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Evidence of Interaction Between MTDH and PABPN1

The interaction score between MTDH and PABPN1 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MTDH and PABPN1 = 0.88

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MTDH and PABPN1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MTDH andPABPN1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MTDH has 248 interactors and PABPN1 has 1186 interactors of which there are 113 common interactors.

Common InteractorName of Common InteractorScore for MTDH-Interactor (?)Score for PABPN1-Interactor (?)
CDV3 CDV3, H41: Protein CDV3 homolog 0.082 0.0479
C14orf32 N/A 0.082 0.027
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.082 0.081
P15 SUB1, PC4, RPO2TC1: Activated RNA polymerase II transcriptional coactivator p15 0.082 0.0479
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.082 0.276
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.082 4.88
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.027 0.066
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.027 0.276
TARDBP TARDBP, TDP43: TAR DNA-binding protein 43 0.027 0.789
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.027 0.435
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.027 0.066
SFRS2IP SFRS2IP, CASP11, SIP1: SFRS2-interacting protein 0.027 0.025
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.027 1.62
PDF PDF, PDF1A: Peptide deformylase, mitochondrial precursor 0.027 0.027
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.027 0.276
HNRPU N/A 0.027 0.044
RBBP6 N/A 0.027 0.027
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.027 0.385
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.027 1.62
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.027 1.81
QARS QARS: Glutaminyl-tRNA synthetase 0.027 0.141
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.027 0.042
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.027 1.62
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.027 0.276
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.027 0.394
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.027 0.917
DDX47 E4-DBP: DEAD box protein 0.027 0.081
HNRPDL N/A 0.027 0.263
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.027 0.081
MBD4 MBD4, MED1: Methyl-CpG-binding domain protein 4 0.027 0.042
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.027 0.575
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.027 0.276
ANP32A ANP32A, C15orf1, LANP, MAPM, PHAP1: Acidic leucine-rich nuclear phosphoprotein 3 0.027 0.081
RBM25 RBM25, RNPC7: Probable RNA-binding protein 25 0.027 0.507
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.027 0.185
HRB2 KRR1, HRB2: KRR1 small subunit processome component homolog 0.027 1.07
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.129
SART3 SART3, KIAA0156, TIP110: Squamous cell carcinoma antigen recognized by T-cells 3 0.027 0.263
PPARBP N/A 0.027 0.141
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.027 0.090
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.027 0.129
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.027 0.515
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.053
COPS2 N/A 0.027 0.042
LOC653118 N/A 0.027 0.027
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.027 1.62
KIAA0863 ADNP2, KIAA0863, ZNF508: ADNP homeobox protein 2 0.027 0.027
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.027 0.822
NBN NBN, NBS, NBS1, P95: Nibrin 0.027 0.144
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.027 0.066
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.027 0.129
MAGOH MAGOH: Protein mago nashi homolog 0.027 0.030
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.027 0.038
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.027 0.763
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.027 1.71
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.027 0.822
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.027 0.276
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.027 0.141
DDX21 DDX21: Nucleolar RNA helicase 2 0.027 0.917
KIAA1012 KIAA1012: Protein TRS85 homolog 0.027 0.276
FNBP1 N/A 0.027 0.129
RNF138 N/A 0.027 0.027
CLIC1 CLIC1, NCC27: Chloride intracellular channel protein 1 0.027 0.137
OFD1 OFD1, CXorf5: Oral-facial-digital syndrome 1 protein 0.027 0.027
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.027 0.051
UBE1 UBE1, A1S9T: Ubiquitin-activating enzyme E1 0.027 0.0479
HNRPA3 HNRPA3: Heterogeneous nuclear ribonucleoprotein A3 0.027 0.263
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.027 0.038
SUMO2 SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor 0.027 0.038
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.027 0.276
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.057
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.027 0.129
LRRFIP1 N/A 0.027 0.025
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.027 0.081
THOC2 N/A 0.027 0.0479
HNRPM N/A 0.027 0.049
HMGN4 HMGN4, HMG17L3, NHC: High mobility group nucleosome-binding domain-containing pr 0.027 0.137
EIF3S7 EIF3S7: Eukaryotic translation initiation factor 3 subunit 7 0.027 0.0479
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.027 0.276
SFPQ SFPQ, PSF: Splicing factor, proline- and glutamine-rich 0.027 0.263
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.027 0.141
NCBP2 NCBP2, CBP20, PIG55: Nuclear cap-binding protein subunit 2 0.027 0.263
HNRPK N/A 0.027 0.141
HNRPD N/A 0.027 0.027
DCLRE1C N/A 0.027 0.025
PTMA N/A 0.027 0.307
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.027 0.090
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.027 0.385
SYK SYK: Tyrosine-protein kinase SYK 0.027 0.040
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.027 0.328
SFRS3 SFRS3, SRP20: Splicing factor, arginine/serine-rich 3 0.027 0.263
NONO NONO, NRB54: Non-POU domain-containing octamer-binding protein 0.027 0.263
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.027 1.62
CPSF6 CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6 0.027 0.293
C20orf6 ESF1, ABTAP, HDCMC28P, C20orf6: ESF1 homolog 0.027 0.507
SCC-112 N/A 0.027 0.081
PMS2L3 PMS2L3: Uncharacterized protein PMS2L3 0.027 0.027
CBFB Core binding factor beta isoform PEBP2B 0.027 0.027
YY1 YY1: Transcriptional repressor protein YY1 0.027 0.276
ELF1 ELF1: ETS-related transcription factor Elf-1 0.027 0.144
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.027 0.038
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.027 0.276
RPS23 RPS23: 40S ribosomal protein S23 0.027 0.038
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.027 0.852
EIF3S10 EIF3S10, KIAA0139: Eukaryotic translation initiation factor 3 subunit 10 0.027 0.042
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.027 1.62
IFI16 N/A 0.027 0.144
BCLAF1 BTF, BCLAF1, KIAA0164: Bcl-2-associated transcription factor 1 0.027 0.053
PSME2 PSME2: Proteasome activator complex subunit 2 0.027 0.025
YTHDF2 YTHDF2, HGRG8: YTH domain family protein 2 0.027 0.0479
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.027 0.057
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.027 1.62
MTIF2 MTIF2: Translation initiation factor IF-2, mitochondrial precursor 0.027 0.043
0.228
Total Score 2.50