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Evidence of Interaction Between PDGFRB and SHC3

The interaction score between PDGFRB and SHC3 is 3.38E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PDGFRB and SHC3 = -0.09

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismPDGFRB OrthologueSHC3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00022296 0.132 IPI00217895 0.171
human IPI00027721 0.325 IPI00217895 0.171
human IPI00018335 1 IPI00217895 0.171
human IPI00021396 1 IPI00217895 0.171
human IPI00293565 0.322 IPI00217895 0.171
human IPI00005722 0.081 IPI00217895 0.171
human IPI00022296 0.132 IPI00643176 0.34
human IPI00027721 0.325 IPI00643176 0.34
human IPI00018335 1 IPI00643176 0.34
  • Y2H
  • InVitro
  • InVivo

Get References From PubMed
human IPI00021396 1 IPI00643176 0.34
  • Y2H

Get References From PubMed
human IPI00293565 0.322 IPI00643176 0.34
  • InVitro
  • InVivo

Get References From PubMed
human IPI00005722 0.081 IPI00643176 0.34
  • InVitro
  • InVivo

Get References From PubMed
worm P34892 0.084 Q9TYT3 0.34
worm O76698 1 Q9TYT3 0.34
worm Q21038 1 Q9TYT3 0.34
worm Q21041 1 Q9TYT3 0.34

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.58
Domains Domains present in PDGFRB and SHC3:
Domains in PDGFRBDomains in SHC3
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in PDGFRB and SHC3 are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001245 Tyrosine protein kinase IPR000980 SH2 motif 238.73
IPR001824 Receptor tyrosine kinase, class III IPR000980 SH2 motif 101.074
IPR007110 Immunoglobulin-like IPR000980 SH2 motif 94.9752
IPR001245 Tyrosine protein kinase IPR011993 PH_type. 88.2896
IPR008266 Tyrosine protein kinase, active site IPR011993 PH_type. 85.0032
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR003599 Immunoglobulin subtype IPR000980 SH2 motif 66.4833
IPR003598 Immunoglobulin C-2 type IPR000980 SH2 motif 64.7072
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR000980 SH2 motif 49.095
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR013151 Immunoglobulin. IPR000980 SH2 motif 36.9251
IPR011009 Protein kinase-like IPR011993 PH_type. 21.3114
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR011993 PH_type. 3.65681
IPR001824 Receptor tyrosine kinase, class III IPR011993 PH_type. 3.54397
IPR003599 Immunoglobulin subtype IPR011993 PH_type. 2.87015
IPR007110 Immunoglobulin-like IPR011993 PH_type. 1.73192
IPR013151 Immunoglobulin. IPR011993 PH_type. 0.399518
IPR011009 Protein kinase-like IPR006020 Phosphotyrosine interaction domain 0.203907
IPR003598 Immunoglobulin C-2 type IPR011993 PH_type. 0.0205778
IPR008266 Tyrosine protein kinase, active site IPR006020 Phosphotyrosine interaction domain 0.0178144
IPR001245 Tyrosine protein kinase IPR006020 Phosphotyrosine interaction domain 0.0104833
IPR000719 Protein kinase IPR006020 Phosphotyrosine interaction domain 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in PDGFRB
  • Yellow Domain is only present in SHC3
  • Green Domain is present in both PDGFRB and SHC3

 0.217
Post-translational Modifications

Protein: PDGFRB

PTMResidueReference
Dephosphorylation 562 PubMed, HPRD
Dephosphorylation 579 PubMed, HPRD
Dephosphorylation 740 PubMed, HPRD
Dephosphorylation 751 PubMed, HPRD
Dephosphorylation 771 PubMed, HPRD
Dephosphorylation 857 PubMed, HPRD
Dephosphorylation 1009 PubMed, HPRD
Dephosphorylation 1021 PubMed, HPRD
Phosphorylation 579 PubMed, HPRD
Phosphorylation 581 PubMed, HPRD
Phosphorylation 716 PubMed, HPRD
Phosphorylation 740 PubMed, HPRD
Phosphorylation 751 PubMed, HPRD
Phosphorylation 763 PubMed, HPRD
Phosphorylation 771 PubMed, HPRD
Phosphorylation 775 PubMed, HPRD
Phosphorylation 857 PubMed, HPRD
Phosphorylation 1009 PubMed, HPRD
Phosphorylation 1021 PubMed, HPRD
Phosphotyrosine 751 PubMed, HPRD
Phosphotyrosine 857 PubMed, HPRD

Protein: SHC3

PTMResidueReference
Localisation

Protein: PDGFRB

LocalisationReference
Plasma membrane HPRD

Protein: SHC3

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between PDGFRB and SHC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PDGFRB andSHC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PDGFRB has 1323 interactors and SHC3 has 346 interactors of which there are 156 common interactors.

