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Evidence of Interaction Between FADD and TRADD

The interaction score between FADD and TRADD is 165.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FADD and TRADD = 0.45

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology N/A N/A
Domains Domains present in FADD and TRADD:
Domains in FADDDomains in TRADD
IPR011029 DEATH-like
IPR000488 Death domain
IPR001875 Death effector protein
IPR011029 DEATH-like
IPR000488 Death domain
IPR009095 TRADD, N-terminal

The Chi square scores for co-occurrence of domains that are present in FADD and TRADD are listed below.

Domain 1Domain 2Chi Square
IPR011029 DEATH-like IPR011029 DEATH-like 869.796
IPR011029 DEATH-like IPR000488 Death domain 434.384
IPR001875 Death effector protein IPR011029 DEATH-like 354.836
IPR001875 Death effector protein IPR000488 Death domain 289.546
IPR000488 Death domain IPR000488 Death domain 281.479
IPR011029 DEATH-like IPR009095 TRADD, N-terminal 222.64
IPR000488 Death domain IPR009095 TRADD, N-terminal 219.455

The background colour of the table refers to:

  • Blue Domain is only present in FADD
  • Yellow Domain is only present in TRADD
  • Green Domain is present in both FADD and TRADD

 0.980
Post-translational Modifications

Protein: FADD

PTMResidueReference
Phosphorylation 194 PubMed, HPRD

Protein: TRADD

PTMResidueReference
Acetylation 225 PubMed, HPRD
Localisation

Protein: FADD

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: TRADD

LocalisationReference
ER HPRD
Golgi HPRD
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between FADD and TRADD that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FADD andTRADD. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FADD has 1134 interactors and TRADD has 1077 interactors of which there are 650 common interactors.

