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Evidence of Interaction Between LSM7 and LSM2

The interaction score between LSM7 and LSM2 is 8.04E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LSM7 and LSM2 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismLSM7 OrthologueLSM2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YNL147W 1 YBL026W 1
  • Y2H
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q23543 1 P92022 1
  • Other

Get References From PubMed
fly Q9VJI7 1 Q9VTW6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in LSM7 and LSM2:
Domains in LSM7Domains in LSM2
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM7 and LSM2 are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR010920 Small nuclear-like ribonucleoprotein IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1143.95

The background colour of the table refers to:

  • Blue Domain is only present in LSM7
  • Yellow Domain is only present in LSM2
  • Green Domain is present in both LSM7 and LSM2

 0.265
Post-translational Modifications

Protein: LSM7

PTMResidueReference

Protein: LSM2

PTMResidueReference
Phosphotyrosine 35 HPRD
Localisation

Protein: LSM7

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: LSM2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LSM7 and LSM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM7 andLSM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM7 has 270 interactors and LSM2 has 894 interactors of which there are 202 common interactors.

Common InteractorName of Common InteractorScore for LSM7-Interactor (?)Score for LSM2-Interactor (?)
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 3.51E3 1.28E3
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 1.64E3 691.00
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 1.64E3
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 691.00 778.00
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 323.00 323.00
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 205.00 1.59E3
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 205.00 1.22
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 195.00 592.00
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 69.60 32.60
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 69.60 122.00
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 15.50
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 1.36
SART1 SART1: U4/U6.U5 tri-snRNP-associated protein 1 6.52 3.59
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 3.89 1.10
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 3.05 3.05
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 2.91
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 383.00
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.60 1.22
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.60 1.59E3
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 1.82 1.10
FLJ36874 N/A 0.593 1.15
DCP1A DCP1A, SMIF: mRNA-decapping enzyme 1A 0.364 1.20
XRN1 XRN1, SEP1: 5'-3' exoribonuclease 1 0.354 0.354
GNB2L1 Lung cancer oncogene 7 0.293 0.515
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.515
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.293 0.137
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.137
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.293 0.067
WDR41 N/A 0.293 0.083
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.293 0.287
BAT1 N/A 0.263 0.074
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.263 0.060
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.263 0.156
DDX47 E4-DBP: DEAD box protein 0.263 0.074
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.074
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.263 0.074
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.263 0.461
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.263 0.074
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.263 0.074
NUP43 N/A 0.263 0.074
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.237
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.237
DDX6 N/A 0.236 0.953
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.156 0.141
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.083
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.137 0.067
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.416
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.137 0.852
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.060
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.123 0.123
WDR18 N/A 0.123 0.074
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.123 0.060
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.123 0.263
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.123 0.074
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.461
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.123
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.123 0.263
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.123 0.074
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.123 0.060
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.074
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.763
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.123 0.263
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.123 0.074
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.074
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.123 0.074
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.123 0.372
WDR39 CIAO1, WDR39: Protein CIAO1 0.123 0.074
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.461
TSSC1 TSSC1: Protein TSSC1 0.123 0.074
NUP37 NUP37: Nucleoporin Nup37 0.123 0.123
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.060
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.123 0.074
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.074
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.123 0.257
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.060
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.123 0.461
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.123 0.461
LOC197135 N/A 0.119 0.119
NULL N/A 0.119 3.01
LOC645472 hCG_23490: Uncharacterized protein ENSP00000329276 0.117 0.119
SNRPEL1 RP11-390F4.1-001: Small nuclear ribonucleoprotein polypeptide E-like protein 1. 0.105 0.354
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.050
WDR8 WDR8: WD repeat-containing protein 8 0.083 0.067
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.461
WDR12 WDR12: WD repeat-containing protein 12 0.074 0.074
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.074 0.372
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.074 0.225
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.074 0.044
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.074 0.461
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.044
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.074 0.044
CORO7 CORO7: Coronin-7 0.074 0.044
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.074 0.225
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.074
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.074 0.060
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.074 0.074
SEC31L1 N/A 0.074 0.093
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.225
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.060
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.074 0.060
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.074 0.074
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.074 0.036
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.074 0.123
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.074 0.074
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.074 0.044
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.060
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.074 0.036
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.074
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.074 0.275
AAMP AAMP: Angio-associated migratory cell protein 0.074 0.060
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.074 0.060
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.074 0.257
LOC119358 similar to small nuclear ribonucleoprotein D2 0.071 1.79
DDB2 DDB2: DNA damage-binding protein 2 0.067 0.083
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.067 0.050
WDR1 N/A 0.067 0.307
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.065 0.032
CDC20 CDC20: Cell division cycle protein 20 homolog 0.060 0.461
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.060 0.275
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.060 9.09
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.060 0.060
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.060 0.275
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.060 0.461
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.060 0.060
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.060 0.123
NBEAL2 N/A 0.060 0.044
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.060 0.093
CORO1A CORO1A, CORO1: Coronin-1A 0.060 0.044
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.044
COPB2 COPB2: Coatomer subunit beta' 0.060 0.093
COPA COPA: Coatomer subunit alpha 0.060 0.275
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.060 0.074
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.044
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.044
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.060 0.225
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.059 0.0968
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.055 0.0331
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.055 0.0331
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.050 0.067
WDR13 WDR13: WD repeat-containing protein 13 0.050 0.041
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.049 0.144
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.044 0.044
WDR37 N/A 0.044 0.028
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.044 0.028
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.060
RAE1 RAE1, MRNP41: mRNA export factor 0.044 0.036
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.044 0.028
AAAS AAAS, ADRACALA, GL003: Aladin 0.044 0.044
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.044 0.044
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.044 0.225
WDR42A N/A 0.044 0.036
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.225
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.044 0.275
CORO1C CORO1C, CRNN4: Coronin-1C 0.044 0.225
WDR45L N/A 0.044 0.036
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.044 0.036
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.044 0.171
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.044 0.225
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.225
WDR67 WDR67: WD repeat-containing protein 67 0.044 0.036
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.044 0.036
TTF2 TTF2: Transcription termination factor 2 0.044 0.060
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.041
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.039 0.683
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.036 0.036
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.028
FBXW4 N/A 0.0308 0.0308
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.028
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.028 0.136
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.028 0.171
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.028 0.036
CORO1B CORO1B: Coronin-1B 0.028 0.028
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.028 0.136
DYNC1I2 N/A 0.028 0.037
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.025
PRMT1 N/A 0.027 0.027
LBR LBR: Lamin-B receptor 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
WDR72 N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
WDR17 N/A 0.027 0.027
BRWD1 N/A 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
WDR54 N/A 0.027 0.165
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
PHF1 N/A 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
KIF21A N/A 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.165
WDR53 N/A 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.056
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
FLJ20920 FLJ20920: Putative uncharacterized protein FLJ20920 0.0258 0.0258
SNRPB N/A 0.0258 0.0258
0.572
Total Score 8.04E5