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Evidence of Interaction Between FYN and GRAP

The interaction score between FYN and GRAP is 1.58E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismFYN OrthologueGRAP OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00029769 0.172 IPI00299763 0.071
human IPI00016871 0.411 IPI00299763 0.071
human IPI00013864 0.058 IPI00299763 0.071
human IPI00298625 0.117 IPI00299763 0.071
human IPI00479530 0.12 IPI00299763 0.071
human IPI00396447 0.309 IPI00299763 0.071
human IPI00013981 0.47 IPI00299763 0.071
human IPI00328867 0.386 IPI00299763 0.071
human IPI00306217 0.097 IPI00299763 0.071
human IPI00029769 0.172 IPI00472451 0.077
human IPI00016871 0.411 IPI00472451 0.077
human IPI00013864 0.058 IPI00472451 0.077
human IPI00298625 0.117 IPI00472451 0.077
human IPI00479530 0.12 IPI00472451 0.077
human IPI00396447 0.309 IPI00472451 0.077
human IPI00013981 0.47 IPI00472451 0.077
human IPI00328867 0.386 IPI00472451 0.077
human IPI00306217 0.097 IPI00472451 0.077
human IPI00029769 0.172 IPI00410080 0.074
human IPI00016871 0.411 IPI00410080 0.074
human IPI00013864 0.058 IPI00410080 0.074
human IPI00298625 0.117 IPI00410080 0.074
human IPI00479530 0.12 IPI00410080 0.074
human IPI00396447 0.309 IPI00410080 0.074
human IPI00013981 0.47 IPI00410080 0.074
human IPI00328867 0.386 IPI00410080 0.074
human IPI00306217 0.097 IPI00410080 0.074
human IPI00029769 0.172 IPI00013981 0.053
human IPI00016871 0.411 IPI00013981 0.053
human IPI00013864 0.058 IPI00013981 0.053
human IPI00298625 0.117 IPI00013981 0.053
human IPI00479530 0.12 IPI00013981 0.053
human IPI00396447 0.309 IPI00013981 0.053
human IPI00013981 0.47 IPI00013981 0.053
  • InVitro
  • InVivo

Get References From PubMed

human IPI00328867 0.386 IPI00013981 0.053
human IPI00306217 0.097 IPI00013981 0.053
human IPI00029769 0.172 IPI00328867 0.05
human IPI00016871 0.411 IPI00328867 0.05
human IPI00013864 0.058 IPI00328867 0.05
human IPI00298625 0.117 IPI00328867 0.05
human IPI00479530 0.12 IPI00328867 0.05
human IPI00396447 0.309 IPI00328867 0.05
human IPI00013981 0.47 IPI00328867 0.05
human IPI00328867 0.386 IPI00328867 0.05
human IPI00306217 0.097 IPI00328867 0.05
human IPI00029769 0.172 IPI00399054 0.058
human IPI00016871 0.411 IPI00399054 0.058
human IPI00013864 0.058 IPI00399054 0.058
human IPI00298625 0.117 IPI00399054 0.058
human IPI00479530 0.12 IPI00399054 0.058
human IPI00396447 0.309 IPI00399054 0.058
human IPI00013981 0.47 IPI00399054 0.058
human IPI00328867 0.386 IPI00399054 0.058
human IPI00306217 0.097 IPI00399054 0.058
bakers yeast YBL007C 0.058 YBL007C 1
worm Q9BKW3 1 P29355 0.106

