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Evidence of Interaction Between PIK3R2 and PDGFRB

The interaction score between PIK3R2 and PDGFRB is 7.21E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PIK3R2 and PDGFRB = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismPIK3R2 OrthologuePDGFRB OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00607759 0.536 IPI00022296 0.132
  • Y2H

Get References From PubMed
human IPI00607759 0.536 IPI00027721 0.325
human IPI00607759 0.536 IPI00018335 1
human IPI00607759 0.536 IPI00021396 1
human IPI00607759 0.536 IPI00293565 0.322
human IPI00607759 0.536 IPI00005722 0.081
human IPI00465250 0.585 IPI00022296 0.132
human IPI00465250 0.585 IPI00027721 0.325
human IPI00465250 0.585 IPI00018335 1
human IPI00465250 0.585 IPI00021396 1
human IPI00465250 0.585 IPI00293565 0.322
human IPI00465250 0.585 IPI00005722 0.081
worm Q9N597 0.536 P34892 0.084
worm Q9N597 0.536 O76698 1
worm Q9N597 0.536 Q21038 1
worm Q9N597 0.536 Q21041 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in PIK3R2 and PDGFRB:
Domains in PIK3R2Domains in PDGFRB
IPR008936 Rho GTPase activation protein
IPR001452 SH3
IPR000198 RhoGAP domain
IPR000980 SH2 motif
IPR001720 PI3 kinase, P85 regulatory subunit
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.

The Chi square scores for co-occurrence of domains that are present in PIK3R2 and PDGFRB are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR001452 SH3 IPR008266 Tyrosine protein kinase, active site 164.706
IPR000980 SH2 motif IPR001824 Receptor tyrosine kinase, class III 101.074
IPR001452 SH3 IPR001245 Tyrosine protein kinase 100.857
IPR000980 SH2 motif IPR007110 Immunoglobulin-like 94.9752
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR003599 Immunoglobulin subtype 66.4833
IPR000980 SH2 motif IPR003598 Immunoglobulin C-2 type 64.7072
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR009134 Vascular endothelial growth factor receptor, VEGFR 49.095
IPR000980 SH2 motif IPR013151 Immunoglobulin. 36.9251
IPR001452 SH3 IPR001824 Receptor tyrosine kinase, class III 32.2626
IPR001720 PI3 kinase, P85 regulatory subunit IPR008266 Tyrosine protein kinase, active site 28.9958
IPR001452 SH3 IPR000719 Protein kinase 27.1334
IPR001452 SH3 IPR003598 Immunoglobulin C-2 type 26.0449
IPR001452 SH3 IPR003599 Immunoglobulin subtype 22.2905
IPR001720 PI3 kinase, P85 regulatory subunit IPR001245 Tyrosine protein kinase 20.8688
IPR001452 SH3 IPR011009 Protein kinase-like 20.4416
IPR001452 SH3 IPR007110 Immunoglobulin-like 20.3228
IPR001452 SH3 IPR013151 Immunoglobulin. 14.5395
IPR001720 PI3 kinase, P85 regulatory subunit IPR011009 Protein kinase-like 9.64929
IPR001720 PI3 kinase, P85 regulatory subunit IPR000719 Protein kinase 9.22233
IPR008936 Rho GTPase activation protein IPR008266 Tyrosine protein kinase, active site 9.21621
IPR001452 SH3 IPR009134 Vascular endothelial growth factor receptor, VEGFR 8.64336
IPR000198 RhoGAP domain IPR008266 Tyrosine protein kinase, active site 7.61405
IPR008936 Rho GTPase activation protein IPR001245 Tyrosine protein kinase 5.16024
IPR000198 RhoGAP domain IPR001245 Tyrosine protein kinase 3.84971
IPR008936 Rho GTPase activation protein IPR003599 Immunoglobulin subtype 1.51613
IPR008936 Rho GTPase activation protein IPR000719 Protein kinase 0.485319
IPR000198 RhoGAP domain IPR000719 Protein kinase 0.472387
IPR008936 Rho GTPase activation protein IPR007110 Immunoglobulin-like 0.211409
IPR008936 Rho GTPase activation protein IPR011009 Protein kinase-like 0.0380864
IPR000198 RhoGAP domain IPR011009 Protein kinase-like 0.00301614
IPR000198 RhoGAP domain IPR007110 Immunoglobulin-like 0.000704171

The background colour of the table refers to:

  • Blue Domain is only present in PIK3R2
  • Yellow Domain is only present in PDGFRB
  • Green Domain is present in both PIK3R2 and PDGFRB

