Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to USP3

Evidence of Interaction Between USP3 and VPS18

The interaction score between USP3 and VPS18 is 2.17.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismUSP3 OrthologueVPS18 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q9GRV2 1 Q23194 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in USP3 and VPS18:
Domains in USP3Domains in VPS18
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase family 2
IPR001607 Zn-finger in ubiquitin thiolesterase
IPR001841 Zn-finger, RING
IPR007810 Pep3/Vps18/deep orange
IPR000547 7-Fold repeat in clathrin and VPS proteins

The Chi square scores for co-occurrence of domains that are present in USP3 and VPS18 are listed below.

Domain 1Domain 2Chi Square
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase family 2 IPR001841 Zn-finger, RING 19.1024

The background colour of the table refers to:

  • Blue Domain is only present in USP3
  • Yellow Domain is only present in VPS18
  • Green Domain is present in both USP3 and VPS18

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction

Protein: VPS18

LocalisationReference
Lysosome HPRD
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between USP3 and VPS18 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between USP3 andVPS18. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , USP3 has 117 interactors and VPS18 has 108 interactors of which there are 36 common interactors.

Common InteractorName of Common InteractorScore for USP3-Interactor (?)Score for VPS18-Interactor (?)
TRIM38 TRIM38, RNF15, RORET: Tripartite motif-containing protein 38 0.293 0.027
TRIM21 TRIM21, RNF81, RO52, SSA1: 52 kDa Ro protein 0.067 0.027
TRIM26 TRIM26, RNF95, ZNF173: Tripartite motif-containing protein 26 0.050 0.027
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.041 0.027
PARC RP3-330M21.2, PARC, RP3-330M21.2-001, hCG_1818381: OTTHUMP00000016423 0.039 0.027
VPS11 VPS11, RNF108, PP3476: Vacuolar protein sorting-associated protein 11 homolog 0.035 1.94
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.032 0.027
RFPL1 RFPL1, RFPL1L, RNF78: Ret finger protein-like 1 0.0308 0.027
TRAF3 TRAF3, CAP1, CRAF1: TNF receptor-associated factor 3 0.0308 0.027
RFP TRIM27, RFP, RNF76: Zinc finger protein RFP 0.027 0.027
TRIM55 TRIM55, MURF2, RNF29: Tripartite motif-containing protein 55 0.027 0.027
TRIM43 TRIM43: Tripartite motif-containing protein 43 0.027 0.027
MID2 N/A 0.027 0.027
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.027 0.027
TRIM15 TRIM15, RNF93, ZNF178, ZNFB7: Tripartite motif-containing protein 15 0.027 0.027
RNF39 HZFW, RNF39: RING finger protein 39 0.027 0.027
TRIM6 TRIM6, RNF89: Tripartite motif-containing protein 6 0.027 0.027
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
TRIM49 TRIM49, RNF18: Tripartite motif-containing protein 49 0.027 0.027
TRIM50C TRIM74, TRIM50C: Tripartite motif-containing protein 74 0.027 0.027
TRIM7 TRIM7, GNIP, RNF90: Tripartite motif-containing protein 7 0.027 0.027
TRIM35 TRIM35, HLS5, KIAA1098: Tripartite motif-containing protein 35 0.027 0.027
PML PML, MYL, RNF71, TRIM19: Probable transcription factor PML 0.027 0.027
TRIM50B TRIM73, TRIM50B: Tripartite motif-containing protein 73 0.027 0.027
TRIM11 TRIM11, RNF92: Tripartite motif-containing protein 11 0.027 0.027
TRIM5 TRIM5, RNF88: Tripartite motif-containing protein 5 0.027 0.027
RNF36 TRIM69, RNF36, HSD34, HSD-34: Tripartite motif-containing protein 69 0.027 0.027
TRIM41 TRIM41: Tripartite motif-containing protein 41 0.027 0.027
TRIM63 TRIM63, IRF, MURF1, RNF28, SMRZ: E3 ubiquitin-protein ligase TRIM63 0.027 0.027
TRIM47 TRIM47, GOA, RNF100: Tripartite motif-containing protein 47 0.027 0.027
TRIM6 TRIM34, IFP1, RNF21: Tripartite motif-containing protein 34 0.027 0.027
TRIM4 TRIM4, RNF87: Tripartite motif-containing protein 4 0.027 0.027
TRIM50A TRIM50, TRIM50A: Tripartite motif-containing protein 50 0.027 0.027
TRIM52 TRIM52, RNF102: Tripartite motif-containing protein 52 0.027 0.027
TRIM54 TRIM54, MURF, MURF3, RNF30: Tripartite motif-containing protein 54 0.027 0.027
TRIM17 TRIM17, RBCC, RNF16, TERF: Tripartite motif-containing protein 17 0.027 0.027
0.228
Total Score 2.17