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Evidence of Interaction Between ACVR2A and ACVR1B

The interaction score between ACVR2A and ACVR1B is 808.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismACVR2A OrthologueACVR1B OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00020431 0.091 IPI00005733 0.57
  • Immunoprecipitation
  • Y2H
  • InVivo

Get References From PubMed
human IPI00437565 0.634 IPI00005733 0.57
worm Q8ITX8 1 P20792 0.57
fly Q24229 1 Q8MKS1 0.313

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in ACVR2A and ACVR1B:
Domains in ACVR2ADomains in ACVR1B
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor
IPR000719 Protein kinase
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in ACVR2A and ACVR1B are listed below.

Domain 1Domain 2Chi Square
IPR000333 Activin type II receptor IPR000472 TGF-beta receptor/activin receptor, type I/II 139.82
IPR000472 TGF-beta receptor/activin receptor, type I/II IPR000472 TGF-beta receptor/activin receptor, type I/II 120.212
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR000719 Protein kinase IPR008271 Serine/threonine protein kinase, active site 6.25263
IPR008271 Serine/threonine protein kinase, active site IPR008271 Serine/threonine protein kinase, active site 5.82656
IPR011009 Protein kinase-like IPR000719 Protein kinase 2.94434
IPR011009 Protein kinase-like IPR008271 Serine/threonine protein kinase, active site 2.11823
IPR000333 Activin type II receptor IPR008271 Serine/threonine protein kinase, active site 2.08498
IPR000472 TGF-beta receptor/activin receptor, type I/II IPR008271 Serine/threonine protein kinase, active site 0.960112
IPR000719 Protein kinase IPR000472 TGF-beta receptor/activin receptor, type I/II 0.743605
IPR011009 Protein kinase-like IPR000472 TGF-beta receptor/activin receptor, type I/II 0.26297
IPR000333 Activin type II receptor IPR000719 Protein kinase 0.128195

The background colour of the table refers to:

  • Blue Domain is only present in ACVR2A
  • Yellow Domain is only present in ACVR1B
  • Green Domain is present in both ACVR2A and ACVR1B

 8.18E-3
Post-translational Modifications

Protein: ACVR2A

PTMResidueReference

Protein: ACVR1B

PTMResidueReference
Phosphorylation 380 PubMed, HPRD
Phosphotyrosine 380 HPRD
Localisation

Protein: ACVR2A

LocalisationReference
Plasma membrane HPRD

Protein: ACVR1B

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between ACVR2A and ACVR1B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ACVR2A andACVR1B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ACVR2A has 176 interactors and ACVR1B has 1029 interactors of which there are 112 common interactors.

