PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between VPS4B and CHMP4C

The interaction score between VPS4B and CHMP4C is 2.02E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	VPS4B Orthologue		CHMP4C Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00411356	0.489	IPI00025974	0.157	Other Y2H InVivo Get References From PubMed
human	IPI00411356	0.489	IPI00023068	0.279	Y2H InVivo Get References From PubMed
bakers yeast	YPR173C	1	YLR025W	0.279	Y2H Other AffinityCaptureMS Get References From PubMed
worm	Q9BL83	1	Q18886	0.157
fly	Q9Y162	1	Q8T0Q4	0.246

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01

Domains

No domains were used in calculating likelihood of interaction

0.141

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

Protein: VPS4B

Localisation	Reference
Endosome	HPRD
Vacuole	HPRD
Cytoplasm	HPRD

Protein: CHMP4C

Localisation	Reference
Cytosol	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between VPS4B and CHMP4C that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between VPS4B andCHMP4C. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , VPS4B has 94 interactors and CHMP4C has 25 interactors of which there are 15 common interactors.

Common Interactor	Name of Common Interactor	Score for VPS4B-Interactor (?)	Score for CHMP4C-Interactor (?)
CHMP4A	N/A	171.00	319.00
CHMP4B	CHMP4B, C20orf178, SHAX1: Charged multivesicular body protein 4b	169.00	319.00
CHMP6	CHMP6, VPS20: Charged multivesicular body protein 6	83.90	319.00
PDCD6IP	PDCD6IP, AIP1, ALIX, KIAA1375: Programmed cell death 6-interacting protein	1.84	0.143
CHMP1B	CHMP1B, C18orf2: Charged multivesicular body protein 1b	0.724	0.265
VPS24	VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3	0.606	169.00
CHMP7	CHMP7: Charged multivesicular body protein 7	0.438	0.265
CHMP2B	CHMP2B, CGI-84: Charged multivesicular body protein 2b	0.392	0.237
CHMP2A	CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a	0.392	12.60
CHMP5	CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul	0.317	0.237
LOC283683	N/A	0.119	0.064
SRPR	SRPR: Uncharacterized protein SRPR	0.067	0.027
VPS4A	VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A	0.044	3.58
PCOLN3	CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a	0.0288	0.0288
FBXO34	CGI-301: Protein CGI-301	0.0288	0.0288

0.299

Total Score

2.02E4