PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between EIF3S9 and EIF3S8

The interaction score between EIF3S9 and EIF3S8 is 2.39E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between EIF3S9 and EIF3S8 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	EIF3S9 Orthologue		EIF3S8 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YOR361C	1	YMR309C	1	Other AffinityCaptureMS AffinityCaptureWestern CoPurification Get References From PubMed
worm	Q9XWI6	1	O02328	1
fly	Q9V837	1	Q8MR49	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in EIF3S9 and EIF3S8:

Domains in EIF3S9

Domains in EIF3S8

IPR000504	RNA-binding region RNP-1 (RNA recognition motif)
IPR012677	a_b_plait_nuc_bd.
IPR011400	eIF3b.

IPR000717	Proteasome component region PCI
IPR008905	Eukaryotic translation initiation factor 3 subunit 8, N-terminal

The Chi square scores for co-occurrence of domains that are present in EIF3S9 and EIF3S8 are listed below.

Domain 1		Domain 2		Chi Square
IPR000504	RNA-binding region RNP-1 (RNA recognition motif)	IPR000717	Proteasome component region PCI	10.865
IPR012677	a_b_plait_nuc_bd.	IPR000717	Proteasome component region PCI	10.3587

The background colour of the table refers to:

Blue Domain is only present in EIF3S9
Yellow Domain is only present in EIF3S8
Green Domain is present in both EIF3S9 and EIF3S8

0.040

Post-translational Modifications

Protein: EIF3S9

PTM	Residue	Reference
Phosphorylation	83	PubMed, HPRD
Phosphorylation	85	PubMed, HPRD
Phosphorylation	125	PubMed, HPRD
Phosphoserine	83	HPRD
Phosphoserine	85	HPRD
Phosphoserine	125	HPRD

Protein: EIF3S8

PTM	Residue	Reference
Phosphorylation	166	PubMed, HPRD
Phosphorylation	524	PubMed, HPRD
Phosphorylation	909	PubMed, HPRD
Phosphoserine	166	HPRD
Phosphothreonine	524	HPRD

Localisation

Protein: EIF3S9

Localisation	Reference
Cytoplasm	HPRD
Ribosome	HPRD

Protein: EIF3S8

Localisation	Reference
Cytoplasm	HPRD

Transitive Score

The common interactors between EIF3S9 and EIF3S8 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EIF3S9 andEIF3S8. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EIF3S9 has 1144 interactors and EIF3S8 has 1028 interactors of which there are 650 common interactors.