Common InteractorName of Common InteractorScore for FADD-Interactor (?)Score for TRADD-Interactor (?)
RPS10 RPS10: 40S ribosomal protein S10 2.46 4.07
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 2.46 3.28
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 2.42 1.81
THOC1 THOC1, HPR1: THO complex subunit 1 1.98 1.98
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 1.81 5.42
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 1.48 3.28
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 1.30 0.980
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 1.13 1.50
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 1.13 0.970
CIITA CIITA, MHC2TA: MHC class II transactivator 1.13 2.42
CASP9 CASP9, MCH6: Caspase-9 precursor 0.980 1.30
CASP8 CASP8, MCH5: Caspase-8 precursor 0.980 1.05
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.980 1.30
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.975 0.581
PSMD12 PSMD12: 26S proteasome non-ATPase regulatory subunit 12 0.825 0.692
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.654 0.872
NFKB2 N/A 0.617 0.617
QRICH1 N/A 0.547 0.666
DEDD DEDD, DEDPRO1, KE05, DEFT: Death effector domain-containing protein 0.547 0.305
MYD88 0.491 0.677
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.416 0.166
CARD8 CARD8, KIAA0955, NDPP1: Caspase recruitment domain-containing protein 8 0.404 1.36
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.404 0.402
CASP4 CASP4, ICH2: Caspase-4 precursor 0.404 0.824
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.404 0.666
FLII FLII, FLIL: Protein flightless-1 homolog 0.340 0.515
BIRC2 BIRC2, API1, IAP2, MIHB, RNF48: Baculoviral IAP repeat-containing protein 2 0.330 0.824
TNFRSF21 TNFRSF21, DR6, UNQ437/PRO868: Tumor necrosis factor receptor superfamily member 0.305 0.200
IRAK3 IRAK3: Interleukin-1 receptor-associated kinase 3 0.305 0.251
TNFRSF25 TNFRSF25, APO3, UNQ455/PRO779, DDR3, DR3, TNFRSF12, WSL, WSL1: Tumor necrosis fa 0.265 0.217
FAS Tumor necrosis factor receptor superfamily, member 6 isoform 1 variant (Fragment 0.265 0.141
TNFRSF10A TNFRSF10A, APO2, DR4, TRAILR1: Tumor necrosis factor receptor superfamily member 0.265 0.217
TNFRSF10B TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9: Tumor necrosis factor receptor 0.265 0.217
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.261 0.547
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.251 0.274
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.251 0.051
CARD15 NOD2, CARD15, IBD1: Nucleotide-binding oligomerization domain-containing protein 0.251 0.402
NALP11 NLRP11, NALP11, NOD17, PYPAF6: NACHT, LRR and PYD domains-containing protein 11 0.217 0.265
DEDD2 DEDD2, FLAME3, PSEC0004: DNA-binding death effector domain-containing protein 2 0.217 0.265
NALP1 NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1: NACHT, LRR and PYD domains-containin 0.217 0.265
NALP4 N/A 0.217 0.265
NALP12 NLRP12, NALP12, PYPAF7, RNO: NACHT, LRR and PYD domains-containing protein 12 0.217 0.265
PYCARD PYCARD, ASC, CARD5, TMS1: Apoptosis-associated speck-like protein containing a C 0.217 0.265
NALP5 NLRP5, MATER, NALP5: NACHT, LRR and PYD domains-containing protein 5 0.217 0.265
CARD12 NLRC4, CARD12, UNQ6189/PRO20215, CLAN, CLAN1, IPAF: NLR family CARD domain-conta 0.217 0.265
APAF1 N/A 0.217 0.265
NALP14 NLRP14, NALP14, NOD5: NACHT, LRR and PYD domains-containing protein 14 0.217 0.265
BIRC3 BIRC3, API2, IAP1, MIHC, RNF49: Baculoviral IAP repeat-containing protein 3 0.217 0.265
NALP13 NLRP13, NALP13, NOD14: NACHT, LRR and PYD domains-containing protein 13 0.217 0.265
BCL10 BCL10, CIPER, CLAP: B-cell lymphoma/leukemia 10 0.217 0.265
NALP10 NLRP10, NALP10, NOD8, PYNOD: NACHT, LRR and PYD domains-containing protein 10 0.217 0.265
ICEBERG ICEBERG, UNQ5804/PRO19611: Caspase-1 inhibitor Iceberg 0.217 0.265
NALP6 NLRP6, NALP6, PYPAF5: NACHT, LRR and PYD domains-containing protein 6 0.217 0.265
C9orf89 C9orf89: Bcl10-interacting CARD protein 0.217 0.265
CARD14 CARD14, CARMA2: Caspase recruitment domain-containing protein 14 0.217 0.265
CARD11 CARD11, CARMA1: Caspase recruitment domain-containing protein 11 0.217 0.265
COASY COASY, PSEC0106: Bifunctional coenzyme A synthase 0.214 0.128
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.214 0.166
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.214 0.677
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.210 0.127
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.202 0.064
TBCE TBCE: Tubulin-specific chaperone E 0.202 0.191
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.202 0.416
CASP3 CASP3, CPP32: Caspase-3 precursor 0.202 0.191
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.202 0.191
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.202 0.307
BIRC1 BIRC1, NAIP: Baculoviral IAP repeat-containing protein 1 0.200 0.402
CRADD CRADD, RAIDD: Death domain-containing protein CRADD 0.200 0.174
CASP10 N/A 0.200 0.244
CARD4 NOD1, CARD4: Nucleotide-binding oligomerization domain-containing protein 1 0.200 0.305
UNC5B N/A 0.197 0.129
TNFRSF11B TNFRSF11B, OCIF, OPG: Tumor necrosis factor receptor superfamily member 11B prec 0.197 0.105
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.191 0.0407
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.191 0.067
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.191 0.067
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.191 0.082
UNC5C UNC5C, UNC5H3: Netrin receptor UNC5C precursor 0.174 0.129
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.173 0.202
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.166 0.307
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.166 0.109
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.166 0.251
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.166 0.307
OPTC OPTC, OPT: Opticin precursor 0.165 0.109
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.165 0.044
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.165 0.0688
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.165 0.044
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.165 0.044
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.165 0.044
EDA N/A 0.165 0.044
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.165 0.044
CARD10 CARD10, CARMA3: Caspase recruitment domain-containing protein 10 0.162 0.174