 0.980
Post-translational Modifications

Protein: PIK3R2

PTMResidueReference
Phosphotyrosine 464 HPRD

Protein: PDGFRB

PTMResidueReference
Dephosphorylation 562 PubMed, HPRD
Dephosphorylation 579 PubMed, HPRD
Dephosphorylation 740 PubMed, HPRD
Dephosphorylation 751 PubMed, HPRD
Dephosphorylation 771 PubMed, HPRD
Dephosphorylation 857 PubMed, HPRD
Dephosphorylation 1009 PubMed, HPRD
Dephosphorylation 1021 PubMed, HPRD
Phosphorylation 579 PubMed, HPRD
Phosphorylation 581 PubMed, HPRD
Phosphorylation 716 PubMed, HPRD
Phosphorylation 740 PubMed, HPRD
Phosphorylation 751 PubMed, HPRD
Phosphorylation 763 PubMed, HPRD
Phosphorylation 771 PubMed, HPRD
Phosphorylation 775 PubMed, HPRD
Phosphorylation 857 PubMed, HPRD
Phosphorylation 1009 PubMed, HPRD
Phosphorylation 1021 PubMed, HPRD
Phosphotyrosine 751 PubMed, HPRD
Phosphotyrosine 857 PubMed, HPRD
Localisation

Protein: PIK3R2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: PDGFRB

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between PIK3R2 and PDGFRB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PIK3R2 andPDGFRB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PIK3R2 has 968 interactors and PDGFRB has 1323 interactors of which there are 604 common interactors.

