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Evidence of Interaction Between FIGF and KDR

The interaction score between FIGF and KDR is 4.86E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FIGF and KDR = 0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismFIGF OrthologueKDR OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00028076 0.22 IPI00293565 0.322
  • Immunoprecipitation
  • InVitroBinding
  • Other
  • InVivo

Get References From PubMed
human IPI00028076 0.22 IPI00005722 0.081
fly Q9BLX1 0.22 Q7KTI7 0.274

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in FIGF and KDR:
Domains in FIGFDomains in KDR
IPR000072 Platelet-derived growth factor (PDGF)
IPR004153 CXCXC repeat
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR009136 Vascular endothelial growth factor receptor 2, VEGFR2
IPR013106 V-set.
IPR013098 I-set.

The Chi square scores for co-occurrence of domains that are present in FIGF and KDR are listed below.

Domain 1Domain 2Chi Square
IPR000072 Platelet-derived growth factor (PDGF) IPR009134 Vascular endothelial growth factor receptor, VEGFR 75.9139
IPR000072 Platelet-derived growth factor (PDGF) IPR001824 Receptor tyrosine kinase, class III 63.1082
IPR000072 Platelet-derived growth factor (PDGF) IPR003598 Immunoglobulin C-2 type 34.7151
IPR000072 Platelet-derived growth factor (PDGF) IPR007110 Immunoglobulin-like 20.1534
IPR000072 Platelet-derived growth factor (PDGF) IPR008266 Tyrosine protein kinase, active site 2.08627
IPR000072 Platelet-derived growth factor (PDGF) IPR000719 Protein kinase 0.0118644

The background colour of the table refers to:

  • Blue Domain is only present in FIGF
  • Yellow Domain is only present in KDR
  • Green Domain is present in both FIGF and KDR

 0.109
Post-translational Modifications

Protein: FIGF

PTMResidueReference
Proteolytic Cleavage 88 PubMed, HPRD
Proteolytic Cleavage 99 PubMed, HPRD

Protein: KDR

PTMResidueReference
Phosphorylation 951 PubMed, HPRD
Phosphorylation 996 PubMed, HPRD
Phosphorylation 1054 PubMed, HPRD
Phosphorylation 1059 PubMed, HPRD
Phosphorylation 1175 PubMed, HPRD
Phosphorylation 1214 PubMed, HPRD
Localisation

Protein: FIGF

LocalisationReference
Secreted HPRD

Protein: KDR

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between FIGF and KDR that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FIGF andKDR. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FIGF has 498 interactors and KDR has 1358 interactors of which there are 372 common interactors.

