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Evidence of Interaction Between PSMB2 and PSMB7

The interaction score between PSMB2 and PSMB7 is 6.29E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMB2 and PSMB7 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismPSMB2 OrthologuePSMB7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER012W 1 YOR157C 1
  • AffinityCaptureMS

Get References From PubMed
worm P91477 1 O62102 1
fly Q9VQE5 0.109 Q9VUJ1 1
fly Q9VJJ0 1 Q9VUJ1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMB2 and PSMB7:
Domains in PSMB2Domains in PSMB7
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits

The Chi square scores for co-occurrence of domains that are present in PSMB2 and PSMB7 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMB2
  • Yellow Domain is only present in PSMB7
  • Green Domain is present in both PSMB2 and PSMB7

 0.265
Post-translational Modifications

Protein: PSMB2

PTMResidueReference

Protein: PSMB7

PTMResidueReference
Phosphotyrosine 154 HPRD
Localisation

Protein: PSMB2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMB7

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMB2 and PSMB7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMB2 andPSMB7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMB2 has 257 interactors and PSMB7 has 911 interactors of which there are 158 common interactors.

Common InteractorName of Common InteractorScore for PSMB2-Interactor (?)Score for PSMB7-Interactor (?)
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 691.00 1.59E3
PSMA5 PSMA5: Proteasome subunit alpha type-5 691.00 3.41E3
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 2.07E3
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 691.00 1.59E3
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 691.00 691.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 323.00 691.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 691.00
PSMB3 PSMB3: Proteasome subunit beta type-3 323.00 1.64E3
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 195.00 691.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 23.40
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
CDK2 CDK2: Cell division protein kinase 2 6.55 0.461
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 1.82 0.048
RAD23B RAD23B: UV excision repair protein RAD23 homolog B 1.82 1.82
PSMC1 PSMC1: 26S protease regulatory subunit 4 1.82 0.276
VCP VCP: Transitional endoplasmic reticulum ATPase 1.82 0.129
PSMB4 N/A 1.82 19.70
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 1.82 0.078
NULL RcPSMB3 (Fragment) 1.37 34.70
RPL8 RPL8: 60S ribosomal protein L8 1.10 0.078
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 1.10 0.129
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.890 0.078
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.612 0.141
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.596
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.491 0.666
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.354 0.025
PSMA1 N/A 0.354 0.354
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.354 0.025
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 1.62
CDK4 CDK4: Cell division protein kinase 4 0.263 0.461
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.95
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.878
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.179 0.179
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.179 0.179
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.179 0.221
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.137 0.515
BUB1 0.123 0.060
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.123 0.074
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.060
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.074
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.123 0.372
NULL N/A 0.119 0.119
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.108 2.47
RAD23A RAD23A: UV excision repair protein RAD23 homolog A 0.082 0.108
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.074 0.275
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.074 0.372
CDK7 CDK7, MO15: Cell division protein kinase 7 0.074 0.461
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.074 0.763
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.074 0.763
WEE1 WEE1: Wee1-like protein kinase 0.074 0.275
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.461
STK16 N/A 0.067 0.251
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.307
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.067 0.067
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.060 0.123
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.060 0.275
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.060 0.372
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.060 0.060
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.060 0.461
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.060 0.763
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.059 0.059
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.059 0.304
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.059 0.059
ROCK1 ROCK1: Rho-associated protein kinase 1 0.050 0.307
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.050 0.083
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.093
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.044 0.461
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.225
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.044 0.372
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.060
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.044 0.372
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.044 0.372
RPS6KB1 N/A 0.044 0.372
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.044 0.275
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.044
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.044 0.074
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.060
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.044 0.225
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.044
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.372
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.044 0.275
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.044 0.461
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.044 0.276
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.041 0.067
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.251
EIF2AK1 N/A 0.041 0.041
VRK3 N/A 0.041 0.050
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.041 0.140
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.038 0.160
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.036 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.036 0.275
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.036 0.372
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.036 0.171
CSNK1D CSNK1D: Casein kinase I isoform delta 0.036 0.060
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.036 0.275
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.036 0.093
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.036 0.036
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.036 0.275
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.036 0.171
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.076
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.036 0.275
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.036 0.126
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.036 0.372
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.036 0.036
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.036 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.275
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.036
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.036 0.111
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.047
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.035 0.047
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0308 0.251
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0308 0.191
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.0308 0.0308
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.0308
LIMK2 LIMK2: LIM domain kinase 2 0.0308 0.085
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
GAK GAK: Cyclin G-associated kinase 0.029 0.035
CDK6 CDK6: Cell division protein kinase 6 0.028 0.225
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.028 0.036
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.028 0.275
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.028 0.036
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.028 0.225
PIM1 N/A 0.028 0.028
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.028 0.275
STK10 STK10: Uncharacterized protein STK10 0.028 0.225
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.225
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.028 0.036
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.028 0.136
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
MAPKAPK5 N/A 0.027 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
CDC2L2 N/A 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
MAP2K5 N/A 0.027 0.056
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.056
MAPK15 N/A 0.027 0.165
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
0.228
Total Score 6.29E4