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07
Domains Domains present in FYN and GRAP:
Domains in FYNDomains in GRAP
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001452 SH3
IPR000980 SH2 motif
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in FYN and GRAP are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001245 Tyrosine protein kinase IPR000980 SH2 motif 238.73
IPR008266 Tyrosine protein kinase, active site IPR001452 SH3 164.706
IPR001245 Tyrosine protein kinase IPR001452 SH3 100.857
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR001452 SH3 IPR000980 SH2 motif 59.5667
IPR008266 Tyrosine protein kinase, active site IPR000108 Neutrophil cytosol factor 2 43.9279
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR000719 Protein kinase IPR001452 SH3 27.1334
IPR001245 Tyrosine protein kinase IPR000108 Neutrophil cytosol factor 2 22.4767
IPR000980 SH2 motif IPR000108 Neutrophil cytosol factor 2 21.5484
IPR011009 Protein kinase-like IPR001452 SH3 20.4416
IPR001452 SH3 IPR000108 Neutrophil cytosol factor 2 10.5439
IPR000719 Protein kinase IPR000108 Neutrophil cytosol factor 2 4.72045
IPR001452 SH3 IPR001452 SH3 3.15089
IPR011009 Protein kinase-like IPR000108 Neutrophil cytosol factor 2 2.89179

The background colour of the table refers to:

  • Blue Domain is only present in FYN
  • Yellow Domain is only present in GRAP
  • Green Domain is present in both FYN and GRAP

0.265
Post-translational Modifications

Protein: FYN

PTMResidueReference
Dephosphorylation 420 PubMed, HPRD
Dephosphorylation 531 PubMed, HPRD
Myristoylation 2 PubMed, HPRD
Palmitoylation 3 PubMed, HPRD
Phosphorylation 28 PubMed, HPRD
Phosphorylation 30 PubMed, HPRD
Phosphorylation 39 PubMed, HPRD
Phosphorylation 420 PubMed, HPRD
Phosphorylation 531 PubMed, HPRD
Phosphotyrosine 530 HPRD
Proteolytic Cleavage 19 PubMed, HPRD

Protein: GRAP

PTMResidueReference
Localisation

Protein: FYN

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: GRAP

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between FYN and GRAP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FYN andGRAP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FYN has 1745 interactors and GRAP has 466 interactors of which there are 384 common interactors.

