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Evidence of Interaction Between RFC4 and RFC5

The interaction score between RFC4 and RFC5 is 1.58E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and RFC5 = 0.88

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRFC4 OrthologueRFC5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YNL290W 1
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • AffinityCaptureWestern
  • ReconstitutedComplex
  • CoPurification

Get References From PubMed
worm P53016 1 P34429 1
fly Q9VX15 1 Q9VKW3 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in RFC4 and RFC5:
Domains in RFC4Domains in RFC5
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C

The Chi square scores for co-occurrence of domains that are present in RFC4 and RFC5 are listed below.

Domain 1Domain 2Chi Square
IPR008921 DNA polymerase III clamp loader subunit, C-terminal IPR000862 RFC 1447.35
IPR000862 RFC IPR000862 RFC 1295.13
IPR000862 RFC IPR013748 Replication factor C 1125.48
IPR003959 AAA ATPase, central region IPR000862 RFC 182.174
IPR003959 AAA ATPase, central region IPR003959 AAA ATPase, central region 167.459
IPR003593 AAA ATPase IPR003959 AAA ATPase, central region 133.351
IPR003593 AAA ATPase IPR000862 RFC 128.851
IPR003593 AAA ATPase IPR003593 AAA ATPase 89.0695

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in RFC5
  • Green Domain is present in both RFC4 and RFC5

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: RFC5

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC4 and RFC5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andRFC5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and RFC5 has 116 interactors of which there are 88 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for RFC5-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 1.05E4 691.00
RFC2 RFC2: Replication factor C subunit 2 62.80 319.00
PCNA PCNA: Proliferating cell nuclear antigen 54.70 54.70
RFC1 N/A 9.26 1.10
RAD17 RAD17, R24L: Cell cycle checkpoint protein RAD17 4.78 0.0258
ASF1B ASF1B: Histone chaperone ASF1B 2.15 2.15
MCM6 MCM6: DNA replication licensing factor MCM6 0.620 0.207
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.354
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.263 0.263
ORC6L ORC6L: Origin recognition complex subunit 6 0.207 0.0968
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.0968
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.207
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.620
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.207
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.207
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.207 0.207
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.207 0.207
ASF1A ASF1A, CGI-98, HSPC146: Histone chaperone ASF1A 0.203 0.123
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.137 0.137
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.137
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.123
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.123
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.123 0.123
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.123
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.117 0.055
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.231
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.0968 0.0968
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.0968
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.059
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.207
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.083
SMC4L1 N/A 0.082 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.082 0.027
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.081 0.038
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.074
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.074 0.060
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.074
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.074 0.074
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.074
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.074 0.123
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.074 0.074
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.074 0.074
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.074 0.074
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.074 0.074
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.067
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.044
MDN1 MDN1, KIAA0301: Midasin 0.060 0.060
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.060 0.060
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.060 0.060
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.0278
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.059 0.059
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.059
CNAP1 NCAPD2, CAPD2, CNAP1, KIAA0159: Condensin complex subunit 1 0.053 0.053
ORC3L ORC3L, LATHEO: Origin recognition complex subunit 3 0.053 0.039
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.051 0.051
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.047 0.047
XRCC3 XRCC3: DNA-repair protein XRCC3 0.047 0.059
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.047 0.047
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.044
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.036
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.060
BCS1L BCS1L, BCS1: Mitochondrial chaperone BCS1 0.044 0.044
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.050
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.036 0.036
NUBP1 NUBP1, NBP, NBP1: Nucleotide-binding protein 1 0.036 0.036
PEX1 PEX1: Peroxisome biogenesis factor 1 0.036 0.036
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.0331 0.055
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.0288
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 0.028 0.028
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.027
MCM10 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
TMPO N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
ZWINT N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
C18orf56 N/A 0.027 0.027
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.027
ITGB3BP N/A 0.027 0.027
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.027
AFG3L2 AFG3L2: AFG3-like protein 2 0.027 0.027
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
RAD51L1 RAD51L1, RAD51B, REC2: DNA repair protein RAD51 homolog 2 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD51L3 RAD51L3, RAD51D: DNA repair protein RAD51 homolog 4 0.027 0.027
0.572
Total Score 1.58E5