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Evidence of Interaction Between EPOR and MAP2K2

The interaction score between EPOR and MAP2K2 is 15.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and MAP2K2 = 0.34

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology N/A N/A
Domains Domains present in EPOR and MAP2K2:
Domains in EPORDomains in MAP2K2
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in EPOR and MAP2K2 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR008271 Serine/threonine protein kinase, active site 30.5883
IPR003961 Fibronectin, type III IPR002290 Serine/threonine protein kinase 13.198
IPR003528 Long hematopoietin receptor, single chain IPR011009 Protein kinase-like 3.32619
IPR002996 Cytkn_recept_B/G. IPR002290 Serine/threonine protein kinase 2.93674
IPR003528 Long hematopoietin receptor, single chain IPR000719 Protein kinase 1.94307
IPR002996 Cytkn_recept_B/G. IPR011009 Protein kinase-like 1.93327
IPR002996 Cytkn_recept_B/G. IPR000719 Protein kinase 1.43014
IPR009167 Erythropoietin receptor IPR000719 Protein kinase 0.93762
IPR003961 Fibronectin, type III IPR000719 Protein kinase 0.712801
IPR003961 Fibronectin, type III IPR011009 Protein kinase-like 0.616354
IPR009167 Erythropoietin receptor IPR011009 Protein kinase-like 0.331462

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in MAP2K2
  • Green Domain is present in both EPOR and MAP2K2