TEP1 TEP1, TLP1, TP1: Telomerase protein component 1 0.162 0.244
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.155 0.060
CDK4 CDK4: Cell division protein kinase 4 0.153 0.096
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.153 0.155
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.152 0.051
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.152 0.063
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.152 0.082
TLR4 TLR4: Toll-like receptor 4 precursor 0.152 0.0407
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.152 0.072
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.152 0.126
GP9 GP9: Platelet glycoprotein IX precursor 0.152 0.081
CASP5 CASP5, ICH3: Caspase-5 precursor 0.143 0.174
NALP2 NLRP2, NALP2, NBS1, PAN1, PYPAF2: NACHT, LRR and PYD domains-containing protein 0.143 0.244
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.128 0.126
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.128 0.228
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.127 0.091
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.127 0.105
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.127 0.063
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.126 0.103
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.124 0.210
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.124 0.260
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.124 0.210
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.124 0.210
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.124 0.096
CSK CSK: Tyrosine-protein kinase CSK 0.124 0.260
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.124 0.155
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.124 0.127
EEF2 EEF2, EF2: Elongation factor 2 0.124 0.155
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.124 0.127
CDK2 CDK2: Cell division protein kinase 2 0.124 0.077
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.124 0.430
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.124 0.096
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.124 0.210
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.124 0.210
STAT6 STAT6: Signal transducer and activator of transcription 6 0.124 0.430
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.123 0.029
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
MEP1B MEP1B: Meprin A subunit beta precursor 0.123 0.065
GP1BA N/A 0.123 0.065
GP1BB GP1BB: Platelet glycoprotein Ib beta chain precursor 0.123 0.065
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.110 0.065
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.109 0.165
CASP6 CASP6, MCH2: Caspase-6 precursor 0.109 0.165
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.109 0.165
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.109 0.165
CASP14 CASP14: Caspase-14 precursor 0.109 0.056
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.109 0.165
TSHR N/A 0.109 0.081
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.109 0.029
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.109 0.045
GP5 GP5: Platelet glycoprotein V precursor 0.109 0.029
TUFM TUFM: Elongation factor Tu, mitochondrial precursor 0.105 0.0513
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.105 0.081
DOK1 DOK1: Docking protein 1 0.101 0.070
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.101 0.052
MEP1A MEP1A: Meprin A subunit alpha precursor 0.098 0.029
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.096 0.0453
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.096 0.075
CFP CFP, PFC: Properdin precursor 0.096 0.0513
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.096 0.075
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.096 0.0453
OSM OSM: Oncostatin-M precursor 0.096 0.031
RNF7 RNF7, RBX2, ROC2, SAG: RING-box protein 2 0.0955 0.129
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.091 0.096
STK10 STK10: Uncharacterized protein STK10 0.091 0.430
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.091 0.155
ROCK1 ROCK1: Rho-associated protein kinase 1 0.091 0.155
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.091 0.041
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.091 0.048
RPS6KB1 N/A 0.091 0.260
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.091 0.430
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.091 0.260
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.091 0.096
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.091 0.210
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.091 0.210
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.091 0.127
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.091 0.210
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.091 0.132
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.091 0.127
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.091 0.096
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.091 0.051
GMIP GMIP: GEM-interacting protein 0.091 0.087
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.091 0.062
CDK7 CDK7, MO15: Cell division protein kinase 7 0.091 0.096
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.091 0.127
WEE1 WEE1: Wee1-like protein kinase 0.091 0.055
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.091 0.210
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.091 0.077
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.091 0.260
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.091 0.430
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.091 0.077
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.091 0.210
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.091 0.155
LIMK2 LIMK2: LIM domain kinase 2 0.091 0.096
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.087 0.036
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.085 0.124
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.083 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.083 0.049
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.083 0.049
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.083 0.04
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.083
DSP DSP: Desmoplakin 0.083 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.083 0.049
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.083 0.04
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.083 0.049
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.083 0.04
