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Evidence of Interaction Between SNAP23 and VAMP4

The interaction score between SNAP23 and VAMP4 is 2.93E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismSNAP23 OrthologueVAMP4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00010470 1 IPI00553138 1
human IPI00010470 1 IPI00549343 0.403
human IPI00010470 1 IPI00477258 0.678
bakers yeast YGR009C 1 YAL030W 1
  • Immunoprecipitation
  • InVitroBinding
  • SyntheticLethal
  • AffinityCaptureWestern
  • ReconstitutedComplex

Get References From PubMed

bakers yeast YMR017W 0.082 YAL030W 1
bakers yeast YGR009C 1 YOR327C 1
  • Immunoprecipitation
  • AffinityChromatography

Get References From PubMed

bakers yeast YMR017W 0.082 YOR327C 1
  • AffinityChromatography
  • ReconstitutedComplex

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in SNAP23 and VAMP4:
Domains in SNAP23Domains in VAMP4
IPR000727 Target SNARE coiled-coil domain
IPR000928 SNAP-25
IPR001388 Synaptobrevin

The Chi square scores for co-occurrence of domains that are present in SNAP23 and VAMP4 are listed below.

Domain 1Domain 2Chi Square
IPR000727 Target SNARE coiled-coil domain IPR001388 Synaptobrevin 1090.58
IPR000928 SNAP-25 IPR001388 Synaptobrevin 274.355

The background colour of the table refers to:

  • Blue Domain is only present in SNAP23
  • Yellow Domain is only present in VAMP4
  • Green Domain is present in both SNAP23 and VAMP4

0.540
Post-translational Modifications

Protein: SNAP23

PTMResidueReference
Acetylation 1 PubMed, HPRD
N-acetylmethionine 1 HPRD
Palmitoylation 80 PubMed, HPRD
Palmitoylation 83 PubMed, HPRD
Palmitoylation 85 PubMed, HPRD
Palmitoylation 87 PubMed, HPRD
Phosphorylation 23 PubMed, HPRD
Phosphorylation 24 PubMed, HPRD
Phosphorylation 161 PubMed, HPRD

Protein: VAMP4

PTMResidueReference
Phosphorylation 30 PubMed, HPRD
Localisation

Protein: SNAP23

LocalisationReference
Golgi HPRD
Nucleus HPRD
Plasma membrane HPRD
Endosome HPRD
Cytoplasm HPRD

Protein: VAMP4

LocalisationReference
Golgi HPRD
Transitive Score

The common interactors between SNAP23 and VAMP4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNAP23 andVAMP4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNAP23 has 637 interactors and VAMP4 has 137 interactors of which there are 50 common interactors.

Common InteractorName of Common InteractorScore for SNAP23-Interactor (?)Score for VAMP4-Interactor (?)
STX1A STX1A, STX1: Syntaxin-1A 128.00 173.00
SNAP25 SNAP25, SNAP: Synaptosomal-associated protein 25 62.80 24.80
SEC22L1 SEC22B, SEC22L1: Vesicle-trafficking protein SEC22b 33.30 0.326
STX7 STX7: Syntaxin-7 13.70 86.70
TSNARE1 TSNARE1: T-SNARE domain containing 1 6.75 10.30
EPIM STX2, EPIM, STX2A, STX2B, STX2C: Syntaxin-2 6.70 262.00
STX11 STX11: Syntaxin-11 6.70 302.00
STX12 STX12: Syntaxin-12 6.70 78.40
STX3A STX3, STX3A: Syntaxin-3 6.70 172.00
STX4A STX4, STX4A: Syntaxin-4 6.70 659.00
STX1B2 STX1B, STX1B1, STX1B2: Syntaxin-1B 6.70 262.00
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.980 0.540
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.878 0.318
STXBP2 STXBP2, UNC18B: Syntaxin-binding protein 2 0.715 0.547
BET1 BET1: BET1 homolog 0.265 0.200
STX8 STX8: Syntaxin-8 0.265 0.547
STX17 STX17: Syntaxin-17 0.265 0.244
SNAP29 SNAP29: Synaptosomal-associated protein 29 0.237 0.214
STXBP1 N/A 0.232 5.86
NAPA N/A 0.196 0.053
STXBP3 STXBP3: Syntaxin-binding protein 3 0.143 5.60
STX6 STX6: Syntaxin-6 0.141 0.265
STX18 STX18, GIG9: Syntaxin-18 0.141 0.244
STX5A N/A 0.126 38.40
VTI1A VTI1A: Vesicle transport through interaction with t-SNAREs homolog 1A 0.126 62.80
STX10 STX10, hCG_27761: Uncharacterized protein STX10 0.126 62.80
DDI1 DDI1: DDI1 homolog 1 0.119 0.119
STX19 STX19: Syntaxin-19 0.119 0.119
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.109 0.0688
DDI2 N/A 0.08 0.326
SRPR SRPR: Uncharacterized protein SRPR 0.049 0.032
SCFD1 SCFD1, C14orf163, FKSG23, KIAA0917, STXBP1L2: Sec1 family domain-containing prot 0.046 2.90
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.044 0.032
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.036 0.032
RYR2 RYR2: Ryanodine receptor 2 0.034 0.026
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.030 0.0446
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.030 0.025
NAPB CDNA FLJ39175 fis, clone OCBBF2003593, highly similar to BETA-SOLUBLE NSF ATTACH 0.029 3.01
STX1B1 N/A 0.0288 0.0288
STX1B2 STX1B2: Syntaxin 1B2 alternative isoform deltaTM 0.0288 0.0288
VTI1B VTI1B, VTI1, VTI1L, VTI1L1, VTI2: Vesicle transport through interaction with t-S 0.0288 0.0288
LILRB1 N/A 0.028 0.032
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.028 0.026
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.028
ABI2 ABI2, ARGBPIA: Abl interactor 2 0.0258 0.0258
STX16 STX16: Syntaxin-16 0.0258 6.83
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.025 0.029
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.025 0.025
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.025 0.0425
SORL1 SORL1: Sortilin-related receptor precursor 0.025 0.046
0.572
Total Score 2.93E4