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Evidence of Interaction Between PIK3R2 and CSF1R

The interaction score between PIK3R2 and CSF1R is 5.72E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PIK3R2 and CSF1R = -0.13

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismPIK3R2 OrthologueCSF1R OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00607759 0.536 IPI00015902 0.126
  • SurfacePlasmonResonance

Get References From PubMed
human IPI00607759 0.536 IPI00018335 0.126
human IPI00607759 0.536 IPI00021396 0.126
human IPI00465250 0.585 IPI00015902 0.126
  • Other
  • Immunoprecipitation
  • InVivo

Get References From PubMed
human IPI00465250 0.585 IPI00018335 0.126
human IPI00465250 0.585 IPI00021396 0.126
worm Q9N597 0.536 O76698 0.126
worm Q9N597 0.536 Q21038 0.126
worm Q9N597 0.536 Q21041 0.126

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in PIK3R2 and CSF1R:
Domains in PIK3R2Domains in CSF1R
IPR008936 Rho GTPase activation protein
IPR001452 SH3
IPR000198 RhoGAP domain
IPR000980 SH2 motif
IPR001720 PI3 kinase, P85 regulatory subunit
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR013151 Immunoglobulin.
IPR013106 V-set.

The Chi square scores for co-occurrence of domains that are present in PIK3R2 and CSF1R are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR001452 SH3 IPR008266 Tyrosine protein kinase, active site 164.706
IPR000980 SH2 motif IPR001824 Receptor tyrosine kinase, class III 101.074
IPR001452 SH3 IPR001245 Tyrosine protein kinase 100.857
IPR000980 SH2 motif IPR007110 Immunoglobulin-like 94.9752
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR003599 Immunoglobulin subtype 66.4833
IPR000980 SH2 motif IPR003598 Immunoglobulin C-2 type 64.7072
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR013151 Immunoglobulin. 36.9251
IPR001452 SH3 IPR001824 Receptor tyrosine kinase, class III 32.2626
IPR001720 PI3 kinase, P85 regulatory subunit IPR008266 Tyrosine protein kinase, active site 28.9958
IPR001452 SH3 IPR000719 Protein kinase 27.1334
IPR001452 SH3 IPR003598 Immunoglobulin C-2 type 26.0449
IPR001452 SH3 IPR003599 Immunoglobulin subtype 22.2905
IPR001720 PI3 kinase, P85 regulatory subunit IPR001245 Tyrosine protein kinase 20.8688
IPR001452 SH3 IPR011009 Protein kinase-like 20.4416
IPR001452 SH3 IPR007110 Immunoglobulin-like 20.3228
IPR000980 SH2 motif IPR013106 V-set. 15.1643
IPR001452 SH3 IPR013151 Immunoglobulin. 14.5395
IPR001452 SH3 IPR013106 V-set. 9.84819
IPR001720 PI3 kinase, P85 regulatory subunit IPR011009 Protein kinase-like 9.64929
IPR001720 PI3 kinase, P85 regulatory subunit IPR000719 Protein kinase 9.22233
IPR008936 Rho GTPase activation protein IPR008266 Tyrosine protein kinase, active site 9.21621
IPR000198 RhoGAP domain IPR008266 Tyrosine protein kinase, active site 7.61405
IPR008936 Rho GTPase activation protein IPR001245 Tyrosine protein kinase 5.16024
IPR000198 RhoGAP domain IPR001245 Tyrosine protein kinase 3.84971
IPR008936 Rho GTPase activation protein IPR003599 Immunoglobulin subtype 1.51613
IPR008936 Rho GTPase activation protein IPR000719 Protein kinase 0.485319
IPR000198 RhoGAP domain IPR000719 Protein kinase 0.472387
IPR008936 Rho GTPase activation protein IPR007110 Immunoglobulin-like 0.211409
IPR008936 Rho GTPase activation protein IPR011009 Protein kinase-like 0.0380864
IPR000198 RhoGAP domain IPR011009 Protein kinase-like 0.00301614
IPR000198 RhoGAP domain IPR007110 Immunoglobulin-like 0.000704171

The background colour of the table refers to:

  • Blue Domain is only present in PIK3R2
  • Yellow Domain is only present in CSF1R
  • Green Domain is present in both PIK3R2 and CSF1R

 0.980
Post-translational Modifications

Protein: PIK3R2

PTMResidueReference
Phosphotyrosine 464 HPRD

Protein: CSF1R

PTMResidueReference
N-linked 302 PubMed, HPRD
N-linked 353 PubMed, HPRD
Phosphorylation 723 PubMed, HPRD
Phosphorylation 809 PubMed, HPRD
Localisation

Protein: PIK3R2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: CSF1R

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between PIK3R2 and CSF1R that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PIK3R2 andCSF1R. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PIK3R2 has 968 interactors and CSF1R has 1458 interactors of which there are 615 common interactors.

