PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between MCM3 and MCM7

The interaction score between MCM3 and MCM7 is 4.78E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between MCM3 and MCM7 = 0.91

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.082

Orthology

Organism	MCM3 Orthologue		MCM7 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YEL032W	1	YBR202W	1	Y2H DosageRescue Get References From PubMed
worm	Q9XVR7	1	O16297	1
fly	P91675	1	Q9XYU0	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in MCM3 and MCM7:

Domains in MCM3

Domains in MCM7

IPR003593	AAA ATPase
IPR008994	Nucleic acid-binding OB-fold
IPR001208	MCM
IPR008046	MCM protein 3

IPR003593	AAA ATPase
IPR001208	MCM
IPR008050	MCM protein 7

The Chi square scores for co-occurrence of domains that are present in MCM3 and MCM7 are listed below.

Domain 1		Domain 2		Chi Square
IPR001208	MCM	IPR001208	MCM	364.867
IPR001208	MCM	IPR008050	MCM protein 7	315.618
IPR008994	Nucleic acid-binding OB-fold	IPR001208	MCM	301.459
IPR008994	Nucleic acid-binding OB-fold	IPR008050	MCM protein 7	169.761
IPR003593	AAA ATPase	IPR001208	MCM	127.202
IPR003593	AAA ATPase	IPR003593	AAA ATPase	89.0695
IPR008994	Nucleic acid-binding OB-fold	IPR003593	AAA ATPase	36.1462
IPR003593	AAA ATPase	IPR008050	MCM protein 7	15.8734

The background colour of the table refers to:

Blue Domain is only present in MCM3
Yellow Domain is only present in MCM7
Green Domain is present in both MCM3 and MCM7

0.027

Post-translational Modifications

Protein: MCM3

PTM	Residue	Reference
Phosphorylation	713	PubMed, HPRD
Phosphorylation	722	PubMed, HPRD
Phosphoserine	535	PubMed, HPRD
Phosphothreonine	713	HPRD
Phosphothreonine	722	HPRD

Protein: MCM7

PTM	Residue	Reference

Localisation

Protein: MCM3

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD

Protein: MCM7

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between MCM3 and MCM7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM3 andMCM7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM3 has 1106 interactors and MCM7 has 165 interactors of which there are 157 common interactors.

