PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between PDGFRB and GRAP

The interaction score between PDGFRB and GRAP is 3.04E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between PDGFRB and GRAP = -0.17

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.48E-3

Orthology

Organism	PDGFRB Orthologue		GRAP Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00022296	0.132	IPI00299763	0.071
human	IPI00027721	0.325	IPI00299763	0.071
human	IPI00018335	1	IPI00299763	0.071
human	IPI00021396	1	IPI00299763	0.071
human	IPI00293565	0.322	IPI00299763	0.071
human	IPI00005722	0.081	IPI00299763	0.071
human	IPI00022296	0.132	IPI00472451	0.077
human	IPI00027721	0.325	IPI00472451	0.077
human	IPI00018335	1	IPI00472451	0.077
human	IPI00021396	1	IPI00472451	0.077
human	IPI00293565	0.322	IPI00472451	0.077
human	IPI00005722	0.081	IPI00472451	0.077
human	IPI00022296	0.132	IPI00410080	0.074
human	IPI00027721	0.325	IPI00410080	0.074
human	IPI00018335	1	IPI00410080	0.074
human	IPI00021396	1	IPI00410080	0.074
human	IPI00293565	0.322	IPI00410080	0.074
human	IPI00005722	0.081	IPI00410080	0.074
human	IPI00022296	0.132	IPI00013981	0.053	InVitro Get References From PubMed
human	IPI00027721	0.325	IPI00013981	0.053
human	IPI00018335	1	IPI00013981	0.053	InVivo Get References From PubMed
human	IPI00021396	1	IPI00013981	0.053	InVitro Get References From PubMed
human	IPI00293565	0.322	IPI00013981	0.053
human	IPI00005722	0.081	IPI00013981	0.053
human	IPI00022296	0.132	IPI00328867	0.05
human	IPI00027721	0.325	IPI00328867	0.05
human	IPI00018335	1	IPI00328867	0.05
human	IPI00021396	1	IPI00328867	0.05
human	IPI00293565	0.322	IPI00328867	0.05
human	IPI00005722	0.081	IPI00328867	0.05
human	IPI00022296	0.132	IPI00399054	0.058	InVitro InVivo Get References From PubMed
human	IPI00027721	0.325	IPI00399054	0.058	InVitro InVivo Get References From PubMed
human	IPI00018335	1	IPI00399054	0.058	InVitro Get References From PubMed
human	IPI00021396	1	IPI00399054	0.058	InVitro Get References From PubMed
human	IPI00293565	0.322	IPI00399054	0.058
human	IPI00005722	0.081	IPI00399054	0.058
worm	P34892	0.084	P29355	0.106
worm	O76698	1	P29355	0.106
worm	Q21038	1	P29355	0.106
worm	Q21041	1	P29355	0.106

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.58

Domains

Domains present in PDGFRB and GRAP:

Domains in PDGFRB

Domains in GRAP

IPR000719	Protein kinase
IPR001245	Tyrosine protein kinase
IPR008266	Tyrosine protein kinase, active site
IPR011009	Protein kinase-like
IPR003598	Immunoglobulin C-2 type
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like
IPR001824	Receptor tyrosine kinase, class III
IPR009134	Vascular endothelial growth factor receptor, VEGFR
IPR013151	Immunoglobulin.

IPR001452	SH3
IPR000108	Neutrophil cytosol factor 2
IPR000980	SH2 motif

The Chi square scores for co-occurrence of domains that are present in PDGFRB and GRAP are listed below.

