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Evidence of Interaction Between MCM5 and MCM2

The interaction score between MCM5 and MCM2 is 4.78E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM5 and MCM2 = 0.94

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology
OrganismMCM5 OrthologueMCM2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YLR274W 1 YBL023C 1
  • Y2H
  • CoLocalization
  • CoFractionation

Get References From PubMed
worm Q21902 1 Q9XXI9 1
fly Q9VGW6 1 P49735 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MCM5 and MCM2:
Domains in MCM5Domains in MCM2
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008048 MCM protein 5
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008045 MCM protein 2

The Chi square scores for co-occurrence of domains that are present in MCM5 and MCM2 are listed below.

Domain 1Domain 2Chi Square
IPR001208 MCM IPR001208 MCM 364.867
IPR008994 Nucleic acid-binding OB-fold IPR001208 MCM 301.459
IPR008994 Nucleic acid-binding OB-fold IPR008994 Nucleic acid-binding OB-fold 191.222
IPR008994 Nucleic acid-binding OB-fold IPR008045 MCM protein 2 51.0284

The background colour of the table refers to:

  • Blue Domain is only present in MCM5
  • Yellow Domain is only present in MCM2
  • Green Domain is present in both MCM5 and MCM2

 0.027
Post-translational Modifications

Protein: MCM5

PTMResidueReference

Protein: MCM2

PTMResidueReference
Phosphorylation 26 PubMed, HPRD
Phosphorylation 27 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD
Phosphorylation 139 PubMed, HPRD
Phosphoserine 27 HPRD
Phosphoserine 41 HPRD
Phosphoserine 108 PubMed, HPRD
Phosphothreonine 106 HPRD
Localisation

Protein: MCM5

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: MCM2

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between MCM5 and MCM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM5 andMCM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM5 has 251 interactors and MCM2 has 983 interactors of which there are 182 common interactors.

