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Evidence of Interaction Between RFC2 and RFC5

The interaction score between RFC2 and RFC5 is 7.31E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRFC2 OrthologueRFC5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YOL094C 1 YNL290W 1
  • Y2H
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • ReconstitutedComplex
  • CoFractionation

Get References From PubMed
worm O44175 1 P34429 1
  • Y2H
  • Other

Get References From PubMed
fly P53034 1 Q9VKW3 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in RFC2 and RFC5:
Domains in RFC2Domains in RFC5
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR000862 RFC
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C

The Chi square scores for co-occurrence of domains that are present in RFC2 and RFC5 are listed below.

Domain 1Domain 2Chi Square
IPR000862 RFC IPR008921 DNA polymerase III clamp loader subunit, C-terminal 1447.35
IPR000862 RFC IPR000862 RFC 1295.13
IPR000862 RFC IPR013748 Replication factor C 1125.48
IPR003959 AAA ATPase, central region IPR000862 RFC 182.174
IPR003959 AAA ATPase, central region IPR003959 AAA ATPase, central region 167.459
IPR003593 AAA ATPase IPR003959 AAA ATPase, central region 133.351
IPR003593 AAA ATPase IPR000862 RFC 128.851
IPR003593 AAA ATPase IPR003593 AAA ATPase 89.0695

The background colour of the table refers to:

  • Blue Domain is only present in RFC2
  • Yellow Domain is only present in RFC5
  • Green Domain is present in both RFC2 and RFC5

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC2

LocalisationReference
Nucleolus HPRD
Nucleoplasm HPRD

Protein: RFC5

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC2 and RFC5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC2 andRFC5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC2 has 46 interactors and RFC5 has 116 interactors of which there are 33 common interactors.

Common InteractorName of Common InteractorScore for RFC2-Interactor (?)Score for RFC5-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 62.80 691.00
RFC4 RFC4: Replication factor C subunit 4 62.80 691.00
PSMC4 PSMC4, MIP224, TBP7: 26S protease regulatory subunit 6B 6.33 6.33
PCNA PCNA: Proliferating cell nuclear antigen 4.98 54.70
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 3.48 0.0968
RFC1 N/A 0.354 1.10
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.354
H2AFX H2AFX, H2AX: Histone H2A.x 0.196 1.01
HIST1H2AC HIST1H2AC, H2AFL: Histone H2A type 1-C 0.196 0.146
POLA2 POLA2: DNA polymerase subunit alpha B 0.196 1.01
ASF1B ASF1B: Histone chaperone ASF1B 0.196 2.15
H2AFJ H2A histone family member J. 0.119 0.119
HIST3H2A HIST3H2A: Histone H2A type 3 0.039 0.039
HIST2H2AB HIST2H2AB: Histone H2A type 2-B 0.039 0.039
ASF1A ASF1A, CGI-98, HSPC146: Histone chaperone ASF1A 0.039 0.123
HIST1H2AG HIST1H2AH, HIST1H2AI: Histone H2A type 1-H 0.039 0.039
HIST1H2AA HIST1H2AA: Histone H2A type 1-A 0.039 0.039
HIST1H2AB N/A 0.039 0.0455
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.039 0.039
HIST1H2AK HIST1H2AJ, H2AFE: Histone H2A type 1-J 0.039 0.039
HIST1H2AG HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2A 0.039 0.0455
HIST2H2AA HIST2H2AA3, H2AFO, HIST2H2AA: Histone H2A type 2-A 0.039 0.039
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.0288
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.027 0.137
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.027 0.067
RAD51L1 RAD51L1, RAD51B, REC2: DNA repair protein RAD51 homolog 2 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD51L3 RAD51L3, RAD51D: DNA repair protein RAD51 homolog 4 0.027 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.137
SRPR SRPR: Uncharacterized protein SRPR 0.027 0.050
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.027 0.083
RAD17 RAD17, R24L: Cell cycle checkpoint protein RAD17 0.0258 0.0258
0.572
Total Score 7.31E4