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Evidence of Interaction Between RPA2 and RPA1

The interaction score between RPA2 and RPA1 is 1.12E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RPA2 and RPA1 = 0.57

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismRPA2 OrthologueRPA1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YNL312W 1 YAR007C 1
  • Other
  • AffinityCaptureMS
  • ReconstitutedComplex
  • CoPurification

Get References From PubMed
worm Q8I7G2 0.133 Q19537 1
worm Q95Y97 1 Q19537 1
  • Y2H
  • Other

Get References From PubMed
fly Q8SXG3 1 Q24492 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in RPA2 and RPA1:
Domains in RPA2Domains in RPA1
IPR004365 OB-fold nucleic acid binding
IPR011991 Wing_hlx_DNA_bd.
IPR012340 OB_NA_bd_sub.
IPR008994 Nucleic acid-binding OB-fold
IPR004365 OB-fold nucleic acid binding
IPR004591 Replication factor-a protein 1 Rpa1
IPR007199 Replication factor-A protein 1, N-terminal
IPR012340 OB_NA_bd_sub.

The Chi square scores for co-occurrence of domains that are present in RPA2 and RPA1 are listed below.

Domain 1Domain 2Chi Square
IPR012340 OB_NA_bd_sub. IPR008994 Nucleic acid-binding OB-fold 168.682
IPR012340 OB_NA_bd_sub. IPR012340 OB_NA_bd_sub. 73.6747
IPR004365 OB-fold nucleic acid binding IPR008994 Nucleic acid-binding OB-fold 29.2304
IPR011991 Wing_hlx_DNA_bd. IPR008994 Nucleic acid-binding OB-fold 1.13582

The background colour of the table refers to:

  • Blue Domain is only present in RPA2
  • Yellow Domain is only present in RPA1
  • Green Domain is present in both RPA2 and RPA1

 0.027
Post-translational Modifications

Protein: RPA2

PTMResidueReference
N-acetylmethionine 1 HPRD
Phosphorylation 4 PubMed, HPRD
Phosphorylation 8 PubMed, HPRD
Phosphorylation 11 PubMed, HPRD
Phosphorylation 12 PubMed, HPRD
Phosphorylation 13 PubMed, HPRD
Phosphorylation 21 PubMed, HPRD
Phosphorylation 23 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphoserine 29 PubMed, HPRD
Phosphoserine 33 PubMed, HPRD
Phosphothreonine 21 PubMed, HPRD

Protein: RPA1

PTMResidueReference
Localisation

Protein: RPA2

LocalisationReference
Nucleus HPRD

Protein: RPA1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between RPA2 and RPA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RPA2 andRPA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RPA2 has 1321 interactors and RPA1 has 291 interactors of which there are 182 common interactors.