Common InteractorName of Common InteractorScore for FYN-Interactor (?)Score for GRAP-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 1.01E3 147.00
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 1.01E3 133.00
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 563.00 0.274
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 563.00 76.00
JAK2 JAK2: Tyrosine-protein kinase JAK2 563.00 0.218
ZAP70 ZAP70: Uncharacterized protein ZAP70 563.00 0.360
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 563.00 31.80
STAT5B STAT5B: Signal transducer and activator of transcription 5B 422.00 0.029
KIT KIT: Mast/stem cell growth factor receptor precursor 422.00 61.50
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 422.00 61.50
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 422.00 55.50
WASL WASL: Neural Wiskott-Aldrich syndrome protein 199.00 4.72
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 170.00 27.60
SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 114.00 7.56
SORBS3 SORBS3, SCAM1: Vinexin 71.20 7.56
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 46.90 9.04
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 22.10 1.29
SHC2 N/A 12.40 1.29
RASA4 RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4 11.50 0.036
ADAM28 ADAM28, ADAM23, MDCL: ADAM 28 precursor 9.04 9.04
ADAM9 ADAM9, KIAA0021, MCMP, MDC9, MLTNG: ADAM 9 precursor 9.04 9.04
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 7.88 7.31
WASPIP N/A 7.88 9.63
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 7.88 7.31
FNBP1 N/A 4.22 1.93
CTTN CTTN, EMS1: Src substrate cortactin 4.22 0.674
JAK1 1.30 0.305
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 1.30 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.30 0.265
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 1.30 0.050
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 1.30 0.174
BLNK BLNK, BASH, SLP65: B-cell linker protein 1.30 0.0308
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.30 0.244
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 1.30 0.027
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.30 0.244
TXK TXK, PTK4: Tyrosine-protein kinase TXK 1.30 0.402
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 1.30 0.305
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.30 0.265
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 1.30 0.0308
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 1.30 0.0308
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.265
BMX N/A 1.30 0.197
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 1.30 0.197
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.30 0.244
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 1.30 0.402
SYK SYK: Tyrosine-protein kinase SYK 1.30 0.244
LNK SH2B3, LNK: SH2B adapter protein 3 1.30 0.027
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 1.30 0.402
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 1.30 0.027
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 1.17 0.036
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.17 0.218
LYN LYN: Tyrosine-protein kinase Lyn 1.17 0.218
CSK CSK: Tyrosine-protein kinase CSK 1.17 0.440
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 1.17 0.028
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 1.17 0.177
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 1.17 0.141
HCK N/A 1.17 0.156
NCK2 NCK2: Cytoplasmic protein NCK2 1.17 13.20
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 1.17 0.156
CRKL CRKL: Crk-like protein 1.17 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 1.17 2.04
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 0.237
STAT6 STAT6: Signal transducer and activator of transcription 6 1.17 13.20
VAV1 VAV1, VAV: Proto-oncogene vav 1.17 0.036
APS SH2B2, APS: SH2B adapter protein 2 1.17 0.028
MET N/A 1.07 1.07
LOC392481 N/A 1.07 1.07
PTPRS N/A 1.07 1.07
SHC4 SHC-transforming protein 4 1.07 1.07
ADAM15 ADAM15: ADAM15 isoform 6b 1.07 1.07
SYNJ1 SYNJ1, KIAA0910: Synaptojanin-1 1.00 2.95
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.980 0.145
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.980 0.032
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.217
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.217
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.980 0.145
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.980 0.129
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.980 0.217
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.217
MET MET: Hepatocyte growth factor receptor precursor 0.980 0.143
INSR INSR: Insulin receptor precursor 0.878 61.50
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.878 0.179
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.878 0.179
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.878 0.145
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.878 61.50
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.195
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.878 0.115
STAT4 STAT4: Signal transducer and activator of transcription 4 0.878 0.035
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.878 0.128
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.878 0.128
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.195
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.878 2.13
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.878 0.128
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.878 0.179
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.878 9.04
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 0.195
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.878 61.50
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.878 0.128
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.878 0.115
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.878 0.115
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.878 0.145
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.878 2.98
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.714 0.065
WIRE WIPF2, WICH, PP10631, WIRE: WAS/WASL-interacting protein family member 2 0.682 0.837
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.617 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.617 0.0288
FLT4 VEGFR3 long form 0.553 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.553 0.0258