 0.083
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: MAP2K2

PTMResidueReference
Dephosphorylation 244 PubMed, HPRD
Phosphorylation 394 PubMed, HPRD
Phosphothreonine 394 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: MAP2K2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and MAP2K2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andMAP2K2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and MAP2K2 has 1492 interactors of which there are 617 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for MAP2K2-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.077
OSM OSM: Oncostatin-M precursor 1.48 0.046
IFNG IFNG: Interferon gamma precursor 0.980 0.04
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.923 0.043
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.902 0.037
IL5 IL5: Interleukin-5 precursor 0.731 0.0263
IL3 IL3: Interleukin-3 precursor 0.731 0.030
LIF LIF, HILDA: Leukemia inhibitory factor precursor 0.644 0.030
PRL PRL: Prolactin precursor 0.644 0.0263
IL6 IL6, IFNB2: Interleukin-6 precursor 0.644 0.030
EPO EPO: Erythropoietin precursor 0.581 0.027
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.0425
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.372
TFRC TFRC: Transferrin receptor protein 1 0.307 0.052
KEL KEL: Kell blood group glycoprotein 0.307 0.032
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.029
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.032
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.087
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.188
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.049
CRLF3 N/A 0.191 0.070
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.078
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.046
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.139
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.028
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.148
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.083
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.028
FN1 N/A 0.165 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.028
BSG N/A 0.165 0.025
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.148
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.025
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.165
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.025
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.025
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.025
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.028
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.148
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.083
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.028
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.083
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.148
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.028
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.025
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.025
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.028
CAT CAT: Catalase 0.157 0.038
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.078
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.078
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.062
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.056
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.069
CRKL CRKL: Crk-like protein 0.126 0.372
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.064
RDX RDX: Radixin 0.126 0.136
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.078
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.123
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.225
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.078
CD2AP CD2AP: CD2-associated protein 0.126 0.139
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.078
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.040
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.046
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.241
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.096
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.044
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.136
GHR GHR: Growth hormone receptor precursor 0.123 0.096
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.026
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.062
UROD UROD: Uroporphyrinogen decarboxylase 0.111 0.038
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.136
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MAPK15 N/A 0.109 0.083
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.148
PSCD2 N/A 0.109 0.165
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.025
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.075
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.075
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.049
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.025
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.148
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.075
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.083
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.075
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
F3 F3: Tissue factor precursor 0.109 0.062
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.127
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.056
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.069
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.0425
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.044
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.077
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.096
ITGB4 N/A 0.109 0.062
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.056
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.127
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.049
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.097
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.062
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.110
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.097
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.062
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.038
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.096
PRLR PRLR: Prolactin receptor precursor 0.109 0.056
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.072
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.063
DOK1 DOK1: Docking protein 1 0.100 0.275
PLD2 PLD2: Phospholipase D2 0.100 0.136
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.372
IFNW1 IFNW1: Interferon omega-1 precursor 0.100 0.0263
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.096
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.275
CP CP: Ceruloplasmin precursor 0.100 0.033
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.275
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.069
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.097
RPS6KB1 N/A 0.100 0.063
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.372
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.046
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.063
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.225
PTPRZ1 N/A 0.098 0.088
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.062
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.099
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.032
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.044
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.070
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.046
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.077
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.139
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.087 0.035
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.114
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.028
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.083
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.083
EDA N/A 0.083 0.028
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.025
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.083 0.028
ATRN N/A 0.083 0.025
KIR3DL1 N/A 0.083 0.028
CDH6 CDH6: Cadherin-6 precursor 0.083 0.028
DLK1 DLK1, DLK: Delta-like protein precursor 0.083 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.075
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.028
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.025
JAG2 JAG2: Jagged-2 precursor 0.083 0.025
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.028
OPTC OPTC, OPT: Opticin precursor 0.083 0.028
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.028
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.088
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.086
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.067
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.275
DLG2 DLG2: Disks large homolog 2 0.081 0.026
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.086
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.251
STK16 N/A 0.081 0.0425
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.038
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.225
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.275
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.171
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.275
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.123
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.152
F5 F5: Coagulation factor V precursor 0.081 0.037
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.037
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.136
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.225
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 370.00
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.038
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.251
HCK N/A 0.081 0.171
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.461
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.155
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.032
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.046
ITGA2B ITGA2B, GP2B, ITGAB: Integrin alpha-IIb precursor 0.077 0.029
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.087
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.032
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.063
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.078
WEE1 WEE1: Wee1-like protein kinase 0.075 0.046
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.046
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.078
CDK2 CDK2: Cell division protein kinase 2 0.075 0.063
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.075 0.036
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.046
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.078
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.087
SPTAN1 N/A 0.0727 0.055
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.123
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.0425
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.136
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.109
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.225
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.225
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.251
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.136
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.171
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.191
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 7.12
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.251
VIL2 N/A 0.072 0.225
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.127
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.191
GAB2 N/A 0.072 0.152
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.111
BMX N/A 0.072 0.110
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.065
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.275
MSN MSN: Moesin 0.072 0.275
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.136
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.049
FNBP1 N/A 0.072 0.188
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.275
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.275
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.139
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.111
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 23.60
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.191
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.139
PLD1 PLD1: Phospholipase D1 0.072 0.136
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.275
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.049
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.086
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.191
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.097
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.191
JAK1 0.072 0.225
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.152
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.461
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.307
PSD TYL: TYL protein 0.072 0.097
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.225
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.372
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.155
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.123
CXorf9 N/A 0.072 0.139
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.0425
TFR2 TFR2, hCG_20451: Uncharacterized protein TFR2 0.070 0.032
SLC7A5 SLC7A5, CD98LC, LAT1, MPE16: Large neutral amino acids transporter small subunit 0.070 0.038
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.044
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.191
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.0425
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.111
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.099
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.097
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.225
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.225
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.225
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.136
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.099
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.097
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.056
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.097
F8 F8, F8C: Coagulation factor VIII precursor 0.065 0.033
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.097
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.056
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.098
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.032
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.181
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.032
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.046
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.049
CD44 N/A 0.062 0.127
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.062 0.029
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.052
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.055
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.062 0.0425