Domain 1		Domain 2		Chi Square
IPR008266	Tyrosine protein kinase, active site	IPR000980	SH2 motif	383.26
IPR001245	Tyrosine protein kinase	IPR000980	SH2 motif	238.73
IPR008266	Tyrosine protein kinase, active site	IPR001452	SH3	164.706
IPR001824	Receptor tyrosine kinase, class III	IPR000980	SH2 motif	101.074
IPR001245	Tyrosine protein kinase	IPR001452	SH3	100.857
IPR007110	Immunoglobulin-like	IPR000980	SH2 motif	94.9752
IPR000719	Protein kinase	IPR000980	SH2 motif	82.1364
IPR003599	Immunoglobulin subtype	IPR000980	SH2 motif	66.4833
IPR003598	Immunoglobulin C-2 type	IPR000980	SH2 motif	64.7072
IPR011009	Protein kinase-like	IPR000980	SH2 motif	59.6059
IPR009134	Vascular endothelial growth factor receptor, VEGFR	IPR000980	SH2 motif	49.095
IPR008266	Tyrosine protein kinase, active site	IPR000108	Neutrophil cytosol factor 2	43.9279
IPR013151	Immunoglobulin.	IPR000980	SH2 motif	36.9251
IPR001824	Receptor tyrosine kinase, class III	IPR001452	SH3	32.2626
IPR000719	Protein kinase	IPR001452	SH3	27.1334
IPR003598	Immunoglobulin C-2 type	IPR001452	SH3	26.0449
IPR001245	Tyrosine protein kinase	IPR000108	Neutrophil cytosol factor 2	22.4767
IPR003599	Immunoglobulin subtype	IPR001452	SH3	22.2905
IPR011009	Protein kinase-like	IPR001452	SH3	20.4416
IPR007110	Immunoglobulin-like	IPR001452	SH3	20.3228
IPR013151	Immunoglobulin.	IPR001452	SH3	14.5395
IPR001824	Receptor tyrosine kinase, class III	IPR000108	Neutrophil cytosol factor 2	9.24001
IPR009134	Vascular endothelial growth factor receptor, VEGFR	IPR001452	SH3	8.64336
IPR000719	Protein kinase	IPR000108	Neutrophil cytosol factor 2	4.72045
IPR009134	Vascular endothelial growth factor receptor, VEGFR	IPR000108	Neutrophil cytosol factor 2	3.30483
IPR011009	Protein kinase-like	IPR000108	Neutrophil cytosol factor 2	2.89179
IPR007110	Immunoglobulin-like	IPR000108	Neutrophil cytosol factor 2	2.23913
IPR003599	Immunoglobulin subtype	IPR000108	Neutrophil cytosol factor 2	2.21022
IPR003598	Immunoglobulin C-2 type	IPR000108	Neutrophil cytosol factor 2	1.88257
IPR013151	Immunoglobulin.	IPR000108	Neutrophil cytosol factor 2	1.39708

The background colour of the table refers to:

Blue Domain is only present in PDGFRB
Yellow Domain is only present in GRAP
Green Domain is present in both PDGFRB and GRAP

0.217

Post-translational Modifications

Protein: PDGFRB

PTM	Residue	Reference
Dephosphorylation	562	PubMed, HPRD
Dephosphorylation	579	PubMed, HPRD
Dephosphorylation	740	PubMed, HPRD
Dephosphorylation	751	PubMed, HPRD
Dephosphorylation	771	PubMed, HPRD
Dephosphorylation	857	PubMed, HPRD
Dephosphorylation	1009	PubMed, HPRD
Dephosphorylation	1021	PubMed, HPRD
Phosphorylation	579	PubMed, HPRD
Phosphorylation	581	PubMed, HPRD
Phosphorylation	716	PubMed, HPRD
Phosphorylation	740	PubMed, HPRD
Phosphorylation	751	PubMed, HPRD
Phosphorylation	763	PubMed, HPRD
Phosphorylation	771	PubMed, HPRD
Phosphorylation	775	PubMed, HPRD
Phosphorylation	857	PubMed, HPRD
Phosphorylation	1009	PubMed, HPRD
Phosphorylation	1021	PubMed, HPRD
Phosphotyrosine	751	PubMed, HPRD
Phosphotyrosine	857	PubMed, HPRD

Protein: GRAP

PTM	Residue	Reference

Localisation

Protein: PDGFRB

Localisation	Reference
Plasma membrane	HPRD

Protein: GRAP

Localisation	Reference
Cytoplasm	HPRD

Transitive Score

The common interactors between PDGFRB and GRAP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PDGFRB andGRAP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PDGFRB has 1323 interactors and GRAP has 466 interactors of which there are 212 common interactors.