Common Interactor	Name of Common Interactor	Score for MCM3-Interactor (?)	Score for MCM7-Interactor (?)
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	1.29E3	209.00
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	1.29E3	69.60
MCM6	MCM6: DNA replication licensing factor MCM6	209.00	0.789
MCM5	MCM5, CDC46: DNA replication licensing factor MCM5	209.00	69.60
CCNB2	CCNB2: G2/mitotic-specific cyclin-B2	69.60	0.263
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	63.90	1.82
CCNB1	Cyclin B1	40.60	0.263
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	1.62	0.123
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	1.62	69.60
PCNA	PCNA: Proliferating cell nuclear antigen	1.62	0.789
DNMT1	DNMT1, AIM, DNMT: DNA	0.852	0.137
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.852	0.293
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.822	0.038
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.763	0.123
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.763	0.074
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.763	0.123
RFC5	RFC5: Replication factor C subunit 5	0.620	0.207
MCM10	MCM10, PRO2249: Protein MCM10 homolog	0.593	0.593
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.515	0.053
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.515	0.067
RB1	RB1: Retinoblastoma-associated protein	0.515	0.083
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.503	0.059
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.503	0.059
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.503	0.0968
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.461	0.060
MTA1	MTA1: Metastasis-associated protein MTA1	0.461	0.074
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.461	0.074
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.461	0.060
ELF1	ELF1: ETS-related transcription factor Elf-1	0.416	0.050
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.416	0.067
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.372	0.060
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.372	0.044
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.372	0.044
MDN1	MDN1, KIAA0301: Midasin	0.372	0.060
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.372	0.044
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.307	0.049
IRF3	IRF3: Interferon regulatory factor 3	0.307	0.041
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.304	0.059
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.304	0.059
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.293	0.137
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.275	0.036
RPA1	RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit	0.263	0.123
ABCE1	ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil	0.263	0.123
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.263	0.263
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.257	0.123
ERG	ERG: Transcriptional regulator ERG	0.251	0.041
GTF2F2	N/A	0.251	0.041
H1FX	H1FX: Histone H1x	0.251	0.050
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.245	0.047
KARS	KARS, KIAA0070: Lysyl-tRNA synthetase	0.231	0.108
TAF9	AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6	0.231	0.108
CSDA	CSDA, DBPA: DNA-binding protein A	0.225	0.044
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.225	0.036
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.225	0.028
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.225	0.028
CCNH	CCNH: Cyclin-H	0.225	0.028
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.225	0.028
RFC4	RFC4: Replication factor C subunit 4	0.207	0.207
PLK4	PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4	0.207	0.207
RFC3	RFC3: Replication factor C subunit 3	0.207	0.207
SRPR	SRPR: Uncharacterized protein SRPR	0.202	0.032
CDC45L	CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein	0.196	0.196
ERF	ERF: ETS domain-containing transcription factor ERF	0.191	0.0308
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.191	0.0308
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.171	0.028
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.165	0.027
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.165	0.027
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.165	0.027
CUL2	CUL2: Cullin-2	0.156	0.044
FEN1	FEN1, RAD2: Flap endonuclease 1	0.144	0.0739
RFX5	RFX5: DNA-binding protein RFX5	0.137	0.083
CCNF	CCNF: G2/mitotic-specific cyclin-F	0.137	0.137
CCNG1	CCNG1, CCNG, CYCG1: Cyclin-G1	0.123	0.074
MRPS28	MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28	0.123	0.074
SCYE1	SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe	0.123	0.060
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.123	0.060
ORC6L	ORC6L: Origin recognition complex subunit 6	0.123	0.123
ORC2L	ORC2L, ORC2: Origin recognition complex subunit 2	0.123	0.123