Common InteractorName of Common InteractorScore for PIK3R2-Interactor (?)Score for CSF1R-Interactor (?)
INSR INSR: Insulin receptor precursor 388.00 0.171
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 315.00 112.00
BMX N/A 2.42 0.644
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.98 0.581
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 1.53 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 1.53 0.051
FLT4 VEGFR3 long form 1.37 0.046
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 1.33 53.10
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.980
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.20 0.081
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.17 422.00
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 0.980
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 1.07 0.808
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 1.07 30.80
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.07 0.577
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.05 0.980
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 1.01 53.10
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.165
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.975 0.581
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.975 0.902
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.902 0.123
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 71.20
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.878 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.874 0.520
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.872 0.731
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.808 0.097
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.808 0.088
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.808 112.00
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.808 53.10
CSK CSK: Tyrosine-protein kinase CSK 0.781 1.33
JAK1 0.781 1.13
LYN LYN: Tyrosine-protein kinase Lyn 0.781 2.73
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.781 1.06E3
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.781 0.655
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.781 0.731
SYK SYK: Tyrosine-protein kinase SYK 0.781 1.81
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.781 1.81
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.775 0.644
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.770 1.48
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.098
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.731 0.123
HCK N/A 0.694 4.52
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.694 2.73
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.694 0.520
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.655 0.088
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.655 46.80
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.655 0.088
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.655 0.097
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.655 42.20
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.051
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.586 0.111
KIT KIT: Mast/stem cell growth factor receptor precursor 0.577 46.80
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.577 0.136
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.553 0.046
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.520 53.10
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.520 0.136
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.520 0.136
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.483 46.90
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.448 0.098
ALK ALK: ALK tyrosine kinase receptor precursor 0.361 0.073
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.225 0.029
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.225 0.032
TLN2 TLN2: Uncharacterized protein TLN2 0.225 0.058
FGFR2 N/A 0.217 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.191 0.032
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.191 0.902
CTTN CTTN, EMS1: Src substrate cortactin 0.191 0.065
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.191 0.029
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.191 0.065
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.191 0.0727
FYN N/A 0.176 0.330
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.176 0.162
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.171 0.090
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.171 0.065
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.171 0.064
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.171 0.026
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.171 0.058
MYO3A MYO3A: Myosin IIIA 0.171 0.026
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.171 0.029
PRLR PRLR: Prolactin receptor precursor 0.166 0.109
TP73 TP73, P73: Tumor protein p73 0.166 0.045
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.166 0.049
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.049
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.109
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
NF2 NF2, SCH: Merlin 0.165 0.109
MAPK15 N/A 0.165 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.109
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.072
SPTAN1 N/A 0.152 0.072
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.152 0.072
ARHGEF7 N/A 0.148 0.098
STAT3 0.148 0.878
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.098
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.148 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.878
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.148 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.075
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.980
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.044
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.044
ELMO1 N/A 0.148 0.098
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.148 0.098
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.148 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.098
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.148 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.044
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.143 0.0308
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.136 0.088
RDX RDX: Radixin 0.136 0.064
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.136 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.136 0.029
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.136 30.80
DAB1 DAB1: Disabled homolog 1 0.136 0.058
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.136 0.026
CDK5 CDK5: Cell division protein kinase 5 0.136 0.033
PLD1 PLD1: Phospholipase D1 0.136 0.064
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.136 0.026
TTN N/A 0.136 0.064
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.126 0.0794
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.126 0.049
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.125 0.033
CDKL5 N/A 0.123 0.037
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.123 0.072
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.037
COBL N/A 0.123 0.032
GRLF1 N/A 0.123 0.065
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.123 0.027
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.081
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.166
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.113 0.041
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.111 0.029
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.655
WEE1 WEE1: Wee1-like protein kinase 0.111 0.032
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.111 0.058
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.111 0.148
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.111 0.033
