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Evidence of Interaction Between GNAO1 and SSTR2

The interaction score between GNAO1 and SSTR2 is 1.58E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismGNAO1 OrthologueSSTR2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00337415 0.544 IPI00306173 0.296
human IPI00337415 0.544 IPI00030283 0.332
  • InVitro
  • InVivo

Get References From PubMed
human IPI00337415 0.544 IPI00018079 0.386
human IPI00337415 0.544 IPI00298305 0.142
  • InVivo

Get References From PubMed
human IPI00337415 0.544 IPI00012736 0.125
human IPI00337415 0.544 IPI00017705 0.075
human IPI00337415 0.544 IPI00645316 0.149
human IPI00337415 0.544 IPI00470664 0.123
human IPI00337415 0.544 IPI00514084 0.164
  • InVivo

Get References From PubMed
human IPI00337415 0.544 IPI00419835 0.157
worm P51875 1 Q23033 1
fly P16378 1 Q8IQS9 1
fly P16378 1 Q9VVQ1 0.254

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in GNAO1 and SSTR2:
Domains in GNAO1Domains in SSTR2
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR011025 Transducin, alpha subunit, insertion
IPR000276 Rhodopsin-like GPCR superfamily
IPR000586 Somatostatin receptor
IPR002074 Somatostatin receptor, type 2

The Chi square scores for co-occurrence of domains that are present in GNAO1 and SSTR2 are listed below.

Domain 1Domain 2Chi Square
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit IPR000276 Rhodopsin-like GPCR superfamily 1146.41
IPR011025 Transducin, alpha subunit, insertion IPR000276 Rhodopsin-like GPCR superfamily 1012.26
IPR001408 G-protein alpha subunit, group I IPR000276 Rhodopsin-like GPCR superfamily 485.37

The background colour of the table refers to:

  • Blue Domain is only present in GNAO1
  • Yellow Domain is only present in SSTR2
  • Green Domain is present in both GNAO1 and SSTR2

 0.265
Post-translational Modifications

Protein: GNAO1

PTMResidueReference
ADP-ribosylarginine 178 PubMed, HPRD
ADP-ribosylcysteine 350 PubMed, HPRD

Protein: SSTR2

PTMResidueReference
Localisation

Protein: GNAO1

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: SSTR2

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between GNAO1 and SSTR2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between GNAO1 andSSTR2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , GNAO1 has 1138 interactors and SSTR2 has 97 interactors of which there are 26 common interactors.

Common InteractorName of Common InteractorScore for GNAO1-Interactor (?)Score for SSTR2-Interactor (?)
RGS20 RGS20, RGSZ1, ZGAP1: Regulator of G-protein signaling 20 93.60 9.04
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 33.70 173.00
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 33.70 105.00
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 33.70 182.00
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 33.70 105.00
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 33.70 85.00
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 33.70 85.00
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 1.33 105.00
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.878 5.94
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.714 0.177
GNAI2 Galphai2 protein 0.714 0.158
KLHL2 KLHL2: Uncharacterized protein KLHL2 0.356 0.356
KLHL17 KLHL17: Kelch-like protein 17 0.356 0.356
HTR1F HTR1F, HTR1EL: 5-hydroxytryptamine receptor 1F 0.265 0.027
ADORA3 ADORA3, UNQ1931/PRO4406: Adenosine A3 receptor 0.265 0.027
HTR2A HTR2A, HTR2: 5-hydroxytryptamine receptor 2A 0.237 0.036
ADORA1 ADORA1: Adenosine receptor A1 0.237 0.028
RGS17 RGS17: Regulator of G-protein signaling 17 0.195 0.029
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.036 3.30
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.036 2.57
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.028 0.402
GNAL GNAL: Guanine nucleotide-binding protein G(olf) subunit alpha 0.028 0.305
GNAS GNAS, GNAS1, GSP: Guanine nucleotide-binding protein G(s) subunit alpha isoforms 0.028 0.265
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.028 0.176
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.025 0.177
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.025 0.177
0.347
Total Score 1.58E4