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Evidence of Interaction Between VAMP2 and STX1A

The interaction score between VAMP2 and STX1A is 3.67E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between VAMP2 and STX1A = 0.62

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

7.78E-3
Orthology
OrganismVAMP2 OrthologueSTX1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00549343 0.403 IPI00166679 0.078
human IPI00477258 0.678 IPI00166679 0.078
bakers yeast YAL030W 1 YMR183C 1
  • AffinityCaptureWestern

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bakers yeast YOR327C 1 YMR183C 1
  • PhenotypicEnhancement
  • AffinityCaptureWestern

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bakers yeast YAL030W 1 YPL232W 0.673
  • AffinityCaptureWestern
  • ReconstitutedComplex

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bakers yeast YOR327C 1 YPL232W 0.673
  • AffinityCaptureWestern

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worm O02495 1 O18657 1
fly Q86BQ0 1 Q24547 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in VAMP2 and STX1A:
Domains in VAMP2Domains in STX1A
IPR001388 Synaptobrevin
IPR000727 Target SNARE coiled-coil domain
IPR006011 Syntaxin, N-terminal
IPR006012 Syntaxin/epimorphin family

The Chi square scores for co-occurrence of domains that are present in VAMP2 and STX1A are listed below.

Domain 1Domain 2Chi Square
IPR001388 Synaptobrevin IPR000727 Target SNARE coiled-coil domain 1090.58
IPR001388 Synaptobrevin IPR006012 Syntaxin/epimorphin family 761.571
IPR001388 Synaptobrevin IPR006011 Syntaxin, N-terminal 732.41

The background colour of the table refers to:

  • Blue Domain is only present in VAMP2
  • Yellow Domain is only present in STX1A
  • Green Domain is present in both VAMP2 and STX1A

0.217
Post-translational Modifications

Protein: VAMP2

PTMResidueReference

Protein: STX1A

PTMResidueReference
Phosphorylation 14 PubMed, HPRD
Phosphorylation 188 PubMed, HPRD
Localisation

Protein: VAMP2

LocalisationReference
Golgi HPRD
Plasma membrane HPRD
Endosome HPRD
Cytoplasm HPRD

Protein: STX1A

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between VAMP2 and STX1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between VAMP2 andSTX1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , VAMP2 has 57 interactors and STX1A has 239 interactors of which there are 24 common interactors.

Common InteractorName of Common InteractorScore for VAMP2-Interactor (?)Score for STX1A-Interactor (?)
SNAP25 SNAP25, SNAP: Synaptosomal-associated protein 25 171.00 171.00
STX12 STX12: Syntaxin-12 129.00 0.028
SNAP23 SNAP23: Synaptosomal-associated protein 23 33.30 128.00
STX1B2 STX1B, STX1B1, STX1B2: Syntaxin-1B 10.30 0.682
EPIM STX2, EPIM, STX2A, STX2B, STX2C: Syntaxin-2 10.30 0.682
STX7 STX7: Syntaxin-7 9.54 0.097
STX4A STX4, STX4A: Syntaxin-4 7.73 0.404
STX11 STX11: Syntaxin-11 6.81 0.404
STX3A STX3, STX3A: Syntaxin-3 6.14 0.448
SCFD1 SCFD1, C14orf163, FKSG23, KIAA0917, STXBP1L2: Sec1 family domain-containing prot 0.443 0.0273
STXBP2 STXBP2, UNC18B: Syntaxin-binding protein 2 0.352 0.477
STX6 STX6: Syntaxin-6 0.265 0.027
SEC22L1 SEC22B, SEC22L1: Vesicle-trafficking protein SEC22b 0.210 7.47
STXBP3 STXBP3: Syntaxin-binding protein 3 0.181 0.107
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.141 0.109
NAPB CDNA FLJ39175 fis, clone OCBBF2003593, highly similar to BETA-SOLUBLE NSF ATTACH 0.119 0.028
STXBP1 N/A 0.119 0.232
STX19 STX19: Syntaxin-19 0.119 0.064
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.116 0.113
NAPA N/A 0.092 0.067
SNAP29 SNAP29: Synaptosomal-associated protein 29 0.084 0.084
RPIP8 N/A 0.027 0.027
STXBP1 STXBP1, UNC18A: Syntaxin-binding protein 1 0.027 0.265
GAP43 GAP43: Neuromodulin 0.027 0.025
0.572
Total Score 3.67E4