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.111 0.041
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.111 0.029
CDK2 CDK2: Cell division protein kinase 2 0.111 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.111 0.026
CDK4 CDK4: Cell division protein kinase 4 0.111 0.029
DAB2 DAB2, DOC2: Disabled homolog 2 0.111 0.181
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.111 0.033
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.111 0.029
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.111 0.029
STAM2 STAM2: Signal transducing adapter molecule 2 0.111 0.090
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.111 0.073
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.111 24.40
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.111 0.033
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.111 0.026
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.111 0.058
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.111 0.044
PSD TYL: TYL protein 0.111 0.058
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.111 0.051
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.111 0.067
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.111 0.058
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.111 0.029
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.110 0.0446
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.110 0.075
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.110 2.46
PRKAA1 N/A 0.110 0.032
VASP VASP: Vasodilator-stimulated phosphoprotein 0.110 0.274
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.110 2.46
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.110 0.340
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.165
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.165
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.083
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.083
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.165
NULL A1BG: Alpha-1B-glycoprotein precursor 0.109 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.165
KIR3DL1 N/A 0.109 0.165
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
FN1 N/A 0.109 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.165
IRS2 IRS2: Insulin receptor substrate 2 0.109 0.274
CNN3 CNN3: Calponin-3 0.109 0.072
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.109 0.0453
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.109
GAB2 N/A 0.109 0.274
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.072
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.109 0.032
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.100 0.109
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.109
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.100 0.098
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.100 0.041
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.099 0.0818
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.099 0.041
WASPIP N/A 0.099 0.067
PSCD4 PSCD4, CYT4: Cytohesin-4 0.099 0.245
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.099 0.148
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.099 0.245
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.099 0.113
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.099 0.041
VAV1 VAV1, VAV: Proto-oncogene vav 0.099 1.62
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.099 0.808
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.099 0.148
ATM ATM: Serine-protein kinase ATM 0.099 0.033
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.099 0.655
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.099 0.090
FNBP1 N/A 0.099 0.113
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.099 0.113
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.099 0.067
STAT6 STAT6: Signal transducer and activator of transcription 6 0.099 1.06E3
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.099 0.067
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.099 0.245
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.099 0.113
DOK1 DOK1: Docking protein 1 0.099 0.245
RPS6KB1 N/A 0.099 0.041
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.099 0.090
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.099 0.073
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.099 0.181
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.098 0.037
STK16 N/A 0.098 0.037
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.098 0.081
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.098 0.037
ROCK1 ROCK1: Rho-associated protein kinase 1 0.098 0.126
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.098 0.731
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.098 0.581
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.098 0.274
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.098 0.731
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.098 0.202
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.098 0.075
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.030
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.098 232.00
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.098 0.030
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.098 0.062
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.030
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 71.20
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.097 0.033
PLD2 PLD2: Phospholipase D2 0.097 0.064
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.064
RASA3 RASA3: Ras GTPase-activating protein 3 0.097 0.064
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.097 0.029
DYRK3 N/A 0.097 0.026
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.097 0.073
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.097 0.113
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.097 0.051
SORBS3 SORBS3, SCAM1: Vinexin 0.097 30.80
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.097 0.111
CRKL CRKL: Crk-like protein 0.097 388.00
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.097 0.041
CDK7 CDK7, MO15: Cell division protein kinase 7 0.097 0.029
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.097 0.067
TLN1 TLN1: Uncharacterized protein TLN1 0.097 0.181
CDK6 CDK6: Cell division protein kinase 6 0.097 0.0453
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.097 0.111
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.097 0.032
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.093 0.058
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.090 0.037
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.090 0.028
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.090 0.318
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.090 0.046
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.090 0.069
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.090 0.041
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.088 0.041
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.088 0.148
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.088 0.064
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.088 0.113
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.088 0.067
CD2AP CD2AP: CD2-associated protein 0.088 0.073
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.088 0.181
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.088 0.137
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.088 0.111
VIL2 N/A 0.088 0.113
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.088 0.073
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.088 0.274
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.088 0.069
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.088 0.026
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.088 0.148
