PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between MCM3 and MCM2

The interaction score between MCM3 and MCM2 is 2.96E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between MCM3 and MCM2 = 0.91

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.082

Orthology

Organism	MCM3 Orthologue		MCM2 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YEL032W	1	YBL023C	1	Y2H Immunoprecipitation AffinityChromatography SyntheticLethal AffinityCaptureWestern CoLocalization CoFractionation DosageLethality Get References From PubMed
worm	Q9XVR7	1	Q9XXI9	1
fly	P91675	1	P49735	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in MCM3 and MCM2:

Domains in MCM3

Domains in MCM2

IPR003593	AAA ATPase
IPR008994	Nucleic acid-binding OB-fold
IPR001208	MCM
IPR008046	MCM protein 3

IPR008994	Nucleic acid-binding OB-fold
IPR001208	MCM
IPR008045	MCM protein 2

The Chi square scores for co-occurrence of domains that are present in MCM3 and MCM2 are listed below.

Domain 1		Domain 2		Chi Square
IPR001208	MCM	IPR001208	MCM	364.867
IPR008994	Nucleic acid-binding OB-fold	IPR001208	MCM	301.459
IPR008994	Nucleic acid-binding OB-fold	IPR008994	Nucleic acid-binding OB-fold	191.222
IPR003593	AAA ATPase	IPR001208	MCM	127.202
IPR008994	Nucleic acid-binding OB-fold	IPR008045	MCM protein 2	51.0284
IPR003593	AAA ATPase	IPR008994	Nucleic acid-binding OB-fold	36.1462
IPR003593	AAA ATPase	IPR008045	MCM protein 2	26.073

The background colour of the table refers to:

Blue Domain is only present in MCM3
Yellow Domain is only present in MCM2
Green Domain is present in both MCM3 and MCM2

0.165

Post-translational Modifications

Protein: MCM3

PTM	Residue	Reference
Phosphorylation	713	PubMed, HPRD
Phosphorylation	722	PubMed, HPRD
Phosphoserine	535	PubMed, HPRD
Phosphothreonine	713	HPRD
Phosphothreonine	722	HPRD

Protein: MCM2

PTM	Residue	Reference
Phosphorylation	26	PubMed, HPRD
Phosphorylation	27	PubMed, HPRD
Phosphorylation	41	PubMed, HPRD
Phosphorylation	106	PubMed, HPRD
Phosphorylation	139	PubMed, HPRD
Phosphoserine	27	HPRD
Phosphoserine	41	HPRD
Phosphoserine	108	PubMed, HPRD
Phosphothreonine	106	HPRD

Localisation

Protein: MCM3

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD

Protein: MCM2

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD

Transitive Score

The common interactors between MCM3 and MCM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM3 andMCM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM3 has 1106 interactors and MCM2 has 983 interactors of which there are 958 common interactors.

