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Evidence of Interaction Between RFC4 and RAD17

The interaction score between RFC4 and RAD17 is 4.13.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRFC4 OrthologueRAD17 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P53016 1 O62196 1
  • Y2H

Get References From PubMed
fly Q9VX15 1 O96532 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.415
Domains Domains present in RFC4 and RAD17:
Domains in RFC4Domains in RAD17
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR004582 Checkpoint protein Rad24
IPR000862 RFC

The Chi square scores for co-occurrence of domains that are present in RFC4 and RAD17 are listed below.

Domain 1Domain 2Chi Square
IPR008921 DNA polymerase III clamp loader subunit, C-terminal IPR000862 RFC 1447.35
IPR000862 RFC IPR000862 RFC 1295.13
IPR013748 Replication factor C IPR000862 RFC 1125.48
IPR000862 RFC IPR004582 Checkpoint protein Rad24 984.025
IPR008921 DNA polymerase III clamp loader subunit, C-terminal IPR004582 Checkpoint protein Rad24 837.188
IPR003959 AAA ATPase, central region IPR000862 RFC 182.174
IPR003593 AAA ATPase IPR000862 RFC 128.851
IPR003959 AAA ATPase, central region IPR004582 Checkpoint protein Rad24 105.554
IPR003593 AAA ATPase IPR004582 Checkpoint protein Rad24 99.0885

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in RAD17
  • Green Domain is present in both RFC4 and RAD17

 0.029
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: RAD17

PTMResidueReference
Phosphorylation 646 PubMed, HPRD
Phosphorylation 656 PubMed, HPRD
Phosphoserine 646 PubMed, HPRD
Phosphoserine 656 PubMed, HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: RAD17

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RFC4 and RAD17 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andRAD17. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and RAD17 has 29 interactors of which there are 15 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for RAD17-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 1.05E4 0.0258
RFC5 RFC5: Replication factor C subunit 5 691.00 0.0258
RFC2 RFC2: Replication factor C subunit 2 62.80 0.0258
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.046
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.046
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.046
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.046
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.046
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.046
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.046
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.046
MDN1 MDN1, KIAA0301: Midasin 0.060 0.046
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.046
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.051
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.617
2.15E-3
Total Score 4.13