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Evidence of Interaction Between TGFB1 and TGFBR1

The interaction score between TGFB1 and TGFBR1 is 336.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TGFB1 and TGFBR1 = 0.11

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismTGFB1 OrthologueTGFBR1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00021780 0.3 IPI00293271 0.211
  • Immunoprecipitation
  • Other
  • InVitro

Get References From PubMed
human IPI00021780 0.3 IPI00029219 0.262
human IPI00021780 0.3 IPI00302552 0.527
fly Q9V4E6 0.3 Q8MKS1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in TGFB1 and TGFBR1:
Domains in TGFB1Domains in TGFBR1
IPR002400 Growth factor, cystine knot
IPR001839 Transforming growth factor beta
IPR001111 Transforming growth factor beta (TGFb), N-terminal
IPR003911 Transforming growth factor beta TGFb
IPR003939 Transforming growth factor, beta 1
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR003605 TGF beta receptor, GS motif
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor

The Chi square scores for co-occurrence of domains that are present in TGFB1 and TGFBR1 are listed below.

Domain 1Domain 2Chi Square
IPR001839 Transforming growth factor beta IPR000472 TGF-beta receptor/activin receptor, type I/II 1864.47
IPR001839 Transforming growth factor beta IPR000333 Activin type II receptor 1635.59
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000472 TGF-beta receptor/activin receptor, type I/II 1502.1
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000333 Activin type II receptor 1405.74
IPR001839 Transforming growth factor beta IPR003605 TGF beta receptor, GS motif 861.134
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR003605 TGF beta receptor, GS motif 807.41
IPR002400 Growth factor, cystine knot IPR000472 TGF-beta receptor/activin receptor, type I/II 625.909
IPR002400 Growth factor, cystine knot IPR000333 Activin type II receptor 428.465
IPR002400 Growth factor, cystine knot IPR003605 TGF beta receptor, GS motif 150.057
IPR001839 Transforming growth factor beta IPR008271 Serine/threonine protein kinase, active site 113.519
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR008271 Serine/threonine protein kinase, active site 82.2948
IPR001839 Transforming growth factor beta IPR000719 Protein kinase 46.8332
IPR001839 Transforming growth factor beta IPR011009 Protein kinase-like 33.7075
IPR002400 Growth factor, cystine knot IPR008271 Serine/threonine protein kinase, active site 32.5032
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000719 Protein kinase 26.4504
IPR002400 Growth factor, cystine knot IPR000719 Protein kinase 15.838
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR011009 Protein kinase-like 13.6144
IPR002400 Growth factor, cystine knot IPR011009 Protein kinase-like 4.6692

The background colour of the table refers to:

  • Blue Domain is only present in TGFB1
  • Yellow Domain is only present in TGFBR1
  • Green Domain is present in both TGFB1 and TGFBR1

 0.980
Post-translational Modifications

Protein: TGFB1

PTMResidueReference
N-linked 82 PubMed, HPRD

Protein: TGFBR1

PTMResidueReference
Phosphorylation 172 PubMed, HPRD
Phosphorylation 176 PubMed, HPRD
Localisation

Protein: TGFB1

LocalisationReference
Secreted HPRD

Protein: TGFBR1

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between TGFB1 and TGFBR1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TGFB1 andTGFBR1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TGFB1 has 732 interactors and TGFBR1 has 887 interactors of which there are 307 common interactors.