Common Interactor	Name of Common Interactor	Score for EIF3S9-Interactor (?)	Score for EIF3S8-Interactor (?)
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	217.00	0.066
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	122.00	48.90
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	102.00	10.50
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	73.00	10.50
CSNK2A1	CSNK2A1: CSNK2A1 protein	73.00	0.129
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	60.10	16.60
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	60.10	34.20
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	49.80	6.31
EIF5	EIF5: Eukaryotic translation initiation factor 5	30.70	3.59
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	20.60	8.55
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	17.50	0.078
EIF3S10	EIF3S10, KIAA0139: Eukaryotic translation initiation factor 3 subunit 10	11.10	323.00
RPS10	RPS10: 40S ribosomal protein S10	10.50	0.078
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	10.00	2.12
OSBP	OSBP, OSBP1: Oxysterol-binding protein 1	8.55	0.063
CSNK2B	CSNK2B, CK2N, G5A: Casein kinase II subunit beta	5.94	5.94
ACTN4	ACTN4: Alpha-actinin-4	3.06	0.025
HAT1	HAT1: Histone acetyltransferase type B catalytic subunit	3.05	1.84
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	1.81	0.206
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	1.62	0.066
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	1.62	0.394
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	1.62	0.185
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	1.62	0.185
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	1.62	0.185
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	1.62	0.185
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	1.62	0.185
SSB	SSB: Lupus La protein	1.62	0.185
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	1.62	0.066
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	1.62	0.276
ITGB4BP	ITGB4BP, EIF3A, OK/SW-cl.27, EIF6: Eukaryotic translation initiation factor 6	1.15	1.15
EIF1B	EIF1B: Eukaryotic translation initiation factor 1b	1.10	1.10
XPO1	XPO1, CRM1: Exportin-1	1.07	0.129
DDX21	DDX21: Nucleolar RNA helicase 2	0.917	0.074
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.852	0.206
RBM14	RBM14, SIP: RNA-binding protein 14	0.852	0.206
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.822	0.040
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.822	0.066
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.763	0.112
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.763	0.185
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.763	0.185
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.763	0.394
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.763	0.078
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.763	0.032
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.763	0.185
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.763	0.066
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.763	0.185
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.763	0.185
TIAL1	TIAL1: Nucleolysin TIAR	0.763	0.112
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.763	0.185
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.704	0.093
RPS7	RPS7: 40S ribosomal protein S7	0.614	1.84
RPS8	RPS8, OK/SW-cl.83: 40S ribosomal protein S8	0.593	0.593
RPS15A	RPS15A, OK/SW-cl.82: 40S ribosomal protein S15a	0.593	0.593
EIF1	EIF1, SUI1: Eukaryotic translation initiation factor 1	0.583	0.722
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.575	0.157
FUBP1	N/A	0.561	0.087
U2AF1	U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit	0.549	0.0262
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.515	0.206
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.515	0.074
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.515	0.206
MATR3	MATR3, KIAA0723: Matrin-3	0.515	0.125
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.515	0.125
ARS2	ARS2, ASR2: Arsenite-resistance protein 2	0.507	0.027
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.503	0.146
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.484	0.078
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.461	0.040
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.461	0.112
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.461	0.185
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.206
GNB2L1	Lung cancer oncogene 7	0.430	0.074
TCOF1	N/A	0.430	0.036
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.416
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.430	0.0446
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.430	0.0446
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.416	0.101
RBM6	RBM6, DEF3: RNA-binding protein 6	0.416	0.061
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.385	0.129
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.385	0.040
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.385	0.040
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.385	0.040
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.385	0.040
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.385	0.040
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.372	0.067
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.372	0.040
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.372	0.090
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.372	0.090
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.372	0.090
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.372	0.090
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.372	0.090
IPO7	IPO7: Uncharacterized protein IPO7	0.340	0.052
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.307	0.074
UBAP2	N/A	0.307	0.087
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.307	0.144
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.307	0.074
DNMT1	DNMT1, AIM, DNMT: DNA	0.307	0.0446
PTMA	N/A	0.307	0.074
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.307	0.206
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.304	0.129
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.304	0.129
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.304	0.078
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.304	0.078
CPSF6	CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6	0.293	0.0471
CBX3	CBX3: Chromobox protein homolog 3	0.276	0.066
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.276	0.032
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.276	0.066
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.276	0.040
LIG1	LIG1: DNA ligase 1	0.276	0.032
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.276	0.066
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.276	0.066
NOL1	N/A	0.276	0.040
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.066
NPM1	NPM1, NPM: Nucleophosmin	0.276	0.040
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.276	0.040
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.276	0.066
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.276	0.040
