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Evidence of Interaction Between MCM3 and MCM5

The interaction score between MCM3 and MCM5 is 4.78E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM3 and MCM5 = 0.91

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology
OrganismMCM3 OrthologueMCM5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YEL032W 1 YLR274W 1
  • Y2H
  • Immunoprecipitation
  • CoLocalization
  • DosageRescue

Get References From PubMed
worm Q9XVR7 1 Q21902 1
fly P91675 1 Q9VGW6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MCM3 and MCM5:
Domains in MCM3Domains in MCM5
IPR003593 AAA ATPase
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008046 MCM protein 3
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008048 MCM protein 5

The Chi square scores for co-occurrence of domains that are present in MCM3 and MCM5 are listed below.

Domain 1Domain 2Chi Square
IPR001208 MCM IPR001208 MCM 364.867
IPR008994 Nucleic acid-binding OB-fold IPR001208 MCM 301.459
IPR008994 Nucleic acid-binding OB-fold IPR008994 Nucleic acid-binding OB-fold 191.222
IPR003593 AAA ATPase IPR001208 MCM 127.202
IPR003593 AAA ATPase IPR008994 Nucleic acid-binding OB-fold 36.1462

The background colour of the table refers to:

  • Blue Domain is only present in MCM3
  • Yellow Domain is only present in MCM5
  • Green Domain is present in both MCM3 and MCM5

 0.027
Post-translational Modifications

Protein: MCM3

PTMResidueReference
Phosphorylation 713 PubMed, HPRD
Phosphorylation 722 PubMed, HPRD
Phosphoserine 535 PubMed, HPRD
Phosphothreonine 713 HPRD
Phosphothreonine 722 HPRD

Protein: MCM5

PTMResidueReference
Localisation

Protein: MCM3

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: MCM5

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between MCM3 and MCM5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM3 andMCM5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM3 has 1106 interactors and MCM5 has 251 interactors of which there are 206 common interactors.