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.052
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.043
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.056
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.077
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.066
CDK6 CDK6: Cell division protein kinase 6 0.057 0.029
CDK4 CDK4: Cell division protein kinase 4 0.057 0.063
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.063
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 501.00
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.052
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.055
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.032
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.052
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.026
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.026
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.038
LILRB1 N/A 0.055 0.032
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.038
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.026
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.046
GP9 GP9: Platelet glycoprotein IX precursor 0.055 0.026
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.052
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.052
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.044
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.0425
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.070
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.055 0.038
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.049
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.026
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.127
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.070
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.032
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.032
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.032
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.0425
CD69 CD69: Early activation antigen CD69 0.055 0.0425
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.0425
GP1BB GP1BB: Platelet glycoprotein Ib beta chain precursor 0.055 0.026
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.026
ATP1B3 ATP1B3: Sodium/potassium-transporting ATPase subunit beta-3 0.052 0.046
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.052 0.038
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PTPRA N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 5.20
C9orf88 N/A 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.073
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.113
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.0818
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.056
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.026
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.025
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.025
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.025
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.028
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.075
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.025
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.028
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.025
SNX3 N/A 0.049 0.075
CNN2 CNN2: Calponin-2 0.049 0.075
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.075
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.028
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.025
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.025
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.025
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.083
MAPKAPK5 N/A 0.049 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.028
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.025
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.052
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.075
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.025
PPEF1 N/A 0.049 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.025
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.034
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.065
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.052
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.078
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.038
FUBP1 N/A 0.0453 0.070
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.139
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.225
DAB1 DAB1: Disabled homolog 1 0.0453 0.088
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.233
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.032
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.046
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.096
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.086
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.148
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.100
PLEK PLEK, P47: Pleckstrin 0.045 0.202
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.148
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.072
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.166
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.063
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.078
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.063
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.063
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
EFNA1 EFNA1, EPLG1, LERK1, TNFAIP4: Ephrin-A1 precursor 0.044 0.040
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.042 0.032
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.064
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.063
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.073
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.148
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.075
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.111
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.127
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.026
CDKN3 CDKN3, CDI1, CIP2, KAP: Cyclin-dependent kinase inhibitor 3 0.039 0.0308
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.027
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.040
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.042
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.063
COPA COPA: Coatomer subunit alpha 0.037 0.046
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.078
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.046
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.038
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.046
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.052
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.251
STK10 STK10: Uncharacterized protein STK10 0.037 0.046
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.038
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.029
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.026
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.086
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.032
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.026
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.063
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.046
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.052
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.097
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.070
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.063
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.046
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 41.40
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.026
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.086
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.046
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.139
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.171
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.046
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.046
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.046
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.0971
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.049
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.036
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 21.10
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.210
NDP NDP: Norrin precursor 0.033 0.0727
ATM ATM: Serine-protein kinase ATM 0.032 0.086
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
GMIP GMIP: GEM-interacting protein 0.032 0.114
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.0425
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.029
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 82.20
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.052
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.056
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.114
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.046
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.155
LCP1 LCP1, PLS2: Plastin-2 0.032 0.046
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.139
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.029
GRLF1 N/A 0.032 0.096
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.058
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.049
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.0971
CHP CHP: Calcium-binding protein p22 0.032 0.038
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.111
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.029
PRKAA1 N/A 0.032 0.032
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.086
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 13.90
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.114
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.275
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.032 0.063
LRRC59 LRRC59, PRO1855: Leucine-rich repeat-containing protein 59 0.032 0.063
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.087
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.032 0.026
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.028
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.032
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.032
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.040
MDN1 MDN1, KIAA0301: Midasin 0.030 0.046
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.030 0.029
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.026
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.029
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.086
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.029
CDK5 CDK5: Cell division protein kinase 5 0.029 0.029
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 3.66
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.049
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.038
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.029
CNN3 CNN3: Calponin-3 0.029 0.044
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.044
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.088
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 3.66
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.040
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.083
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.083
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.028 0.075
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.028
TMPRSS9 N/A 0.028 0.025
FGFR2 N/A 0.028 0.025
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.028 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.083
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.083
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.083
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.148
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.025
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.075
PILRA PILRA: Paired immunoglobulin-like type 2 receptor alpha precursor 0.028 0.028
GPRC5A GPRC5A, GPCR5A, RAI3, RAIG1: Retinoic acid-induced protein 3 0.028 0.028
SNAP25 N/A 0.028 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.083
AQP4 AQP4: Aquaporin-4 0.028 0.075
ITGB1 N/A 0.028 0.028
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.028 0.025
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.028 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.075
LAIR1 LAIR1, CD305: Leukocyte-associated immunoglobulin-like receptor 1 precursor 0.028 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.075
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.025
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.075
ATP1B1 N/A 0.028 0.025
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.052
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.028 0.025
DRD2 DRD2: D(2) dopamine receptor 0.028 0.028
PCDH7 N/A 0.028 0.028
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.028
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.028
TREML1 TREML1, TLT1, UNQ1825/PRO3438: Trem-like transcript 1 protein precursor 0.028 0.028
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.028 0.025
SLC7A3 SLC7A3, ATRC3, CAT3: Cationic amino acid transporter 3 0.028 0.025
CSF3R N/A 0.028 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.028 0.025
C2orf7 PAP21, C2orf7, UNQ833/PRO1760: Protease-associated domain-containing protein of 0.028 0.025
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.028 0.028
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.025
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.083
PTPRA N/A 0.028 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.052
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.028 0.028
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ASB5 ASB5: Ankyrin repeat and SOCS box protein 5 0.027 0.027
PTPRD PTPRD: PTPRD protein 0.027 0.027
ASB11 ASB11: Ankyrin repeat and SOCS box protein 11 0.027 0.027
TPTE TPTE: Putative tyrosine-protein phosphatase TPTE 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PTPRO PTPRO, GLEPP1, PTPU2: Receptor-type tyrosine-protein phosphatase O precursor 0.027 0.027
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.078
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.063
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.046
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.078
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.188
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.056
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.127
NPR3 NPR3, ANPRC: Atrial natriuretic peptide clearance receptor precursor 0.026 0.026
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.026 0.063
SLC2A2 SLC2A2, GLUT2: Solute carrier family 2, facilitated glucose transporter member 2 0.026 0.0308
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.026 0.046
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.026 0.0425
RHO RHO, OPN2: Rhodopsin 0.026 0.049
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.026 0.029
FADD FADD, MORT1: Protein FADD 0.026 0.210
GNB2L1 Lung cancer oncogene 7 0.025 0.0446
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.067
ETS2 ETS2: Protein C-ets-2 0.025 0.0453
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.111
0.299
Total Score 15.10