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Evidence of Interaction Between RFC4 and KPNA6

The interaction score between RFC4 and KPNA6 is 2.06.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and KPNA6 = 0.41

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology
OrganismRFC4 OrthologueKPNA6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YNL189W 1
  • Immunoprecipitation
  • AffinityCaptureMS

Get References From PubMed
fly Q9VX15 1 O76521 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in RFC4 and KPNA6:
Domains in RFC4Domains in KPNA6
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR000225 Armadillo
IPR002652 Importin alpha-like protein, beta-binding region
IPR011989 ARM-like.

The Chi square scores for co-occurrence of domains that are present in RFC4 and KPNA6 are listed below.

Domain 1Domain 2Chi Square
IPR003959 AAA ATPase, central region IPR011989 ARM-like. 1.29744
IPR003593 AAA ATPase IPR011989 ARM-like. 0.00003165

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in KPNA6
  • Green Domain is present in both RFC4 and KPNA6

 5.38E-3
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: KPNA6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RFC4 and KPNA6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andKPNA6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and KPNA6 has 369 interactors of which there are 10 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for KPNA6-Interactor (?)
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.108
KPNA5 KPNA5: Importin subunit alpha-6 1.18 1.45
KPNA1 KPNA1, RCH2: Importin subunit alpha-1 0.647 0.725
IMPDH1 IMPDH1: Uncharacterized protein IMPDH1 0.593 0.119
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.074 0.408
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.050
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.408
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.053 9.63
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.051 0.364
CCNB1 Cyclin B1 0.051 0.0732
2.15E-3
Total Score 2.06