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.088 0.064
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.088 0.064
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.088 0.051
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.088 0.113
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.088 0.029
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.088 0.051
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.088 0.051
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.088 0.090
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.088 0.041
CXorf9 N/A 0.088 0.181
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.088 1.16E3
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.088 0.0818
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.088 0.075
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.083 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.04
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.081 0.031
IL9R IL9R: Interleukin-9 receptor precursor 0.081 0.098
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.081 0.041
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.081 0.355
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.081 0.105
GHR GHR: Growth hormone receptor precursor 0.081 0.109
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.081 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.081 0.109
EPOR EPOR: Erythropoietin receptor precursor 0.081 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.081 0.623
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.080 0.072
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.078 0.037
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.041
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.078 0.181
STK10 STK10: Uncharacterized protein STK10 0.078 0.0818
MSN MSN: Moesin 0.078 0.181
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.073 0.088
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.073 0.037
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.073 0.063
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.073 0.111
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.0727 0.416
PLEK PLEK, P47: Pleckstrin 0.0727 0.128
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0727 1.00
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.0727 0.515
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.0727 0.852
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.0727 0.307
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.0727 0.416
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.0727 0.416
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.0727 0.251
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.0727 0.416
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.072 0.123
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.110
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.109
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.072 0.109
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.072 0.109
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.072 0.055
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.109
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.072 0.123
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.072 0.109
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.072 0.055
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.071 0.065
NCK2 NCK2: Cytoplasmic protein NCK2 0.070 388.00
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.069 0.027
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.109
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.067 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.067 0.109
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.065 0.461
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.065 0.071
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.065 0.318
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.065 0.109
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.109
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.065 0.152
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.152
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.065 0.109
F3 F3: Tissue factor precursor 0.065 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.065 0.152
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.515
CCR5 CCR5: CCR5 receptor (Fragment) 0.065 0.096
ETS2 ETS2: Protein C-ets-2 0.065 0.039
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.065 0.307
LILRB1 N/A 0.065 0.852
MCF2 MCF2, DBL: Proto-oncogene DBL 0.064 0.065
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.064 0.049
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.064 0.057
SOS1 SOS1: Son of sevenless homolog 1 0.064 0.046
HD HD, IT15: Huntingtin 0.062 0.037
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.060 0.065
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.058 0.152
STAT4 STAT4: Signal transducer and activator of transcription 4 0.058 0.318
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.058 353.00
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.225
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.058 0.307
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.057 0.064
DLG2 DLG2: Disks large homolog 2 0.057 0.064
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.057 0.049
MAP2K5 N/A 0.056 0.049
CNN2 CNN2: Calponin-2 0.056 0.109
PMP2 PMP2: Myelin P2 protein 0.056 0.027
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.056 0.0453
FUBP1 N/A 0.056 0.081
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.054 0.073
S100A16 S100A16, AAG13: Protein S100-A16 0.052 0.109
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.052 0.361
PTPRA N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
GRB10 N/A 0.051 0.617
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
UBAP2L N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.105
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.098
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.051 0.098
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.051 0.109
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.051 0.136
LDLR LDLR: Low-density lipoprotein receptor precursor 0.051 0.049
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.050 0.044
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.050 0.109
GMIP GMIP: GEM-interacting protein 0.050 0.304
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.049 0.081
SNCB SNCB: Beta-synuclein 0.048 0.072
S100A7 S100A7, PSOR1: Protein S100-A7 0.048 0.072
GJA5 GJA5: Gap junction alpha-5 protein 0.047 0.059
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.030
CDC25C CDC25C: M-phase inducer phosphatase 3 0.047 0.098
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.047 0.109
GSN GSN: Gelsolin precursor 0.047 0.036
CDC25A CDC25A: M-phase inducer phosphatase 1 0.047 0.098
SVIL SVIL: Supervillin 0.047 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.047 0.098
ACTN4 ACTN4: Alpha-actinin-4 0.047 0.098
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 265.00
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.046
RIN1 RIN1: Ras and Rab interactor 1 0.046 0.808
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.046 0.099
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.046 0.111
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.0453 0.109
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.0453 0.096
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.045 0.061
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.074
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.044 0.041
WWC2 WW and C2 domain containing 2 0.044 0.026
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.044 0.051