Common InteractorName of Common InteractorScore for MCM5-Interactor (?)Score for MCM2-Interactor (?)
MCM3 MCM3: DNA replication licensing factor MCM3 209.00 1.29E3
MCM6 MCM6: DNA replication licensing factor MCM6 69.60 69.60
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 69.60 209.00
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 69.60 69.60
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 32.60 431.00
C10orf117 NOC3L, AD24, C10orf117, FAD24: Nucleolar complex protein 3 homolog 3.89 1.82
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 1.82 0.129
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 1.10 63.90
CORO1C CORO1C, CRNN4: Coronin-1C 0.890 0.046
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.354 0.047
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.137
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.263 0.263
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.263 0.763
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.263 1.29E3
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.231 0.108
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.207 0.207
RFC4 RFC4: Replication factor C subunit 4 0.207 0.207
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.207 0.0968
RFC5 RFC5: Replication factor C subunit 5 0.207 0.207
CDC45L CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein 0.196 0.196
CCNF CCNF: G2/mitotic-specific cyclin-F 0.137 0.293
RFX5 RFX5: DNA-binding protein RFX5 0.137 0.067
MYH9 MYH9: Myosin-9 0.132 0.038
ORC6L ORC6L: Origin recognition complex subunit 6 0.123 0.123
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.123 0.263
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.074
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.123 0.060
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.123 0.123
CCNB1 Cyclin B1 0.123 1.62
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.123 0.123
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.123 0.461
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.123 0.123
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.123 0.032
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.108 0.065
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.108 0.108
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.0968 0.059
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.0968 0.059
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.0968 0.304
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.0968 0.059
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.0968 0.0968
RFC3 RFC3: Replication factor C subunit 3 0.0968 0.207
DNMT1 DNMT1, AIM, DNMT: DNA 0.083 0.515
MUTYH N/A 0.083 0.083
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.083 0.852
RB1 RB1: Retinoblastoma-associated protein 0.083 0.515
POT1 POT1: Protection of telomeres protein 1 0.083 0.067
ZWINT N/A 0.082 0.082
C18orf56 N/A 0.082 0.082
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.074 0.372
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.763
CUL2 CUL2: Cullin-2 0.074 0.126
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.074 0.461
XRCC3 XRCC3: DNA-repair protein XRCC3 0.074 0.074
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.074 0.060
RPS23 RPS23: 40S ribosomal protein S23 0.074 0.044
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.074 0.372
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.074 0.156
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.074 0.044
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.074 0.763
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.763
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.074 0.461
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.144
IRF5 IRF5: Interferon regulatory factor 5 0.067 0.041
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.067 0.515
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.067 0.050
ELF1 ELF1: ETS-related transcription factor Elf-1 0.067 0.307
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.067 0.041
H1FX H1FX: Histone H1x 0.067 0.251
CCND2 CCND2: G1/S-specific cyclin-D2 0.060 0.044
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.060 0.372
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.060 0.275
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.060 0.372
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.060 0.044
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.060 0.060
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.060 0.044
MTA1 MTA1: Metastasis-associated protein MTA1 0.060 0.372
TFDP1 TFDP1, DP1: Transcription factor Dp-1 0.060 0.123
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.059 0.269
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.059 0.245
VCP VCP: Transitional endoplasmic reticulum ATPase 0.059 0.245
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.059 0.304
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.059 0.059
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.059 0.503
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.055 0.0331
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.053 0.241
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.053 0.241
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.053 0.065
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.053 0.515
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.053 0.241
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.053 0.146
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.053 0.241
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.053 0.241
SRPR SRPR: Uncharacterized protein SRPR 0.053 0.166
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.050 0.307
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.050 0.0308
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.047 0.304
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.047 0.047
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.047 0.035
CCND3 CCND3: G1/S-specific cyclin-D3 0.044 0.036
MYST3 MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3 0.044 0.028
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.044 0.171
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.044 0.036
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.044 0.275
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.044 0.225
CCNC CCNC: Cyclin-C 0.044 0.036
CCNI CCNI: Cyclin-I 0.044 0.028
MDN1 MDN1, KIAA0301: Midasin 0.044 0.275
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.044 0.171
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.060
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.060
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.044 0.036
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.044 0.036
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.276
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.042 0.185
DDX21 DDX21: Nucleolar RNA helicase 2 0.042 0.260
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.042 0.260
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.042 0.260
IRF2 IRF2: Interferon regulatory factor 2 0.041 0.0308
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.041 0.251
IRF3 IRF3: Interferon regulatory factor 3 0.041 0.191
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.041 0.041
ERG ERG: Transcriptional regulator ERG 0.041 0.251
GTF2F2 N/A 0.041 0.251
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.038 0.081
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.038 0.081
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.038 0.233
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.038 0.233
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.038 0.038
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.038 0.233
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.036 0.225
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.036 0.275
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.036 0.171
H1F0 H1F0, H1FV: Histone H1.0 0.036 0.093
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.275
PAX5 PAX5: Paired box protein Pax-5 0.036 0.028
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.035 0.029
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.035 0.035
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.035 0.060
DVL2 DVL2: Segment polarity protein dishevelled homolog DVL-2 0.035 0.035
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.035 0.035
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.0331 0.027
ERF ERF: ETS domain-containing transcription factor ERF 0.0308 0.191
E2F2 E2F2: Transcription factor E2F2 0.0308 0.041
ETS2 ETS2: Protein C-ets-2 0.0308 0.152
RBM14 RBM14, SIP: RNA-binding protein 14 0.0278 0.163
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.0278 0.163
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.028 0.171
CCNH CCNH: Cyclin-H 0.028 0.171
DVL1 DVL1: Segment polarity protein dishevelled homolog DVL-1 0.028 0.028
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.028 0.111
POLD3 POLD3, KIAA0039: DNA polymerase subunit delta-3 0.027 0.027
NUSAP1 NUSAP1, ANKT, BM-037, PRO0310: Nucleolar and spindle-associated protein 1 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.025
ZWILCH Protein zwilch homolog. 0.027 0.027
C22orf18 N/A 0.027 0.027
TMPO N/A 0.027 0.082
SMC4L1 N/A 0.027 0.082
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.027 0.053
GMNN GMNN: Geminin 0.027 0.053
DUT DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
RAD51AP1 N/A 0.027 0.027
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.082
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.027
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.027 0.027
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
OGG1 N/A 0.027 0.027
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.027 0.165
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.027 0.165
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.027 0.165
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.0255 0.0255
0.572
Total Score 4.78E4