Common Interactor	Name of Common Interactor	Score for MCM3-Interactor (?)	Score for MCM2-Interactor (?)
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	1.29E3	1.29E3
MCM5	MCM5, CDC46: DNA replication licensing factor MCM5	209.00	209.00
MCM7	MCM7, CDC47, MCM2: DNA replication licensing factor MCM7	209.00	209.00
MCM6	MCM6: DNA replication licensing factor MCM6	209.00	69.60
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	73.00	0.129
CCNB2	CCNB2: G2/mitotic-specific cyclin-B2	69.60	0.263
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	63.90	63.90
CCNB1	Cyclin B1	40.60	1.62
CDK2	CDK2: Cell division protein kinase 2	27.40	0.515
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	1.62	0.763
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	1.62	431.00
PCNA	PCNA: Proliferating cell nuclear antigen	1.62	0.827
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.917	0.260
DNMT1	DNMT1, AIM, DNMT: DNA	0.852	0.515
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.852	0.852
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.827	0.276
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.827	0.276
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.827	0.129
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.822	0.233
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.822	0.276
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.763	0.763
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.763	0.763
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.763	0.461
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.763	0.372
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.763	0.461
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.704	0.425
RFC5	RFC5: Replication factor C subunit 5	0.620	0.207
MCM10	MCM10, PRO2249: Protein MCM10 homolog	0.593	0.593
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.575	0.269
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.515	0.241
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.515	0.241
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.515	0.276
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.515	0.146
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.515	0.241
CDK4	CDK4: Cell division protein kinase 4	0.515	0.515
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.515	0.515
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.515	0.515
TP53	TP53, P53: Cellular tumor antigen p53	0.515	0.241
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.515	0.241
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.515	0.241
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.515	0.515
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.515	0.515
RB1	RB1: Retinoblastoma-associated protein	0.515	0.515
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.503	0.304
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.503	0.503
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.503	0.304
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.461	0.763
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.461	0.461
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.461	0.372
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.461	0.372
MTA1	MTA1: Metastasis-associated protein MTA1	0.461	0.372
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.430	0.260
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.260
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.430	0.210
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.423	0.141
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.416	0.307
ELF1	ELF1: ETS-related transcription factor Elf-1	0.416	0.307
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.394	0.185
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.233
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.233
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.372	0.225
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.372	0.275
MDN1	MDN1, KIAA0301: Midasin	0.372	0.275
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.372	0.372
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.372	0.275
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.307	0.144
ESPL1	N/A	0.307	0.307
MKI67	MKI67: Antigen KI-67	0.307	0.307
CENPA	CENPA: Histone H3-like centromeric protein A	0.307	0.307
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.307	0.144
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.307	0.923
IRF3	IRF3: Interferon regulatory factor 3	0.307	0.191
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.304	0.245
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.304	0.304
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.293	0.137
CDC20	CDC20: Cell division cycle protein 20 homolog	0.276	0.276
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.276	0.129
MAD2L1	MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A	0.276	0.129
NUP153	N/A	0.276	0.276
UNG	N/A	0.276	0.129
NPM1	NPM1, NPM: Nucleophosmin	0.276	0.129
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.276	0.129
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.276	0.129
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.276	0.827
CBX3	CBX3: Chromobox protein homolog 3	0.276	0.276
KIF11	N/A	0.276	0.276
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.276	0.276
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.276	0.078
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.276	0.129
LIG1	LIG1: DNA ligase 1	0.276	0.276
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.276	0.276
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.276	0.129
POLA2	POLA2: DNA polymerase subunit alpha B	0.276	0.276
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.276	0.129
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.276	0.129
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.276	0.276
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.275	0.171
RBM14	RBM14, SIP: RNA-binding protein 14	0.269	0.163
RPA1	RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit	0.263	69.60
ABCE1	ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil	0.263	0.123
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.263	0.263
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.257	0.156
FUBP1	N/A	0.253	0.124
H1FX	H1FX: Histone H1x	0.251	0.251
GTF2F2	N/A	0.251	0.251
ERG	ERG: Transcriptional regulator ERG	0.251	0.251
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.245	0.245
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.241	0.241
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.241	0.078
SSB	SSB: Lupus La protein	0.241	0.241
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.241	0.146
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.241	0.241
TIAL1	TIAL1: Nucleolysin TIAR	0.241	0.146
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.241	0.146
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.241	0.146
HDAC3	HDAC3: Histone deacetylase 3	0.241	0.129
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.241	0.146
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.241	0.241
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.233	0.188
TAF9	AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6	0.231	0.108
KARS	KARS, KIAA0070: Lysyl-tRNA synthetase	0.231	0.065