SYNJ2 SYNJ2, KIAA0348: Synaptojanin-2 0.536 0.746
ALK ALK: ALK tyrosine kinase receptor precursor 0.483 0.094
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.483 0.126
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.366 0.0294
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.366 0.039
ADAM19 N/A 0.356 0.356
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.265 0.305
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.265 0.027
SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 0.265 0.041
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.265 0.244
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.265 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.265 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.265 0.027
FYN N/A 0.265 0.305
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.265 0.0308
RIN3 N/A 0.237 0.028
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.237 0.237
VAV3 VAV3: Protein vav-3 0.237 0.028
CAP1 CAP1, CAP: Adenylyl cyclase-associated protein 1 0.232 0.547
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.217 0.200
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.217 0.251
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.217 0.162
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.217 0.200
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.217 0.200
FGFR2 N/A 0.217 0.217
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.217 0.145
RET urf-ret: Urf-ret protein 0.217 0.162
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.195 0.296
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.195 0.145
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.195 0.128
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.195 0.128
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.195 0.195
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.165 0.041
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.027
MAPK15 N/A 0.165 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.165 0.050
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.165 0.027
PSCD2 N/A 0.165 0.027
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.165 0.0308
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.165 0.0308
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.027
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.165 0.041
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.165 0.0308
PRKAA1 N/A 0.165 0.0308
ROCK1 ROCK1: Rho-associated protein kinase 1 0.165 0.0308
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.027
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.165 0.050
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.027
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.165 0.027
CDK6 CDK6: Cell division protein kinase 6 0.165 0.0308
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.165 0.0308
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.165 0.0308
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.165 0.041
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.027
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.165 0.0308
MAP2K5 N/A 0.165 0.027
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.165 0.050
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.027
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.165 0.041
MAPKAPK5 N/A 0.165 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.165 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.027
STK16 N/A 0.165 0.0308
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.165 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.027
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.165 0.050
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.148 0.036
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.148 0.028
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.148 0.028
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.148 0.036
ATM ATM: Serine-protein kinase ATM 0.148 0.060
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.148 1.21
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.148 0.028
CDK4 CDK4: Cell division protein kinase 4 0.148 0.028
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.148 0.044
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.148 0.028
RPS6KB1 N/A 0.148 0.044
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.148 0.036
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.148 0.036
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.148 0.028
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.148 0.028
DOK1 DOK1: Docking protein 1 0.148 0.028
STK10 STK10: Uncharacterized protein STK10 0.148 0.036
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.148 0.272
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.148 0.036
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.148 0.060
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.148 0.028
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.148 0.036
PSCD4 PSCD4, CYT4: Cytohesin-4 0.148 0.028
CXorf9 N/A 0.148 0.036
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.148 1.02
VIL2 N/A 0.148 0.036
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.148 0.036
RASA3 RASA3: Ras GTPase-activating protein 3 0.148 0.028
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.148 0.036
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.148 0.036
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.148 0.028
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.148 0.028
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.148 0.028
CDK2 CDK2: Cell division protein kinase 2 0.148 0.028
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.148 0.036
CD2AP CD2AP: CD2-associated protein 0.148 0.028
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.148 0.028
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.148 0.028
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.148 8.58
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.148 0.036
PPP1CC N/A 0.119 0.593
RPL27A RPL27A: 60S ribosomal protein L27a 0.119 0.902
SH3YL1 N/A 0.119 0.593
UNC50 UNC50, UNCL, HSD23, HSD-23: Protein unc-50 homolog 0.119 0.443
RPL19 RPL19: 60S ribosomal protein L19 0.119 1.10
AAK1 N/A 0.119 0.593
RAD52 RAD52: DNA repair protein RAD52 homolog 0.119 0.593
