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Evidence of Interaction Between TGFB1 and TGFBR2

The interaction score between TGFB1 and TGFBR2 is 258.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TGFB1 and TGFBR2 = 0.28

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains Domains present in TGFB1 and TGFBR2:
Domains in TGFB1Domains in TGFBR2
IPR002400 Growth factor, cystine knot
IPR001839 Transforming growth factor beta
IPR001111 Transforming growth factor beta (TGFb), N-terminal
IPR003911 Transforming growth factor beta TGFb
IPR003939 Transforming growth factor, beta 1
IPR000719 Protein kinase
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor

The Chi square scores for co-occurrence of domains that are present in TGFB1 and TGFBR2 are listed below.

Domain 1Domain 2Chi Square
IPR001839 Transforming growth factor beta IPR000472 TGF-beta receptor/activin receptor, type I/II 1864.47
IPR001839 Transforming growth factor beta IPR000333 Activin type II receptor 1635.59
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000472 TGF-beta receptor/activin receptor, type I/II 1502.1
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000333 Activin type II receptor 1405.74
IPR002400 Growth factor, cystine knot IPR000472 TGF-beta receptor/activin receptor, type I/II 625.909
IPR002400 Growth factor, cystine knot IPR000333 Activin type II receptor 428.465
IPR001839 Transforming growth factor beta IPR008271 Serine/threonine protein kinase, active site 113.519
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR008271 Serine/threonine protein kinase, active site 82.2948
IPR001839 Transforming growth factor beta IPR000719 Protein kinase 46.8332
IPR002400 Growth factor, cystine knot IPR008271 Serine/threonine protein kinase, active site 32.5032
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000719 Protein kinase 26.4504
IPR002400 Growth factor, cystine knot IPR000719 Protein kinase 15.838

The background colour of the table refers to:

  • Blue Domain is only present in TGFB1
  • Yellow Domain is only present in TGFBR2
  • Green Domain is present in both TGFB1 and TGFBR2

 0.980
Post-translational Modifications

Protein: TGFB1

PTMResidueReference
N-linked 82 PubMed, HPRD

Protein: TGFBR2

PTMResidueReference
Phosphorylation 238 PubMed, HPRD
Phosphorylation 250 PubMed, HPRD
Phosphorylation 253 PubMed, HPRD
Phosphorylation 254 PubMed, HPRD
Phosphorylation 284 PubMed, HPRD
Phosphorylation 361 PubMed, HPRD
Phosphorylation 434 PubMed, HPRD
Phosphorylation 441 PubMed, HPRD
Phosphorylation 449 PubMed, HPRD
Phosphorylation 576 PubMed, HPRD
Phosphorylation 578 PubMed, HPRD
Localisation

Protein: TGFB1

LocalisationReference
Secreted HPRD

Protein: TGFBR2

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TGFB1 and TGFBR2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TGFB1 andTGFBR2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TGFB1 has 732 interactors and TGFBR2 has 843 interactors of which there are 262 common interactors.