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.231	0.108
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.225	0.225
CSDA	CSDA, DBPA: DNA-binding protein A	0.225	0.275
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.225	0.171
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.225	0.171
CCNH	CCNH: Cyclin-H	0.225	0.171
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.225	0.171
RFC4	RFC4: Replication factor C subunit 4	0.207	0.207
PLK4	PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4	0.207	0.207
RFC3	RFC3: Replication factor C subunit 3	0.207	0.207
SRPR	SRPR: Uncharacterized protein SRPR	0.202	0.166
CDC45L	CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein	0.196	0.196
ERF	ERF: ETS domain-containing transcription factor ERF	0.191	0.191
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.191	0.251
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.188	0.139
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.188	0.114
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.139
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.188	0.188
ETS1	ETS1, EWSR2: Protein C-ets-1	0.171	0.111
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.171	0.275
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.165	0.165
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.165	0.165
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.165	0.165
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.163	0.0971
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.163	0.163
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.163	0.132
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.163	0.132
MATR3	MATR3, KIAA0723: Matrin-3	0.163	0.132
CUL2	CUL2: Cullin-2	0.156	0.126
ETS2	ETS2: Protein C-ets-2	0.152	0.152
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.148	0.148
CCNT2	CCNT2: Cyclin-T2	0.148	0.148
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.148	0.148
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.148	0.148
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.148	0.148
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.148	0.148
RBL1	RBL1: Retinoblastoma-like protein 1	0.148	0.148
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.148	0.148
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.148	0.148
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.148	0.148
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.146	0.118
HDAC2	HDAC2: Histone deacetylase 2	0.146	0.078
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.146	0.118
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.146	0.515
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.146	0.118
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.146	0.118
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.146	0.118
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.146	0.146
WEE1	WEE1: Wee1-like protein kinase	0.146	0.146
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.146	0.146
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.146	0.118
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.146	0.118
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.146	0.087
ABCF1	N/A	0.144	0.087
KIF23	N/A	0.144	0.144
TCOF1	N/A	0.144	0.070
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.144	0.087
NBN	NBN, NBS, NBS1, P95: Nibrin	0.144	0.070
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.144	0.144
PTMA	N/A	0.144	0.144
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.144	0.070
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.144	0.087
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.087
SET	SET: Protein SET	0.144	0.070
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.087
PA2G4	PA2G4, EBP1: Proliferation-associated protein 2G4	0.144	0.0479
DKC1	DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4	0.144	0.0479
KNTC2	KNTC2, HEC, HEC1: Kinetochore protein Hec1	0.144	0.144
FEN1	FEN1, RAD2: Flap endonuclease 1	0.144	0.144
CTPS	CTPS: CTP synthase 1	0.141	0.066
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.141	0.066
CCT8	CCT8: Uncharacterized protein CCT8	0.141	0.040
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.141	0.141
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.141	0.040
CDC23	CDC23: Cell division cycle protein 23 homolog	0.141	0.066
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.141	0.066
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.141	0.066
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.141	0.423
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.141	0.040
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.141	0.040
XPO1	XPO1, CRM1: Exportin-1	0.141	0.066
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.141	0.066
HSPD1		0.141	0.066
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.141	0.066
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	0.141	0.066
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.139	0.114
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.139	0.114
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.139	0.114
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.139	0.114
SNRPA	SNRPA: U1 small nuclear ribonucleoprotein A	0.139	0.065
RFX5	RFX5: DNA-binding protein RFX5	0.137	0.067
MUTYH	N/A	0.137	0.083
CCNF	CCNF: G2/mitotic-specific cyclin-F	0.137	0.293
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.136	0.111
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.136	0.136
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.132	0.132
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.132	0.0971
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.132	0.0971
PPP1R8	N/A	0.129	0.063
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.129	0.129
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.129	0.078
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.129	0.078
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.078
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.078
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.129	0.129
MYBL2	MYBL2, BMYB: Myb-related protein B	0.129	0.276
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.129	0.129
H2AFX	H2AFX, H2AX: Histone H2A.x	0.129	0.276
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.129	0.129
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.129	0.063
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.129	0.078
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.129	0.078
NOL1	N/A	0.129	0.063
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.126	0.100
MRPS28	MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28	0.123	0.123
CCNG1	CCNG1, CCNG, CYCG1: Cyclin-G1	0.123	0.060
SCYE1	SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe	0.123	0.060
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.123	0.074
ORC6L	ORC6L: Origin recognition complex subunit 6	0.123	0.123
ORC2L	ORC2L, ORC2: Origin recognition complex subunit 2	0.123	0.123
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.118	0.087
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.118	0.146
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.118	0.087
CDK7	CDK7, MO15: Cell division protein kinase 7	0.118	0.087
RBM7		0.118	0.071
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.118	0.087
RPS6KB1	N/A	0.118	0.087