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.049
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.083 0.04
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.083 0.049
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.081 0.109
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.080 0.101
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.0794 0.340
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.0794 0.072
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.077 0.0453
KIT KIT: Mast/stem cell growth factor receptor precursor 0.077 0.032
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.077 0.037
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.077 0.0453
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.077 0.037
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.077 0.0453
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.077 0.037
HCK N/A 0.075 0.127
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.075 0.155
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.075 0.062
SYK SYK: Tyrosine-protein kinase SYK 0.075 0.132
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.075 0.077
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.075 0.155
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.075 0.155
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.075 0.077
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.075 0.051
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.075 0.260
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.075 0.055
LYN LYN: Tyrosine-protein kinase Lyn 0.075 0.132
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.075 0.155
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.075 0.155
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.075 0.048
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.075 0.096
HSP90AA1 Hsp89-alpha-delta-N 0.075 0.077
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.075 0.210
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.075 0.062
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.075 0.127
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.075 0.210
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.075 0.055
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.049
VAV1 VAV1, VAV: Proto-oncogene vav 0.075 0.144
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.075 0.155
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.075 0.155
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.075 0.210
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.075 0.096
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.075 0.096
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.075 0.096
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.074 0.052
VCP VCP: Transitional endoplasmic reticulum ATPase 0.074 0.052
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.070 0.157
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.070 0.037
RNF20 0.0688 0.109
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.0688 0.109
C20orf18 N/A 0.0688 0.109
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.0688 0.109
UHRF1 0.0688 0.109
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.0688 0.109
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.0688 0.109
RABGGTA RABGGTA: Geranylgeranyl transferase type-2 subunit alpha 0.067 0.067
BFAR BFAR, BAR, RNF47: Bifunctional apoptosis regulator 0.067 0.053
ANP32A ANP32A, C15orf1, LANP, MAPM, PHAP1: Acidic leucine-rich nuclear phosphoprotein 3 0.067 0.053
RNH1 RNH1, PRI, RNH: Ribonuclease inhibitor 0.065 0.067
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.063 0.124
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.063 0.037
PDK1 PDK1: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precu 0.063 0.085
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.062 0.029
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.062 0.0453
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.062 0.029
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.096
PLD1 PLD1: Phospholipase D1 0.061 0.026
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.061 0.039
PSCD4 PSCD4, CYT4: Cytohesin-4 0.061 0.144
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.057 0.210
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.057 0.077
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.057 0.055
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.057 0.049
ATM ATM: Serine-protein kinase ATM 0.057 0.430
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.057 0.210
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.057 0.127
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.057 0.127
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.057 0.096
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.057 0.077
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.057 0.062
JAK1 0.057 0.260
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.057 0.062
DAPK2 DAPK2: Death-associated protein kinase 2 0.057 0.077
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.057 0.155
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.057 0.132
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.057 0.260
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.057 0.917
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.057 0.210
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.056 0.0688
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.056 0.026
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.056 0.029
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.056 0.056
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.055 0.032
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.055 0.027
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.055 0.027
MET MET: Hepatocyte growth factor receptor precursor 0.055 0.029
CASP7 CASP7, MCH3: Caspase-7 precursor 0.053 0.067
TRIM26 TRIM26, RNF95, ZNF173: Tripartite motif-containing protein 26 0.053 0.050
LRRC41 LRRC41, MUF1, PP7759: Leucine-rich repeat-containing protein 41 0.053 0.041
TRIM21 TRIM21, RNF81, RO52, SSA1: 52 kDa Ro protein 0.053 0.067
ANP32E ANP32E: Acidic leucine-rich nuclear phosphoprotein 32 family member E 0.053 0.0308
ITGB7 ITGB7: Integrin beta-7 precursor 0.052 0.074
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.052 0.032
