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Evidence of Interaction Between HTR2A and BDKRB2

The interaction score between HTR2A and BDKRB2 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HTR2A and BDKRB2 = 0.14

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in HTR2A and BDKRB2:
Domains in HTR2ADomains in BDKRB2
IPR000276 Rhodopsin-like GPCR superfamily
IPR002231 5-Hydroxytryptamine receptor
IPR000455 5-Hydroxytryptamine 2A receptor
IPR000276 Rhodopsin-like GPCR superfamily
IPR000496 Bradykinin receptor
IPR001504 B2 bradykinin receptor

The Chi square scores for co-occurrence of domains that are present in HTR2A and BDKRB2 are listed below.

Domain 1Domain 2Chi Square
IPR002231 5-Hydroxytryptamine receptor IPR000276 Rhodopsin-like GPCR superfamily 126
IPR000276 Rhodopsin-like GPCR superfamily IPR000276 Rhodopsin-like GPCR superfamily 11.8987

The background colour of the table refers to:

  • Blue Domain is only present in HTR2A
  • Yellow Domain is only present in BDKRB2
  • Green Domain is present in both HTR2A and BDKRB2

 0.012
Post-translational Modifications

Protein: HTR2A

PTMResidueReference

Protein: BDKRB2

PTMResidueReference
Palmitoylation 351 PubMed, HPRD
Phosphorylation 156 PubMed, HPRD
Phosphorylation 347 PubMed, HPRD
Phosphorylation 358 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 369 PubMed, HPRD
Phosphorylation 373 PubMed, HPRD
Phosphorylation 375 PubMed, HPRD
Localisation

Protein: HTR2A

LocalisationReference
Plasma membrane HPRD

Protein: BDKRB2

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between HTR2A and BDKRB2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HTR2A andBDKRB2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HTR2A has 183 interactors and BDKRB2 has 423 interactors of which there are 80 common interactors.