CDK4	CDK4: Cell division protein kinase 4	0.276	0.129
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.276	0.763
BRPF1	BRPF1, BR140: Peregrin	0.275	0.046
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.275	0.090
RBM7		0.275	0.067
CSDA	CSDA, DBPA: DNA-binding protein A	0.275	0.038
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.269	0.070
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.260	0.087
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.260	0.036
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.251	0.037
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.040
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.040
MCM3	MCM3: DNA replication licensing factor MCM3	0.241	0.066
NOLC1	NOLC1, KIAA0035: Nucleolar phosphoprotein p130	0.241	0.025
RBM25	RBM25, RNPC7: Probable RNA-binding protein 25	0.237	0.027
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.233	0.040
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.233	0.032
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.233	0.461
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.233	0.040
SYMPK	SYMPK, SPK: Symplekin	0.233	0.078
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.233	0.032
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.227	0.078
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.227	0.078
EEF2	EEF2, EF2: Elongation factor 2	0.227	0.129
HTATSF1	HTATSF1: HIV Tat-specific factor 1	0.225	0.054
GRLF1	N/A	0.191	0.026
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.188	0.063
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.188	0.054
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.188	0.032
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.188	0.040
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.188	0.063
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.188	0.032
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.185	6.03
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.185	6.03
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.185	3.64
HDLBP	HDLBP, HBP, VGL: Vigilin	0.181	0.046
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.165	0.04
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.165	0.04
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.165	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.165	0.04
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.155	0.032
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.153	0.515
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.148	0.036
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.148	0.036
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.148	0.047
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.148	0.036
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.148	0.036
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.148	0.036
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.148	0.036
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.148	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.148	0.036
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.148	0.036
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.148	0.036
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.148	0.036
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.148	0.036
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.146	0.078
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.144	0.036
SET	SET: Protein SET	0.144	0.0446
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.144	0.027
ABCF1	N/A	0.144	0.144
C20orf6	ESF1, ABTAP, HDCMC28P, C20orf6: ESF1 homolog	0.143	0.027
SAFB2	SAFB2, KIAA0138: Scaffold attachment factor B2	0.143	0.027
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.141	0.078
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.141	0.078
CCT8	CCT8: Uncharacterized protein CCT8	0.141	0.078
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.141	0.078
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.141	0.129
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.141	0.078
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.141	0.129
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.141	0.129
QARS	QARS: Glutaminyl-tRNA synthetase	0.141	0.276
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.139	0.063
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.139	0.040
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.139	2.12
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.139	0.032
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.137	0.063
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.137	0.078
PLEK	PLEK, P47: Pleckstrin	0.132	0.0446
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.132	0.124
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.129	0.040
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.066
TP53	TP53, P53: Cellular tumor antigen p53	0.129	0.503
YY1	YY1: Transcriptional repressor protein YY1	0.129	0.066
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.129	0.129
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.129	0.066
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.129	0.141
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.129	0.040
PCNA	PCNA: Proliferating cell nuclear antigen	0.129	0.032
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.129	0.040
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.129
POLA2	POLA2: DNA polymerase subunit alpha B	0.129	0.066
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.129	0.129
NUP153	N/A	0.129	0.040
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.066
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.129	0.040
HDAC2	HDAC2: Histone deacetylase 2	0.129	0.040
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.032
H2AFX	H2AFX, H2AX: Histone H2A.x	0.129	0.032
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.129	0.063
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.129	0.040
PPP1R8	N/A	0.129	0.040
MTA1	MTA1: Metastasis-associated protein MTA1	0.129	0.040
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.129	0.066
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.129	0.063
UNG	N/A	0.129	0.040
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.129	0.066
CDK2	CDK2: Cell division protein kinase 2	0.129	0.063
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.129	0.040
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.129	0.066
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.129	0.066
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.129	0.066
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.129
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.129	0.066
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.129	0.066
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.127	0.152
YWHAQ	YWHAQ: 14-3-3 protein theta	0.125	0.087
HD	HD, IT15: Huntingtin	0.124	0.260
NULL	N/A	0.119	0.119
LOC388076	similar to ribosomal protein S8 isoform 2	0.119	0.119
LOC644790	similar to ribosomal protein S15a	0.119	0.119
NULL	hCG_2006325: Uncharacterized protein ENSP00000249480	0.119	0.119