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.118	0.087
SSBP1	SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor	0.117	0.0331
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.114	0.086
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.114	0.086
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.114	0.114
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.114	0.086
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.112	0.090
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.111	0.111
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.111	0.0818
ELK1	ELK1: ETS domain-containing protein Elk-1	0.111	0.111
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.111	0.111
RERE	RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei	0.111	0.097
ETV1	ETV1, ER81: ETS translocation variant 1	0.110	0.098
SPAST	SPAST, KIAA1083, SPG4: Spastin	0.098	0.098
RFX1	RFX1: MHC class II regulatory factor RFX1	0.097	0.097
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.097	0.111
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.097	0.088
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.097	0.111
FOXL2	FOXL2: Forkhead box protein L2	0.097	0.097
ROCK1	ROCK1: Rho-associated protein kinase 1	0.0971	0.060
SRP54	SRP54: Signal recognition particle 54 kDa protein	0.0968	0.059
ATAD3A	ATAD3A: ATPase family AAA domain-containing protein 3A	0.0968	0.0968
PSMC3	PSMC3, TBP1: 26S protease regulatory subunit 6A	0.0968	0.0968
RUVBL1	RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1	0.0968	0.047
DARS	DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic	0.0968	0.059
EXOSC7	EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42	0.0968	0.059
CSK	CSK: Tyrosine-protein kinase CSK	0.090	0.067
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.090	0.067
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.090	0.067
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.090	0.090
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.090	0.090
CDK5R1	CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor	0.088	0.088
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.087	0.070
TOP2B	N/A	0.087	0.070
SREBF2	N/A	0.087	0.052
API5	N/A	0.087	0.070
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.087	0.070
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.087	0.087
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.087	0.070
GNB2L1	Lung cancer oncogene 7	0.087	0.052
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.070
UBAP2	N/A	0.087	0.087
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.087	0.070
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.087	0.087
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.087	0.071
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.087	0.071
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.087	0.071
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.087	0.054
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.087	0.054
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.087	0.087
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.087	0.038
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.087	0.071
HTATSF1	HTATSF1: HIV Tat-specific factor 1	0.087	0.071
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.087	0.071
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.087	0.071
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.087	0.071
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.087	0.087
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.087	0.054
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.087	0.071
EIF5	EIF5: Eukaryotic translation initiation factor 5	0.086	0.116
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.083
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.083	0.083
POT1	POT1: Protection of telomeres protein 1	0.083	0.067
C22orf18	N/A	0.082	0.027
C18orf56	N/A	0.082	0.082
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.081	0.081
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.081	0.081
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.080	0.026
STK16	N/A	0.080	0.060
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.080	0.080
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.080	0.080
RBM6	RBM6, DEF3: RNA-binding protein 6	0.080	0.060
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.080	0.132
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.080	0.060
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.080	0.060
YY1	YY1: Transcriptional repressor protein YY1	0.078	0.078
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.078	0.063
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.078
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.078	0.046
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.078	0.063
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.078	0.063
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.078	0.063
PHF10	N/A	0.078	0.078
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.078	0.078
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.078
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.078	0.046
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.078	0.078
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.078	0.046
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.078	0.129
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.078	0.078
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.063
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.075
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.075
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.075	0.025
RPS23	RPS23: 40S ribosomal protein S23	0.074	0.044
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	0.074	0.044
EIF1AX	EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal	0.074	0.060
XRCC3	XRCC3: DNA-repair protein XRCC3	0.074	0.074
GTF2E2	GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta	0.074	0.036
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.074	0.027
RP4-691N24.2	GINS1, KIAA0186, PSF1: DNA replication complex GINS protein PSF1	0.0739	0.0739
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.074
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.074	0.0446
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.074	0.0446
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.074	0.036
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.074	0.157
EXOSC4	EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41	0.0735	0.060
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.073	0.064
CDK6	CDK6: Cell division protein kinase 6	0.071	0.071
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.071	0.071
SOS1	SOS1: Son of sevenless homolog 1	0.071	0.043
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.071	0.054
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.071	0.071
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.071	0.054
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.071	0.054
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.071	0.087
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.071	0.054
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.071	0.054
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.070	0.070
