	563.00	76.00
JAK2	JAK2: Tyrosine-protein kinase JAK2	563.00	0.218
ZAP70	ZAP70: Uncharacterized protein ZAP70	563.00	0.360
PDGFRA	PDGFRA: Alpha-type platelet-derived growth factor receptor precursor	422.00	55.50
CSF1R	CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor	422.00	61.50
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	422.00	0.029
KIT	KIT: Mast/stem cell growth factor receptor precursor	422.00	61.50
WASL	WASL: Neural Wiskott-Aldrich syndrome protein	199.00	4.72
SH3KBP1	SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1	170.00	27.60
SHC3	SHC3, NSHC, SHCC: SHC-transforming protein 3	114.00	7.56
SORBS3	SORBS3, SCAM1: Vinexin	71.20	7.56
ADAM33	ADAM33, UNQ873/PRO1891: ADAM 33 precursor	46.90	9.04
BCAR1	BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1	22.10	1.29
SHC2	N/A	12.40	1.29
RASA4	RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4	11.50	0.036
ADAM9	ADAM9, KIAA0021, MCMP, MDC9, MLTNG: ADAM 9 precursor	9.04	9.04
ADAM28	ADAM28, ADAM23, MDCL: ADAM 28 precursor	9.04	9.04
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	7.88	7.31
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	7.88	7.31
WASPIP	N/A	7.88	9.63
FNBP1	N/A	4.22	1.93
CTTN	CTTN, EMS1: Src substrate cortactin	4.22	0.674
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	1.30	0.402
PTPN6	PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6	1.30	0.027
LNK	SH2B3, LNK: SH2B adapter protein 3	1.30	0.027
SLA2	SLA2, C20orf156, SLAP2: Src-like-adapter 2	1.30	0.027
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	1.30	0.265
PLCG1	PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1	1.30	0.050
JAK1		1.30	0.305
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	1.30	0.174
BLNK	BLNK, BASH, SLP65: B-cell linker protein	1.30	0.0308
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	1.30	0.244
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	1.30	0.027
INSL3	JAK3: Tyrosine-protein kinase JAK3	1.30	0.244
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	1.30	0.402
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	1.30	0.305
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	1.30	0.265
SOCS3	SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3	1.30	0.0308
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	1.30	0.0308
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	1.30	0.265
BMX	N/A	1.30	0.197
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	1.30	0.197
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	1.30	0.244
SYK	SYK: Tyrosine-protein kinase SYK	1.30	0.244
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	1.30	0.402
STAT6	STAT6: Signal transducer and activator of transcription 6	1.17	13.20
VAV1	VAV1, VAV: Proto-oncogene vav	1.17	0.036
APS	SH2B2, APS: SH2B adapter protein 2	1.17	0.028
LYN	LYN: Tyrosine-protein kinase Lyn	1.17	0.218
GRAP2	GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2	1.17	0.036
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	1.17	0.218
CSK	CSK: Tyrosine-protein kinase CSK	1.17	0.440
NCK1	NCK1, NCK: Cytoplasmic protein NCK1	1.17	0.028
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	1.17	0.177
NCK2	NCK2: Cytoplasmic protein NCK2	1.17	13.20
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	1.17	0.141
HCK	N/A	1.17	0.156
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	1.17	0.156
CRKL	CRKL: Crk-like protein	1.17	0.028
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	1.17	0.237
GRB2	GRB2, ASH: Growth factor receptor-bound protein 2	1.17	2.04
MET	N/A	1.07	1.07
LOC392481	N/A	1.07	1.07
PTPRS	N/A	1.07	1.07
SHC4	SHC-transforming protein 4	1.07	1.07
ADAM15	ADAM15: ADAM15 isoform 6b	1.07	1.07
SYNJ1	SYNJ1, KIAA0910: Synaptojanin-1	1.00	2.95
FGFR1	FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor	0.980	0.217
MET	MET: Hepatocyte growth factor receptor precursor	0.980	0.143
MERTK	MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor	0.980	0.145
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.980	0.032
FGFR3	FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor	0.980	0.217
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.980	0.217
ERBB4	ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor	0.980	0.145
TEK	TEK, TIE2: Angiopoietin-1 receptor precursor	0.980	0.129
RET	RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor	0.980	0.217
EPHB3	EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor	0.878	0.128
EPHB2	EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor	0.878	0.115
EPHA7	EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor	0.878	61.50
