PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and LSM5

The interaction score between SNRPG and LSM5 is 1.58E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between SNRPG and LSM5 = 0.89

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	SNRPG Orthologue		LSM5 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YFL017W-A	1	YER146W	1	AffinityCaptureMS Get References From PubMed
worm	Q9N4G9	1	O18694	1
fly	Q9VXE0	1	Q9VRT7	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in SNRPG and LSM5:

Domains in SNRPG

Domains in LSM5

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR006649	snRNP domain

The Chi square scores for co-occurrence of domains that are present in SNRPG and LSM5 are listed below.

Domain 1		Domain 2		Chi Square
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR006649	snRNP domain	1325.87
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001163	Small nuclear ribonucleoprotein (Sm protein)	1297.61
IPR006649	snRNP domain	IPR006649	snRNP domain	1206.57
IPR010920	Small nuclear-like ribonucleoprotein	IPR006649	snRNP domain	1168.89
IPR010920	Small nuclear-like ribonucleoprotein	IPR001163	Small nuclear ribonucleoprotein (Sm protein)	1143.95

The background colour of the table refers to:

Blue Domain is only present in SNRPG
Yellow Domain is only present in LSM5
Green Domain is present in both SNRPG and LSM5

0.265

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: LSM5

PTM	Residue	Reference
N-acetylalanine	1	HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: LSM5