Common InteractorName of Common InteractorScore for PDGFRB-Interactor (?)Score for SHC3-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.01E3 114.00
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 600.00 16.30
NCK2 NCK2: Cytoplasmic protein NCK2 600.00 7.56
CRKL CRKL: Crk-like protein 536.00 7.56
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 532.00 61.50
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 422.00 11.50
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 281.00 67.50
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 281.00 6.81
VAV1 VAV1, VAV: Proto-oncogene vav 281.00 7.67
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 277.00 74.90
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 277.00 0.177
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 250.00 6.81
JAK2 JAK2: Tyrosine-protein kinase JAK2 250.00 0.156
HCK N/A 250.00 67.50
STAT6 STAT6: Signal transducer and activator of transcription 6 250.00 7.67
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 232.00 9.04
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 183.00 207.00
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 137.00 5.94
GRAP GRAP: GRB2-related adapter protein 133.00 7.56
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 112.00 55.50
KIT KIT: Mast/stem cell growth factor receptor precursor 112.00 69.80
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 82.20 61.50
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 74.00 173.00
PRKCG PRKCG, PKCG: Protein kinase C gamma type 12.50 10.50
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 12.50 0.044
SPRED2 SPRED2: Sprouty-related, EVH1 domain-containing protein 2 5.94 0.028
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 1.13 0.157
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.265
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.265
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.027
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.237
BMX N/A 0.902 0.244
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.156
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.731 0.197
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.197
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.156
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.654 0.141
SYK SYK: Tyrosine-protein kinase SYK 0.654 0.141
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.654 0.141
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.644 0.156
JAK1 0.644 0.141
CSK CSK: Tyrosine-protein kinase CSK 0.586 0.141
LYN LYN: Tyrosine-protein kinase Lyn 0.586 0.141
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.581 0.157
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.581 0.174
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.520 67.50
ABL1 N/A 0.356 0.642
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.251 0.200
ABL2 N/A 0.234 0.479
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.217 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.217 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.217 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.217 0.027
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.171 55.50
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.217
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.195
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.217
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.217
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.152 0.251
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.195
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 93.60
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.195
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.136 0.128
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.136 0.145
INSR INSR: Insulin receptor precursor 0.136 61.50
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.136 0.145
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.136 0.115
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.136 0.145
FYN N/A 0.129 0.174
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.129 0.197
MET MET: Hepatocyte growth factor receptor precursor 0.123 0.162
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.053
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.115 0.074
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.111 0.145
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.111 0.128
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.111 0.145
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.027
PSCD2 N/A 0.109 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.027
CNN2 CNN2: Calponin-2 0.109 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.027
NF2 NF2, SCH: Merlin 0.109 0.027
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.109 0.039
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.109 0.361
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.098 0.039
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.126
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.237
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.128
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.097 0.145
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.097 0.490
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.090 0.036
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.090 0.028
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.088 0.035
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.088 0.128
SPTAN1 N/A 0.081 0.067
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.197
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.073 0.028
TLN2 TLN2: Uncharacterized protein TLN2 0.073 0.044
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.073 0.028
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.0308
GAB1 GAB1: GRB2-associated-binding protein 1 0.072 0.0308
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.0308
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.065 0.028
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.065 0.028
ALK ALK: ALK tyrosine kinase receptor precursor 0.064 0.094
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.064 0.036
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.064 0.044
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.063 0.032
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.060 0.145
PSD TYL: TYL protein 0.058 0.060
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.058 0.074
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.058 0.060
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.058 0.028
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.055 0.039
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.052 0.036
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.0288
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.0288
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.049 0.032
MT3 MT3: Metallothionein-3 0.049 0.083
MAP2K5 N/A 0.049 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.027
MAPK15 N/A 0.049 0.027
FLT4 VEGFR3 long form 0.046 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.0258
SOS1 SOS1: Son of sevenless homolog 1 0.046 5.35
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.041 0.028
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.041 0.129
SASH1 SASH1, KIAA0790, PEPE1: SAM and SH3 domain-containing protein 1 0.039 0.036
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.037 0.047
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.037 0.029
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.033 0.036
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.033 17.40
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.033 0.044
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.033 0.036
COBL N/A 0.032 0.050
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.029 0.028
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
FGFR2 N/A 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
CDK5 CDK5: Cell division protein kinase 5 0.026 0.060
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.026 0.044
FES N/A 0.0258 0.0258
0.572
Total Score 3.38E4