Common InteractorName of Common InteractorScore for TGFB1-Interactor (?)Score for TGFBR1-Interactor (?)
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 422.00 71.20
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 142.00 10.50
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 1.13 0.097
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.917 0.026
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.917 0.026
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.917 0.026
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.917 0.032
LYN LYN: Tyrosine-protein kinase Lyn 0.757 0.073
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.678 0.033
STK10 STK10: Uncharacterized protein STK10 0.678 0.033
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.541 0.026
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.318 0.064
CSK CSK: Tyrosine-protein kinase CSK 0.318 0.090
HCK N/A 0.318 0.064
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.318 0.033
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.318 0.073
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.318 0.033
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.275 0.033
SORL1 SORL1: Sortilin-related receptor precursor 0.253 0.026
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.245 0.049
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.245 0.043
ITGB7 ITGB7: Integrin beta-7 precursor 0.227 0.029
ROCK1 ROCK1: Rho-associated protein kinase 1 0.214 0.081
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.210 0.026
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.192 0.064
SYK SYK: Tyrosine-protein kinase SYK 0.192 0.064
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.192 0.033
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.192 0.033
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.192 0.033
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.192 0.148
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.192 0.033
JAK1 0.192 0.090
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.192 0.033
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.192 0.027
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.192 0.029
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.173 0.030
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.173 0.037
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.173 0.037
OPTC OPTC, OPT: Opticin precursor 0.165 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.165 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.165 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.165 0.028
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.156 27.30
RPS6KB1 N/A 0.155 0.027
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.155 0.033
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.155 0.113
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.155 0.033
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.155 0.090
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.155 0.033
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.155 0.041
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.155 0.051
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.155 0.027
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.155 0.058
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.153 0.062
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.153 0.026
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.153 0.032
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.152 0.731
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.152 0.081
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.137 0.054
ACVR2B ACVR2B: Activin receptor type-2B precursor 0.130 0.028
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.128 0.037
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.128 0.030
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.128 0.0263
CIITA CIITA, MHC2TA: MHC class II transactivator 0.128 0.032
CGA CGA: Glycoprotein hormones alpha chain precursor 0.123 0.072
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.123 0.037
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.114 0.027
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.114 0.113
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.028
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.028
FSHB FSHB: Follitropin subunit beta precursor 0.109 0.072
LHB LHB: Lutropin subunit beta precursor 0.109 0.072
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.109 0.032
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.105 0.046
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.105 0.126
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.105 0.026
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.105 0.0263
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.105 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.100 0.049
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.100 0.026
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.099 0.033
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.099 0.056
TSHB TSHB: Thyrotropin subunit beta precursor 0.098 0.072
INHA INHA: Inhibin alpha chain precursor 0.098 0.644
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.098 0.072
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.098 0.025
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.098 0.025
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.025
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.098 0.047
JAG2 JAG2: Jagged-2 precursor 0.098 0.025
VWF VWF, F8VWF: von Willebrand factor precursor 0.097 0.808
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.094 0.148
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.094 0.029
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.094 0.027
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.094 0.041
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.094 0.033
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.094 0.041
CDK4 CDK4: Cell division protein kinase 4 0.094 0.027
ATM ATM: Serine-protein kinase ATM 0.094 0.041
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.091 0.026
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.091 0.032
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.091 0.026
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.091 0.026
CD7 CD7: T-cell antigen CD7 precursor 0.091 0.032
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.088 0.655
NDP NDP: Norrin precursor 0.088 0.065
FADD FADD, MORT1: Protein FADD 0.087 0.077
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.083 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.083 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.083 0.049
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.0794 0.081
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.077 0.0453
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.076 27.30
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.076 0.0453
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.075 0.032
CCR5 CCR5: CCR5 receptor (Fragment) 0.075 0.048
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.075 0.062
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.075 0.026
CNTN1 CNTN1: Contactin-1 precursor 0.075 0.025
CNTN4 CNTN4: Contactin-4 precursor 0.075 0.025
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.074 0.062
CD44 N/A 0.074 0.062
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.074 0.055
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.073 0.069
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.073 0.086
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.071 0.033
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.071 0.027
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.071 0.051
CDK2 CDK2: Cell division protein kinase 2 0.071 0.033
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.071 0.026
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.071 0.027
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.071 0.027
MAPKAPK5 N/A 0.0688 0.04
CDC2 CDC2: Cell division control protein 2 homolog 0.0688 0.036
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.0688 0.04
EEF2K EEF2K: Elongation factor 2 kinase 0.0688 0.098
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.0688 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.0688 0.049
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.0688 0.04
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.0688 0.04
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.0688 0.036
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.0688 0.04
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.0688 0.049
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.0688 0.04
MAPK15 N/A 0.0688 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.0688 0.036
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.067 0.0308
