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Evidence of Interaction Between SNRPG and DDX47

The interaction score between SNRPG and DDX47 is 14.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and DDX47 = 0.78

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPG OrthologueDDX47 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YHR065C 1
worm Q9N4G9 1 P34580 1
fly Q9VXE0 1 Q8MRB7 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and DDX47:
Domains in SNRPGDomains in DDX47
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR000629 ATP-dependent helicase, DEAD-box
IPR001410 DEAD/DEAH box helicase
IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH_N.

The Chi square scores for co-occurrence of domains that are present in SNRPG and DDX47 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR000629 ATP-dependent helicase, DEAD-box 129.429
IPR006649 snRNP domain IPR000629 ATP-dependent helicase, DEAD-box 117.853
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR000629 ATP-dependent helicase, DEAD-box 115.254
IPR010920 Small nuclear-like ribonucleoprotein IPR001410 DEAD/DEAH box helicase 54.2779
IPR006649 snRNP domain IPR001410 DEAD/DEAH box helicase 48.949
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001410 DEAD/DEAH box helicase 47.7536
IPR010920 Small nuclear-like ribonucleoprotein IPR011545 DEAD/DEAH_N. 32.4775
IPR006649 snRNP domain IPR011545 DEAD/DEAH_N. 28.8609
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR011545 DEAD/DEAH_N. 28.0511
IPR010920 Small nuclear-like ribonucleoprotein IPR001650 Helicase, C-terminal 22.3985
IPR006649 snRNP domain IPR001650 Helicase, C-terminal 19.7813
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001650 Helicase, C-terminal 19.1958

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in DDX47
  • Green Domain is present in both SNRPG and DDX47

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: DDX47

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and DDX47 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andDDX47. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and DDX47 has 232 interactors of which there are 64 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for DDX47-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.263
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.123
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.123
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.123
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.081
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.123
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.263
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.074
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.123
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 1.82 0.038
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.123
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.074
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.074
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.890 0.053
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.090
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.090
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.081
BAT1 N/A 0.263 0.081
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.263 0.038
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.038
GNB2L1 Lung cancer oncogene 7 0.137 0.059
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.042
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.090
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.090
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.137 0.0278
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.0278
WDR41 N/A 0.137 0.059
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.053
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.038
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.081
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.242
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.038
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.081
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.053
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.083 0.059
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.042
SERBP1 N/A 0.082 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.027
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.038
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.038
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.081
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.074
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 0.038
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.081
WDR8 WDR8: WD repeat-containing protein 8 0.067 0.0278
WDR1 N/A 0.067 0.0278
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.060 0.038
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.038
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.060 0.038
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.231
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.0968
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.038
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.044 0.081
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.039 0.027
NOL7 NOL7, C6orf90, NOP27: Nucleolar protein 7 0.027 0.027
HNRPD N/A 0.027 0.027
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.027
BUB3 N/A 0.027 0.027
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.027
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.231
0.299
Total Score 14.70