MYB	MYB: Myb proto-oncogene protein	0.070	0.070
ARFGAP1	N/A	0.070	0.052
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.070	0.070
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.070	0.0425
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.070	0.052
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.070	0.0425
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.070	0.052
IFI16	N/A	0.070	0.0425
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.052
CHUK	N/A	0.070	0.070
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.070	0.070
KIAA0853	N/A	0.070	0.070
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.052
IRF4	IRF4, MUM1: Interferon regulatory factor 4	0.067	0.050
ADAR	ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase	0.067	0.041
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.066	0.040
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.066	0.040
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.066	0.040
LDHB	LDHB: L-lactate dehydrogenase B chain	0.066	0.040
THOP1	THOP1: Thimet oligopeptidase	0.066	0.040
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.066	0.032
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.066	0.040
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.066	0.032
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.066	0.040
TK1	TK1: Thymidine kinase, cytosolic	0.066	0.066
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.066	0.040
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.066	0.040
HNRPK	N/A	0.066	0.040
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.066	0.141
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.066	0.040
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.066	0.032
QARS	QARS: Glutaminyl-tRNA synthetase	0.066	0.040
RBM28	RBM28: RNA-binding protein 28	0.065	0.039
U2AF1	U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit	0.065	0.065
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.063	0.046
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.063	0.046
WBSCR20A	N/A	0.063	0.046
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.038
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.063	0.078
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.046
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.038
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.063	0.046
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.063	0.046
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.063	0.046
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.046
COPB2	COPB2: Coatomer subunit beta'	0.063	0.046
SRF	SRF: Serum response factor	0.063	0.063
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.078
FNBP1	N/A	0.063	0.046
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.063	0.046
KLHDC4	N/A	0.063	0.046
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.046
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.063	0.046
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.063	0.046
CUL5	CUL5, VACM1: Cullin-5	0.063	0.046
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.063	0.046
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.063	0.063
ABCB9	ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor	0.062	0.062
ABCC1	ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1	0.062	0.062
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.060	0.048
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.060	0.060
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.060	0.048
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.060	0.060
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.060	0.060
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.060	0.060
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.060	0.048
STAT2	STAT2: Signal transducer and activator of transcription 2	0.060	0.048
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.060	0.032
CCNC	CCNC: Cyclin-C	0.060	0.036
E2F3	E2F3, KIAA0075: Transcription factor E2F3	0.060	0.044
CCND2	CCND2: G1/S-specific cyclin-D2	0.060	0.044
RECQL	RECQL, RECQL1: ATP-dependent DNA helicase Q1	0.060	0.044
RECQL4	RECQL4, RECQ4: ATP-dependent DNA helicase Q4	0.060	0.123
TFDP1	TFDP1, DP1: Transcription factor Dp-1	0.060	0.123
DVL2	DVL2: Segment polarity protein dishevelled homolog DVL-2	0.059	0.035
PSMC6	PSMC6, SUG2: 26S protease regulatory subunit S10B	0.059	0.059
XAB1	XAB1, MBDIN, HUSSY-23: XPA-binding protein 1	0.055	0.027
BRAF	BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase	0.054	0.041
STAT6	STAT6: Signal transducer and activator of transcription 6	0.054	0.041
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.054	0.043
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.054	0.043
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.054	0.043
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.054	0.029
HDAC6	HDAC6, JM21: Histone deacetylase 6	0.054	0.029
STK10	STK10: Uncharacterized protein STK10	0.054	0.043
ATM	ATM: Serine-protein kinase ATM	0.054	0.035
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.054	0.043
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.054	0.043
NOLC1	NOLC1, KIAA0035: Nucleolar phosphoprotein p130	0.053	0.025
GMNN	GMNN: Geminin	0.053	0.053
TPX2	TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2	0.053	0.053
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.053	0.025
BUB1B	BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet	0.053	0.053
TTK	TTK, MPS1L1: Dual specificity protein kinase TTK	0.053	0.053
MELK	MELK, KIAA0175: Maternal embryonic leucine zipper kinase	0.053	0.053
AURKB	AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12	0.053	0.053
HRB2	KRR1, HRB2: KRR1 small subunit processome component homolog	0.0525	0.032
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.052	0.052
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.052	0.052
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.052	0.052
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.052	0.052
MAPK15	N/A	0.052	0.052
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.052	0.052
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.052	0.052
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.052	0.052
MAPKAPK5	N/A	0.052	0.052
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.052	0.052
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.052	0.052
HDAC8	N/A	0.052	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.052	0.052
PLEK	PLEK, P47: Pleckstrin	0.052	0.0425
ZNF267	ZNF267: Zinc finger protein 267	0.052	0.0425
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.0425
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.052	0.0425
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.0425
WDR1	N/A	0.052	0.032
SMARCC2	N/A	0.052	0.0425
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.052	0.052
AFF1	N/A	0.052	0.070
TRRAP	N/A	0.052	0.0425
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.0425
NCOA3	N/A	0.052	0.0425
XRCC1	XRCC1: DNA-repair protein XRCC1	0.052	0.052
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.052	0.0425
SP100	N/A	0.052	0.0425
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.052	0.0425
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.0425
RFC1	RFC1, RFC140: Replication factor C subunit 1	0.051	0.051