Common InteractorName of Common InteractorScore for FIGF-Interactor (?)Score for KDR-Interactor (?)
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 283.00 82.20
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 82.20
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 71.40 0.171
KIT KIT: Mast/stem cell growth factor receptor precursor 30.80 0.171
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 27.80 0.136
C1S C1S: Complement C1s subcomponent precursor 0.307 0.0453
THBD THBD, THRM: Thrombomodulin precursor 0.307 0.103
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.275 0.090
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.251 0.081
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.251 0.086
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.251 0.100
C1R C1R: Complement C1r subcomponent precursor 0.251 0.057
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.225 0.041
TNC TNC, HXB: Tenascin precursor 0.225 0.136
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.201 0.075
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.191 0.046
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.152
NOTCH4 N/A 0.191 0.056
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.191 0.061
SHBG SHBG: Sex hormone-binding globulin precursor 0.191 0.032
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.166 0.307
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.109
COL5A1 N/A 0.161 0.166
F7 F7: Coagulation factor VII precursor 0.156 0.044
CFI CFI, IF: Complement factor I precursor 0.152 0.057
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.152 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.152 0.202
LGALS3 LGALS3, MAC2: Galectin-3 0.152 0.037
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.152 0.081
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.152 0.037
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.148 0.056
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.148 0.136
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.098
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.148
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.044
BMP1 N/A 0.148 0.098
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.148 0.040
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.137 0.114
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.137 0.098
C7 C7: Complement component C7 precursor 0.136 0.041
C6 C6: Complement component C6 precursor 0.136 0.033
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.136 0.041
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.136 0.148
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.136 0.113
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.136 0.029
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.130 0.057
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.129 0.113
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.126 0.191
C8A C8A: Complement component C8 alpha chain precursor 0.123 0.037
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.098
APCS APCS, PTX2: Serum amyloid P-component precursor 0.123 0.081
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.123 0.166
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.123 0.098
F9 F9: Coagulation factor IX precursor 0.117 0.041
F10 F10: Coagulation factor X precursor 0.117 0.056
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.113 0.275
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.113 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.113 0.111
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.113 0.225
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.111 0.051
C8B C8B: Complement component C8 beta chain precursor 0.111 0.033
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.111 0.148
ALK ALK: ALK tyrosine kinase receptor precursor 0.111 0.090
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.165
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
TMPRSS9 N/A 0.109 0.025
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.165
DLK1 DLK1, DLK: Delta-like protein precursor 0.109 0.083
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
KIR3DL1 N/A 0.109 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.165
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.165
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.083
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.109 0.123
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.109 0.062
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.123
F12 F12: Coagulation factor XII precursor 0.109 0.037
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.109 0.074
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.109 0.061
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.109 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.109 0.109
MUC2 MUC2, SMUC: Mucin-2 precursor 0.109 0.037
UMOD UMOD: Uromodulin precursor 0.109 0.055
PROC PROC: Vitamin K-dependent protein C precursor 0.103 0.033
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.102 0.073
GPA33 GPA33: Cell surface A33 antigen precursor 0.100 0.123
SELE SELE, ELAM1: E-selectin precursor 0.100 0.152
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.100 0.096
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.109
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.109
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.100 0.123
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.100 0.307
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.100 0.123
PVR PVR, PVS: Poliovirus receptor precursor 0.100 0.152
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.100 0.123
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.098 0.109
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.098 0.109
CSPG2 N/A 0.098 0.072
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.098 0.123
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.098 0.123
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
JAG2 JAG2: Jagged-2 precursor 0.098 0.075
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.148
BSG N/A 0.098 0.148
ATRN N/A 0.098 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.148
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.148
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.097 0.088
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.097 0.049
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.097 0.148
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.090 0.056
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.090 0.097
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.087 0.100
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.081 0.123
EGF EGF: Pro-epidermal growth factor precursor 0.081 0.123
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.081 0.191
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.081 0.123
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.081 0.152
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.081 0.109
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.081 0.123
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.109
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.081 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.081 0.049
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0782 0.0955
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.078 0.090
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.171
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.073 0.136
MEP1B MEP1B: Meprin A subunit beta precursor 0.073 0.136
DCC DCC: Netrin receptor DCC precursor 0.073 0.136
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.073 0.136
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.073 0.069
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.097
LDLR LDLR: Low-density lipoprotein receptor precursor 0.073 0.056
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.0727 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.0727 0.109
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0727 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.072 0.123
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.072 0.251
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.072 0.152
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.109
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.072 0.109
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.072 0.097
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.109
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.072 0.109
ITGB4 N/A 0.072 0.109
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.109
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.055
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.072 0.109
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.072 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.072 0.109
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.123
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.072 0.109
AREG AREG, SDGF: Amphiregulin precursor 0.072 0.055
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.070 0.126
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.070 0.075
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.0688 0.034
VSIG4 VSIG4, Z39IG, UNQ317/PRO362: V-set and immunoglobulin domain-containing protein 0.065 0.0308
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.123