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.878	2.98
IGF1R	IGF1R: Insulin-like growth factor 1 receptor precursor	0.878	0.115
FLT3	FLT3, STK1: FL cytokine receptor precursor	0.878	0.145
INSR	INSR: Insulin receptor precursor	0.878	61.50
EPHA1	EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor	0.878	0.179
FGFR4	FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor	0.878	0.179
EPHB4	EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor	0.878	0.145
EPHB1	EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor	0.878	61.50
EGFR	EGFR, ERBB1: Epidermal growth factor receptor precursor	0.878	0.195
EPHA4	EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor	0.878	0.115
KDR	KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor	0.878	0.128
ERBB2	ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor	0.878	0.128
ERBB3	ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor	0.878	0.195
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.878	2.13
EPHA2	EPHA2, ECK: Ephrin type-A receptor 2 precursor	0.878	0.128
STAT4	STAT4: Signal transducer and activator of transcription 4	0.878	0.035
MST1R	MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor	0.878	0.179
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.878	9.04
EPHA8	EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor	0.878	0.195
PPP1CB	PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit	0.714	0.065
WIRE	WIPF2, WICH, PP10631, WIRE: WAS/WASL-interacting protein family member 2	0.682	0.837
PTK7	PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor	0.617	0.0288
NTRK2	NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor	0.617	0.0288
NTRK1	NTRK1, TRK: High affinity nerve growth factor receptor precursor	0.617	0.0288
EPHA3	EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor	0.617	0.0288
FLT4	VEGFR3 long form	0.553	0.0258
TNK2	TNK2, ACK1: Activated CDC42 kinase 1	0.553	0.0258
SYNJ2	SYNJ2, KIAA0348: Synaptojanin-2	0.536	0.746
EPHA5	EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor	0.483	0.126
ALK	ALK: ALK tyrosine kinase receptor precursor	0.483	0.094
SLC2A1	SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1	0.366	0.0294
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.366	0.039
ADAM19	N/A	0.356	0.356
SH2D1A	SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A	0.265	0.0308
MATK	DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212	0.265	0.305
SRMS	SRMS, C20orf148: Tyrosine-protein kinase Srms	0.265	0.265
SH2D1B	SH2D1B, EAT2: SH2 domain-containing protein 1B	0.265	0.027
SOCS1	SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1	0.265	0.041
PLK4	PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4	0.265	0.244
SOCS4	SOCS4, SOCS7: Suppressor of cytokine signaling 4	0.265	0.027
BRDG1	STAP1, BRDG1: Signal-transducing adaptor protein 1	0.265	0.027
CISH	CISH, G18: Cytokine-inducible SH2-containing protein	0.265	0.027
FYN	N/A	0.265	0.305
VAV3	VAV3: Protein vav-3	0.237	0.028
RIN3	N/A	0.237	0.028
TNK1	TNK1: Non-receptor tyrosine-protein kinase TNK1	0.237	0.237
CAP1	CAP1, CAP: Adenylyl cyclase-associated protein 1	0.232	0.547
MUSK	MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor	0.217	0.200
TIE1	TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor	0.217	0.162
STYK1	STYK1, NOK: Tyrosine protein-kinase STYK1	0.217	0.200
RYK	RYK, JTK5A: Tyrosine-protein kinase RYK precursor	0.217	0.251
AMHR2	AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor	0.217	0.200
FGFR2	N/A	0.217	0.217
TYRO3	TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor	0.217	0.145
RET	urf-ret: Urf-ret protein	0.217	0.162
LTK	LTK, TYK1: Leukocyte tyrosine kinase receptor precursor	0.195	0.296
INSRR	INSRR, IRR: Insulin receptor-related protein precursor	0.195	0.145
ROR1	ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor	0.195	0.128
ROR2	ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor	0.195	0.128
DDR1	DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con	0.195	0.195
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.165	0.027
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.165	0.041
MAPKAPK5	N/A	0.165	0.027
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.165	0.027
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.165	0.027
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.165	0.050
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.165	0.027
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.165	0.027
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.165	0.050
STK16	N/A	0.165	0.0308