SSBP1	SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor	0.117	0.055
SRP54	SRP54: Signal recognition particle 54 kDa protein	0.0968	0.059
ATAD3A	ATAD3A: ATPase family AAA domain-containing protein 3A	0.0968	0.0968
DARS	DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic	0.0968	0.059
PSMC3	PSMC3, TBP1: 26S protease regulatory subunit 6A	0.0968	0.0968
RUVBL1	RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1	0.0968	0.059
POT1	POT1: Protection of telomeres protein 1	0.083	0.083
C22orf18	N/A	0.082	0.027
C18orf56	N/A	0.082	0.082
GTF2E2	GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta	0.074	0.044
RPS23	RPS23: 40S ribosomal protein S23	0.074	0.060
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	0.074	0.060
EIF1AX	EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal	0.074	0.060
XRCC3	XRCC3: DNA-repair protein XRCC3	0.074	0.074
RP4-691N24.2	GINS1, KIAA0186, PSF1: DNA replication complex GINS protein PSF1	0.0739	0.0739
ORC3L	ORC3L, LATHEO: Origin recognition complex subunit 3	0.067	0.050
IRF4	IRF4, MUM1: Interferon regulatory factor 4	0.067	0.041
ADAR	ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase	0.067	0.050
TFDP1	TFDP1, DP1: Transcription factor Dp-1	0.060	0.074
CCNC	CCNC: Cyclin-C	0.060	0.044
E2F3	E2F3, KIAA0075: Transcription factor E2F3	0.060	0.044
CCND2	CCND2: G1/S-specific cyclin-D2	0.060	0.036
DVL2	DVL2: Segment polarity protein dishevelled homolog DVL-2	0.059	0.047
PSMC6	PSMC6, SUG2: 26S protease regulatory subunit S10B	0.059	0.059
XAB1	XAB1, MBDIN, HUSSY-23: XPA-binding protein 1	0.055	0.0331
GMNN	GMNN: Geminin	0.053	0.027
TPX2	TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2	0.053	0.027
ELF4	ELF4, ELFR, MEF: ETS-related transcription factor Elf-4	0.050	0.041
IRF5	IRF5: Interferon regulatory factor 5	0.050	0.041
OBFC1	OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1	0.050	0.041
RUVBL2	RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2	0.047	0.047
NARS	NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic	0.047	0.035
H1F0	H1F0, H1FV: Histone H1.0	0.046	0.036
MYST3	MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3	0.044	0.036
GABPA	GABPA, E4TF1A: GA-binding protein alpha chain	0.044	0.036
CCND3	CCND3: G1/S-specific cyclin-D3	0.044	0.044
IRF2	IRF2: Interferon regulatory factor 2	0.041	0.0308
EIF1AY	EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal	0.036	0.044
GCLC	GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit	0.036	0.044
CCNI	CCNI: Cyclin-I	0.036	0.028
FLI1	FLI1: Friend leukemia integration 1 transcription factor	0.036	0.028
CCNL2	CCNL2, SB138: Cyclin-L2	0.036	0.036
PAX5	PAX5: Paired box protein Pax-5	0.036	0.028
E2F5	E2F5: Transcription factor E2F5	0.036	0.028
VPS4A	VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A	0.035	0.029
NUBP1	NUBP1, NBP, NBP1: Nucleotide-binding protein 1	0.035	0.029
BCS1L	BCS1L, BCS1: Mitochondrial chaperone BCS1	0.035	0.029
PRSS15	LONP1, PRSS15: Lon protease homolog, mitochondrial precursor	0.0331	0.027
E2F2	E2F2: Transcription factor E2F2	0.0308	0.0308
RAD51C	RAD51C, RAD51L2: DNA repair protein RAD51 homolog 3	0.030	0.030
PEX1	PEX1: Peroxisome biogenesis factor 1	0.029	0.029
DVL1	DVL1: Segment polarity protein dishevelled homolog DVL-1	0.028	0.036
NAB1	NAB1: NGFI-A-binding protein 1	0.028	0.028
MYST1	MYST1, MOF, PP7073: Probable histone acetyltransferase MYST1	0.028	0.028
DUT	DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor	0.027	0.027
TMPO	N/A	0.027	0.027
CDCA8	CDCA8, PESCRG3: Borealin	0.027	0.027
ZWINT	N/A	0.027	0.027
ILF2	ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2	0.027	0.027
RAD51AP1	N/A	0.027	0.027
SMC4L1	N/A	0.027	0.027
KIAA0101	PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor	0.027	0.027
HMMR	HMMR: Hyaluronan-mediated motility receptor	0.027	0.027
MCM10	N/A	0.027	0.027
ABCC4	ABCC4, MRP4: Multidrug resistance-associated protein 4	0.027	0.027
CLPX	CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr	0.027	0.027
SPIC	SPIC: Transcription factor Spi-C	0.027	0.027
RPA3	RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit	0.027	0.027
C20orf116	C20orf116: Uncharacterized protein C20orf116 precursor	0.027	0.027
ABCF2	ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2	0.027	0.027
PAX3	PAX3, HUP2: Paired box protein Pax-3	0.027	0.027
IRF7	IRF7: Interferon regulatory factor 7	0.027	0.027
HILS1	HILS1: Spermatid-specific linker histone H1-like protein	0.027	0.027
FOXQ1	FOXQ1, HFH1: Forkhead box protein Q1	0.027	0.027
DNAH11	N/A	0.027	0.027
HSFY1	HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked	0.027	0.027
ZCCHC17	ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa	0.027	0.027
GTSE1	GTSE1: G2 and S phase-expressed protein 1	0.025	0.027
TACC3	TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3	0.025	0.027

0.572

Total Score

4.78E4