Common InteractorName of Common InteractorScore for PIK3R2-Interactor (?)Score for PDGFRB-Interactor (?)
INSR INSR: Insulin receptor precursor 388.00 0.136
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 250.00 112.00
BMX N/A 2.42 0.902
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.98 0.731
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 1.53 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 1.53 0.051
FLT4 VEGFR3 long form 1.37 0.046
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 1.33 0.136
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.980
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.20 0.081
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.17 1.01E3
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 0.980
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 1.07 277.00
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 1.07 74.00
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.07 277.00
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.05 0.980
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 1.01 0.136
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.165
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.975 0.731
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.975 0.581
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.902 0.152
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 0.148
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.878 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.874 0.655
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.872 0.581
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.808 0.097
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.808 183.00
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.808 0.111
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.808 0.136
JAK1 0.781 0.644
CSK CSK: Tyrosine-protein kinase CSK 0.781 0.586
LYN LYN: Tyrosine-protein kinase Lyn 0.781 0.586
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.781 250.00
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.781 0.520
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.781 0.644
SYK SYK: Tyrosine-protein kinase SYK 0.781 0.654
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.781 0.654
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.775 1.13
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.770 0.654
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.123
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.731 0.251
HCK N/A 0.694 250.00
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.694 0.808
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.694 281.00
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.655 0.111
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.655 532.00
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.655 0.136
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.655 0.097
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.655 0.111
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.051
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.586 0.136
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.577 0.088
KIT KIT: Mast/stem cell growth factor receptor precursor 0.577 112.00
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.553 0.046
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.520 0.097
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.520 82.20
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.520 0.171
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.483 0.098
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.448 0.109
ALK ALK: ALK tyrosine kinase receptor precursor 0.361 0.064
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.225 0.033
TLN2 TLN2: Uncharacterized protein TLN2 0.225 0.073
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.225 0.0453
FGFR2 N/A 0.217 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.191 0.032
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.191 0.644
CTTN CTTN, EMS1: Src substrate cortactin 0.191 0.126
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.191 0.037
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.191 0.081
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.191 0.072
FYN N/A 0.176 0.129
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.176 0.129
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.171 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.171 0.073
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.171 0.090
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.171 0.026
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.171 0.064
MYO3A MYO3A: Myosin IIIA 0.171 0.041
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.171 0.033
PRLR PRLR: Prolactin receptor precursor 0.166 0.123
TP73 TP73, P73: Tumor protein p73 0.166 0.051
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.166 0.055
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.049
PSCD2 N/A 0.165 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.109
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
NF2 NF2, SCH: Merlin 0.165 0.109
MAPK15 N/A 0.165 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.109
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.065
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.152 0.065
SPTAN1 N/A 0.152 0.081
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.148 0.029
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
ARHGEF7 N/A 0.148 0.098
STAT3 0.148 0.878
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.148 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.098
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.148 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 422.00
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.980
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.075
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.044
ELMO1 N/A 0.148 0.098
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.148 0.098
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.148 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.044
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.148 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.044
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.145 0.060
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.143 0.041
RDX RDX: Radixin 0.136 0.073
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.136 0.171
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.136 0.033
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.136 0.029
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.136 84.00
DAB1 DAB1: Disabled homolog 1 0.136 0.064
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.136 0.041
CDK5 CDK5: Cell division protein kinase 5 0.136 0.026
PLD1 PLD1: Phospholipase D1 0.136 0.073
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.136 0.026
TTN N/A 0.136 0.073
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.126 0.063
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.126 0.055
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.125 0.916
CDKL5 N/A 0.123 0.0453
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.123 0.072
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.032
COBL N/A 0.123 0.032
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.072
GRLF1 N/A 0.123 0.072
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.126
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.113 0.033
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.586
WEE1 WEE1: Wee1-like protein kinase 0.111 0.032
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.111 0.058
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.111 0.033
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.111 15.80
CDK2 CDK2: Cell division protein kinase 2 0.111 0.026
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.111 0.029
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.111 0.065
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.111 0.033
DAB2 DAB2, DOC2: Disabled homolog 2 0.111 0.148
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.111 0.029
CDK4 CDK4: Cell division protein kinase 4 0.111 0.029
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.111 0.051
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.111 12.50
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.111 0.033
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.111 0.029
STAM2 STAM2: Signal transducing adapter molecule 2 0.111 0.064
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.111 0.113
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.111 0.033
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.111 0.044
PSD TYL: TYL protein 0.111 0.058
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.111 0.073
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.111 0.033
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.111 0.033
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.111 0.051
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.111 0.058
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.110 0.581
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.110 0.032
PRKAA1 N/A 0.110 0.032
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.110 0.654
VASP VASP: Vasodilator-stimulated phosphoprotein 0.110 0.065
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.110 0.0727
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.165
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.083
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.083
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
NULL A1BG: Alpha-1B-glycoprotein precursor 0.109 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.165
KIR3DL1 N/A 0.109 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.165
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
FN1 N/A 0.109 0.165
IRS2 IRS2: Insulin receptor substrate 2 0.109 0.072
CNN3 CNN3: Calponin-3 0.109 0.202
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.109 0.032
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.098
GAB2 N/A 0.109 0.065
