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Evidence of Interaction Between LSM7 and LSM4

The interaction score between LSM7 and LSM4 is 3.76E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LSM7 and LSM4 = 0.79

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismLSM7 OrthologueLSM4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YNL147W 1 YER112W 1
  • Y2H
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • AffinityCaptureWestern

Get References From PubMed
worm Q23543 1 Q19952 1
  • Other

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in LSM7 and LSM4:
Domains in LSM7Domains in LSM4
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM7 and LSM4 are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR010920 Small nuclear-like ribonucleoprotein IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1143.95

The background colour of the table refers to:

  • Blue Domain is only present in LSM7
  • Yellow Domain is only present in LSM4
  • Green Domain is present in both LSM7 and LSM4

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: LSM7

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: LSM4

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LSM7 and LSM4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM7 andLSM4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM7 has 270 interactors and LSM4 has 263 interactors of which there are 203 common interactors.

Common InteractorName of Common InteractorScore for LSM7-Interactor (?)Score for LSM4-Interactor (?)
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 3.51E3 691.00
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 3.51E3 323.00
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 691.00 323.00
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 323.00
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 323.00 323.00
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 205.00 1.22
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 205.00 323.00
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 195.00 803.00
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 69.60 69.60
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 69.60 32.60
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 25.60
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 2.91
SART1 SART1: U4/U6.U5 tri-snRNP-associated protein 1 6.52 1.84
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 3.89 1.10
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 3.89 3.89
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 3.05 3.05
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 2.91
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 1.22
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.60 691.00
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.60 323.00
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 1.82 1.10
FLJ36874 N/A 0.593 0.593
DCP1A DCP1A, SMIF: mRNA-decapping enzyme 1A 0.364 0.298
XRN1 XRN1, SEP1: 5'-3' exoribonuclease 1 0.354 0.354
FLJ31121 ZMAT2: Zinc finger matrin-type protein 2 0.354 0.354
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.293 0.083
WDR41 N/A 0.293 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.293 0.293
GNB2L1 Lung cancer oncogene 7 0.293 0.083
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.137
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.293 0.137
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.263 0.123
DDX47 E4-DBP: DEAD box protein 0.263 0.123
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.123
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.263 0.074
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.263 0.123
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.263 0.074
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.263 0.123
NUP43 N/A 0.263 0.137
BAT1 N/A 0.263 0.123
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.263 0.074
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.265
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.265
DDX6 N/A 0.236 0.187
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.156 0.156
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.083
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.137 0.083
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.083
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.137 0.137
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.123 0.263
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.123 0.123
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.074
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.123
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.123 0.074
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.123 0.074
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.123 0.123
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.123
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.123
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.123 0.293
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.123 0.137
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.123
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.123 0.074
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.123 0.060
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.074
TSSC1 TSSC1: Protein TSSC1 0.123 0.074
NUP37 NUP37: Nucleoporin Nup37 0.123 0.137
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.074
WDR39 CIAO1, WDR39: Protein CIAO1 0.123 0.074
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.123
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.123 0.123
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.074
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.123 0.123
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.123 0.123
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.123 0.123
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.123 0.074
WDR18 N/A 0.123 0.123
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.060
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.123 0.060
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
LOC197135 N/A 0.119 0.119
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.067
WDR8 WDR8: WD repeat-containing protein 8 0.083 0.067
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.060
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.074 0.060
CORO7 CORO7: Coronin-7 0.074 0.044
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.074 0.060
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.074
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.074 0.060
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.074 0.123
SEC31L1 N/A 0.074 0.060
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.060
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.060
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.074 0.060
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.074 0.067
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.074 0.044
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.074 0.123
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.074 0.123
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.074 0.060
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.060
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.074 0.036
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.074
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.074 0.060
AAMP AAMP: Angio-associated migratory cell protein 0.074 0.074
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.074 0.044
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.074 0.074
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.060
WDR12 WDR12: WD repeat-containing protein 12 0.074 0.123
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.074 0.074
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.074 0.044
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.074 0.074
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.074 0.036
LOC119358 similar to small nuclear ribonucleoprotein D2 0.071 0.071
DDB2 DDB2: DNA damage-binding protein 2 0.067 0.083
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.067 0.041
WDR1 N/A 0.067 0.083
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.065 0.039
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.060 0.074
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.060 0.067
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.060 0.123
NBEAL2 N/A 0.060 0.067
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.060 0.060
CORO1A CORO1A, CORO1: Coronin-1A 0.060 0.044
COPA COPA: Coatomer subunit alpha 0.060 15.90
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.044
COPB2 COPB2: Coatomer subunit beta' 0.060 0.074
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.060 0.074
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.044
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.044
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.060 0.044
CDC20 CDC20: Cell division cycle protein 20 homolog 0.060 0.137
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.060 0.044
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.060 0.036
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.060 0.060
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.060 0.044
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.059 0.207
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.027
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.055 0.0331
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.055 0.027
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.050 0.067
WDR13 WDR13: WD repeat-containing protein 13 0.050 0.041
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.044 0.044
WDR42A N/A 0.044 0.041
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.044 0.044
CORO1C CORO1C, CRNN4: Coronin-1C 0.044 0.060
WDR45L N/A 0.044 0.044
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.044 0.028
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.044
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.044 0.060
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.044 0.028
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.036
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.044 0.036
WDR67 WDR67: WD repeat-containing protein 67 0.044 0.041
TTF2 TTF2: Transcription termination factor 2 0.044 0.060
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.044 0.041
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.044 0.060
WDR37 N/A 0.044 0.036
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.044 0.036
RAE1 RAE1, MRNP41: mRNA export factor 0.044 0.044
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.044 0.036
AAAS AAAS, ADRACALA, GL003: Aladin 0.044 0.050
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.044 0.044
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.060
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.0308
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.039 0.039
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.036 0.041
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.036
BRWD2 BRWD2, WDR11, WDR15: Bromodomain and WD repeat-containing protein 2 0.0331 0.027
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.028 0.036
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.028 0.036
CORO1B CORO1B: Coronin-1B 0.028 0.028
DYNC1I2 N/A 0.028 0.028
CETN2 CETN2, CALT, CEN2: Centrin-2 0.028 0.0308
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.041
BUB3 N/A 0.027 0.027
SERBP1 N/A 0.027 0.027
PRMT1 N/A 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.027
WDR17 N/A 0.027 0.027
BRWD1 N/A 0.027 0.027
WDR54 N/A 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
PHF1 N/A 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
KIF21A N/A 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.027
WDR53 N/A 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
WDR72 N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
SNRPB N/A 0.0258 0.0258
0.572
Total Score 3.76E5