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.165	0.027
MAPK15	N/A	0.165	0.027
AMPH	AMPH, AMPH1: Amphiphysin	0.165	0.027
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.165	0.027
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.165	0.050
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.165	0.041
NCF1	Neutrophil cytosolic factor 1 variant (Fragment)	0.165	0.0308
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.165	0.0308
PRKACB	PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit	0.165	0.027
PSCD2	N/A	0.165	0.027
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.165	0.041
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.165	0.0308
PRKAA1	N/A	0.165	0.0308
ROCK1	ROCK1: Rho-associated protein kinase 1	0.165	0.0308
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.165	0.027
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.165	0.027
ABI1	ABI1, SSH3BP1: Abl interactor 1	0.165	0.027
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.165	0.050
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.165	0.027
CDK6	CDK6: Cell division protein kinase 6	0.165	0.0308
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.165	0.0308
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.165	0.027
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.165	0.0308
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.165	0.041
DNM3	DNM3: Uncharacterized protein DNM3	0.165	0.027
NEDD9	NEDD9, CASL: Enhancer of filamentation 1	0.165	0.027
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.165	0.027
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.165	0.0308
MAP2K5	N/A	0.165	0.027
NF2	NF2, SCH: Merlin	0.165	0.027
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.148	0.036
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.148	0.028
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.148	0.028
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.148	0.028
CDK2	CDK2: Cell division protein kinase 2	0.148	0.028
RASA3	RASA3: Ras GTPase-activating protein 3	0.148	0.028
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.148	0.036
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.148	0.028
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.148	0.028
FRS3	FRS3: Fibroblast growth factor receptor substrate 3	0.148	8.58
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.148	0.036
PRKCQ	PRKCQ, PRKCT: Protein kinase C theta type	0.148	0.036
CD2AP	CD2AP: CD2-associated protein	0.148	0.028
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.148	0.028
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.148	0.036
ATM	ATM: Serine-protein kinase ATM	0.148	0.060
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.148	1.21
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.148	0.036
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.148	0.028
CDK4	CDK4: Cell division protein kinase 4	0.148	0.028
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.148	0.044
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.148	0.028
RPS6KB1	N/A	0.148	0.044
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.148	0.036
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.148	0.036
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.148	0.028
DOK1	DOK1: Docking protein 1	0.148	0.028
STK10	STK10: Uncharacterized protein STK10	0.148	0.036
EPS15L1	EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1	0.148	0.272
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.148	0.028
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.148	0.028
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.148	0.060
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.148	0.036
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.148	0.036
PSCD4	PSCD4, CYT4: Cytohesin-4	0.148	0.028
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.148	0.028
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.148	1.02
VIL2	N/A	0.148	0.036
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.148	0.036
CXorf9	N/A	0.148	0.036
RPL6	RPL6, TXREB1: 60S ribosomal protein L6	0.119	0.902
RPL35	RPL35: 60S ribosomal protein L35	0.119	1.10
TRIP10	TRIP10, CIP4, STOT, STP: Cdc42-interacting protein 4	0.119	0.593
PPP1CC	N/A	0.119	0.593
RPL27A	RPL27A: 60S ribosomal protein L27a	0.119	0.902
SH3YL1	N/A	0.119	0.593
RPL19	RPL19: 60S ribosomal protein L19	0.119	1.10
AAK1	N/A	0.119	0.593
RAD52	RAD52: DNA repair protein RAD52 homolog	0.119	0.593
UNC50	UNC50, UNCL, HSD23, HSD-23: Protein unc-50 homolog	0.119	0.443