Common Interactor	Name of Common Interactor	Score for PDGFRB-Interactor (?)	Score for GRAP-Interactor (?)
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	1.01E3	114.00
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	600.00	31.80
NCK2	NCK2: Cytoplasmic protein NCK2	600.00	13.20
CRKL	CRKL: Crk-like protein	536.00	0.028
PDGFRA	PDGFRA: Alpha-type platelet-derived growth factor receptor precursor	532.00	55.50
GRB2	GRB2, ASH: Growth factor receptor-bound protein 2	422.00	2.04
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	372.00	0.029
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	281.00	0.218
GRAP2	GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2	281.00	0.036
VAV1	VAV1, VAV: Proto-oncogene vav	281.00	0.036
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	277.00	0.156
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	277.00	0.274
NCK1	NCK1, NCK: Cytoplasmic protein NCK1	250.00	0.028
JAK2	JAK2: Tyrosine-protein kinase JAK2	250.00	0.218
HCK	N/A	250.00	0.156
STAT6	STAT6: Signal transducer and activator of transcription 6	250.00	13.20
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	232.00	9.04
FLT1	FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor	183.00	147.00
SHC3	SHC3, NSHC, SHCC: SHC-transforming protein 3	147.00	7.56
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	137.00	2.13
CSF1R	CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor	112.00	61.50
KIT	KIT: Mast/stem cell growth factor receptor precursor	112.00	61.50
FRS3	FRS3: Fibroblast growth factor receptor substrate 3	84.00	8.58
KDR	KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor	82.20	0.128
PTK2	PTK2, FAK, FAK1: Focal adhesion kinase 1	74.00	76.00
SHC2	N/A	29.70	1.29
LOC392481	N/A	2.58	1.07
SHC4	SHC-transforming protein 4	2.58	1.07
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	1.13	0.174
PTPRS	N/A	1.07	1.07
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	0.980	0.027
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.980	0.265
LNK	SH2B3, LNK: SH2B adapter protein 3	0.980	0.027
PTPN6	PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6	0.980	0.027
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.980	0.265
SLA2	SLA2, C20orf156, SLAP2: Src-like-adapter 2	0.980	0.027
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.980	0.265
BMX	N/A	0.902	0.197
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.808	0.141
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.731	0.244
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.731	0.244
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.655	0.177
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.654	0.305
SYK	SYK: Tyrosine-protein kinase SYK	0.654	0.244
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.654	0.402
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.644	0.402
SOCS3	SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3	0.644	0.0308
JAK1		0.644	0.305
PLCG1	PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1	0.644	0.050
CSK	CSK: Tyrosine-protein kinase CSK	0.586	0.440
APS	SH2B2, APS: SH2B adapter protein 2	0.586	0.028
LYN	LYN: Tyrosine-protein kinase Lyn	0.586	0.218
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.581	0.402
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.581	0.0308
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.581	0.0308
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.581	0.197
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.520	0.360
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.360	0.032
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.318	2.98
STAT4	STAT4: Signal transducer and activator of transcription 4	0.286	0.035
SRMS	SRMS, C20orf148: Tyrosine-protein kinase Srms	0.265	0.265
TEK	TEK, TIE2: Angiopoietin-1 receptor precursor	0.251	0.129
CISH	CISH, G18: Cytokine-inducible SH2-containing protein	0.217	0.027
SOCS4	SOCS4, SOCS7: Suppressor of cytokine signaling 4	0.217	0.027
SH2D1B	SH2D1B, EAT2: SH2 domain-containing protein 1B	0.217	0.027
BRDG1	STAP1, BRDG1: Signal-transducing adaptor protein 1	0.217	0.027
ERBB2	ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor	0.171	0.128
FGFR3	FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor	0.165	0.217
RET	RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor	0.165	0.217
FGFR1	FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor	0.165	0.217
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.165	0.217
MERTK	MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor	0.152	0.145
EPHA8	EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor	0.148	0.195
EGFR	EGFR, ERBB1: Epidermal growth factor receptor precursor	0.148	0.195
ADAM33	ADAM33, UNQ873/PRO1891: ADAM 33 precursor	0.148	9.04
ERBB3	ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor	0.148	0.195
SOCS1	SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1	0.143	0.041
FGFR4	FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor	0.136	0.179
EPHB2	EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor	0.136	0.115
INSR	INSR: Insulin receptor precursor	0.136	61.50
EPHB3	EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor	0.136	0.128
EPHB4	EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor	0.136	0.145
IGF1R	IGF1R: Insulin-like growth factor 1 receptor precursor	0.136	0.115
FYN	N/A	0.129	0.305
SH2D1A	SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A	0.129	0.0308
MATK	DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212	0.129	0.305
VAV3	VAV3: Protein vav-3	0.128	0.028
CTTN	CTTN, EMS1: Src substrate cortactin	0.126	0.674
MET	MET: Hepatocyte growth factor receptor precursor	0.123	0.143
PTPN1	PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1	0.123	0.039
RIN3	N/A	0.115	0.028
MST1R	MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor	0.111	0.179
EPHA1	EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor	0.111	0.179
EPHB1	EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor	0.111	61.50
CD3D	CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor	0.110	0.032
HLA-DPB1	HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor	0.110	0.032
CD47	CD47, MER6: Leukocyte surface antigen CD47 precursor	0.110	0.032
AMPH	AMPH, AMPH1: Amphiphysin	0.109	0.027
ABI1	ABI1, SSH3BP1: Abl interactor 1	0.109	0.027
PSCD2	N/A	0.109	0.027
NEDD9	NEDD9, CASL: Enhancer of filamentation 1	0.109	0.027
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.109	0.027
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.109	0.027
