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Evidence of Interaction Between HMGCL and APOC4

The interaction score between HMGCL and APOC4 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HMGCL and APOC4 = 0.87

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between HMGCL and APOC4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HMGCL andAPOC4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HMGCL has 24 interactors and APOC4 has 151 interactors of which there are 17 common interactors.

Common InteractorName of Common InteractorScore for HMGCL-Interactor (?)Score for APOC4-Interactor (?)
HPD HPD, PPD: 4-hydroxyphenylpyruvate dioxygenase 0.0739 0.082
ALDOB ALDOB, ALDB: Fructose-bisphosphate aldolase B 0.0739 0.027
CYP4A22 CYP4A22, RP1-18D14.1-001: Cytochrome P450 4A22. 0.0739 0.082
CGREF1 CGREF1: Uncharacterized protein CGREF1 0.049 0.082
ASL ASL: Argininosuccinate lyase 0.049 0.082
ECHS1 ECHS1: Enoyl-CoA hydratase, mitochondrial precursor 0.044 0.027
TST TST: Thiosulfate sulfurtransferase 0.044 0.030
PCK2 PCK2, PEPCK2: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor 0.044 0.027
ACOX2 ACOX2, hCG_22723: Uncharacterized protein ACOX2 0.044 0.027
C4B C4B, XXbac-BCX116I9.7-001, XXbac-BPG116M5.7-001: C4B1 0.027 0.027
RARRES2 RARRES2, TIG2: Retinoic acid receptor responder protein 2 precursor 0.027 0.027
GAMT GAMT, hCG_21569: cDNA FLJ76206, highly similar to Homo sapiens guanidinoacetate 0.027 0.082
SAA4 SAA4, CSAA: Serum amyloid A-4 protein precursor 0.027 0.160
TM4SF5 TM4SF5: Transmembrane 4 L6 family member 5 0.027 0.027
SPP2 SPP2, SPP24: Secreted phosphoprotein 24 precursor 0.027 0.027
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.027 0.053
LR8 TMEM176B, LR8: Transmembrane protein 176B 0.027 0.027
0.228
Total Score 2.50