HDLBP HDLBP, HBP, VGL: Vigilin 0.044 0.027
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.044 0.067
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.044 0.027
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.044 0.054
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.044 0.165
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.044 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.044 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.044 0.165
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.044 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.044 0.165
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.044 0.025
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.043 0.058
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.043 0.073
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.043 0.072
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.042 0.034
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.0407 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.0407 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.0407 0.109
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0407 0.055
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.0407 0.109
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.041 0.028
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.041 0.0308
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.041 0.028
HPN HPN, TMPRSS1: Serine protease hepsin 0.041 0.062
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.041 0.0308
BSG N/A 0.040 0.148
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.040 0.062
CNTN4 CNTN4: Contactin-4 precursor 0.040 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.040 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 0.148
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.245
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.039 0.032
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.038 0.0338
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.038 0.0338
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.038 0.033
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.037 0.029
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.037 0.030
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.037 0.082
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.037 0.166
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.037 0.098
SELE SELE, ELAM1: E-selectin precursor 0.037 0.098
VWF VWF, F8VWF: von Willebrand factor precursor 0.037 0.090
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.037 0.033
MCOLN1 MCOLN1, ML4, MSTP080: Mucolipin-1 0.037 0.094
PTPRZ1 N/A 0.036 0.109
NEO1 NEO1, NGN: Neogenin precursor 0.036 0.099
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.036 0.030
CETN1 CETN1, CEN1, CETN: Centrin-1 0.036 0.0688
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.035 0.090
CHP CHP: Calcium-binding protein p22 0.035 0.148
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.035 0.064
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.035 0.274
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.034 0.561
CNN1 CNN1: Calponin-1 0.034 0.0338
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.034 0.566
CDC42EP3 CDC42EP3, BORG2, CEP3: Cdc42 effector protein 3 0.034 0.055
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.033 0.181
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.033 0.051
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.033 0.033
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.0333 0.034
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.033 0.202
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.033 0.098
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.033 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.251
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.033 0.062
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.033 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.033 0.098
SDC4 SDC4: Syndecan-4 precursor 0.033 0.028
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.033 0.049
MEP1B MEP1B: Meprin A subunit beta precursor 0.033 0.097
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.033 0.086
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.033 0.065
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.033 0.033
ATP2B1 N/A 0.032 0.062
ACTN1 ACTN1: Alpha-actinin-1 0.031 0.073
LCP1 LCP1, PLS2: Plastin-2 0.031 0.181
SEC24B SEC24B: Protein transport protein Sec24B 0.031 0.041
FLII FLII, FLIL: Protein flightless-1 homolog 0.031 0.0818
RYR2 RYR2: Ryanodine receptor 2 0.031 0.045
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.031 0.100
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.031 0.0446
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.0308 15.80
PLAT PLAT: Tissue-type plasminogen activator precursor 0.030 0.049
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.030 0.030
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.0296 0.064
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0296 0.181
DCC DCC: Netrin receptor DCC precursor 0.030 0.097
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.030 0.071
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.030 0.188
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.030 0.097
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.030 0.097
CD7 CD7: T-cell antigen CD7 precursor 0.029 0.123
SORL1 SORL1: Sortilin-related receptor precursor 0.029 0.307
CRLF3 N/A 0.029 0.307
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.029 0.123
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.029 0.191
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.029 0.077
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.029 0.114
ITGB7 ITGB7: Integrin beta-7 precursor 0.029 0.136
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.029 0.0425
ITGB4 N/A 0.029 0.123
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.123
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.029 0.109
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.029 0.307
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.029 0.191
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.029 0.139
PARVA PARVA, MXRA2: Alpha-parvin 0.029 0.029
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.028 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.028 0.049
F9 F9: Coagulation factor IX precursor 0.028 0.051
RYR1 0.028 0.041
C6 C6: Complement component C6 precursor 0.028 0.032
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.028 0.029
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.028 0.113
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.028 0.073
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.028 0.041
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.0273 0.053
CD44 N/A 0.027 0.210
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.0263 0.0971
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.026 0.251
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.026 0.251
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.026 0.035
FES N/A 0.0258 0.0258
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.026 0.037
C1R C1R: Complement C1r subcomponent precursor 0.025 0.032
C1S C1S: Complement C1s subcomponent precursor 0.025 0.032
CSH2 GH1: Somatotropin precursor 0.025 0.100
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.044
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.025 0.044
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.025 0.044
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
CFL2 CFL2: Cofilin-2 0.025 0.036
TSC2 TSC2, TSC4: Tuberin 0.025 0.049
MYO18A 0.025 0.049
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.025 0.044
0.572
Total Score 5.72E4