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Evidence of Interaction Between MSH6 and BUB3

The interaction score between MSH6 and BUB3 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MSH6 and BUB3 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MSH6 and BUB3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MSH6 andBUB3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MSH6 has 857 interactors and BUB3 has 258 interactors of which there are 87 common interactors.

Common InteractorName of Common InteractorScore for MSH6-Interactor (?)Score for BUB3-Interactor (?)
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 37.30 0.027
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 1.82 0.027
CBX3 CBX3: Chromobox protein homolog 3 1.62 0.027
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.923 0.027
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.917 0.027
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.852 0.027
MCM3 MCM3: DNA replication licensing factor MCM3 0.827 0.027
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.763 0.027
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.027
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.307 0.027
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.276 0.027
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.276 0.027
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.027
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.276 0.027
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 0.027
SSB SSB: Lupus La protein 0.276 0.027
NUP153 N/A 0.276 0.027
POLA2 POLA2: DNA polymerase subunit alpha B 0.276 0.027
ABCF1 N/A 0.144 0.027
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.027
DDX21 DDX21: Nucleolar RNA helicase 2 0.144 0.027
PTMA N/A 0.144 0.027
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.141 0.027
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.141 0.027
CCT8 CCT8: Uncharacterized protein CCT8 0.141 0.027
XPO1 XPO1, CRM1: Exportin-1 0.141 0.027
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.141 0.027
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.141 0.027
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.141 0.027
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.141 0.027
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.027
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.129 0.027
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.027
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.129 0.027
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.129 0.027
TP53 TP53, P53: Cellular tumor antigen p53 0.129 0.027
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.027
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.027
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.129 0.027
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.027
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.082
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.129 0.027
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.129 0.027
TIAL1 TIAL1: Nucleolysin TIAR 0.129 0.027
NOL1 N/A 0.129 0.027
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.027
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.129 0.027
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.087 0.027
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.078 0.027
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.078 0.027
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.027
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.027
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.027
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.027
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.027
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.066 0.027
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.066 0.027
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.066 0.027
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.066 0.027
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.027
CDC23 CDC23: Cell division cycle protein 23 homolog 0.066 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.053 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.027
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.048 0.027
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.048 0.027
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.048 0.027
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 0.048 0.027
RAD21 RAD21, HR21, KIAA0078, NXP1: Double-strand-break repair protein rad21 homolog 0.0479 0.027
DKC1 DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4 0.0479 0.027
PRMT5 PRMT5, HRMT1L5, IBP72, JBP1, SKB1: Protein arginine N-methyltransferase 5 0.0479 0.027
SLBP SLBP, HBP: Histone RNA hairpin-binding protein 0.0479 0.027
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0479 0.027
FUBP1 N/A 0.0446 0.027
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.027
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.040 0.027
HNRPK N/A 0.040 0.027
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.040 0.027
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.037 0.027
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.033 0.082
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.033 0.027
TCP1 CCT1, CCTA, TCP1: T-complex protein 1 subunit alpha 0.033 0.027
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
E2IG3 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
SERBP1 N/A 0.027 0.027
PAICS PAICS, ADE2, AIRC, PAIS: Multifunctional protein ADE2 [Includes: Phosphoribosyla 0.027 0.027
0.228
Total Score 2.50