LOC646119	similar to ribosomal protein S8	0.119	0.119
NULL	Uncharacterized protein ENSP00000303953	0.119	0.119
LOC647058	similar to suppressor of initiator codon mutations, related sequence 1	0.119	0.119
LOC391656	Uncharacterized protein ENSP00000348155	0.119	0.119
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.114	0.046
KIAA0690	N/A	0.114	0.038
EHD1	EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1	0.111	0.046
HNRPK	HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K	0.109	0.028
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.098	0.047
RSN	CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1	0.098	0.025
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.0971	0.032
LCP1	LCP1, PLS2: Plastin-2	0.090	0.078
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.087	0.027
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.087	0.0446
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.087	0.0446
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.087	0.087
KIAA0853	N/A	0.087	0.036
MKI67	MKI67: Antigen KI-67	0.087	0.027
SREBF2	N/A	0.087	0.0446
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.087	0.0446
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.087	0.070
ESPL1	N/A	0.087	0.052
ARFGAP1	N/A	0.087	0.0446
TOP2B	N/A	0.087	0.0446
NBN	NBN, NBS, NBS1, P95: Nibrin	0.087	0.0446
RB1	RB1: Retinoblastoma-associated protein	0.087	0.036
KIF23	N/A	0.087	0.027
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.087	0.052
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.0446
CENPA	CENPA: Histone H3-like centromeric protein A	0.087	0.036
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.087	0.087
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.087	0.038
HELZ	HELZ, KIAA0054: Probable helicase with zinc finger domain	0.086	0.086
C20orf18	N/A	0.083	0.04
ZC3H7A	ZC3H7A, ZC3H7, HSPC055, ZC3HDC7: Zinc finger CCCH domain-containing protein 7A	0.083	0.067
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.0818	0.046
PHF10	N/A	0.078	0.032
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.078	0.063
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.078	0.129
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.078	0.040
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.078	0.078
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.078	0.112
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.078	0.040
WBSCR20A	N/A	0.078	0.040
KLHDC4	N/A	0.078	0.078
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.078	0.046
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.078	0.066
MDN1	MDN1, KIAA0301: Midasin	0.078	0.046
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.078	0.040
COPE	COPE: Coatomer subunit epsilon	0.078	0.763
COPB2	COPB2: Coatomer subunit beta'	0.078	0.040
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.078	0.067
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.078	0.040
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.078	0.066
KIF11	N/A	0.078	0.032
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.078	0.078
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.078	0.078
RPS6KB1	N/A	0.078	0.063
WEE1	WEE1: Wee1-like protein kinase	0.078	0.046
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.038
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.078	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.078	0.078
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.078	0.063
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.078	0.038
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.078	0.032
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.077	0.0453
NIPBL	N/A	0.075	0.025
PHB2	PHB2, BAP, REA: Prohibitin-2	0.074	0.144
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.087
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.071	0.051
EMD	EMD, EDMD, STA: Emerin	0.070	0.027
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.070	0.027
ELF1	ELF1: ETS-related transcription factor Elf-1	0.070	0.0446
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.070	0.070
XRCC1	XRCC1: DNA-repair protein XRCC1	0.070	0.027
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.070	0.070
WDR1	N/A	0.070	0.0446
IRF3	IRF3: Interferon regulatory factor 3	0.070	0.036
IFI16	N/A	0.070	0.0446
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.070	0.036
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.070	0.027
NCOA3	N/A	0.070	0.036
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.070	0.027
TRRAP	N/A	0.070	0.070
API5	N/A	0.070	0.052
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.027
CHUK	N/A	0.070	0.052
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.067	0.038
IQGAP1	IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1	0.067	0.046
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.067	0.171
GSTP1	GSTP1, FAEES3, GST3: Glutathione S-transferase P	0.067	0.046
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.066	0.129
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.066	0.078
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.066	0.078
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	0.066	20.60
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.066	0.129
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.066	0.129
RPL8	RPL8: 60S ribosomal protein L8	0.066	0.129
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.066	0.078
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.066	0.063
LDHB	LDHB: L-lactate dehydrogenase B chain	0.066	0.078
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.066	0.078
HNRPK	N/A	0.066	0.129
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.066	0.129
TK1	TK1: Thymidine kinase, cytosolic	0.066	0.046
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.066	0.078
CDC23	CDC23: Cell division cycle protein 23 homolog	0.066	0.461
CTPS	CTPS: CTP synthase 1	0.066	0.063
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.066	0.078
FRG1	FRG1: Protein FRG1	0.066	0.078
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.066	0.129
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.066	0.078
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.066	0.129
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.066	0.129
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.066	0.078
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.066	0.129
HSPD1		0.066	0.063
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.066	0.078
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.063	0.066
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.063	0.040
ARMET	ARMET, ARP: Protein ARMET precursor	0.063	0.032
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.063	0.046
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.063	0.063
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.063	0.078
KIAA1012	KIAA1012: Protein TRS85 homolog	0.063	0.461
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.063	0.032
EP300	N/A	0.063	0.032
SEC31L1	N/A	0.063	0.032
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.063	0.063