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.064 0.0308
KIT KIT: Mast/stem cell growth factor receptor precursor 0.064 0.044
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.064 0.069
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.063 0.037
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.063 0.037
PRKAA1 N/A 0.063 0.037
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.062 0.036
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.062 0.036
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.062 0.036
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.062 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.062 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.062 0.036
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.062 0.044
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.062 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.062 0.044
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.062 0.030
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.062 0.036
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.062 0.036
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.062 0.098
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.062 0.044
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.062 0.036
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.062 0.036
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.062 0.036
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.062 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.062 0.030
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.058 0.029
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.058 0.056
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.058 0.029
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.058 0.044
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.057 0.029
WEE1 WEE1: Wee1-like protein kinase 0.057 0.033
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.057 0.073
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.057 0.026
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.057 0.032
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.057 0.077
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.026
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.052 0.111
NEO1 NEO1, NGN: Neogenin precursor 0.052 0.069
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.051 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.051 0.037
DAPK2 DAPK2: Death-associated protein kinase 2 0.051 0.037
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.051 0.037
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.051 0.064
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.051 0.0263
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.051 0.037
GP9 GP9: Platelet glycoprotein IX precursor 0.051 0.026
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.049 0.165
TMPRSS9 N/A 0.049 0.025
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.083
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.049 0.028
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.049 0.028
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.049 0.028
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.049 0.028
EDA N/A 0.049 0.028
DLK1 DLK1, DLK: Delta-like protein precursor 0.049 0.028
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.049 0.028
TBXA2R TBXA2R: Thromboxane A2 receptor 0.049 0.052
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.049 0.028
KIR3DL1 N/A 0.049 0.028
DRD2 DRD2: D(2) dopamine receptor 0.049 0.028
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.083
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.046 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.046 0.027
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.046 0.065
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.046 0.058
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.046 0.033
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.046 0.027
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.046 0.033
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.046 0.073
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.046 0.057
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.046 0.027
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.0453 0.096
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.0453 0.026
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.077
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.0453 0.026
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.045 0.051
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.045 0.072
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.044 0.025
ATRN N/A 0.044 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.075
BSG N/A 0.044 0.025
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.041 0.033
MYO3A MYO3A: Myosin IIIA 0.041 0.041
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.041 0.033
BMX N/A 0.041 0.081
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.041 0.100
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.041 0.030
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.041 0.033
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.041 0.054
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.041 0.029
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.038 0.033
VAV1 VAV1, VAV: Proto-oncogene vav 0.038 0.090
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.038 0.090
STAT6 STAT6: Signal transducer and activator of transcription 6 0.038 0.090
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.038 0.073
CXorf9 N/A 0.038 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.038 0.033
MSN MSN: Moesin 0.038 0.090
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.038 0.090
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.038 0.033
GMIP GMIP: GEM-interacting protein 0.038 0.073
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.030
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.037 0.026
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.037 0.032
ITGB4 N/A 0.037 0.062
MT2A MT2A, CES1, MT2: Metallothionein-2 0.037 0.029
LOC645745 MT1H: Metallothionein-1H 0.037 0.033
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.037 0.027
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.037 0.027
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.037 0.064
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.036 0.055
MT1X MT1X: Metallothionein-1X 0.033 0.029
MT1F MT1F, PRO0376: Metallothionein-1F 0.033 0.033
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.033 0.034
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.033 0.064
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.032 0.026
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.032 0.052
HTR6 HTR6: 5-hydroxytryptamine receptor 6 0.032 0.026
EGF EGF: Pro-epidermal growth factor precursor 0.032 0.055
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.049
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.077
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.032 0.062
F5 F5: Coagulation factor V precursor 0.032 0.032
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.032 0.072
OSM OSM: Oncostatin-M precursor 0.032 0.0263
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.032 0.029
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.030 29.60
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.029 0.088
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.029 0.026
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.029 0.026
RHO RHO, OPN2: Rhodopsin 0.029 0.077
PVR PVR, PVS: Poliovirus receptor precursor 0.029 0.026
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.055
THOC1 THOC1, HPR1: THO complex subunit 1 0.029 0.029
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.083
FN1 N/A 0.028 0.028
IFNG IFNG: Interferon gamma precursor 0.028 0.04
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
OXTR OXTR: Oxytocin receptor 0.028 0.028
STK16 N/A 0.027 0.046
LIMK2 LIMK2: LIM domain kinase 2 0.027 0.037
GDF1 GDF1: Embryonic growth/differentiation factor 1 precursor 0.027 0.217
GDF7 gdf7: Growth differentiation factor 7 0.027 0.217
GDNF GDNF: Glial cell line-derived neurotrophic factor precursor 0.027 0.217
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.027 0.026
CD69 CD69: Early activation antigen CD69 0.027 0.032
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.027 0.096
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.026 0.049
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.026 0.032
HLA-DQB2 HLA-DQB2, DASS-256O6.1-002, XXbac-BCX231H22.1-002, XXbac-BPG3L13.3-002: Major hi 0.026 0.026
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.026 0.081
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.026 0.030
CRLF3 N/A 0.025 0.026
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.025
2.15E-3
Total Score 336.00