CRLF3 N/A 0.052 0.0446
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.052 0.037
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.052 0.0446
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.052 0.027
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.052 0.027
CD44 N/A 0.052 0.0446
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.052 0.027
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.052 0.157
TPR TPR: Nucleoprotein TPR 0.052 0.036
PCGF6 PCGF6, MBLR, RNF134: Polycomb group RING finger protein 6 0.051 0.051
IFI16 IFI16, IFNGIP1: Gamma-interferon-inducible protein Ifi-16 0.051 0.051
CHD3 CHD3: Chromodomain-helicase-DNA-binding protein 3 0.051 0.051
ERBB2IP ERBB2IP, ERBIN, KIAA1225, LAP2: Protein LAP2 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
TRIM24 TRIM24, RNF82, TIF1, TIF1A: Transcription intermediary factor 1-alpha 0.051 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.051 0.072
VIM VIM: Vimentin 0.0513 0.091
RNF34 RNF34: E3 ubiquitin-protein ligase RNF34 0.050 0.053
LRCH4 LRCH4, LRN, LRRN1, LRRN4: Leucine-rich repeat and calponin homology domain-conta 0.050 0.231
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.049 0.055
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.049 0.027
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.049 0.033
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.083
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.049 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.083
MAP2K5 N/A 0.049 0.083
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.049 0.083
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.083
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.049 0.083
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.049 0.083
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.049 0.083
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.049 0.052
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.049 0.052
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.049 0.083
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.083
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.049 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.083
MAPKAPK5 N/A 0.049 0.083
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.083
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.083
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.083
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.083
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.083
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.049 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.083
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.083
MAPK15 N/A 0.049 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.083
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.049 0.083
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.049 0.083
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.049 0.083
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.049 0.083
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.049 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.083
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.049 0.083
GIT2 N/A 0.049 0.083
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.046 0.0425
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.046 0.032
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.046 0.087
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.046 0.087
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.0453 0.096
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.0453 0.210
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.0453 0.049
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.0453 0.055
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.0453 0.062
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.077
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.0453 0.096
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.0453 0.055
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.0453 0.055
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.055
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.0453 0.127
PRKAA1 N/A 0.0453 0.096
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.0453 0.077
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0453 0.127
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.0453 0.096
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.0453 0.062
RASA3 RASA3: Ras GTPase-activating protein 3 0.0453 0.030
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.0453 0.210
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.0453 0.055
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.045 0.081
MDM4 MDM4, MDMX: Mdm4 protein 0.045 0.081
ABCF1 N/A 0.0446 0.052
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.0446 0.0425
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.0446 0.087
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.0446 0.0425
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.0446 0.087
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.0446 0.032
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.0446 0.052
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.0446 0.070
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.0446 0.087
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.0446 0.052
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.0446 0.087
HNRPK N/A 0.0446 0.087
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.0446 0.0425
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.0446 0.052
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.044 0.038
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.0425 0.027
HLA-DRA 0.0425 0.036
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.0425 0.036
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.0425 0.036
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.0425 0.027
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.0425 0.027
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.0425 0.0446
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.0425 0.036
RNF11 RNF11, CGI-123: RING finger protein 11 0.041 0.065
NFKBIB NFKBIB, IKBB, TRIP9: NF-kappa-B inhibitor beta 0.0407 0.0407
LRRC8D LRRC8D, LRRC5, UNQ213/PRO239: Leucine-rich repeat-containing protein 8D 0.041 0.039