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.063	0.063
CDK7	CDK7, MO15: Cell division protein kinase 7	0.063	0.063
COPA	COPA: Coatomer subunit alpha	0.063	0.078
CORO1C	CORO1C, CRNN4: Coronin-1C	0.063	0.040
FKBP4	FKBP4: FK506-binding protein 4	0.063	0.275
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.063	0.181
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.063	0.063
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.063	0.040
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.063	0.038
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.063	0.063
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.063	0.032
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.063	0.032
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.063	0.275
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.063	0.046
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.063	0.078
DIAPH1	Diaphanous 1	0.063	0.063
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.063	0.038
SAPS3	N/A	0.063	0.046
FNBP1	N/A	0.063	0.078
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.063	0.040
CUL5	CUL5, VACM1: Cullin-5	0.063	0.245
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.063	0.046
SRF	SRF: Serum response factor	0.063	0.032
NEDD4L	NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein	0.062	0.026
MDM4	MDM4, MDMX: Mdm4 protein	0.062	0.030
FLNA	FLNA, FLN, FLN1: Filamin-A	0.061	0.052
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.060	0.026
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.060	0.075
YWHAB	YWHAB: 14-3-3 protein beta/alpha	0.054	0.063
FLNB	FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B	0.054	0.046
YWHAZ	YWHAZ: 14-3-3 protein zeta/delta	0.054	0.046
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.054	0.041
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.053	0.025
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.052	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.052	0.04
H1FX	H1FX: Histone H1x	0.052	0.036
GTF3C1	N/A	0.052	0.036
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.027
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.052	0.070
ZNF267	ZNF267: Zinc finger protein 267	0.052	0.027
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.052	0.036
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.052	0.036
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.052	0.070
COIL	COIL, CLN80: Coilin	0.052	0.027
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.052
AFF1	N/A	0.052	0.027
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.052	0.027
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.070
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.052	0.052
STK16	N/A	0.052	0.0425
SP100	N/A	0.052	0.036
SMARCC2	N/A	0.052	0.027
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.027
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.052	0.027
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.052	0.032
ZC3H7B	ZC3H7B, KIAA1031: Zinc finger CCCH domain-containing protein 7B	0.051	0.051
JUP	JUP, CTNNG, DP3: Junction plakoglobin	0.051	0.038
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.049	0.033
FASN	FASN, FAS: Fatty acid synthase	0.049	0.028
AMPH	AMPH, AMPH1: Amphiphysin	0.049	0.028
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.049	0.028
PPARG	CREB3L2-PPARgamma	0.049	0.033
DKC1	DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4	0.0479	5.94
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.047	0.036
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.046	0.063
DOK1	DOK1: Docking protein 1	0.046	0.063
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.046	0.275
RELA	RELA, NFKB3: Transcription factor p65	0.046	0.032
CXorf9	N/A	0.046	0.046
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.046	0.063
MYH9	MYH9: Myosin-9	0.046	0.032
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.046	0.063
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.032
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.046	0.275
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.046	0.032
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.046	0.148
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.046	0.275
TCEB3	TCEB3, MSTP059: Transcription elongation factor B polypeptide 3	0.046	0.032
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.078
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.046	0.063
GSK3B	N/A	0.046	0.063
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.046	0.046
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.046
AIP	AIP, XAP2: AH receptor-interacting protein	0.046	0.372
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.046	0.046
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.225
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.0446	0.052
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.0446	0.210
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.0446	0.052
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.0446	0.087
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.0446	0.087
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.0446	0.070
KIAA0031	EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component	0.044	0.025
ITSN2	ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2	0.044	0.025
EHD4	EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4	0.044	0.025
BIN1	BIN1, AMPHL: Myc box-dependent-interacting protein 1	0.044	0.025
AP1GBP1	AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1	0.044	0.025
VDR	VDR, NR1I1: Vitamin D3 receptor	0.043	0.051
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.127
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.0425	0.0425
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.052
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.0425
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.0425	0.032
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.0425
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.0425	0.052
ETS2	ETS2: Protein C-ets-2	0.0425	0.027
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.032
hfl-B5	PCID1, EIF3M, GA17, hfl-B5, hCG_27316: PCI domain containing 1	0.042	1.22
YWHAG	YWHAG: 14-3-3 protein gamma	0.04	0.028
AXIN1		0.04	0.028
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.040	0.046
THOC1	THOC1, HPR1: THO complex subunit 1	0.040	0.046
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.040	0.063
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.040	0.078
CASP3	CASP3, CPP32: Caspase-3 precursor	0.040	0.046
CD2AP	CD2AP: CD2-associated protein	0.040	0.078
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.040	0.461
HSP90AA1	Hsp89-alpha-delta-N	0.040	0.063
CSK	CSK: Tyrosine-protein kinase CSK	0.040	0.078
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.040	0.129
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.040	0.046
PRDX6	PRDX6, AOP2, KIAA0106: Peroxiredoxin-6	0.040	0.063
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.040	0.078
PPARBP	N/A	0.040	0.078
ACTR3	ACTR3, ARP3: Actin-related protein 3	0.040	0.078
