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Evidence of Interaction Between CDK2 and KIAA0101

The interaction score between CDK2 and KIAA0101 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CDK2 and KIAA0101 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between CDK2 and KIAA0101 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CDK2 andKIAA0101. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CDK2 has 1600 interactors and KIAA0101 has 102 interactors of which there are 40 common interactors.

Common InteractorName of Common InteractorScore for CDK2-Interactor (?)Score for KIAA0101-Interactor (?)
CKS1B CKS1B, CKS1, PNAS-16, PNAS-143: Cyclin-dependent kinases regulatory subunit 1 33.10 0.027
MCM3 MCM3: DNA replication licensing factor MCM3 27.40 0.027
CCNB1 Cyclin B1 21.70 0.027
CKS2 CKS2: Cyclin-dependent kinases regulatory subunit 2 15.50 0.027
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 6.86 0.027
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 6.86 0.027
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 6.55 0.027
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 4.15 0.027
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.917 0.082
KIFC1 KIFC1, HSET, KNSL2: Kinesin-like protein KIFC1 0.614 0.027
MKI67 MKI67: Antigen KI-67 0.575 0.027
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.515 0.027
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.385 0.027
CDC20 CDC20: Cell division cycle protein 20 homolog 0.385 0.027
POLE2 POLE2, DPE2: DNA polymerase epsilon subunit 2 0.366 0.082
KIF11 N/A 0.276 0.082
PCNA PCNA: Proliferating cell nuclear antigen 0.276 0.082
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.276 0.027
CDK4 CDK4: Cell division protein kinase 4 0.276 0.027
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.269 0.027
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.263 0.027
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.144 0.027
MAD2L1 MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A 0.129 0.027
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.129 0.027
LIG1 LIG1: DNA ligase 1 0.129 0.027
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.129 0.027
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.129 0.027
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.129 0.027
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.129 0.027
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.027
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.129 0.027
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.027
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.129 0.027
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.101 0.027
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.053 0.027
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0479 0.082
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.038 0.027
C18orf56 N/A 0.027 0.082
ZWINT N/A 0.027 0.027
GMNN GMNN: Geminin 0.025 0.027
0.228
Total Score 2.50