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Evidence of Interaction Between KPNA2 and RELB

The interaction score between KPNA2 and RELB is 2.28E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KPNA2 and RELB = 0.26

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3
Orthology
OrganismKPNA2 OrthologueRELB OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00002214 1 IPI00386448 0.08
  • InVitro

Get References From PubMed

human IPI00374362 0.069 IPI00386448 0.08
fly P52295 1 P15330 0.08

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.58
Domains Domains present in KPNA2 and RELB:
Domains in KPNA2Domains in RELB
IPR000225 Armadillo
IPR002652 Importin alpha-like protein, beta-binding region
IPR011989 ARM-like.
IPR002909 Cell surface receptor IPT/TIG
IPR008967 p53-like transcription factor, DNA-binding
IPR000451 NF-kappa-B/Rel/dorsal
IPR011539 RHD.

The Chi square scores for co-occurrence of domains that are present in KPNA2 and RELB are listed below.

Domain 1Domain 2Chi Square
IPR011989 ARM-like. IPR008967 p53-like transcription factor, DNA-binding 0.196485

The background colour of the table refers to:

  • Blue Domain is only present in KPNA2
  • Yellow Domain is only present in RELB
  • Green Domain is present in both KPNA2 and RELB

0.021
Post-translational Modifications

Protein: KPNA2

PTMResidueReference
Acetylation 22 PubMed, HPRD

Protein: RELB

PTMResidueReference
Localisation

Protein: KPNA2

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: RELB

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KPNA2 and RELB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KPNA2 andRELB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KPNA2 has 969 interactors and RELB has 133 interactors of which there are 15 common interactors.

Common InteractorName of Common InteractorScore for KPNA2-Interactor (?)Score for RELB-Interactor (?)
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 19.00 2.80
CREBBP CREBBP, CBP: CREB-binding protein 13.60 5.36
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.124 0.041
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.114 0.028
RELA RELA, NFKB3: Transcription factor p65 0.113 6.55
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.086 1.66
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.0818 0.441
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.063 0.029
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.063 0.029
IRF3 IRF3: Interferon regulatory factor 3 0.0453 0.067
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.0425 0.0255
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.041 4.07
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.038 2.05
MAP2K3 N/A 0.025 0.642
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.025 0.039
0.228
Total Score 2.28E3