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.040	0.063
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.040	0.063
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.040	0.188
CRKL	CRKL: Crk-like protein	0.040	0.063
TBCE	TBCE: Tubulin-specific chaperone E	0.040	0.063
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.040	0.063
THOP1	THOP1: Thimet oligopeptidase	0.040	0.078
STK10	STK10: Uncharacterized protein STK10	0.038	0.046
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.038	0.032
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.038	0.038
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.038	0.046
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.038	0.046
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.063
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.038	0.046
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.038	0.054
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.038	0.046
CDK6	CDK6: Cell division protein kinase 6	0.038	0.038
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.038	0.063
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.038	0.029
JUND	JUND: Transcription factor jun-D	0.038	0.032
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.038
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.038	0.029
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.038
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.038
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.038	0.038
PRPF6	PRPF6, C20orf14: Pre-mRNA-processing factor 6	0.038	0.263
HCA66	UTP6, C17orf40, HCA66, MHAT: U3 small nucleolar RNA-associated protein 6 homolog	0.038	0.074
SCRIB	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4	0.036	0.070
MPG	N/A	0.036	0.144
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.036	0.087
DNM2	N/A	0.036	0.087
LIMS1	N/A	0.036	0.070
SRPR	SRPR: Uncharacterized protein SRPR	0.036	0.144
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.036	0.025
NR4A2	NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2	0.035	0.033
PGR	PGR, NR3C3: Progesterone receptor	0.034	0.032
WWOX	WWOX, FOR, WOX1: WW domain-containing oxidoreductase	0.033	0.029
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.0425
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.032	0.0425
PRKAA1	N/A	0.032	0.026
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.032
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.032	0.0425
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.032	0.032
MARK2	N/A	0.032	0.052
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.032	0.0425
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.032	0.0425
PTPN11	N/A	0.032	0.063
FLII	FLII, FLIL: Protein flightless-1 homolog	0.032	0.078
KIAA0664	KIAA0664: Putative eukaryotic translation initiation factor 3 subunit	0.032	0.372
ENO1	ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase	0.032	0.063
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.032	0.063
PPIG	PPIG: Peptidyl-prolyl cis-trans isomerase G	0.032	0.063
GPI	GPI: Glucose-6-phosphate isomerase	0.032	0.063
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.032	0.038
BAP1	BAP1, KIAA0272, hucep-6: Ubiquitin carboxyl-terminal hydrolase BAP1	0.032	0.063
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.032	0.063
ARHGDIB	ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2	0.032	0.063
ACTG1	ACTB: Actin, cytoplasmic 1	0.032	0.063
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.032	0.146
SENP6	SENP6, KIAA0797, FKSG6, SSP1, SUSP1: Sentrin-specific protease 6	0.032	0.046
WARS	WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic	0.032	0.063
UBE4A	N/A	0.032	0.078
AKR7A2	AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2	0.032	0.078
MDH2	MDH2: Malate dehydrogenase, mitochondrial precursor	0.032	0.063
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.032	0.046
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.032	0.063
TPT1	TPT1: Translationally-controlled tumor protein	0.032	0.063
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.078
LPXN	LPXN, LDLP: Leupaxin	0.032	0.063
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.032	0.063
GAPD	GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase	0.032	0.046
TBK1	TBK1, NAK: Serine/threonine-protein kinase TBK1	0.032	0.046
RAP1A	RAP1A, KREV1: Ras-related protein Rap-1A precursor	0.032	0.063
NR1D1	NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1	0.031	0.029
ATM	ATM: Serine-protein kinase ATM	0.029	0.029
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.029	0.225
PAK4	PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4	0.029	0.038
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.029	0.038
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.029	0.046
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.029	0.029
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.029	0.038
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.029	0.043
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.029	0.029
NULL	Putative uncharacterized protein (Fragment)	0.029	0.119
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
PHLDB2	N/A	0.028	0.028
PPEF1	N/A	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.028
UHRF1		0.028	0.04
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
MAPK15	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
NR4A1	CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor	0.028	0.026
PDF	PDF, PDF1A: Peptide deformylase, mitochondrial precursor	0.027	0.027
DFFA	DFFA, DFF1, H13, DFF45: DNA fragmentation factor subunit alpha	0.027	0.0425
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.027	0.087
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.027	0.070
IFI35	N/A	0.027	0.087
USP21	USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21	0.027	0.0425
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.027	0.052
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.027	0.052
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.032
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.026	0.026
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
MAP2K3	N/A	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
GIT2	N/A	0.025	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
CAMK2A	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
PRKCB1	N/A	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
ELMO1	N/A	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.036
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.025
BCOR	N/A	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.025
RNF20		0.025	0.036
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.025	0.025
EEF2K	EEF2K: Elongation factor 2 kinase	0.025	0.148
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.025
GRK6	N/A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.025	0.025
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
PSME3	PSME3: Proteasome activator complex subunit 3	0.025	0.025
C9orf82	N/A	0.025	0.025
C11orf58	SMAP, C11orf58: Small acidic protein	0.025	0.025

0.572

Total Score

2.39E4