Common InteractorName of Common InteractorScore for HTR2A-Interactor (?)Score for BDKRB2-Interactor (?)
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 173.00 0.497
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 105.00 0.497
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 105.00 0.821
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 60.40 0.355
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.824 0.497
CX3CL1 CX3CL1, A-152E5.2, FKN, NTT, SCYD1: Fractalkine precursor 0.404 0.105
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.360 0.497
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.360 0.497
GNAS GNAS, GNAS1, GSP: Guanine nucleotide-binding protein G(s) subunit alpha isoforms 0.265 0.540
CCL16 CCL16, ILINCK, NCC4, SCYA16: Small-inducible cytokine A16 precursor 0.251 0.129
GNAL GNAL: Guanine nucleotide-binding protein G(olf) subunit alpha 0.244 0.403
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.237 0.540
ARL3 ARL3, ARFL3: ADP-ribosylation factor-like protein 3 0.225 0.162
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.218 0.497
CCL28 CCL28, SCYA28: Small-inducible cytokine A28 precursor 0.217 0.141
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.217 0.540
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.217 0.540
XCL2 XCL2, SCYC2: Cytokine SCM-1 beta precursor 0.217 0.141
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.217 0.540
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.200 0.821
CCL27 CCL27, ILC, SCYA27: Small-inducible cytokine A27 precursor 0.200 0.162
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.200 0.403
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.200 0.497
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.177 0.403
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.176 0.355
CCL11 CCL11, SCYA11: Eotaxin precursor 0.162 1.00
CCL17 CCL17, SCYA17, TARC: Small-inducible cytokine A17 precursor 0.162 0.105
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.162 0.403
GNAI2 Galphai2 protein 0.158 0.320
CCL3 CCL3, G0S19-1, MIP1A, SCYA3: Small-inducible cytokine A3 precursor 0.145 0.0833
CXCL2 CXCL2, GRO2, GROB, MIP2A, SCYB2: Macrophage inflammatory protein 2-alpha precurs 0.145 0.162
CCL5 CCL5, D17S136E, SCYA5: Small-inducible cytokine A5 precursor 0.145 0.360
CCL24 CCL24, MPIF2, SCYA24: Small-inducible cytokine A24 precursor 0.143 0.497
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.143 1.35
PF4V1 PF4V1, SCYB4V1: Platelet factor 4 variant precursor 0.143 0.403
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.143 1.00
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.143 1.00
CCL21 CCL21, SCYA21, UNQ784/PRO1600: Small-inducible cytokine A21 precursor 0.143 0.355
CCL25 CCL25, SCYA25, TECK: Small-inducible cytokine A25 precursor 0.143 0.105
CCL23 MIP3, CCL23, MPIF1, SCYA23: Small-inducible cytokine A23 precursor 0.143 0.0833
CXCL6 CXCL6, GCP2, SCYB6: Small-inducible cytokine B6 precursor 0.143 0.353
CCL19 CCL19, ELC, MIP3B, SCYA19: Small-inducible cytokine A19 precursor 0.143 0.105
CCL7 MCP-3: Monocyte chemotactic protein-3 0.143 2.84
CXCL3 CXCL3, GRO3, GROG, SCYB3: Macrophage inflammatory protein 2-beta precursor 0.143 0.353
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.143 1.35
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.143 0.623
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.143 1.35
CXCL13 CXCL13, BCA1, BLC, SCYB13: Small-inducible cytokine B13 precursor 0.143 0.105
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.141 0.403
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.141 0.403
CCL20 CCL20, LARC, MIP3A, SCYA20: Small-inducible cytokine A20 precursor 0.129 0.105
CCL22 CCL22, A-152E5.1, MDC, SCYA22: Small-inducible cytokine A22 precursor 0.129 0.355
CCL4 CCL4, CCL4L, LAG1, MIP1B, SCYA4, SCYA4L: Small-inducible cytokine A4 precursor 0.129 0.360
CCL18 CCL18, AMAC1, DCCK1, MIP4, PARC, SCYA18: Small-inducible cytokine A18 precursor 0.129 0.0924
XCL1 XCL1, LTN, SCYC1: Lymphotactin precursor 0.129 0.320
PPBP PPBP, CTAP3, SCYB7, TGB1, THBGB1: Platelet basic protein precursor 0.129 0.355
CXCL12 Stromal cell-derived factor 1 delta 0.129 0.403
PF4 PF4, CXCL4, SCYB4: Platelet factor 4 precursor 0.129 0.355
IL8 IL8: Interleukin-8 precursor 0.129 0.623
RGS4 RGS4: Regulator of G-protein signaling 4 0.108 0.0794
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.035 0.063
P2RY4 P2RY4, NRU: P2Y purinoceptor 4 0.0308 0.039
GNAS N/A 0.0288 0.0288
NULL Neutrophil-activating protein 4 (Fragment) 0.0288 0.0288
GNAS Mutant guanine nucleotide-binding protein G(S), alpha subunit 0.0288 0.0288
GNAS Guanine nucleotide-binding protein Gs alpha subunit isoform L2 0.0288 0.0288
GNAS N/A 0.0288 0.0288
NULL N/A 0.0288 0.0288
CXCL14 CXCL14, NJAC, UNQ240/PRO273, SCYB14: Small-inducible cytokine B14 precursor 0.0288 0.0288
GNAS GSA: Alpha subunit of GsGTP binding protein (Fragment) 0.0288 0.0288
GNAS N/A 0.0288 0.0288
CHRM2 CHRM2: Muscarinic acetylcholine receptor M2 0.028 0.031
HTR2C HTR2C, HTR1C: 5-hydroxytryptamine receptor 2C 0.028 0.051
DRD1 DRD1: D(1A) dopamine receptor 0.028 0.031
TBXA2R TBXA2R: Thromboxane A2 receptor 0.027 0.034
C3AR1 C3AR1, AZ3B, C3R1, HNFAG09: C3a anaphylatoxin chemotactic receptor 0.027 0.034
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.027 0.034
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.027 0.034
DRD2 DRD2: D(2) dopamine receptor 0.027 0.034
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.027 0.034
0.572
Total Score 2.50