Common InteractorName of Common InteractorScore for ACVR2A-Interactor (?)Score for ACVR1B-Interactor (?)
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 142.00 422.00
BMP5 BMP5: Bone morphogenetic protein 5 precursor 86.20 0.195
GDF8 MSTN, GDF8: Growth/differentiation factor 8 precursor 69.80 0.195
BMP8B BMP8B, BMP8: Bone morphogenetic protein 8B precursor 69.80 0.195
INHBA INHBA: Inhibin beta A chain precursor 69.80 0.195
INHBB INHBB: Inhibin beta B chain precursor 62.40 0.195
BMP6 BMP6, VGR: Bone morphogenetic protein 6 precursor 61.50 0.195
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 10.50 71.20
ARHGEF7 N/A 9.04 46.90
DAB1 DAB1: Disabled homolog 1 5.94 46.90
OSR2 OSR2: Protein odd-skipped-related 2 1.07 1.07
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.328 6.17
GDF2 GDF2, BMP9: Growth/differentiation factor 2 precursor 0.251 0.217
PSPN PSPN: Persephin precursor 0.251 0.217
ARTN ARTN, EVN: Artemin precursor 0.251 0.217
TSSK2 TSSK2, DGSG, SPOGA2, STK22B: Testis-specific serine/threonine-protein kinase 2 0.234 0.356
INHBC INHBC: Inhibin beta C chain precursor 0.225 0.195
GDF1 GDF1: Embryonic growth/differentiation factor 1 precursor 0.217 0.217
GDNF GDNF: Glial cell line-derived neurotrophic factor precursor 0.217 0.217
GDF7 gdf7: Growth differentiation factor 7 0.217 0.217
AMH AMH, MIF: Muellerian-inhibiting factor precursor 0.200 0.217
GDF9 GDF9: Growth/differentiation factor 9 precursor 0.200 0.217
INHBE INHBE: Inhibin beta E chain precursor 0.200 0.217
GDF11 GDF11, BMP11: Growth/differentiation factor 11 precursor 0.195 0.195
BMP4 BMP4, BMP2B, DVR4: Bone morphogenetic protein 4 precursor 0.195 0.195
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.179 0.878
TGFB2 TGFB2: Transforming growth factor beta-2 precursor 0.162 0.217
LEFTY2 LEFTY2, EBAF, PSEC0024, LEFTA, LEFTYA, TGFB4: Left-right determination factor 2 0.162 0.217
LEFTY1 LEFTY1, LEFTB, UNQ278/PRO317, LEFTYB: Left-right determination factor 1 precurso 0.162 0.217
BMP3 BMP3: Bone morphogenetic protein 3 precursor 0.162 0.217
AP1B1 AP1B1, ADTB1, BAM22, CLAPB2: AP-1 complex subunit beta-1 0.145 0.145
BMP15 BMP15, GDF9B: Bone morphogenetic protein 15 precursor 0.143 0.217
GDF5 GDF5, CDMP1: Growth/differentiation factor 5 precursor 0.143 0.217
NRTN NRTN: Neurturin precursor 0.143 0.217
GDF3 GDF3, UNQ222/PRO248: Growth/differentiation factor 3 precursor 0.143 0.217
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.143 0.980
BMP10 BMP10: Bone morphogenetic protein 10 precursor 0.143 0.217
VWF VWF, F8VWF: von Willebrand factor precursor 0.130 0.878
GDF10 GDF10, BMP3B: Bone morphogenetic protein 3b precursor 0.129 0.217
INHA INHA: Inhibin alpha chain precursor 0.129 0.980
NODAL NODAL: Nodal homolog precursor 0.129 0.217
TGFB3 TGFB3: Transforming growth factor beta-3 precursor 0.128 0.195
BMP2 BMP2, BMP2A: Bone morphogenetic protein 2 precursor 0.128 0.195
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.053 0.044
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.047 0.098
CRKL CRKL: Crk-like protein 0.047 0.098
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.047 0.098
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.039 0.044
NRAS NRAS, HRAS1: GTPase NRas precursor 0.035 0.098
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.035 0.098
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.035 0.098
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.035 0.098
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.035 0.098
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.035 0.098
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.035 0.098
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.035 0.098
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.035 0.098
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.035 0.098
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.035 0.098
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.035 0.098
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.035 0.098
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.035 0.098
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.035 0.098
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.035 0.098
RAC1 RAC1, MIG5: Ras-related C3 botulinum toxin substrate 1 precursor 0.032 0.044
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.032 0.109
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.032 0.044
ROCK1 ROCK1: Rho-associated protein kinase 1 0.032 0.109
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.032 0.109
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.032 0.109
BMP8B BMP8B: BMP8B protein 0.0288 0.0288
GDF6 GDF6, GDF16: Growth/differentiation factor 6 precursor 0.0288 0.0288
ARTN N/A 0.0288 0.0288
JAK1 0.029 0.098
EEF2 EEF2, EF2: Elongation factor 2 0.029 0.098
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.029 0.098
DOK1 DOK1: Docking protein 1 0.029 0.098
LYN LYN: Tyrosine-protein kinase Lyn 0.029 0.098
RAB11A RAB11A, RAB11: Ras-related protein Rab-11A 0.029 0.040
RAC2 RAC2: Ras-related C3 botulinum toxin substrate 2 precursor 0.029 0.040
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.029 0.098
SYK SYK: Tyrosine-protein kinase SYK 0.029 0.098
VAV1 VAV1, VAV: Proto-oncogene vav 0.029 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.029 0.098
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.029 0.098
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.029 0.098
STAT6 STAT6: Signal transducer and activator of transcription 6 0.029 0.098
RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 0.029 0.040
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.029 0.098
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.029 0.098
MSN MSN: Moesin 0.029 0.098
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.029 0.098
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.029 0.098
RIN1 RIN1: Ras and Rab interactor 1 0.029 0.098
RHEB RHEB, RHEB2: GTP-binding protein Rheb precursor 0.029 9.04
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.027 29.60
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.027 0.062
ASB5 ASB5: Ankyrin repeat and SOCS box protein 5 0.027 0.027
PTPRD PTPRD: PTPRD protein 0.027 0.027
PTPRO PTPRO, GLEPP1, PTPU2: Receptor-type tyrosine-protein phosphatase O precursor 0.027 0.027
ASB11 ASB11: Ankyrin repeat and SOCS box protein 11 0.027 0.027
GABRB3 GABRB3: Gamma-aminobutyric acid receptor subunit beta-3 precursor 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.027 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.027 0.165
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.027 0.165
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.027 0.165
GABRB2 GABRB2: Gamma-aminobutyric acid receptor subunit beta-2 precursor 0.027 0.027
TPTE TPTE: Putative tyrosine-protein phosphatase TPTE 0.027 0.027
ARL10 ARL10, ARL10A: ADP-ribosylation factor-like protein 10 0.027 0.027
0.572
Total Score 808.00