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.065 0.109
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.065 0.055
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.065 0.152
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.064 0.111
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.064 0.086
MEP1A MEP1A: Meprin A subunit alpha precursor 0.064 0.097
VWF VWF, F8VWF: von Willebrand factor precursor 0.063 0.148
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.136
ITGB7 ITGB7: Integrin beta-7 precursor 0.058 0.111
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.058 0.097
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.058 0.114
TTN N/A 0.057 0.064
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.165
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.053 0.041
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.052 0.126
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
IGHG1 N/A 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
IGHM N/A 0.051 0.051
IGHD N/A 0.051 0.051
IGHG3 N/A 0.051 0.051
IGHA1 N/A 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
HLA-A N/A 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.051 0.029
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.051 0.111
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.098
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.049 0.041
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.038
FLT4 VEGFR3 long form 0.046 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.046 0.051
MET MET: Hepatocyte growth factor receptor precursor 0.0453 0.152
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.0453 0.111
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.165
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.148
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.044 0.075
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.148
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.0425 0.0407
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.0425 0.072
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.0425 0.126
LUM LUM, LDC: Lumican precursor 0.0425 0.091
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.0416 0.100
LGALS1 LGALS1: Galectin-1 0.0416 0.0453
ISLR ISLR, UNQ189: ISLR precursor 0.041 0.041
LMAN2 LMAN2, C5orf8: Vesicular integral-membrane protein VIP36 precursor 0.041 0.046
MCAM MCAM, MUC18: Cell surface glycoprotein MUC18 precursor 0.039 0.0308
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.038 0.090
CANX CANX: Calnexin precursor 0.037 0.035
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.036 0.136
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.036 0.111
LAMB2 LAMB2, LAMS: Laminin subunit beta-2 precursor 0.036 0.035
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.035 0.051
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.035 0.029
TNN TNN: Tenascin-N precursor 0.034 0.042
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.0338 0.047
MAPK15 N/A 0.034 0.049
CDC2 CDC2: Cell division control protein 2 homolog 0.034 0.044
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.034 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.034 0.044
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.034 0.049
B2M B2M, CDABP0092, HDCMA22P: Beta-2-microglobulin precursor [Contains: Beta-2-micro 0.033 0.033
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.307
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.033 0.069
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.033 0.088
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.033 0.043
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.069
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.033 0.097
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.032 0.029
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.032 0.100
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.032 0.0453
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.032 0.057
F8 F8, F8C: Coagulation factor VIII precursor 0.032 0.081
RLN2 RLN2: Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain] 0.032 0.032
BGN BGN: Biglycan precursor 0.032 0.0286
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.032 0.081
PZP PZP: Pregnancy zone protein precursor 0.032 0.057
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.032 0.081
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.032 0.126
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.032 0.072
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.031 0.731
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.030 0.878
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.030 0.878
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.030 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.030 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.030 0.030
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.030 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.030 0.030
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.030 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.030 0.044
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.030 0.098
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.030 0.098
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.030 0.225
INSR INSR: Insulin receptor precursor 0.029 0.136
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.029 0.099
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.029 0.113
COL4A1 N/A 0.029 0.245
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.029 0.225
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.029 0.064
SPARC SPARC, ON: SPARC precursor 0.029 0.181
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.051
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.051
CD46 N/A 0.028 0.049
OPTC OPTC, OPT: Opticin precursor 0.028 0.083
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.028 0.165
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.083
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.109
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.109
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.109
DSP DSP: Desmoplakin 0.028 0.049
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
IFNG IFNG: Interferon gamma precursor 0.028 0.109
FN1 N/A 0.028 0.165
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.109
DCN DCN: Decorin precursor 0.028 0.049
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.165
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.109
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.083
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.049
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.028 0.044
IL4 IL4: Interleukin-4 precursor 0.028 0.109
C4A C4A: Complement C4-A precursor 0.028 0.109
CGN N/A 0.028 0.109
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.028 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.028 0.033
MYO3A MYO3A: Myosin IIIA 0.028 0.058
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.028 0.064
MADCAM1 MADCAM1: Mucosal addressin cell adhesion molecule 1 precursor 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
SIRPD N/A 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
SIGLEC11 N/A 0.027 0.027
ROBO1 N/A 0.027 0.027
SIGLEC6 N/A 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
FCAR FCAR, CD89: Immunoglobulin alpha Fc receptor precursor 0.027 0.027
LILRB3 LILRB3, ILT5, LIR3: Leukocyte immunoglobulin-like receptor subfamily B member 3 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
PSG4 PSG4, CGM4, PSG9: Pregnancy-specific beta-1-glycoprotein 4 precursor 0.027 0.027
HFE HFE, HLAH: Hereditary hemochromatosis protein precursor 0.027 0.027
C20orf102 N/A 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
MGC33530 N/A 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
HLA-DQA1 HLA-DQA2, HLA-DXA: HLA class II histocompatibility antigen, DQ(6) alpha chain pr 0.027 0.027
CDH5 CDH5: Cadherin-5 precursor 0.027 0.416
LILRB1 N/A 0.026 0.109
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.026 0.056
IFNA14 IFNA14: Interferon alpha-14 precursor 0.026 0.037
IL3 IL3: Interleukin-3 precursor 0.026 0.072
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.026 0.166
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.026 0.0453
C2 C2: Complement C2 precursor 0.026 0.0453
EPO EPO: Erythropoietin precursor 0.026 0.065
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.026 0.100
C3 0.026 0.100
NDP NDP: Norrin precursor 0.026 0.065
ASPN ASPN: ASPN protein 0.026 0.075
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.026 0.072
WNT2B WNT2B, WNT13: Protein Wnt-2b precursor 0.026 0.033
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.026 0.072
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.025 0.032
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.025 0.051
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.025 1.48
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.025 0.037
BMX N/A 0.025 0.644
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.025 0.081
COL18A1 N/A 0.025 0.040
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.098
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.025
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.098
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.098
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.025 0.040
0.347
Total Score 4.86E3