PRIC285	PRIC285, KIAA1769: Peroxisomal proliferator-activated receptor A-interacting com	0.051	0.051
GTF2IRD1	GTF2IRD1, CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, WBSCR12: General transcription	0.051	0.051
ELK3	ELK3, NET, SAP2: ETS domain-containing protein Elk-3	0.051	0.051
ABCA1	ABCA1, ABC1, CERP: ATP-binding cassette sub-family A member 1	0.051	0.051
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.050	0.050
ELF4	ELF4, ELFR, MEF: ETS-related transcription factor Elf-4	0.050	0.0308
IRF5	IRF5: Interferon regulatory factor 5	0.050	0.041
OBFC1	OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1	0.050	0.041
HNRPK	HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K	0.049	0.049
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.048	0.048
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.048	0.039
TP73	TP73, P73: Tumor protein p73	0.048	0.048
PRKAA1	N/A	0.048	0.039
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.060
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.048	0.048
CHAF1A	CHAF1A, CAF, CAF1P150: Chromatin assembly factor 1 subunit A	0.0479	0.0479
SLBP	SLBP, HBP: Histone RNA hairpin-binding protein	0.0479	0.0479
EZH2	EZH2: Enhancer of zeste homolog 2	0.0479	0.0479
RUVBL2	RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2	0.047	0.035
NARS	NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic	0.047	0.035
EXOSC5	EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46	0.047	0.035
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.047	0.047
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.047	0.047
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.047	0.047
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.047	0.047
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.047	0.047
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.047	0.047
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.047	0.047
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.047	0.047
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.047	0.047
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.047	0.047
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.047	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.047	0.047
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.047	0.047
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.047	0.047
CDC2	CDC2: Cell division control protein 2 homolog	0.047	0.047
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.047	0.047
HDAC7A	N/A	0.047	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.047	0.047
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.047	0.047
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.047	0.047
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.047	0.047
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.047	0.047
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.047	0.047
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.047	0.047
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.047	0.047
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.047	0.047
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.047	0.047
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.047	0.047
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.047	0.047
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.047	0.047
GIT2	N/A	0.047	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.047	0.047
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.047	0.047
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.047	0.047
EEF2K	EEF2K: Elongation factor 2 kinase	0.047	0.047
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.047	0.047
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.047	0.047
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.047	0.047
SOX4	SOX4: Transcription factor SOX-4	0.046	0.038
CUL4B	N/A	0.046	0.029
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.046	0.038
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.038
RUNX1	N/A	0.046	0.046
FKBP4	FKBP4: FK506-binding protein 4	0.046	0.046
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.046	0.038
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.046	0.046
EP300	N/A	0.046	0.046
SP3	SP3: Transcription factor Sp3	0.046	0.046
MAFG	MAFG: Transcription factor MafG	0.046	0.063
CRSP2	MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol	0.046	0.038
DIAPH1	Diaphanous 1	0.046	0.038
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.046	0.038
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.046	0.063
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.046	0.046
SYMPK	SYMPK, SPK: Symplekin	0.046	0.046
GGCX	GGCX, GC: Vitamin K-dependent gamma-carboxylase	0.046	0.038
CXorf9	N/A	0.046	0.029
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.038
COPA	COPA: Coatomer subunit alpha	0.046	0.038
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.046	0.038
CORO1C	CORO1C, CRNN4: Coronin-1C	0.046	0.046
ARMET	ARMET, ARP: Protein ARMET precursor	0.046	0.029
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.046	0.063
SAPS3	N/A	0.046	0.038
COPE	COPE: Coatomer subunit epsilon	0.046	0.038
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.046	0.038
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.038
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.046	0.038
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.046	0.046
TUBA6	TUBA1C, TUBA6: Tubulin alpha-1C chain	0.046	0.063
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.071
KIAA1012	KIAA1012: Protein TRS85 homolog	0.046	0.038
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.046	0.078
SEC31L1	N/A	0.046	0.038
WDR79	N/A	0.046	0.046
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.038
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.046	0.038
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.046	0.037
ABCF1	N/A	0.046	0.046
H1F0	H1F0, H1FV: Histone H1.0	0.046	0.093
ABCG2	ABCG2, ABCP, BCRP, BCRP1, MXR: ATP-binding cassette sub-family G member 2	0.046	0.071
CFTR	CFTR: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette s	0.045	0.045
ABCA4	ABCA4, ABCR: Retinal-specific ATP-binding cassette transporter	0.045	0.045
ARS2	ARS2, ASR2: Arsenite-resistance protein 2	0.045	0.045
PHB2	PHB2, BAP, REA: Prohibitin-2	0.0446	0.036
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.0446	0.0446
HD	HD, IT15: Huntingtin	0.0446	0.036
NTHL1	NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1	0.044	0.036
MYST3	MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3	0.044	0.028
GABPA	GABPA, E4TF1A: GA-binding protein alpha chain	0.044	0.036
CCND3	CCND3: G1/S-specific cyclin-D3	0.044	0.036
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.044	0.0308
CDK5	CDK5: Cell division protein kinase 5	0.043	0.043
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.043	0.035
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.043	0.035
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.043	0.035
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.043	0.035
DYRK3	N/A	0.043	0.054
EMD	EMD, EDMD, STA: Emerin	0.0425	0.0425
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.032
COIL	COIL, CLN80: Coilin	0.0425	0.0425
ZFX	ZFX: Zinc finger X-chromosomal protein	0.0425	0.032
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.0425	0.032
GTF3C1	N/A	0.0425	0.026
XRCC4	N/A	0.0425	0.032
