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Evidence of Interaction Between VAMP2 and STX12

The interaction score between VAMP2 and STX12 is 2.97E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between VAMP2 and STX12 = 0.51

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3
Orthology
OrganismVAMP2 OrthologueSTX12 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00549343 0.403 IPI00043560 0.09
human IPI00477258 0.678 IPI00043560 0.09
human IPI00549343 0.403 IPI00289876 0.396
human IPI00477258 0.678 IPI00289876 0.396
bakers yeast YAL030W 1 YOR036W 1
  • SyntheticLethal
  • AffinityCaptureWestern

Get References From PubMed

bakers yeast YOR327C 1 YOR036W 1
worm O02495 1 O62236 1
fly Q86BQ0 1 Q9VP33 0.294

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in VAMP2 and STX12:
Domains in VAMP2Domains in STX12
IPR001388 Synaptobrevin
IPR000727 Target SNARE coiled-coil domain
IPR006011 Syntaxin, N-terminal
IPR006012 Syntaxin/epimorphin family

The Chi square scores for co-occurrence of domains that are present in VAMP2 and STX12 are listed below.

Domain 1Domain 2Chi Square
IPR001388 Synaptobrevin IPR000727 Target SNARE coiled-coil domain 1090.58
IPR001388 Synaptobrevin IPR006012 Syntaxin/epimorphin family 761.571
IPR001388 Synaptobrevin IPR006011 Syntaxin, N-terminal 732.41

The background colour of the table refers to:

  • Blue Domain is only present in VAMP2
  • Yellow Domain is only present in STX12
  • Green Domain is present in both VAMP2 and STX12

0.217
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: VAMP2

LocalisationReference
Golgi HPRD
Plasma membrane HPRD
Endosome HPRD
Cytoplasm HPRD

Protein: STX12

LocalisationReference
Plasma membrane HPRD
Endosome HPRD
Transitive Score

The common interactors between VAMP2 and STX12 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between VAMP2 andSTX12. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , VAMP2 has 57 interactors and STX12 has 64 interactors of which there are 15 common interactors.

Common InteractorName of Common InteractorScore for VAMP2-Interactor (?)Score for STX12-Interactor (?)
SNAP25 SNAP25, SNAP: Synaptosomal-associated protein 25 171.00 10.10
STX1A STX1A, STX1: Syntaxin-1A 160.00 0.028
VTI1A VTI1A: Vesicle transport through interaction with t-SNAREs homolog 1A 62.80 6.33
STX10 STX10, hCG_27761: Uncharacterized protein STX10 62.80 6.33
SNAP23 SNAP23: Synaptosomal-associated protein 23 33.30 6.70
STX7 STX7: Syntaxin-7 9.54 0.044
STX4A STX4, STX4A: Syntaxin-4 7.73 0.044
STX11 STX11: Syntaxin-11 6.81 0.044
STX6 STX6: Syntaxin-6 0.265 0.027
SEC22L1 SEC22B, SEC22L1: Vesicle-trafficking protein SEC22b 0.210 0.274
STX8 STX8: Syntaxin-8 0.145 0.036
NAPB CDNA FLJ39175 fis, clone OCBBF2003593, highly similar to BETA-SOLUBLE NSF ATTACH 0.119 0.730
STX6 N/A 0.119 0.119
NAPA N/A 0.092 0.227
SNAP29 SNAP29: Synaptosomal-associated protein 29 0.084 0.116
0.572
Total Score 2.97E4