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Evidence of Interaction Between LSM6 and LSM5

The interaction score between LSM6 and LSM5 is 3.76E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LSM6 and LSM5 = 0.72

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismLSM6 OrthologueLSM5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDR378C 1 YER146W 1
  • Y2H
  • Other

Get References From PubMed
worm Q95XN6 1 O18694 1
fly Q9W2P5 1 Q9VRT7 1
  • Y2H
  • Other

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in LSM6 and LSM5:
Domains in LSM6Domains in LSM5
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM6 and LSM5 are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR010920 Small nuclear-like ribonucleoprotein IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1143.95

The background colour of the table refers to:

  • Blue Domain is only present in LSM6
  • Yellow Domain is only present in LSM5
  • Green Domain is present in both LSM6 and LSM5

 0.265
Post-translational Modifications

Protein: LSM6

PTMResidueReference

Protein: LSM5

PTMResidueReference
N-acetylalanine 1 HPRD
Localisation

Protein: LSM6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: LSM5

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LSM6 and LSM5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM6 andLSM5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM6 has 213 interactors and LSM5 has 349 interactors of which there are 194 common interactors.

Common InteractorName of Common InteractorScore for LSM6-Interactor (?)Score for LSM5-Interactor (?)
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 691.00 3.41E3
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 323.00 3.51E3
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 323.00 1.28E3
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 323.00 3.51E3
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 323.00 323.00
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 323.00 2.74E3
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 158.00 195.00
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 32.60 32.60
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 68.20
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 0.0968
SNRPE SNRPE: Small nuclear ribonucleoprotein E 2.91 8.73
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 2.91
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 4.86
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 1.49
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 1.22 38.60
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 1.22 205.00
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 1.22 691.00
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 1.10 0.890
FLJ36874 N/A 0.593 0.218
DCP1A DCP1A, SMIF: mRNA-decapping enzyme 1A 0.494 0.918
XRN1 XRN1, SEP1: 5'-3' exoribonuclease 1 0.354 0.354
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.293 0.137
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
BAT1 N/A 0.263 0.123
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.237
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.237
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.141 0.158
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.137
WDR41 N/A 0.137 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.287
DDX21 DDX21: Nucleolar RNA helicase 2 0.137 0.613
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.137 0.083
GNB2L1 Lung cancer oncogene 7 0.137 0.287
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.287
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.123
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.123 0.257
WDR39 CIAO1, WDR39: Protein CIAO1 0.123 0.060
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.074
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.074
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.123 0.263
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.123 0.257
NUP43 N/A 0.123 0.263
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.074
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.074
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.074
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.123 0.123
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.074
CORO1A CORO1A, CORO1: Coronin-1A 0.123 0.044
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.123
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.123 0.074
DDX47 E4-DBP: DEAD box protein 0.123 0.123
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.074
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.123 0.123
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.123 0.126
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.257
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.257
TSSC1 TSSC1: Protein TSSC1 0.123 0.074
LOC197135 N/A 0.119 0.119
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.287
DDB2 DDB2: DNA damage-binding protein 2 0.083 0.083
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.083
WDR8 WDR8: WD repeat-containing protein 8 0.083 0.067
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.083 0.083
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.156
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.074 0.257
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.074
CORO7 CORO7: Coronin-7 0.074 0.044
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.074 0.126
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.074
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 0.123
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.074 0.123
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.060
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.074 0.156
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.074
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.074 0.074
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.156
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.074 0.123
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.074 0.074
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.074 0.123
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.074 0.044
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.123
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.074 0.123
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.074 0.060
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.074 0.074
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.074
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.074 0.093
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.156
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.156
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.074 0.123
NUP37 NUP37: Nucleoporin Nup37 0.074 0.263
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.074 0.060
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.074 0.060
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.074
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.074 0.257
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.074 0.093
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.074 0.060
LOC119358 similar to small nuclear ribonucleoprotein D2 0.071 0.071
WDR1 N/A 0.067 0.103
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.065 0.039
SEC31L1 N/A 0.060 0.126
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.060 0.093
AAMP AAMP: Angio-associated migratory cell protein 0.060 0.060
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.060 0.060
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.060 0.126
NBEAL2 N/A 0.060 0.044
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.060
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.060 0.156
CDC20 CDC20: Cell division cycle protein 20 homolog 0.060 0.156
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.060 0.074
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.060 0.036
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.060
COPA COPA: Coatomer subunit alpha 0.060 0.093
RAE1 RAE1, MRNP41: mRNA export factor 0.060 0.044
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.060 0.156
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.060 0.074
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.060 0.263
WDR12 WDR12: WD repeat-containing protein 12 0.060 0.123
WDR67 WDR67: WD repeat-containing protein 67 0.060 0.044
WDR18 N/A 0.060 0.123
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.060
COPB2 COPB2: Coatomer subunit beta' 0.060 0.126
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.060 0.123
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.060 0.126
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.060 0.060
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.060
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.060 0.093
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.060 0.074
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.060 0.093
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.060
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.055 0.0331
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.041
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.050 0.067
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.050 0.041
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.047 0.059
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.044 0.028
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.044 0.036
WDR45L N/A 0.044 0.036
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.044 0.036
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.076
AAAS AAAS, ADRACALA, GL003: Aladin 0.044 0.044
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.044 0.036
CORO1C CORO1C, CRNN4: Coronin-1C 0.044 0.126
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.036
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.044 0.036
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.044 0.156
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.044 0.028
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.044 0.058
TTF2 TTF2: Transcription termination factor 2 0.044 0.074
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.093
WDR37 N/A 0.044 0.028
WDR42A N/A 0.044 0.028
WDR13 WDR13: WD repeat-containing protein 13 0.041 0.0308
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.041
NUP214 N/A 0.041 0.051
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.039 0.160
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.036 0.046
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.044
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.036 0.058
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.036 0.060
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.036 0.126
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.036 0.028
EIF4A2 EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II 0.036 0.028
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.036 0.156
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.036 0.156
BRWD2 BRWD2, WDR11, WDR15: Bromodomain and WD repeat-containing protein 2 0.0331 0.027
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.0331 0.0331
LBR LBR: Lamin-B receptor 0.0331 0.0331
SH3BP3 0.0308 0.051
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.028 0.044
HNRPD N/A 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
WDR17 N/A 0.027 0.027
PHF1 N/A 0.027 0.027
BRWD1 N/A 0.027 0.027
KIF21A N/A 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
WDR72 N/A 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.056
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
WDR53 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
WDR54 N/A 0.027 0.056
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.056
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
NEDD1 N/A 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.027 0.057
SNRPB N/A 0.0258 0.0258
0.572
Total Score 3.76E5