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPG and LSM5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andLSM5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and LSM5 has 349 interactors of which there are 202 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for LSM5-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	38.60
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	2.07E3	3.41E3
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	691.00	323.00
SNRPD2	SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2	691.00	3.51E3
PRPF4	PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4	69.60	32.60
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	68.20
PRP19	PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19	25.60	0.0968
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	8.73
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	2.91
LSM8	LSM8: U6 snRNA-associated Sm-like protein LSm8	2.60	4.86
LSM7	LSM7: U6 snRNA-associated Sm-like protein LSm7	2.60	3.51E3
SNRPF	SNRPF, PBSCF: Small nuclear ribonucleoprotein F	2.60	205.00
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	2.74E3
PRPF8	PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8	1.84	1.49
LSM6	LSM6: U6 snRNA-associated Sm-like protein LSm6	1.22	1.64E3
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	1.28E3
LSM1	LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1	1.22	195.00
PRPF6	PRPF6, C20orf14: Pre-mRNA-processing factor 6	0.890	0.890
NUP37	NUP37: Nucleoporin Nup37	0.789	0.263
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.293	0.293
DDX21	DDX21: Nucleolar RNA helicase 2	0.293	0.613
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.263	0.257
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.263	0.257
NUP43	N/A	0.263	0.263
CDC20	CDC20: Cell division cycle protein 20 homolog	0.263	0.156
EIF4A1	EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I	0.263	0.263
BAT1	N/A	0.263	0.123
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.263	0.263
BOP1	BOP1, KIAA0124: Ribosome biogenesis protein BOP1	0.263	0.123
LSM10	LSM10: U7 snRNA-associated Sm-like protein LSm10	0.237	0.237
LSM11	LSM11: U7 snRNA-associated Sm-like protein LSm11	0.237	0.237
SNRPN	HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N	0.158	0.158
GTF3C2	GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2	0.137	0.137
SEC13L1	SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog	0.137	0.083
WDR41	N/A	0.137	0.137
GNB2L1	Lung cancer oncogene 7	0.137	0.287
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.287
DDX50	DDX50: ATP-dependent RNA helicase DDX50	0.137	0.137
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.287
DDX47	E4-DBP: DEAD box protein	0.123	0.123
DDX39	DDX39: ATP-dependent RNA helicase DDX39	0.123	0.074
PPP2R2A	PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp	0.123	0.074
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.257
CDC40	CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17	0.123	0.074
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.257
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.257
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.123	0.257
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.156
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.123	0.074
POLD1	POLD1, POLD: DNA polymerase delta catalytic subunit	0.123	0.123
TAF5	TAF5, TAF2D: Transcription initiation factor TFIID subunit 5	0.123	0.123
DDX19A	DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A	0.123	0.074
RBBP7	RBBP7, RBAP46: Histone-binding protein RBBP7	0.123	0.123
WDR77	WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44	0.123	0.123
WDR12	WDR12: WD repeat-containing protein 12	0.123	0.123
DDX18	DDX18: ATP-dependent RNA helicase DDX18	0.123	0.123
WDR3	WDR3: WD repeat-containing protein 3	0.123	0.123
DDX49	DDX49: Probable ATP-dependent RNA helicase DDX49	0.123	0.074
WDR68	WDR68, HAN11: WD repeat-containing protein 68	0.123	0.074
WDR57	WDR57, PRP8BP, SFP38: WD repeat-containing protein 57	0.123	0.074
DDX23	DDX23: Probable ATP-dependent RNA helicase DDX23	0.123	0.074
CNOT7	CNOT7, CAF1: CCR4-NOT transcription complex subunit 7	0.123	0.123
STRAP	STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein	0.123	0.123
RNU3IP2	RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2	0.123	0.060
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.123	0.156
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.123	0.123
WDR18	N/A	0.123	0.123
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.123	0.156
NUTF2	NUTF2, NTF2: Nuclear transport factor 2	0.0968	0.059
FBXW2	FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2	0.083	0.083
SMARCAL1	SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c	0.083	0.083
RAD54B	RAD54B: DNA repair and recombination protein RAD54B	0.083	0.067
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.083	0.287
DDB2	DDB2: DNA damage-binding protein 2	0.083	0.083
SERBP1	N/A	0.082	0.027
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.074	0.156
DDX10	DDX10: Probable ATP-dependent RNA helicase DDX10	0.074	0.123
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.074	0.156
PWP2H	PWP2, PWP2H: Periodic tryptophan protein 2 homolog	0.074	0.074
KIAA0052	SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2	0.074	0.074
DDX27	DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27	0.074	0.074
RECQL	RECQL, RECQL1: ATP-dependent DNA helicase Q1	0.074	0.074
FLJ10439	WDR74, NSA1: WD repeat-containing protein 74	0.074	0.123
CORO1C	CORO1C, CRNN4: Coronin-1C	0.074	0.126
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.074	0.156
LRBA	LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote	0.074	0.074
SEC31L1	N/A	0.074	0.126
IFIH1	IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1	0.074	0.060
DDX54	DDX54: ATP-dependent RNA helicase DDX54	0.074	0.074
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.156
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.074	0.074
POLA	POLA1, POLA: DNA polymerase alpha catalytic subunit	0.074	0.060
COPB2	COPB2: Coatomer subunit beta'	0.074	0.126
COPA	COPA: Coatomer subunit alpha	0.074	0.093
