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Evidence of Interaction Between FLT1 and SHC3

The interaction score between FLT1 and SHC3 is 2.47E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FLT1 and SHC3 = 0.11

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismFLT1 OrthologueSHC3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00021396 1 IPI00217895 0.171
human IPI00293565 0.322 IPI00217895 0.171
human IPI00005722 0.081 IPI00217895 0.171
human IPI00021396 1 IPI00643176 0.34
  • Y2H

Get References From PubMed
human IPI00293565 0.322 IPI00643176 0.34
  • InVitro
  • InVivo

Get References From PubMed
human IPI00005722 0.081 IPI00643176 0.34
  • InVitro
  • InVivo

Get References From PubMed
worm P34892 0.084 Q9TYT3 0.34
worm O76698 1 Q9TYT3 0.34
worm Q21038 1 Q9TYT3 0.34
worm Q21041 1 Q9TYT3 0.34
fly Q7KTI7 1 Q24080 0.171

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.58
Domains Domains present in FLT1 and SHC3:
Domains in FLT1Domains in SHC3
IPR000719 Protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR009135 Vascular endothelial growth factor receptor 1, VEGFR1
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in FLT1 and SHC3 are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001824 Receptor tyrosine kinase, class III IPR000980 SH2 motif 101.074
IPR007110 Immunoglobulin-like IPR000980 SH2 motif 94.9752
IPR008266 Tyrosine protein kinase, active site IPR011993 PH_type. 85.0032
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR000980 SH2 motif 49.095
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR011993 PH_type. 3.65681
IPR001824 Receptor tyrosine kinase, class III IPR011993 PH_type. 3.54397
IPR007110 Immunoglobulin-like IPR011993 PH_type. 1.73192
IPR008266 Tyrosine protein kinase, active site IPR006020 Phosphotyrosine interaction domain 0.0178144
IPR000719 Protein kinase IPR006020 Phosphotyrosine interaction domain 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in FLT1
  • Yellow Domain is only present in SHC3
  • Green Domain is present in both FLT1 and SHC3

 0.217
Post-translational Modifications

Protein: FLT1

PTMResidueReference
Dephosphorylation 1213 PubMed, HPRD
Phosphorylation 794 PubMed, HPRD
Phosphorylation 1169 PubMed, HPRD
Phosphorylation 1213 PubMed, HPRD
Phosphorylation 1242 PubMed, HPRD
Phosphorylation 1327 PubMed, HPRD
Phosphorylation 1333 PubMed, HPRD
Phosphotyrosine 1213 PubMed, HPRD
Phosphotyrosine 1242 PubMed, HPRD
Phosphotyrosine 1327 PubMed, HPRD
Phosphotyrosine 1333 PubMed, HPRD

Protein: SHC3

PTMResidueReference
Localisation

Protein: FLT1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD

Protein: SHC3

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between FLT1 and SHC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FLT1 andSHC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FLT1 has 1443 interactors and SHC3 has 346 interactors of which there are 169 common interactors.

Common InteractorName of Common InteractorScore for FLT1-Interactor (?)Score for SHC3-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.01E3 114.00
NCK2 NCK2: Cytoplasmic protein NCK2 676.00 7.56
CRKL CRKL: Crk-like protein 600.00 7.56
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 214.00 5.94
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 183.00 147.00
GRAP GRAP: GRB2-related adapter protein 147.00 7.56
KIT KIT: Mast/stem cell growth factor receptor precursor 127.00 69.80
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 112.00 55.50
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 112.00 61.50
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 82.20 61.50
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.13 0.197
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.265
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.265
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.027
BMX N/A 0.902 0.244
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 11.50
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.878 0.237
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.808 0.177
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.197
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.731 0.174
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.655 0.156
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.156
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.655 74.90
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.654 0.157
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.644 0.157
CSK CSK: Tyrosine-protein kinase CSK 0.586 0.141
HCK N/A 0.586 67.50
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.586 6.81
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.586 0.141
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.586 67.50
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.586 0.156
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.586 16.30
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.586 67.50
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.586 6.81
LYN LYN: Tyrosine-protein kinase Lyn 0.586 0.141
SYK SYK: Tyrosine-protein kinase SYK 0.586 0.141
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.520 0.141
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.520 0.156
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.483 9.04
VAV1 VAV1, VAV: Proto-oncogene vav 0.465 7.67
JAK1 0.465 0.141
STAT6 STAT6: Signal transducer and activator of transcription 6 0.465 7.67
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.251 0.200
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.217 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.217 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.217 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.217 0.027
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.191 0.251
MET MET: Hepatocyte growth factor receptor precursor 0.191 0.162
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.171 0.145
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.171 0.145
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.171 0.036
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.171 0.115
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.171 0.145
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.171 0.145
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.217
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.217
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.217
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.148 0.195
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.195
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.148 0.126
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.195
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 93.60
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.145 0.074
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.145 0.197
FYN N/A 0.145 0.174
ALK ALK: ALK tyrosine kinase receptor precursor 0.136 0.094
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.136 0.128
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.136 55.50
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.136 0.145
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.136 0.145
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.136 0.361
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.053
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.039
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.123 0.039
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.113 0.036
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.113 173.00
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.113 0.028
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.111 0.035
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.111 0.128
INSR INSR: Insulin receptor precursor 0.111 61.50
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.111 0.490
PSCD2 N/A 0.109 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.027
CNN2 CNN2: Calponin-2 0.109 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.027
NF2 NF2, SCH: Merlin 0.109 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.027
MCF2 MCF2, DBL: Proto-oncogene DBL 0.100 0.0308
GAB1 GAB1: GRB2-associated-binding protein 1 0.100 0.0308
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.237
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.097 0.128
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.097 0.128
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.096 0.032
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.096 0.039
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.090 0.028
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.090 0.074
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.090 0.028
TLN2 TLN2: Uncharacterized protein TLN2 0.090 0.044
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.090 0.044
SPTAN1 N/A 0.081 0.067
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.0308
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.197
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.073 0.060
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.073 0.028
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.073 0.028
PSD TYL: TYL protein 0.064 0.060
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.063 0.032
MT3 MT3: Metallothionein-3 0.062 0.083
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.058 0.036
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.0288
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.0288
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.027
MAP2K5 N/A 0.049 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.027
MAPK15 N/A 0.049 0.027
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.0258
FLT4 VEGFR3 long form 0.046 0.0258
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.046 0.047
COBL N/A 0.0453 0.050
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.044 0.179
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.041 0.060
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.041 0.044
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.041 0.044
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.041 0.029
MAPKAPK5 N/A 0.04 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.04 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.04 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.04 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.04 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.04 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.04 0.027
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.04 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.04 0.027
SOS1 SOS1: Son of sevenless homolog 1 0.037 5.35
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.033 10.50
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.033 0.028
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.033 0.028
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.033 0.044
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.033 0.036
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.033 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.033 0.028
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.0308 0.028
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.0308 0.162
SCN1B SCN1B: Sodium channel subunit beta-1 precursor 0.0308 0.053
RET urf-ret: Urf-ret protein 0.0308 0.200
IL1RAPL1 IL1RAPL1, OPHN4: X-linked interleukin-1 receptor accessory protein-like 1 precur 0.0308 0.053
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.029 0.036
CDK5 CDK5: Cell division protein kinase 5 0.029 0.060
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.036
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.028 0.115
FGFR2 N/A 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.026 17.40
FES N/A 0.0258 0.0258
0.299
Total Score 2.47E4