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Evidence of Interaction Between RRM1 and RRM2

The interaction score between RRM1 and RRM2 is 213.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RRM1 and RRM2 = 0.94

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.082
Orthology
OrganismRRM1 OrthologueRRM2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER070W 0.581 YJL026W 1
  • AffinityCaptureMS

Get References From PubMed

bakers yeast YIL066C 1 YJL026W 1
worm Q03604 1 P42170 0.354
fly P48591 1 P48592 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.119
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: RRM1

PTMResidueReference

Protein: RRM2

PTMResidueReference
Phosphorylation 20 PubMed, HPRD
Localisation

Protein: RRM1

LocalisationReference
Cytoplasm HPRD

Protein: RRM2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RRM1 and RRM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RRM1 andRRM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RRM1 has 72 interactors and RRM2 has 695 interactors of which there are 31 common interactors.

Common InteractorName of Common InteractorScore for RRM1-Interactor (?)Score for RRM2-Interactor (?)
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.01 0.040
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.612 0.032
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.099 0.364
DLG7 DLG7, KIAA0008: Disks large-associated protein DLG7 0.082 0.160
CDCA8 CDCA8, PESCRG3: Borealin 0.082 0.082
TMPO N/A 0.082 0.027
C18orf56 N/A 0.082 0.082
HMMR HMMR: Hyaluronan-mediated motility receptor 0.082 0.082
ZWINT N/A 0.082 0.082
SMC4L1 N/A 0.082 0.027
NUSAP1 NUSAP1, ANKT, BM-037, PRO0310: Nucleolar and spindle-associated protein 1 0.082 0.082
PRC1 PRC1: Protein regulator of cytokinesis 1 0.0739 0.0479
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.144
KNTC2 KNTC2, HEC, HEC1: Kinetochore protein Hec1 0.0739 0.144
SHCBP1 SHCBP1: SHC SH2 domain-binding protein 1 0.0739 0.0479
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.058 0.029
CDC2 N/A 0.049 0.049
RRM2B RRM2B, P53R2: Ribonucleoside-diphosphate reductase subunit M2 B 0.038 1.79
RAD51AP1 N/A 0.027 0.027
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.053
ZWILCH Protein zwilch homolog. 0.027 0.027
CTA-126B4.3 CGI-96: Gastric cancer antigen Zg14 0.027 0.027
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.027 0.025
GMNN GMNN: Geminin 0.027 0.053
C22orf18 N/A 0.027 0.027
CDCA3 CDCA3, C8, GRCC8, TOME1: Cell division cycle-associated protein 3 0.027 0.027
C16orf60 N/A 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.025
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.027 0.053
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.027 0.472
FOXM1 N/A 0.027 0.027
0.228
Total Score 213.00