HIVEP1	N/A	0.0425	0.032
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.041	0.033
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.041	0.033
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.041	0.041
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.041	0.041
HDLBP	HDLBP, HBP, VGL: Vigilin	0.041	0.041
IRF2	IRF2: Interferon regulatory factor 2	0.041	0.0308
ABCB1	ABCB1, MDR1, PGY1: Multidrug resistance protein 1	0.041	0.037
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.04	0.04
MAP2K5	N/A	0.04	0.04
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.04	0.04
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.04	0.04
RPL8	RPL8: 60S ribosomal protein L8	0.040	0.032
CRKL	CRKL: Crk-like protein	0.040	0.032
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.040	0.066
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.040	0.040
HSP90AA1	Hsp89-alpha-delta-N	0.040	0.066
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.040	0.040
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.040	0.032
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.040	0.032
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.040	0.032
CD2AP	CD2AP: CD2-associated protein	0.040	0.032
FRG1	FRG1: Protein FRG1	0.040	0.040
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.040	0.032
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.040	0.032
THOC1	THOC1, HPR1: THO complex subunit 1	0.040	0.040
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.040	0.032
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.040	0.032
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.040	0.032
PPARBP	N/A	0.040	0.032
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.039	0.039
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.034
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.038	0.063
DOK1	DOK1: Docking protein 1	0.038	0.038
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.038	0.029
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.038	0.029
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.038	0.029
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.038	0.063
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.038	0.038
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.038	0.038
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.038	0.029
RANBP9	RANBP9, RANBPM: Ran-binding protein 9	0.038	0.029
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.038	0.029
TCEB3	TCEB3, MSTP059: Transcription elongation factor B polypeptide 3	0.038	0.029
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.038	0.029
MYH9	MYH9: Myosin-9	0.038	0.038
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.038	0.038
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.029
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.038	0.029
TOP3A	TOP3A, TOP3: DNA topoisomerase 3-alpha	0.038	0.038
METTL1	METTL1, C12orf1: tRNA	0.038	0.029
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.038	0.029
GSK3B	N/A	0.038	0.038
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.038	0.029
ZNF551	N/A	0.038	0.038
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.038	0.063
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.038	0.029
FZR1	N/A	0.038	0.038
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.038	0.029
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.038	0.038
LIMK2	LIMK2: LIM domain kinase 2	0.037	0.037
GCLC	GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit	0.036	0.060
CCNI	CCNI: Cyclin-I	0.036	0.028
PAX5	PAX5: Paired box protein Pax-5	0.036	0.028
E2F5	E2F5: Transcription factor E2F5	0.036	0.028
EIF1AY	EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal	0.036	0.060
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.036
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.036	0.027
YWHAQ	YWHAQ: 14-3-3 protein theta	0.036	0.036
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.036	0.027
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.036	0.036
STAT3		0.036	0.036
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.036	0.036
CAMK4	CAMK4: Calcium/calmodulin-dependent protein kinase type IV	0.036	0.036
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.036	0.036
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.035	0.0308
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.035	0.035
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.035	0.035
PAK4	PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4	0.035	0.035
MAP2K4	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k	0.035	0.035
MAP2K6	MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki	0.035	0.0308
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.035	0.035
PRKCA	PRKCA, PKCA, PRKACA: Protein kinase C alpha type	0.035	0.0308
STAT4	STAT4: Signal transducer and activator of transcription 4	0.035	0.028
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.035	0.0308
PPARGC1A	PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor	0.035	0.035
CDKL5	N/A	0.035	0.035
VPS4A	VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A	0.035	0.029
BCS1L	BCS1L, BCS1: Mitochondrial chaperone BCS1	0.035	0.029
AKAP1	AKAP1, AKAP149, PRKA1: A kinase anchor protein 1, mitochondrial precursor	0.035	0.028
GRK1	GRK1, RHOK: Rhodopsin kinase precursor	0.034	0.034
ICK	ICK, KIAA0936: Serine/threonine-protein kinase ICK	0.034	0.034
NEK3	NEK3: Serine/threonine-protein kinase Nek3	0.034	0.034
PRSS15	LONP1, PRSS15: Lon protease homolog, mitochondrial precursor	0.0331	0.027
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.033	0.027
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.033	0.027
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.033	0.033
PRKCQ	PRKCQ, PRKCT: Protein kinase C theta type	0.033	0.027
JAK1		0.033	0.027
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.033	0.027
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.032	0.0425
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.032	0.032
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.032	0.032
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.032	0.026
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.032	0.026
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.032	0.0425
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.032	0.026
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.032	0.032
NFATC1	N/A	0.032	0.026
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.032	0.032
RGS14	N/A	0.032	0.026
PTPN11	N/A	0.032	0.032
IDH2	IDH2: Isocitrate dehydrogenase [NADP], mitochondrial precursor	0.032	0.032
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.032	0.040
CAMK1	CAMK1: Calcium/calmodulin-dependent protein kinase type 1	0.031	0.031
CAMK2D	CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain	0.031	0.031
PAK6	PAK6, PAK5: Serine/threonine-protein kinase PAK 6	0.031	0.031
PAK7	PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7	0.031	0.028
PRKAA2	PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2	0.031	0.028
PRKCE	PRKCE, PKCE: Protein kinase C epsilon type	0.031	0.031
MOS	MOS: Proto-oncogene serine/threonine-protein kinase mos	0.031	0.028
DAPK2	DAPK2: Death-associated protein kinase 2	0.031	0.031
HIPK3	HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3	0.0308	0.0308