Common InteractorName of Common InteractorScore for TGFB1-Interactor (?)Score for TGFBR2-Interactor (?)
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 422.00 0.075
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 388.00 0.097
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.917 0.0425
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.917 0.0425
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.917 0.0425
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.917 0.0425
LYN LYN: Tyrosine-protein kinase Lyn 0.757 0.090
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.541 0.0425
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.484 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.318 0.067
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.318 0.090
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.318 0.126
CSK CSK: Tyrosine-protein kinase CSK 0.318 0.113
HCK N/A 0.318 0.090
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.304 0.026
SORL1 SORL1: Sortilin-related receptor precursor 0.253 0.032
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.253 0.032
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.245 0.026
ITGB7 ITGB7: Integrin beta-7 precursor 0.227 0.038
ACVR1 ACVR1, ACVRLK2: Activin receptor type-1 precursor 0.225 0.028
ROCK1 ROCK1: Rho-associated protein kinase 1 0.214 0.126
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.210 0.026
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.192 0.113
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.192 0.051
JAK1 0.192 0.202
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.192 0.051
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.192 0.075
SYK SYK: Tyrosine-protein kinase SYK 0.192 0.100
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.192 0.081
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.192 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.173 0.075
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.173 0.037
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.165 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.165 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.165 0.028
OPTC OPTC, OPT: Opticin precursor 0.165 0.028
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.156 0.071
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.155 0.067
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.155 0.126
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.155 0.113
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.155 0.090
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.155 0.035
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.153 0.026
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.153 0.096
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.153 0.032
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.153 0.032
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.153 0.026
FPR1 FPR1: fMet-Leu-Phe receptor 0.153 0.026
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.152 0.902
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.152 0.100
TLR4 TLR4: Toll-like receptor 4 precursor 0.148 0.026
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.137 0.038
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.137 0.054
COL5A1 N/A 0.130 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.128 0.091
CIITA CIITA, MHC2TA: MHC class II transactivator 0.128 0.0453
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.124 0.026
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.124 0.026
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.124 0.032
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.123 0.036
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.123 0.057
CGA CGA: Glycoprotein hormones alpha chain precursor 0.123 0.081
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.123 0.036
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.114 0.166
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.111 0.029
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.111 0.027
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.028
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.028
LHB LHB: Lutropin subunit beta precursor 0.109 0.081
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.109 0.0453
FSHB FSHB: Follitropin subunit beta precursor 0.109 0.081
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.105 0.126
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.105 0.033
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.105 0.081
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.099 0.031
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.098 0.065
TSHB TSHB: Thyrotropin subunit beta precursor 0.098 0.072
INHA INHA: Inhibin alpha chain precursor 0.098 0.581
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.028
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.098 0.028
JAG2 JAG2: Jagged-2 precursor 0.098 0.025
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.098 0.028
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.098 0.028
VWF VWF, F8VWF: von Willebrand factor precursor 0.097 0.581
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.094
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.094 0.041
ATM ATM: Serine-protein kinase ATM 0.094 0.067
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.094 0.166
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.094 0.033
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.091 0.032
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.091 0.026
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.091 0.026
CD7 CD7: T-cell antigen CD7 precursor 0.091 0.032
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.091 0.026
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.091 0.032
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.088 0.520
NDP NDP: Norrin precursor 0.088 0.0727
FADD FADD, MORT1: Protein FADD 0.087 0.096
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.083 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.083 0.049
NULL A1BG: Alpha-1B-glycoprotein precursor 0.083 0.028
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.0818 0.029
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.0794 0.126
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.077 0.037
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.076 0.114
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.076 0.075
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.075 0.0425
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.075 0.062
CCR5 CCR5: CCR5 receptor (Fragment) 0.075 0.080
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.075 0.032
CNTN4 CNTN4: Contactin-4 precursor 0.075 0.028
CNTN1 CNTN1: Contactin-1 precursor 0.075 0.028
CD44 N/A 0.074 0.127
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.074 0.077
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.074 0.127
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.074 0.026
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.073 0.086
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.073 0.029
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.072 0.026
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.072 0.029
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.071 0.037
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.071 0.041
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.0688 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.0688 0.049