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.126
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.109 0.033
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.100 0.110
SCML2 SCML2: Sex comb on midleg-like protein 2 0.100 0.025
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.152
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.152
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.100 0.123
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.100 0.041
WASPIP N/A 0.099 0.029
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.099 0.026
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.099 0.026
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.099 0.064
PSCD4 PSCD4, CYT4: Cytohesin-4 0.099 0.065
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.099 0.065
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.099 0.065
VAV1 VAV1, VAV: Proto-oncogene vav 0.099 281.00
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.099 250.00
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.099 0.064
ATM ATM: Serine-protein kinase ATM 0.099 0.029
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.099 0.051
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.099 0.058
FNBP1 N/A 0.099 0.065
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.099 281.00
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.099 0.058
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.099 0.058
DOK1 DOK1: Docking protein 1 0.099 0.058
RPS6KB1 N/A 0.099 0.026
STAT6 STAT6: Signal transducer and activator of transcription 6 0.099 250.00
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.099 0.029
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.099 0.065
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.099 0.065
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.099 0.052
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.099 0.065
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.098 0.033
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.098 0.029
ROCK1 ROCK1: Rho-associated protein kinase 1 0.098 0.0727
STK16 N/A 0.098 0.032
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.098 0.065
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.098 0.644
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.098 0.081
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.098 0.581
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.098 0.731
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.098 0.0727
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.098 0.075
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.030
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.098 232.00
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.098 0.030
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.098 0.062
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.030
PLD2 PLD2: Phospholipase D2 0.097 0.073
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.090
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.097 0.029
DYRK3 N/A 0.097 0.033
RASA3 RASA3: Ras GTPase-activating protein 3 0.097 0.073
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.097 0.029
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.097 0.033
SORBS3 SORBS3, SCAM1: Vinexin 0.097 0.073
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.097 0.090
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.097 0.052
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.097 0.026
CRKL CRKL: Crk-like protein 0.097 536.00
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.097 0.026
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.097 0.041
CDK7 CDK7, MO15: Cell division protein kinase 7 0.097 0.026
CDK6 CDK6: Cell division protein kinase 6 0.097 0.032
TLN1 TLN1: Uncharacterized protein TLN1 0.097 0.064
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.097 0.029
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.093 0.073
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.090 0.035
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.090 0.041
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.090 137.00
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.090 0.033
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.090 0.233
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.090 0.037
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.088 0.090
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.088 0.181
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.088 0.058
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.088 0.041
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.088 0.029
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.088 0.033
CD2AP CD2AP: CD2-associated protein 0.088 0.065
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.088 0.065
VIL2 N/A 0.088 0.064
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.088 0.065
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.088 0.029
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.088 0.072
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.088 0.029
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.088 0.065
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.088 0.029
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.088 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.088 0.026
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.088 0.058
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.088 0.058
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.088 0.058
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.088 0.064
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.088 0.029
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.088 0.026
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.088 0.026
CXorf9 N/A 0.088 0.065
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.088 600.00
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.088 0.029
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.088 0.033
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.086 0.033
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.083 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.04
IL9R IL9R: Interleukin-9 receptor precursor 0.081 0.109
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.081 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.081 0.355
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.081 0.051
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.081 0.098
GHR GHR: Growth hormone receptor precursor 0.081 0.191
EPOR EPOR: Erythropoietin receptor precursor 0.081 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.081 0.098
STAT2 STAT2: Signal transducer and activator of transcription 2 0.081 0.320
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.080 0.081
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.078 0.029
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.078 0.065
STK10 STK10: Uncharacterized protein STK10 0.078 0.029
MSN MSN: Moesin 0.078 0.058
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.073 0.097
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.073 0.037
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.073 0.041
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.073 0.225
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0727 0.360
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.0727 0.110
PLEK PLEK, P47: Pleckstrin 0.0727 0.046
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.0727 0.109
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.0727 0.098
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.0727 0.109
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.0727 0.098
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.0727 0.098
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.0727 0.098
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.0727 0.110
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.109
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.098
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.072 0.251
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.072 0.191
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.072 0.109
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.072 0.049
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.072 0.123
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.098
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.072 0.152
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.072 0.056
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.071 0.073
NCK2 NCK2: Cytoplasmic protein NCK2 0.070 600.00
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.109
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.067 0.123
PVR PVR, PVS: Poliovirus receptor precursor 0.067 0.123
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.065 0.088
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.065 0.041
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.065 0.041
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.110
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.065 0.110
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.098
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.065 0.123
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.065 0.109
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.098
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.065 0.098
F3 F3: Tissue factor precursor 0.065 0.123
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.065 0.098
CCR5 CCR5: CCR5 receptor (Fragment) 0.065 0.056
ETS2 ETS2: Protein C-ets-2 0.065 0.025
LILRB1 N/A 0.065 0.110
MCF2 MCF2, DBL: Proto-oncogene DBL 0.064 0.072
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.064 0.033
SOS1 SOS1: Son of sevenless homolog 1 0.064 0.046
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.064 0.056
HD HD, IT15: Huntingtin 0.062 0.033
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.060 0.065
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.058 0.123
STAT4 STAT4: Signal transducer and activator of transcription 4 0.058 0.286
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.099