TNFRSF14 TNFRSF14, HVEA, UNQ329/PRO509, HVEM: Tumor necrosis factor receptor superfamily 0.041 0.108
RUFY1 N/A 0.041 0.041
SIGIRR SIGIRR, UNQ301/PRO342: Single Ig IL-1-related receptor 0.041 0.065
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.04 0.028
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.04 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.04 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.04 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.04 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.052
ARHGEF7 N/A 0.04 0.028
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.04 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.04 0.028
ELMO1 N/A 0.04 0.028
PSCD2 N/A 0.04 0.028
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.039 0.046
SHOC2 SHOC2, KIAA0862: Leucine-rich repeat protein SHOC-2 0.039 0.067
FBXL14 FBXL14, FBL14: F-box/LRR-repeat protein 14 0.039 0.050
FBXL11 FBXL11, FBL7, JHDM1A, KIAA1004: JmjC domain-containing histone demethylation pro 0.039 0.137
TRIM38 TRIM38, RNF15, RORET: Tripartite motif-containing protein 38 0.039 0.137
SIAH2 SIAH2: E3 ubiquitin-protein ligase SIAH2 0.039 0.0308
SOS1 SOS1: Son of sevenless homolog 1 0.039 0.124
BCL2 BCL2: Apoptosis regulator Bcl-2 0.039 0.085
PSEN2 PSEN2, AD4, PS2, PSNL2, STM2: Presenilin-2 0.039 0.037
PKD1 PKD1: Polycystin-1 precursor 0.038 0.038
IRS2 IRS2: Insulin receptor substrate 2 0.037 0.026
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.037 0.032
APS SH2B2, APS: SH2B adapter protein 2 0.037 0.026
CDK5 CDK5: Cell division protein kinase 5 0.037 0.055
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.037 0.055
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.037 0.062
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.037 0.096
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.037 0.044
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.037 0.055
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.062
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.036 0.070
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.036 0.0425
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.036 0.087
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.036 0.026
COPE COPE: Coatomer subunit epsilon 0.036 0.070
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.036 0.032
MSN MSN: Moesin 0.036 0.087
UBAP2 N/A 0.036 0.026
HSPD1 0.036 0.026
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.036 0.025
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.036 0.052
CTPS CTPS: CTP synthase 1 0.036 0.026
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.036 0.052
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.036 0.032
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.036 0.087
ENO1 ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase 0.036 0.032
VASP VASP: Vasodilator-stimulated phosphoprotein 0.036 0.052
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.036 0.052
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.036 0.087
TLN1 TLN1: Uncharacterized protein TLN1 0.036 0.0425
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.036 0.087
IFI35 N/A 0.036 0.144
GPI GPI: Glucose-6-phosphate isomerase 0.036 0.032
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.036 0.0425
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.036 0.0425
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.036 0.070
XPO1 XPO1, CRM1: Exportin-1 0.036 0.0425
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.036 0.0425
DNM2 N/A 0.036 0.087
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.036 0.052
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.036 0.087
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.036 0.032
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.036 0.052
MPG N/A 0.036 0.070
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.036 0.0425
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.036 0.032
COPA COPA: Coatomer subunit alpha 0.036 0.070
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.036 0.0425
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.036 0.070
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.036 0.0425
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.036 0.087
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.036 0.070
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.036 0.144
LIMS1 N/A 0.036 0.052
CDC23 CDC23: Cell division cycle protein 23 homolog 0.036 0.0425
LCP1 LCP1, PLS2: Plastin-2 0.036 0.087
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.036 0.070
ACTG1 ACTB: Actin, cytoplasmic 1 0.036 0.087
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.036 0.032
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.036 0.052
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.036 0.070
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.036 0.052
CRKL CRKL: Crk-like protein 0.036 0.0425
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.036 0.052
APRT APRT: Adenine phosphoribosyltransferase 0.035 0.051
UBE2G1 UBE2G1, UBE2G: Ubiquitin-conjugating enzyme E2 G1 0.035 0.041
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.034 0.034
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.049
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.034 0.049
PSEN1 PSEN1, AD3, PS1, PSNL1: Presenilin-1 0.034 0.049
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.049
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.034 0.049
BAD BAD, BBC6, BCL2L8: Bcl2 antagonist of cell death 0.033 0.0253
GFAP GFAP: Glial fibrillary acidic protein 0.033 0.056
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.033 0.044
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.033 0.044
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.033 0.056
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.033 0.056
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.033 0.044
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.032 0.055
MYO3A MYO3A: Myosin IIIA 0.032 0.056
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.032 0.056
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.055
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.032 0.055
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.049
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.055
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.055