DNM3	DNM3: Uncharacterized protein DNM3	0.109	0.027
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.109	0.027
NF2	NF2, SCH: Merlin	0.109	0.027
CD28	CD28: T-cell-specific surface glycoprotein CD28 precursor	0.109	0.032
ERBB4	ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor	0.109	0.145
ICAM2	ICAM2: Intercellular adhesion molecule 2 precursor	0.109	0.039
SLAMF1	SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor	0.098	0.032
CD79A	CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain	0.098	0.039
CD2	CD2, SRBC: T-cell surface antigen CD2 precursor	0.098	0.039
HLA-B	HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor	0.098	0.032
CD3E	CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor	0.098	0.032
HLA-G	HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec	0.098	0.032
HLA-A	HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor	0.098	0.032
HLA-DMA	DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP	0.098	0.032
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.098	0.0308
CD22	CD22, SIGLEC2: B-cell receptor CD22 precursor	0.098	0.032
CD3G	CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor	0.098	0.032
HLA-C	HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor	0.098	0.032
EPHA5	EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor	0.098	0.126
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.098	0.237
SH3KBP1	SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1	0.098	27.60
EPHA2	EPHA2, ECK: Ephrin type-A receptor 2 precursor	0.097	0.128
EPHA7	EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor	0.097	61.50
EPHA4	EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor	0.097	0.115
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.090	1.21
WASL	WASL: Neural Wiskott-Aldrich syndrome protein	0.090	4.72
FLT3	FLT3, STK1: FL cytokine receptor precursor	0.088	0.145
CRLF3	N/A	0.088	0.032
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.081	0.244
RASA3	RASA3: Ras GTPase-activating protein 3	0.073	0.028
EPS15L1	EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1	0.073	0.272
SORBS3	SORBS3, SCAM1: Vinexin	0.073	7.56
ROCK1	ROCK1: Rho-associated protein kinase 1	0.0727	0.0308
NCF1	Neutrophil cytosolic factor 1 variant (Fragment)	0.0727	0.0308
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.0727	0.0308
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.065	0.036
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.065	7.31
PSCD4	PSCD4, CYT4: Cytohesin-4	0.065	0.028
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.065	0.036
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.065	0.060
CD2AP	CD2AP: CD2-associated protein	0.065	0.028
FNBP1	N/A	0.065	1.93
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	0.065	7.31
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.065	0.036
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.065	0.028
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.065	0.028
CXorf9	N/A	0.065	0.036
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.065	0.0308
ALK	ALK: ALK tyrosine kinase receptor precursor	0.064	0.094
VIL2	N/A	0.064	0.036
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.064	0.028
ROR1	ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor	0.060	0.128
DOK1	DOK1: Docking protein 1	0.058	0.028
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.058	0.044
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.058	0.028
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.058	0.050
CXCR4	CXCR4: C-X-C chemokine receptor type 4	0.056	0.039
CCR5	CCR5: CCR5 receptor (Fragment)	0.056	0.032
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.052	0.036
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.052	1.02
EPHA3	EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor	0.051	0.0288
PTK7	PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor	0.051	0.0288
NTRK2	NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor	0.051	0.0288
NTRK1	NTRK1, TRK: High affinity nerve growth factor receptor precursor	0.051	0.0288
MS4A1	MS4A1, CD20: B-lymphocyte antigen CD20	0.049	0.032
MAP2K5	N/A	0.049	0.027
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.049	0.027
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.049	0.027
MAPK15	N/A	0.049	0.027
BCAR1	BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1	0.046	1.29
FLT4	VEGFR3 long form	0.046	0.0258
TNK2	TNK2, ACK1: Activated CDC42 kinase 1	0.046	0.0258
SOS1	SOS1: Son of sevenless homolog 1	0.046	2.44
PRKCQ	PRKCQ, PRKCT: Protein kinase C theta type	0.044	0.036
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.041	0.029
TIE1	TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor	0.041	0.162
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.033	0.050
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.033	0.050
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.033	0.028
STK16	N/A	0.032	0.0308
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.0308
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.041
PRKAA1	N/A	0.032	0.0308
CDK6	CDK6: Cell division protein kinase 6	0.032	0.0308
WASPIP	N/A	0.029	9.63
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.029	0.028
ATM	ATM: Serine-protein kinase ATM	0.029	0.060
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.029	0.028
STK10	STK10: Uncharacterized protein STK10	0.029	0.036
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.029	0.028
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.029	0.028
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.029	0.041
CDK4	CDK4: Cell division protein kinase 4	0.029	0.028
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.029	0.028
FES	Proto-oncogene c-fes variant 4	0.0288	0.0288
BTK	BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros	0.0288	0.0288
FES	FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps	0.0288	0.0288
FES	Proto-oncogene c-fes variant 3	0.0288	0.0288
BLK	BLK: Tyrosine-protein kinase BLK	0.0288	0.0288
MPP4	MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4	0.027	0.027
FGFR2	N/A	0.027	0.217
PTPRN2	PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor	0.027	0.027
CDK2	CDK2: Cell division protein kinase 2	0.026	0.028
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.026	0.036
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.026	0.036
RPS6KB1	N/A	0.026	0.044
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.026	0.036
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.026	0.028
FES	N/A	0.0258	0.0258

0.572

Total Score

3.04E4