Common InteractorName of Common InteractorScore for RPA2-Interactor (?)Score for RPA1-Interactor (?)
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 122.00 0.0968
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 61.60 3.99
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 16.60 1.82
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 4.95 0.210
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.763 0.123
RAD52 RAD52: DNA repair protein RAD52 homolog 0.593 0.593
DNA2L DNA2L, KIAA0083: DNA2-like helicase 0.593 0.593
RP11-196G18.6 HIST2H2BF: Histone H2B type 2-F 0.593 0.593
HIST1H2BG HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B 0.538 0.538
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.461 0.263
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.461 0.059
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.430 0.0255
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.416 0.137
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.416 0.067
DDX21 DDX21: Nucleolar RNA helicase 2 0.416 0.137
FUBP1 N/A 0.416 0.108
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.372 0.060
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.372 0.0968
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.372 0.059
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.372 0.074
EEF2 EEF2, EF2: Elongation factor 2 0.372 0.047
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.372 0.044
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.372 0.059
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.372 0.074
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.372 0.074
MCM3 MCM3: DNA replication licensing factor MCM3 0.372 0.263
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.372 0.074
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.372 0.053
HIST1H2BH HIST1H2BH, H2BFJ: Histone H2B type 1-H 0.354 0.354
WDR76 N/A 0.326 0.890
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.275 0.263
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.275 0.044
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.275 0.047
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.275 0.060
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.275 0.059
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.275 0.044
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.275 0.060
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.275 0.074
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.275 0.123
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.275 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.275 0.123
RBM14 RBM14, SIP: RNA-binding protein 14 0.260 0.042
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.260 0.090
ELF1 ELF1: ETS-related transcription factor Elf-1 0.260 0.0255
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.251 0.067
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.233 0.038
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.233 0.038
TIAL1 TIAL1: Nucleolysin TIAR 0.233 0.081
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.233 0.081
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.233 0.038
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.233 0.081
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.233 0.038
HIST1H2BO HIST1H2BO, H2BFH, H2BFN: Histone H2B type 1-O 0.233 0.264
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.225 0.123
CCNB1 Cyclin B1 0.225 0.038
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.225 69.60
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.210 0.042
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.210 0.0255
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.210 0.137
MATR3 MATR3, KIAA0723: Matrin-3 0.210 0.042
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.210 0.0255
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.188 0.051
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.188 0.038
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.188 0.038
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.188 0.081
SSB SSB: Lupus La protein 0.188 0.038
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.188 0.242
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.188 0.038
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.188 0.038
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.188 0.081
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.188 0.123
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.188 0.123
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.188 0.081
CSDA CSDA, DBPA: DNA-binding protein A 0.171 0.036
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.171 0.059
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.171 0.060
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.165 0.027
TUFM TUFM: Elongation factor Tu, mitochondrial precursor 0.155 0.0331
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.152 0.050
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.148 6.33
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.139 0.044
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.139 0.782
HIST1H2BK HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K 0.132 0.108
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.126 0.123
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.123 0.074
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.114 0.044
H2BFS H2BFS: Histone H2B type F-S 0.108 0.108
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.096 0.0255
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.093 0.029
HRB2 KRR1, HRB2: KRR1 small subunit processome component homolog 0.093 0.0968
TP53 TP53, P53: Cellular tumor antigen p53 0.087 0.053
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.086 0.060
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.086 0.074
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.083 0.027
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.083 0.137
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.083 0.231
RFX5 RFX5: DNA-binding protein RFX5 0.083 0.042
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.083 0.231
HIST1H2BD HIST1H2BD, H2BFB, HIRIP2: Histone H2B type 1-D 0.082 0.053
LCP1 LCP1, PLS2: Plastin-2 0.078 0.123
DDX47 E4-DBP: DEAD box protein 0.074 0.123
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.074 0.123
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.074 0.074
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.074 0.123
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.074 0.074
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.074 0.123
HIST1H2BB HIST1H2BB, H2BFF: Histone H2B type 1-B 0.071 0.071
HIST1H2BN N/A 0.071 0.071
HIST1H2BM HIST1H2BM, H2BFE: Histone H2B type 1-M 0.071 0.071
HIST3H2BB HIST3H2BB: Histone H2B type 3-B 0.071 0.071
HIST1H2BL HIST1H2BL, H2BFC: Histone H2B type 1-L 0.071 0.071
HIST1H2BA HIST1H2BA, TSH2B: Histone H2B type 1-A 0.071 0.071
SRPR SRPR: Uncharacterized protein SRPR 0.070 0.065
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.067 0.293
POT1 POT1: Protection of telomeres protein 1 0.067 0.083
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.067 0.067
HIST1H2BJ HIST1H2BJ, H2BFR: Histone H2B type 1-J 0.065 0.065
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.063 25.60
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.063 1.10
MDN1 MDN1, KIAA0301: Midasin 0.063 0.060
BAT1 N/A 0.060 0.123
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.060 0.074
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.060 0.123
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.060 0.074
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.060 0.0968
RPS23 RPS23: 40S ribosomal protein S23 0.060 0.123
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.060 0.263
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.060 0.074
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.060 0.074
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.060 0.0968
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.060 0.123
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.060 0.123
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.060 0.0968
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.060 3.96
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.060 0.060
MUTYH N/A 0.050 0.083
VCP VCP: Transitional endoplasmic reticulum ATPase 0.046 0.059
POLR2A POLR2A: Uncharacterized protein POLR2A 0.046 2.95
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.046 0.0968
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.045 11.10
GSPT1 GSPT1: G1 to S phase transition protein 1 homolog 0.044 0.207
EIF4A2 EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II 0.044 0.036
MCM6 MCM6: DNA replication licensing factor MCM6 0.044 0.123
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.044 0.059
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.044 0.060
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.044 0.035
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.044 69.60
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.044 0.060
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.044 0.123
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.044 0.123
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.044 0.123
FMR1 FMR1: Fragile X mental retardation 1 protein 0.044 0.029
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.044 0.123
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.044 0.074
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.038 0.108
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.038 0.890
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.038 0.047
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.038 0.082
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.037 0.038
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.037 0.081
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.036 0.074
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.036 3.20
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.036 0.060
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.036 0.038
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.036 0.038
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.036 0.036
CCNF CCNF: G2/mitotic-specific cyclin-F 0.0308 0.042
ERCC1 ERCC1: DNA excision repair protein ERCC-1 0.0308 0.0308
CORO1C CORO1C, CRNN4: Coronin-1C 0.029 0.890
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.028 0.044
NAB1 NAB1: NGFI-A-binding protein 1 0.028 0.028
HBS1L HBS1L, HBS1, KIAA1038: HBS1-like protein 0.028 0.047
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.028 0.036
IGF2BP3 IGF2BP3, IMP3, KOC1, VICKZ3: Insulin-like growth factor 2 mRNA-binding protein 3 0.028 0.044
MTIF2 MTIF2: Translation initiation factor IF-2, mitochondrial precursor 0.027 0.055
MRPL3 MRPL3, MRL3, RPML3: Mitochondrial 39S ribosomal protein L3 0.027 0.055
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.027 0.055
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
OGG1 N/A 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.0255 0.042
0.347
Total Score 1.12E4