Common InteractorName of Common InteractorScore for MCM3-Interactor (?)Score for MCM5-Interactor (?)
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 1.29E3 209.00
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 1.29E3 0.263
MCM6 MCM6: DNA replication licensing factor MCM6 209.00 69.60
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 209.00 69.60
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 73.00 1.82
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 69.60 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 63.90 1.10
CCNB1 Cyclin B1 40.60 0.123
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 1.62 0.263
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 1.62 32.60
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.917 0.042
DNMT1 DNMT1, AIM, DNMT: DNA 0.852 0.083
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.852 0.083
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.827 0.044
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.822 0.038
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.763 0.074
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.763 0.074
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.763 0.074
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.763 0.060
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.763 0.074
RFC5 RFC5: Replication factor C subunit 5 0.620 0.207
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.575 0.059
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.515 0.053
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.515 0.053
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.515 0.053
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.515 0.053
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.515 0.053
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.515 0.067
RB1 RB1: Retinoblastoma-associated protein 0.515 0.083
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.503 0.0968
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.503 0.047
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.503 0.059
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.461 0.060
MTA1 MTA1: Metastasis-associated protein MTA1 0.461 0.060
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.461 0.074
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.461 0.123
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.461 0.074
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.430 0.042
DDX21 DDX21: Nucleolar RNA helicase 2 0.430 0.042
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.067
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.416 0.050
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.394 0.042
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.385 0.038
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.385 0.038
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.372 0.074
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.372 0.060
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.372 0.044
MDN1 MDN1, KIAA0301: Midasin 0.372 0.044
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.372 0.044
IRF3 IRF3: Interferon regulatory factor 3 0.307 0.041
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.304 0.059
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.304 0.059
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.275 0.028
RBM14 RBM14, SIP: RNA-binding protein 14 0.269 0.0278
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.263 69.60
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.263 0.123
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.263 0.263
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.257 0.074
ERG ERG: Transcriptional regulator ERG 0.251 0.041
GTF2F2 N/A 0.251 0.041
H1FX H1FX: Histone H1x 0.251 0.067
VCP VCP: Transitional endoplasmic reticulum ATPase 0.245 0.059
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.241 0.053
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.241 0.053
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.231 0.108
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.231 0.108
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.231 0.231
CSDA CSDA, DBPA: DNA-binding protein A 0.225 0.036
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.225 0.036
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.225 0.044
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.225 0.044
CCNH CCNH: Cyclin-H 0.225 0.028
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.225 0.036
RFC4 RFC4: Replication factor C subunit 4 0.207 0.207
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.207 0.207
RFC3 RFC3: Replication factor C subunit 3 0.207 0.0968
SRPR SRPR: Uncharacterized protein SRPR 0.202 0.053
CDC45L CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein 0.196 0.196
ERF ERF: ETS domain-containing transcription factor ERF 0.191 0.0308
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.191 0.041
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.171 0.036
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.027
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.027
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.163 0.0278
CUL2 CUL2: Cullin-2 0.156 0.074
ETS2 ETS2: Protein C-ets-2 0.152 0.0308
FEN1 FEN1, RAD2: Flap endonuclease 1 0.144 0.0739
RFX5 RFX5: DNA-binding protein RFX5 0.137 0.137
MUTYH N/A 0.137 0.083
CCNF CCNF: G2/mitotic-specific cyclin-F 0.137 0.137
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.136 0.028
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.123 0.060
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.123 0.123
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.123 0.123
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.123
ORC6L ORC6L: Origin recognition complex subunit 6 0.123 0.123
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.123 0.123
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.117 0.055
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.0968 0.059
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.0968 0.0968
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.0968 0.0968
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.0968 0.0968
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.0968 0.207
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.0968 0.047
POT1 POT1: Protection of telomeres protein 1 0.083 0.083
C22orf18 N/A 0.082 0.027
C18orf56 N/A 0.082 0.082
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.081 0.038
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.081 0.038
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.074 0.044
RPS23 RPS23: 40S ribosomal protein S23 0.074 0.074
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.074 0.074
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.074 0.074
XRCC3 XRCC3: DNA-repair protein XRCC3 0.074 0.074
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.0735 0.035
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.067 0.067
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.067 0.067
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.065 0.053
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.123
TFDP1 TFDP1, DP1: Transcription factor Dp-1 0.060 0.060
CCNC CCNC: Cyclin-C 0.060 0.044
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.060 0.060
CCND2 CCND2: G1/S-specific cyclin-D2 0.060 0.060
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.060 0.060
DVL2 DVL2: Segment polarity protein dishevelled homolog DVL-2 0.059 0.035
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.059 0.0968
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.055 0.0331
GMNN GMNN: Geminin 0.053 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.027
TARDBP TARDBP, TDP43: TAR DNA-binding protein 43 0.053 0.053
HNRPA3 HNRPA3: Heterogeneous nuclear ribonucleoprotein A3 0.053 0.053
SFRS3 SFRS3, SRP20: Splicing factor, arginine/serine-rich 3 0.053 0.053
SFPQ SFPQ, PSF: Splicing factor, proline- and glutamine-rich 0.053 0.053
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.050 0.050
IRF5 IRF5: Interferon regulatory factor 5 0.050 0.067
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.050 0.041
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.047 0.035
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.047 0.047
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.047 0.035
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.354
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.890
H1F0 H1F0, H1FV: Histone H1.0 0.046 0.036
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.044 0.044
MYST3 MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3 0.044 0.044
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.044 0.044
CCND3 CCND3: G1/S-specific cyclin-D3 0.044 0.044
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.042 0.042
IRF2 IRF2: Interferon regulatory factor 2 0.041 0.041
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.040 0.123
MYH9 MYH9: Myosin-9 0.038 0.132
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.038 0.038
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.038 0.038
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.038 0.038
BAT1 N/A 0.038 0.038
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.036 0.044
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.036 0.044
CCNI CCNI: Cyclin-I 0.036 0.044
FLI1 FLI1: Friend leukemia integration 1 transcription factor 0.036 0.036
CCNL2 CCNL2, SB138: Cyclin-L2 0.036 0.028
PAX5 PAX5: Paired box protein Pax-5 0.036 0.036
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.035 0.035
NUBP1 NUBP1, NBP, NBP1: Nucleotide-binding protein 1 0.035 0.029
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.0331 0.027
E2F2 E2F2: Transcription factor E2F2 0.0308 0.0308
RNF31 ISGF3G, IRF9: Transcriptional regulator ISGF3 subunit gamma 0.0308 0.0308
ERCC1 ERCC1: DNA excision repair protein ERCC-1 0.0308 0.0308
IRF8 IRF8, ICSBP1: Interferon regulatory factor 8 0.0308 0.041
IRF1 IRF1: Interferon regulatory factor 1 0.0308 0.0308
PEX1 PEX1: Peroxisome biogenesis factor 1 0.029 0.029
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 0.029 0.035
CCNT1 CCNT1: Cyclin-T1 0.028 0.028
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.028 0.028
DVL1 DVL1: Segment polarity protein dishevelled homolog DVL-1 0.028 0.028
MYST1 MYST1, MOF, PP7073: Probable histone acetyltransferase MYST1 0.028 0.028
DUT DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor 0.027 0.027
TMPO N/A 0.027 0.027
POLD3 POLD3, KIAA0039: DNA polymerase subunit delta-3 0.027 0.027
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.027
ZWINT N/A 0.027 0.082
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
RAD51AP1 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
HNRPD N/A 0.027 0.027
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.027
ZWILCH Protein zwilch homolog. 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
SERBP1 N/A 0.027 0.027
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.027 0.027
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.027 0.027
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
OGG1 N/A 0.027 0.027
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
DNAH11 N/A 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.0255 0.0255
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.0255 0.042
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.025 0.027
0.572
Total Score 4.78E4