RP1-112K5.2	TSR2: Pre-rRNA-processing protein TSR2 homolog	0.119	0.593
RPL12	Ribosomal protein L12 variant (Fragment)	0.119	0.593
RPL38	RPL38: 60S ribosomal protein L38	0.119	0.902
CAP2	CAP2: Adenylyl cyclase-associated protein 2	0.119	0.593
PCSK7	Proprotein convertase subtilisin/kexin type 7 preproprotein variant (Fragment)	0.119	0.593
NEDD4L	N/A	0.119	0.593
RPL11	RPL11: 60S ribosomal protein L11	0.119	1.10
HIP1R	HIP1R, HIP12, KIAA0655: Huntingtin-interacting protein 1-related protein	0.119	0.685
ICAM2	ICAM2: Intercellular adhesion molecule 2 precursor	0.109	0.039
HLA-C	HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor	0.109	0.032
CXCR4	CXCR4: C-X-C chemokine receptor type 4	0.109	0.039
CD3G	CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor	0.109	0.032
CD47	CD47, MER6: Leukocyte surface antigen CD47 precursor	0.109	0.032
CCR5	CCR5: CCR5 receptor (Fragment)	0.109	0.032
MS4A1	MS4A1, CD20: B-lymphocyte antigen CD20	0.109	0.032
HLA-A	HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor	0.109	0.032
CD22	CD22, SIGLEC2: B-cell receptor CD22 precursor	0.109	0.032
CD79A	CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain	0.109	0.039
HLA-DPB1	HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor	0.109	0.032
CD3D	CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor	0.109	0.032
PTPN1	PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1	0.109	0.039
CD28	CD28: T-cell-specific surface glycoprotein CD28 precursor	0.109	0.032
CD2	CD2, SRBC: T-cell surface antigen CD2 precursor	0.109	0.039
CD3E	CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor	0.109	0.032
HLA-B	HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor	0.109	0.032
CRLF3	N/A	0.109	0.032
HLA-G	HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec	0.109	0.032
SLAMF1	SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor	0.109	0.032
HLA-DMA	DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP	0.109	0.032
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.098	0.029
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.098	0.029
SOS1	SOS1: Son of sevenless homolog 1	0.098	2.44
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.098	0.029
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.098	0.029
GSPT1	GSPT1: G1 to S phase transition protein 1 homolog	0.071	0.326
FNBP1L	N/A	0.064	0.119
LOC390876	similar to 60S ribosomal protein L35	0.064	0.119
TMEM20	N/A	0.064	0.119
BMP2K	N/A	0.064	0.119
NULL	Uncharacterized protein ENSP00000375058	0.064	0.119
NULL	N/A	0.064	0.119
LOC440737	similar to 60S ribosomal protein L35	0.064	0.119
LOC389435	hypothetical protein LOC389435	0.064	0.119
LOC645161	similar to 60S ribosomal protein L12	0.064	0.119
NULL	N/A	0.064	0.119
LOC646875	similar to 60S ribosomal protein L12	0.064	0.119
NULL	N/A	0.064	0.119
LOC441246	LOC154880, tcag7.829: Similar to 60S ribosomal protein L35	0.064	0.119
NULL	N/A	0.064	0.119
LOC653314	Uncharacterized protein ENSP00000339011	0.064	0.119
GRK7	GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor	0.056	0.027
SYN3	SYN3: Synapsin-3	0.046	0.968
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.044	0.029
STX5A	N/A	0.039	0.759
PPP1CA	PPP1CA, PPP1A: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	0.038	0.082
GSPT2	GSPT2: G1 to S phase transition protein 2 homolog	0.038	0.065
NULL	N/A	0.0288	0.0288
FES	FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps	0.0288	0.0288
ROS1	ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor	0.0288	0.0288
FES	Proto-oncogene c-fes variant 4	0.0288	0.0288
AATK	apoptosis-associated tyrosine kinase	0.0288	0.0288
FES	Proto-oncogene c-fes variant 3	0.0288	0.0288
DDR2	DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor	0.0288	0.0288
MUSK	MUSK: MUSK protein	0.0288	0.0288
TESK2	TESK2: Dual specificity testis-specific protein kinase 2	0.0288	0.0288
NULL	N/A	0.0288	0.0288
NTRK3	NTRK3, TRKC: NT-3 growth factor receptor precursor	0.0288	0.0288
NULL	Tyrosine kinase	0.0288	0.0288
BLK	BLK: Tyrosine-protein kinase BLK	0.0288	0.0288
NTRK3	N/A	0.0288	0.0288
TTN	TTN: Uncharacterized protein TTN (Fragment)	0.0288	0.0288
BTK	BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros	0.0288	0.0288
LDLRAP1	LDLRAP1, ARH: Low density lipoprotein receptor adapter protein 1	0.027	0.050
SPRED1	SPRED1: Sprouty-related, EVH1 domain-containing protein 1	0.027	0.027
NOXA1	NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1	0.027	0.027
CAMKK1	CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1	0.027	0.027
ANKK1	ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein	0.027	0.027