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.058 372.00
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.058 0.098
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.057 0.064
DLG2 DLG2: Disks large homolog 2 0.057 0.073
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.057 0.055
MAP2K5 N/A 0.056 0.049
CNN2 CNN2: Calponin-2 0.056 0.109
PMP2 PMP2: Myelin P2 protein 0.056 0.027
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.056 0.112
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.056 0.033
FUBP1 N/A 0.056 0.033
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.054 0.073
S100A16 S100A16, AAG13: Protein S100-A16 0.052 0.109
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.052 0.318
PTPRA N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
GRB10 N/A 0.051 0.617
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
UBAP2L N/A 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
MT3 MT3: Metallothionein-3 0.051 0.049
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.046
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.109
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.051 0.123
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.051 0.191
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.051 0.111
LDLR LDLR: Low-density lipoprotein receptor precursor 0.051 0.056
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.050 0.044
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.050 0.109
GMIP GMIP: GEM-interacting protein 0.050 0.065
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.049 0.0727
SNCB SNCB: Beta-synuclein 0.048 0.065
S100A7 S100A7, PSOR1: Protein S100-A7 0.048 0.081
GJA5 GJA5: Gap junction alpha-5 protein 0.047 0.038
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.038
CDC25C CDC25C: M-phase inducer phosphatase 3 0.047 0.098
CDC25A CDC25A: M-phase inducer phosphatase 1 0.047 0.098
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.047 0.109
GSN GSN: Gelsolin precursor 0.047 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.047 0.098
SVIL SVIL: Supervillin 0.047 0.036
ACTN4 ACTN4: Alpha-actinin-4 0.047 0.098
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 265.00
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.046
RIN1 RIN1: Ras and Rab interactor 1 0.046 0.520
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.046 0.111
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.046 0.088
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.0453 0.123
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.0453 0.127
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.045 0.046
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.037
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.044 0.051
WWC2 WW and C2 domain containing 2 0.044 0.051
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.044 0.029
HDLBP HDLBP, HBP, VGL: Vigilin 0.044 0.033
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.044 0.165
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.044 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.044 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.044 0.165
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.044 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.044 0.165
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.044 0.025
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.043 0.073
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.043 0.073
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.043 0.065
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.042 0.030
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.0407 0.123
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.0407 0.123
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.0407 0.152
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0407 0.062
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.0407 0.109
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.041 0.028
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.041 0.0308
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.041 0.035
HPN HPN, TMPRSS1: Serine protease hepsin 0.041 0.062
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.041 0.0308
BSG N/A 0.040 0.148
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.040 0.062
CNTN4 CNTN4: Contactin-4 precursor 0.040 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.040 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 0.148
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.058
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.039 0.033
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.038 0.047
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.038 0.0338
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.038 0.029
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.037 0.030
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.037 12.50
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.037 0.065
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.037 0.058
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.037 0.109
SELE SELE, ELAM1: E-selectin precursor 0.037 0.152
VWF VWF, F8VWF: von Willebrand factor precursor 0.037 0.245
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.037 0.041
PTPRZ1 N/A 0.036 0.098
NEO1 NEO1, NGN: Neogenin precursor 0.036 0.111
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.036 0.030
CETN1 CETN1, CEN1, CETN: Centrin-1 0.036 0.0688
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.035 0.052
CHP CHP: Calcium-binding protein p22 0.035 0.113
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.035 0.245
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.035 0.081
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.034 0.065
CNN1 CNN1: Calponin-1 0.034 0.059
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.034 0.0338
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.033 0.058
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.033 0.029
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.033 0.029
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.0333 0.096
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.033 0.065
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.033 0.123
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.033 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.152
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.033 0.049
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.033 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.033 0.123
SDC4 SDC4: Syndecan-4 precursor 0.033 0.054
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.033 0.086
MEP1B MEP1B: Meprin A subunit beta precursor 0.033 0.097
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.033 0.233
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.033 0.065
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.033 0.026
ATP2B1 N/A 0.032 0.056
ACTN1 ACTN1: Alpha-actinin-1 0.031 0.064
LCP1 LCP1, PLS2: Plastin-2 0.031 0.065
FLII FLII, FLIL: Protein flightless-1 homolog 0.031 0.026
RYR2 RYR2: Ryanodine receptor 2 0.031 0.045
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.031 0.081
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.0308 37.90
PLAT PLAT: Tissue-type plasminogen activator precursor 0.030 0.049
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.030 0.086
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.0296 0.064
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0296 0.065
DCC DCC: Netrin receptor DCC precursor 0.030 0.097
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.030 0.046
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.030 0.056
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.030 0.372
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.030 0.275
CD7 CD7: T-cell antigen CD7 precursor 0.029 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.029 0.110
CRLF3 N/A 0.029 0.088
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.029 0.098
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.029 0.110
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.029 0.056
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.029 0.044
ITGB7 ITGB7: Integrin beta-7 precursor 0.029 0.088
ITGB4 N/A 0.029 0.109
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.109
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.029 0.251
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.123
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.029 0.098
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.029 0.109
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.029 0.056
PARVA PARVA, MXRA2: Alpha-parvin 0.029 0.111
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.028 0.04
CASP8 CASP8, MCH5: Caspase-8 precursor 0.028 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.028 0.049
F9 F9: Coagulation factor IX precursor 0.028 0.033
RYR1 0.028 0.046
C6 C6: Complement component C6 precursor 0.028 0.037
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.028 0.041
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.028 0.064
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.028 0.052
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.0273 0.030
CD44 N/A 0.027 0.055
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.0263 0.025
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.0263 0.039
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.026 0.109
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.026 0.110
FES N/A 0.0258 0.0258
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.026 0.037
C1R C1R: Complement C1r subcomponent precursor 0.025 0.124
C1S C1S: Complement C1s subcomponent precursor 0.025 0.253
CSH2 GH1: Somatotropin precursor 0.025 0.081
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.044
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.025 0.044
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.025 0.044
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
CFL2 CFL2: Cofilin-2 0.025 0.036
TSC2 TSC2, TSC4: Tuberin 0.025 0.049
MYO18A 0.025 0.049
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.025 0.044
0.572
Total Score 7.21E4