GSK3A	GSK3A: Glycogen synthase kinase-3 alpha	0.0308	0.035
SGK	SGK, SGK1: Serine/threonine-protein kinase Sgk1	0.0308	0.0308
PRKCG	PRKCG, PKCG: Protein kinase C gamma type	0.0308	0.0308
E2F2	E2F2: Transcription factor E2F2	0.0308	0.041
RGS7	RGS7: Regulator of G-protein signaling 7	0.031	0.031
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.029	0.029
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.029	0.029
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.029	0.029
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.029	0.029
GATA2	N/A	0.029	0.038
MTF1	MTF1: Metal regulatory transcription factor 1	0.029	0.029
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.029	0.029
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.029	0.029
RCP9	CRCP: DNA-directed RNA polymerase III subunit RPC9	0.029	0.029
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.029	0.029
BRPF1	BRPF1, BR140: Peregrin	0.029	0.029
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.029	0.029
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.029	0.029
PCAF	PCAF: Histone acetyltransferase PCAF	0.029	0.038
JUND	JUND: Transcription factor jun-D	0.029	0.029
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
CABLES1	N/A	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.028	0.028
SNRPB	N/A	0.028	0.028
BID	BID: BH3-interacting domain death agonist	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
WDR54	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
DSP	DSP: Desmoplakin	0.028	0.028
RAB4A	N/A	0.028	0.028
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.028	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.028
CORO6	N/A	0.028	0.028
IRF7	N/A	0.028	0.028
MITF	MITF: Microphthalmia-associated transcription factor	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.028	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.028	0.028
PHLDB2	N/A	0.028	0.028
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.028	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.028	0.028
C20orf18	N/A	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.028	0.028
DUSP15	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ZNF265	N/A	0.028	0.028
C13orf8	N/A	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
UHRF1		0.028	0.028
PPEF1	N/A	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.028	0.028
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.028	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.028
KIF1B	N/A	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MAP3K10	MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10	0.028	0.028
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.028	0.028
MYO3A	MYO3A: Myosin IIIA	0.028	0.0308
HSPB8	HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8	0.028	0.028
ROCK2	ROCK2, KIAA0619: Rho-associated protein kinase 2	0.028	0.028
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.028	0.0308
DVL1	DVL1: Segment polarity protein dishevelled homolog DVL-1	0.028	0.028
DUT	DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor	0.027	0.027
TMPO	N/A	0.027	0.082
CDCA8	CDCA8, PESCRG3: Borealin	0.027	0.082
ZWINT	N/A	0.027	0.082
POLD3	POLD3, KIAA0039: DNA polymerase subunit delta-3	0.027	0.027
RAD51AP1	N/A	0.027	0.027
SMC4L1	N/A	0.027	0.082
ZWILCH	Protein zwilch homolog.	0.027	0.027
KIAA0101	PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor	0.027	0.027
HMMR	HMMR: Hyaluronan-mediated motility receptor	0.027	0.027
MCM10	N/A	0.027	0.027
C20orf6	ESF1, ABTAP, HDCMC28P, C20orf6: ESF1 homolog	0.027	0.027
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.027	0.027
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	0.027	0.033
ABCC4	ABCC4, MRP4: Multidrug resistance-associated protein 4	0.027	0.027
ABCF2	ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2	0.027	0.027
PAX3	PAX3, HUP2: Paired box protein Pax-3	0.027	0.027
IRF7	IRF7: Interferon regulatory factor 7	0.027	0.027
OGG1	N/A	0.027	0.027
HILS1	HILS1: Spermatid-specific linker histone H1-like protein	0.027	0.027
FOXQ1	FOXQ1, HFH1: Forkhead box protein Q1	0.027	0.027
DNAH11	N/A	0.027	0.027
HSFY1	HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked	0.027	0.027
ZCCHC17	ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa	0.027	0.027
SPIC	SPIC: Transcription factor Spi-C	0.027	0.027
RPA3	RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit	0.027	0.027
C20orf116	C20orf116: Uncharacterized protein C20orf116 precursor	0.027	0.027
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.027	0.027
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.0263	0.0263
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.032
MECP2	MECP2: Methyl-CpG-binding protein 2	0.026	0.026
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.026	0.026
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.026	0.026
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.026	0.026
PER2	PER2, KIAA0347: Period circadian protein homolog 2	0.026	0.026
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.032
RAD54B	RAD54B: DNA repair and recombination protein RAD54B	0.0255	0.0255
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.025	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.025
CAMKK1	N/A	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.025
BRD4	N/A	0.025	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.025
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
FLJ23436	N/A	0.025	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.025	0.025
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
NUP98	N/A	0.025	0.025
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NIPBL	N/A	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
C20orf77	N/A	0.025	0.025
SOX8	SOX8: Transcription factor SOX-8	0.025	0.025
MAX	MAX: Protein max	0.025	0.025
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
TCEA1	N/A	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.025
TFAP4	TFAP4: Transcription factor AP-4	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.025	0.025
DIDO1	N/A	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
MAP2K3	N/A	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
SON		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
HTATIP	N/A	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.025
RNF20		0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.025
PRKCB1	N/A	0.025	0.025
SEC13L1	N/A	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.025	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.025
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.025
NES	N/A	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
CAMK2A	N/A	0.025	0.025
ATXN2L	N/A	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.025
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
GRK6	N/A	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
KCTD1		0.025	0.025
BCOR	N/A	0.025	0.025
ELMO1	N/A	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.025
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
GTSE1	GTSE1: G2 and S phase-expressed protein 1	0.025	0.053
TACC3	TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3	0.025	0.053
HIRIP3	HIRIP3: HIRA-interacting protein 3	0.025	0.025
DBF4	DBF4, ASK: Protein DBF4 homolog	0.025	0.025
DLG7	DLG7, KIAA0008: Disks large-associated protein DLG7	0.025	0.053

0.572

Total Score

2.96E5