MAPK15 N/A 0.0688 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.0688 0.04
EEF2K EEF2K: Elongation factor 2 kinase 0.0688 0.098
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.0688 0.049
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.067 0.039
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.064 0.062
COL5A2 N/A 0.062 0.036
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.062 0.098
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.062 0.049
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.062 0.030
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.062 0.109
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.062 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.062 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.062 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.062 0.044
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.062 0.044
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.062 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.058 0.029
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.057 0.090
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.057 0.041
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.057 0.026
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.057 0.055
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.057 0.026
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.057 0.0425
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.056 0.032
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.052 0.088
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.051 0.113
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.051 0.0453
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.049 0.028
EDA N/A 0.049 0.028
DLK1 DLK1, DLK: Delta-like protein precursor 0.049 0.028
TBXA2R TBXA2R: Thromboxane A2 receptor 0.049 0.052
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.049 0.028
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.049 0.028
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.083
KIR3DL1 N/A 0.049 0.028
DRD2 DRD2: D(2) dopamine receptor 0.049 0.028
TMPRSS9 N/A 0.049 0.025
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.049 0.165
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.083
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.049 0.028
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.049 0.028
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.049 0.028
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.047 0.036
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.046 0.067
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.046 0.032
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.046 0.072
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.046 0.064
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.046 0.073
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.046 0.071
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.0453 0.052
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.0453 0.096
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.0453 0.032
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.096
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.045 0.072
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.045 0.029
FCGR2A FCGR2A: Fc of IgG, low affinity IIa, receptor 0.0446 0.026
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.044 0.025
ATRN N/A 0.044 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.075
BSG N/A 0.044 0.028
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.041 0.029
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.041 0.081
BMX N/A 0.041 0.065
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.041 0.0425
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.041 0.029
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.040 0.029
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.040 0.038
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.038 0.067
STAT6 STAT6: Signal transducer and activator of transcription 6 0.038 0.113
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.038 0.113
MSN MSN: Moesin 0.038 0.148
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.038 0.148
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.038 0.075
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.038 0.067
GMIP GMIP: GEM-interacting protein 0.038 0.113
VAV1 VAV1, VAV: Proto-oncogene vav 0.038 0.113
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.038 0.035
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.038 0.113
FYN N/A 0.037 0.032
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.037 0.032
ITGB4 N/A 0.037 0.055
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.037 0.032
LOC645745 MT1H: Metallothionein-1H 0.037 0.029
MT2A MT2A, CES1, MT2: Metallothionein-2 0.037 0.033
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.037 0.0263
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.037 0.058
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.036 0.077
ITGAE ITGAE: Integrin alpha-E precursor 0.036 0.032
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.036 0.052
LILRB1 N/A 0.035 0.026
MT1X MT1X: Metallothionein-1X 0.033 0.033
MT1F MT1F, PRO0376: Metallothionein-1F 0.033 0.029
GNAI2 Galphai2 protein 0.033 0.032
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.033 0.058
EGF EGF: Pro-epidermal growth factor precursor 0.032 0.077
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.077
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.049
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.032 0.062
OSM OSM: Oncostatin-M precursor 0.032 0.037
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.032 0.202
F5 F5: Coagulation factor V precursor 0.032 0.037
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.032 0.038
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.030 0.062
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.029 0.123
RHO RHO, OPN2: Rhodopsin 0.029 0.049
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.049
PVR PVR, PVS: Poliovirus receptor precursor 0.029 0.026
THOC1 THOC1, HPR1: THO complex subunit 1 0.029 0.041
FN1 N/A 0.028 0.028
IFNG IFNG: Interferon gamma precursor 0.028 0.04
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.083
LIMK2 LIMK2: LIM domain kinase 2 0.027 0.037
GDNF GDNF: Glial cell line-derived neurotrophic factor precursor 0.027 0.217
GDF7 gdf7: Growth differentiation factor 7 0.027 0.217
GDF1 GDF1: Embryonic growth/differentiation factor 1 precursor 0.027 0.217
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.027 0.096
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.027 0.032
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.027 0.0425
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.027 0.032
CD69 CD69: Early activation antigen CD69 0.027 0.0425
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.026 0.049
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.026 0.029
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.026 0.027
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.026 0.032
LOX LOX: Protein-lysine 6-oxidase precursor 0.026 0.036
STC2 STC2: Stanniocalcin-2 precursor 0.026 0.027
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.026 0.081
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.026 0.037
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.026 0.027
CRLF3 N/A 0.025 0.032
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.025
0.572
Total Score 258.00