ASB17	ASB17: Ankyrin repeat and SOCS box protein 17	0.027	0.027
STAC	STAC: SH3 and cysteine-rich domain-containing protein	0.027	0.027
SRA1	APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3	0.027	0.027
SORBS2	N/A	0.027	0.027
ARHGAP4	ARHGAP4, KIAA0131, RGC1, RHOGAP4: Rho GTPase-activating protein 4	0.027	0.050
OSBPL6	OSBPL6, ORP6: Oxysterol-binding protein-related protein 6	0.027	0.027
ASB7	ASB7: Ankyrin repeat and SOCS box protein 7	0.027	0.027
RNASEL	RNASEL, RNS4: 2-5A-dependent ribonuclease	0.027	0.0308
PDIK1L	PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L	0.027	0.027
PLCB2		0.027	0.0308
NEK11	NEK11: Serine/threonine-protein kinase Nek11	0.027	0.027
EFS	EFS: Embryonal Fyn-associated substrate	0.027	0.027
NEK4	NEK4, STK2: Serine/threonine-protein kinase Nek4	0.027	0.027
ASB14	ASB14: Ankyrin repeat and SOCS box protein 14	0.027	0.027
ARHGEF1	ARHGEF1: Rho guanine nucleotide exchange factor 1	0.027	0.027
CDC2L2	N/A	0.027	0.027
PTPN23	PTPN23, KIAA1471: Tyrosine-protein phosphatase non-receptor type 23	0.027	0.027
RIPK5	RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p	0.027	0.027
RANBP3	N/A	0.027	0.0308
PXK	PXK: PX domain-containing protein kinase-like protein	0.027	0.027
FAM43A	N/A	0.027	0.027
APBB1	APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1	0.027	0.027
STK17A	STK17A, DRAK1: Serine/threonine-protein kinase 17A	0.027	0.050
CASKIN1	N/A	0.027	0.027
DAPK3	DAPK3, ZIPK: Death-associated protein kinase 3	0.027	0.041
PPP1R9A	PPP1R9A, KIAA1222: Neurabin-1	0.027	0.027
CENTB5	KIAA1716, CENTB5: Centaurin-beta 5	0.027	0.027
ASB8	ASB8, PP14212: Ankyrin repeat and SOCS box protein 8	0.027	0.041
ARHGEF18	ARHGEF18: ARHGEF18 protein	0.027	0.067
CADPS2	CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2	0.027	0.027
ABI3	ABI3, NESH: ABI gene family member 3	0.027	0.027
STK35	STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35	0.027	0.027
MID2	N/A	0.027	0.027
ASB12	ASB12: Ankyrin repeat and SOCS box protein 12	0.027	0.027
CADPS	CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1	0.027	0.027
DYRK2	DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2	0.027	0.050
PTPRN2	PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor	0.027	0.027
RAB40A	RAB40A: Ras-related protein Rab-40A	0.027	0.0308
PRMT2	PRMT2, HMT1, HRMT1L1: Protein arginine N-methyltransferase 2	0.027	0.041
SHANK1	SHANK1: SH3 and multiple ankyrin repeat domains protein 1	0.027	0.027
PTPN7	PTPN7: Tyrosine-protein phosphatase non-receptor type 7	0.027	0.041
MYLIP	MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP	0.027	0.0308
PSD3	N/A	0.027	0.027
CDK10	CDK10: Cell division protein kinase 10	0.027	0.027
TRIM9	TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9	0.027	0.027
PLEKHA3	PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3	0.027	0.027
VEPH1	VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h	0.027	0.027
PTPN13	N/A	0.027	0.027
OSBPL9	N/A	0.027	0.027
ARHGEF7	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB: Rho guanine nucleotide exchange	0.027	0.0308
NEBL	N/A	0.027	0.027
WSB1	WSB1, SWIP1: WD repeat and SOCS box-containing protein 1	0.027	0.027
ASB2	ASB2: Ankyrin repeat and SOCS box protein 2	0.027	0.027
ASB6	ASB6: Ankyrin repeat and SOCS box protein 6	0.027	0.027
NMI	NMI: N-myc-interactor	0.027	0.0308
RIPK2	RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/	0.027	0.0308
HUNK	HUNK, MAKV: Hormonally up-regulated neu tumor-associated kinase	0.027	0.041
UBL7	UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7	0.027	0.027
MPP4	MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4	0.027	0.027
CSNK1G3	CSNK1G3: Casein kinase I isoform gamma-3	0.027	0.0308
ASB3	ASB3: ASB3 protein	0.027	0.027
SAMD9	SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot	0.027	0.041
DOK6	DOK6: Uncharacterized protein DOK6	0.027	0.027
PLEKHA4	PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4	0.027	0.027
RASGRF2	RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment)	0.027	0.027
DOK5	DOK5, C20orf180: Docking protein 5	0.027	0.027
FANK1	FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr	0.027	0.027
FYB	FYB, SLAP130: FYN-binding protein	0.027	0.041
ASB10	ASB10: Ankyrin repeat and SOCS box protein 10	0.027	0.027
CDKL2	CDKL2: Cyclin-dependent kinase-like 2	0.027	0.027
RASGRF1	RASGRF1, CDC25: Guanine nucleotide-releasing protein	0.027	0.027
SWAP70	SWAP70, KIAA0640, HSPC321: Switch-associated protein 70	0.027	0.041
ALS2CR7	ALS2CR7: Serine/threonine-protein kinase ALS2CR7	0.027	0.027
FES	N/A	0.0258	0.0258

0.347

Total Score

1.58E4