TSSC1	TSSC1: Protein TSSC1	0.074	0.074
POLE	POLE, POLE1: DNA polymerase epsilon catalytic subunit A	0.074	0.074
DDX48	EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III	0.074	0.074
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.156
LOC119358	similar to small nuclear ribonucleoprotein D2	0.071	0.071
WDR1	N/A	0.067	0.103
WDR8	WDR8: WD repeat-containing protein 8	0.067	0.067
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.126
DDX17	DDX17: Probable ATP-dependent RNA helicase DDX17	0.060	0.060
PIK3R4	PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4	0.060	0.060
JMJD2C	JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr	0.060	0.060
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.156
CORO7	CORO7: Coronin-7	0.060	0.044
DDX28	DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28	0.060	0.060
WDR39	CIAO1, WDR39: Protein CIAO1	0.060	0.060
AAMP	AAMP: Angio-associated migratory cell protein	0.060	0.060
GRWD1	GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1	0.060	0.060
DHX35	C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35	0.060	0.060
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.060	0.126
RECQL4	RECQL4, RECQ4: ATP-dependent DNA helicase Q4	0.060	0.060
WDR26	WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26	0.060	0.036
AAAS	AAAS, ADRACALA, GL003: Aladin	0.060	0.044
CNOT8	CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8	0.060	0.060
DHX38	DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica	0.060	0.060
XPMC2H	REXO4, PMC2, XPMC2H: RNA exonuclease 4	0.060	0.074
Nle	NLE1, HUSSY-07: Notchless protein homolog 1	0.060	0.126
TTF2	TTF2: Transcription termination factor 2	0.060	0.074
WIPI2	WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2	0.060	0.060
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.057	0.057
ISG20	ISG20, HEM45: Interferon-stimulated gene 20 kDa protein	0.050	0.041
GNB1L	GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b	0.050	0.041
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.044	0.093
ARPC1A	ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A	0.044	0.044
EML3	EML3: Echinoderm microtubule-associated protein-like 3	0.044	0.044
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.126
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.044	0.093
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.044	0.156
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.044	0.093
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.044	0.076
THRAP5	MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16	0.044	0.036
NBEAL2	N/A	0.044	0.044
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.126
RAE1	RAE1, MRNP41: mRNA export factor	0.044	0.044
CORO1A	CORO1A, CORO1: Coronin-1A	0.044	0.044
LGP2	DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58	0.044	0.036
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.044	0.093
PARN	PARN, DAN: Poly(A)-specific ribonuclease PARN	0.044	0.036
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.093
WDR67	WDR67: WD repeat-containing protein 67	0.044	0.044
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.044	0.048
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.048
WDR13	WDR13: WD repeat-containing protein 13	0.041	0.0308
REV3L	REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit	0.041	0.041
PHF20	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20	0.039	0.039
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.093
WIPI1	WIPI1, WIPI49: WD repeat domain phosphoinositide-interacting protein 1	0.036	0.028
DDX56	DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56	0.036	0.036
DDX52	DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52	0.036	0.044
WDR48	WDR48, KIAA1449: WD repeat-containing protein 48	0.036	0.028
WDR45L	N/A	0.036	0.036
WDR42A	N/A	0.036	0.028
SETDB1	SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1	0.036	0.036
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.036	0.058
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.036	0.058
LBR	LBR: Lamin-B receptor	0.0331	0.0331
RNASEH1	RNASEH1, RNH1: Ribonuclease H1	0.0331	0.0331
POLG	POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1	0.0331	0.0331
NUP214	N/A	0.0308	0.051
CETN2	CETN2, CALT, CEN2: Centrin-2	0.028	0.028
WDR37	N/A	0.028	0.028
DYNC1I2	N/A	0.028	0.046
DDX58	DDX58: Probable ATP-dependent RNA helicase DDX58	0.028	0.028
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.028	0.046
PEX7	PEX7, PTS2R: Peroxisomal targeting signal 2 receptor	0.028	0.028
SMC4L1	N/A	0.027	0.027
TPRKB	TPRKB, CGI-121, My019: TP53RK-binding protein	0.027	0.027
PTD004	N/A	0.027	0.027
RAD51AP1	N/A	0.027	0.027
NOL7	NOL7, C6orf90, NOP27: Nucleolar protein 7	0.027	0.027
HSPC185	CGI-117, HSPC111: UPF0384 protein CGI-117	0.027	0.027
ILF2	ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2	0.027	0.027
HNRPD	N/A	0.027	0.027
BUB3	N/A	0.027	0.027
XTP3TPA	XTP3TPA, CDA03: XTP3-transactivated gene A protein	0.027	0.027
DKFZP586L0724	NOL11, L14: Nucleolar protein 11	0.027	0.027
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.056
NEDD1	N/A	0.027	0.027
WDR34	N/A	0.027	0.027
WDR54	N/A	0.027	0.056
TREX1	TREX1: Three prime repair exonuclease 1	0.027	0.027
ERCC8	ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8	0.027	0.027
REXO1L1	REXO1L1, GOR: Exonuclease GOR	0.027	0.027
RFWD2	RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2	0.027	0.027
FLJ12671	ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2	0.027	0.027
WDR72	N/A	0.027	0.027
WDR17	N/A	0.027	0.027
PHF1	N/A	0.027	0.027
FBXW8	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8	0.027	0.027
WSB1	WSB1, SWIP1: WD repeat and SOCS box-containing protein 1	0.027	0.027
TDRD4	TDRD4: Tudor domain-containing protein 4	0.027	0.027
KIF21A	N/A	0.027	0.027
WDR53	N/A	0.027	0.027
TLE6	TLE6: Transducin-like enhancer protein 6	0.027	0.027
BRWD1	N/A	0.027	0.027
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.056
TAF5L	TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated	0.027	0.027
DDX53	DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53	0.027	0.027
SNRPB	N/A	0.0258	0.0258

0.572

Total Score

1.58E5