RPL38 RPL38: 60S ribosomal protein L38 0.119 0.902
RP1-112K5.2 TSR2: Pre-rRNA-processing protein TSR2 homolog 0.119 0.593
RPL12 Ribosomal protein L12 variant (Fragment) 0.119 0.593
CAP2 CAP2: Adenylyl cyclase-associated protein 2 0.119 0.593
PCSK7 Proprotein convertase subtilisin/kexin type 7 preproprotein variant (Fragment) 0.119 0.593
NEDD4L N/A 0.119 0.593
RPL11 RPL11: 60S ribosomal protein L11 0.119 1.10
HIP1R HIP1R, HIP12, KIAA0655: Huntingtin-interacting protein 1-related protein 0.119 0.685
RPL6 RPL6, TXREB1: 60S ribosomal protein L6 0.119 0.902
RPL35 RPL35: 60S ribosomal protein L35 0.119 1.10
TRIP10 TRIP10, CIP4, STOT, STP: Cdc42-interacting protein 4 0.119 0.593
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.109 0.032
CCR5 CCR5: CCR5 receptor (Fragment) 0.109 0.032
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.109 0.032
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.109 0.032
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.032
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.109 0.039
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.109 0.032
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.109 0.032
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.109 0.039
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.109 0.032
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.109 0.032
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.109 0.039
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.109 0.032
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.109 0.032
CRLF3 N/A 0.109 0.032
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.032
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.109 0.032
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.109 0.032
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.109 0.039
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.109 0.039
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.032
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.098 0.029
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.098 0.029
SOS1 SOS1: Son of sevenless homolog 1 0.098 2.44
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.098 0.029
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.098 0.029
GSPT1 GSPT1: G1 to S phase transition protein 1 homolog 0.071 0.326
NULL N/A 0.064 0.119
LOC440737 similar to 60S ribosomal protein L35 0.064 0.119
LOC389435 hypothetical protein LOC389435 0.064 0.119
LOC645161 similar to 60S ribosomal protein L12 0.064 0.119
NULL N/A 0.064 0.119
LOC646875 similar to 60S ribosomal protein L12 0.064 0.119
NULL N/A 0.064 0.119
LOC441246 LOC154880, tcag7.829: Similar to 60S ribosomal protein L35 0.064 0.119
NULL N/A 0.064 0.119
LOC653314 Uncharacterized protein ENSP00000339011 0.064 0.119
FNBP1L N/A 0.064 0.119
LOC390876 similar to 60S ribosomal protein L35 0.064 0.119
TMEM20 N/A 0.064 0.119
BMP2K N/A 0.064 0.119
NULL Uncharacterized protein ENSP00000375058 0.064 0.119
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.027
SYN3 SYN3: Synapsin-3 0.046 0.968
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.044 0.029
STX5A N/A 0.039 0.759
GSPT2 GSPT2: G1 to S phase transition protein 2 homolog 0.038 0.065
PPP1CA PPP1CA, PPP1A: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0.038 0.082
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
NULL N/A 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
NULL Tyrosine kinase 0.0288 0.0288
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
NULL N/A 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
PTPN23 PTPN23, KIAA1471: Tyrosine-protein phosphatase non-receptor type 23 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
RANBP3 N/A 0.027 0.0308
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
FAM43A N/A 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.027 0.050
CASKIN1 N/A 0.027 0.027
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.027 0.041
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
ASB8 ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 0.027 0.041
ARHGEF18 ARHGEF18: ARHGEF18 protein 0.027 0.067
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
MID2 N/A 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.027 0.050
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
RAB40A RAB40A: Ras-related protein Rab-40A 0.027 0.0308
PRMT2 PRMT2, HMT1, HRMT1L1: Protein arginine N-methyltransferase 2 0.027 0.041
CDK10 CDK10: Cell division protein kinase 10 0.027 0.027
PTPN7 PTPN7: Tyrosine-protein phosphatase non-receptor type 7 0.027 0.041
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.027 0.0308
PSD3 N/A 0.027 0.027
NEBL N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
PTPN13 N/A 0.027 0.027
OSBPL9 N/A 0.027 0.027
ARHGEF7 ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB: Rho guanine nucleotide exchange 0.027 0.0308
HUNK HUNK, MAKV: Hormonally up-regulated neu tumor-associated kinase 0.027 0.041
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
NMI NMI: N-myc-interactor 0.027 0.0308
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.027 0.0308
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.027 0.0308
ASB3 ASB3: ASB3 protein 0.027 0.027
SAMD9 SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot 0.027 0.041
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
FYB FYB, SLAP130: FYN-binding protein 0.027 0.041
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
CDKL2 CDKL2: Cyclin-dependent kinase-like 2 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
SWAP70 SWAP70, KIAA0640, HSPC321: Switch-associated protein 70 0.027 0.041
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
LDLRAP1 LDLRAP1, ARH: Low density lipoprotein receptor adapter protein 1 0.027 0.050
SPRED1 SPRED1: Sprouty-related, EVH1 domain-containing protein 1 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
SORBS2 N/A 0.027 0.027
ARHGAP4 ARHGAP4, KIAA0131, RGC1, RHOGAP4: Rho GTPase-activating protein 4 0.027 0.050
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
RNASEL RNASEL, RNS4: 2-5A-dependent ribonuclease 0.027 0.0308
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
PLCB2 0.027 0.0308
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CDC2L2 N/A 0.027 0.027
FES N/A 0.0258 0.0258
0.347
Total Score 1.58E4