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.032 0.055
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.032 0.062
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.032 0.056
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.032 0.055
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.032 0.049
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.032 0.036
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.032 0.027
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.032 0.0446
CD69 CD69: Early activation antigen CD69 0.032 0.0446
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.032 0.036
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.032 0.074
ZNF294 ZNF294: Uncharacterized protein ZNF294 0.032 0.067
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.032 0.083
NXF1 NXF1, TAP: Nuclear RNA export factor 1 0.032 0.083
FBXL4 FBXL4, FBL4, FBL5: F-box/LRR-repeat protein 4 0.032 0.041
RNF25 RNF25: E3 ubiquitin-protein ligase RNF25 0.032 0.067
UBR2 UBR2, C6orf133, KIAA0349: E3 ubiquitin-protein ligase UBR2 0.032 0.050
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.031 0.057
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.037
STAT2 STAT2: Signal transducer and activator of transcription 2 0.031 0.075
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.031 0.025
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.031 0.057
IL18R1 IL18R1, IL1RRP: Interleukin-18 receptor 1 precursor 0.0308 0.053
TNFSF10 TNFSF10: Uncharacterized protein TNFSF10 0.0308 0.039
TNFRSF7 CD27, TNFRSF7: CD27 antigen precursor 0.0308 0.039
RNF130 RNF130: Goliath homolog precursor 0.0308 0.032
TLR1 TLR1, KIAA0012: Toll-like receptor 1 precursor 0.0308 0.032
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.030 0.026
DES DES: Desmin 0.030 0.039
RNF126 RNF126: RING finger protein 126 0.030 0.065
MKRN2 MKRN2, RNF62, HSPC070: Makorin-2 0.030 0.039
SNRPA1 SNRPA1: U2 small nuclear ribonucleoprotein A' 0.030 0.039
RNF4 RNF4, RES4-26: RING finger protein 4 0.030 0.108
BMX N/A 0.029 0.049
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.029 0.055
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.029 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.056
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.029 0.062
CDKL5 N/A 0.029 0.055
RB1 RB1: Retinoblastoma-associated protein 0.029 0.046
PLEK PLEK, P47: Pleckstrin 0.029 0.0446
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.029 0.125
ANK1 N/A 0.0288 0.0288
CARD9 N/A 0.0288 0.0288
NALP7 NLRP7: NLRP7 protein 0.0288 0.0288
CASP4 mih1/Tx: Mih1/Tx protein 0.0288 0.0288
NOL3 NOL3, ARC, NOP: Nucleolar protein 3 0.0288 0.0288
NULL N/A 0.0288 0.0288
ANK2 ANK2: Ankyrin-2 0.0288 0.0288
CIAS1 N/A 0.0288 0.0288
CARD6 CARD6: Caspase recruitment domain-containing protein 6 0.0288 0.0288
IRAK2 IRAK2: Interleukin-1 receptor-associated kinase-like 2 0.0288 0.0288
ANK3 ANK3: Ankyrin-3 0.0288 0.0288
NFKB1 N/A 0.0288 0.0288
ANK1 ANK1, ANK: Ankyrin-1 0.0288 0.0288
CIITA MHC class II transactivator CIITA 0.0288 0.0288
UNC5A N/A 0.0288 0.0288
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
LNX1 N/A 0.028 0.028
SCRIB N/A 0.028 0.028
TJP1 TJP1, ZO1: Tight junction protein ZO-1 0.027 0.027
NRAS NRAS, HRAS1: GTPase NRas precursor 0.027 0.052
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.027 0.087
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.027 0.0425
LPXN LPXN, LDLP: Leupaxin 0.027 0.144
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.027 0.0425
ZYX ZYX: Zyxin 0.027 0.0425
RRAS RRAS: Ras-related protein R-Ras precursor 0.027 0.0425
MVP MVP, LRP: Major vault protein 0.027 0.025
GSK3B N/A 0.027 0.052
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.027 0.144
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.027 0.0425
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.027 0.0425
FNBP1 N/A 0.027 0.087
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.027 0.032
AIP AIP, XAP2: AH receptor-interacting protein 0.027 0.087
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.027 0.144
FLNA FLNA, FLN, FLN1: Filamin-A 0.027 0.087
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.027 0.026
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.027 0.032
PRDX1 PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1 0.027 0.026
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.027 0.026
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.027 0.026
FRG1 FRG1: Protein FRG1 0.027 0.052
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.027 0.087
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.027 0.087
THOP1 THOP1: Thimet oligopeptidase 0.027 0.032
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.027 0.070
SYMPK SYMPK, SPK: Symplekin 0.027 0.032
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.027 0.144
TPT1 TPT1: Translationally-controlled tumor protein 0.027 0.087
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.027 0.307
YWHAQ YWHAQ: 14-3-3 protein theta 0.027 0.032
FUBP1 N/A 0.027 0.087
HD HD, IT15: Huntingtin 0.027 0.052
PPARBP N/A 0.027 0.070
SAPS3 N/A 0.027 0.052
SEC24B SEC24B: Protein transport protein Sec24B 0.027 0.070
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.070
HDLBP HDLBP, HBP, VGL: Vigilin 0.027 0.026
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.027 0.032
GAPD GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase 0.027 0.026
NAT1 NAT1, AAC1: Arylamine N-acetyltransferase 1 0.027 0.032
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.027 0.052
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.027 0.026
DIAPH1 Diaphanous 1 0.027 0.087
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.027 0.032
CXorf9 N/A 0.027 0.087
KLHDC4 N/A 0.027 0.070
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.027 0.144
CFL1 CFL1, CFL: Cofilin-1 0.027 0.0425
API5 N/A 0.027 0.0425
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.027 0.070
WASPIP N/A 0.027 0.144
PRPH PRPH, NEF4, PRPH1: Peripherin 0.026 0.044
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.026 0.056
CCR5 CCR5: CCR5 receptor (Fragment) 0.026 0.0446
IL7R N/A 0.026 0.0446
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.026 0.027
DLG1 N/A 0.026 0.026
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.026 0.036
STAT4 STAT4: Signal transducer and activator of transcription 4 0.025 0.124
0.228
Total Score 165.00