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Evidence of Interaction Between TBP and TAF1

The interaction score between TBP and TAF1 is 249.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismTBP OrthologueTAF1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00395431 0.192 IPI00100867 0.883
bakers yeast YER148W 1 YGR274C 1
  • Immunoprecipitation
  • CompetitionBinding
  • Other
  • AffinityChromatography
  • InVitroBinding
  • AffinityCaptureMS
  • PhenotypicEnhancement
  • AffinityCaptureWestern
  • ReconstitutedComplex

Get References From PubMed
worm P32085 1 Q9XUL9 1
fly P20227 1 P51123 1
  • Other
  • GelRetardationAssay

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: TBP

LocalisationReference
Nucleus HPRD

Protein: TAF1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Transitive Score

The common interactors between TBP and TAF1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TBP andTAF1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TBP has 180 interactors and TAF1 has 71 interactors of which there are 26 common interactors.

Common InteractorName of Common InteractorScore for TBP-Interactor (?)Score for TAF1-Interactor (?)
TAF9 TAF9, TAF2G, TAFII31: Transcription initiation factor TFIID subunit 9 100.00 0.354
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 80.90 0.354
TAF12 TAF12, TAF15, TAF2J, TAFII20: Transcription initiation factor TFIID subunit 12 48.90 0.354
TAF9B TAF9B, TAF9L: Transcription initiation factor TFIID subunit 9B 32.20 0.071
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 11.70 0.354
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 4.72 0.354
TAF13 TAF13, TAF2K, TAFII18: Transcription initiation factor TFIID subunit 13 4.72 0.354
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 3.82 0.196
TADA2L TADA2L, KL04P: Transcriptional adapter 2-like 2.95 0.354
TAF1L TAF1L: Transcription initiation factor TFIID 210 kDa subunit 1.79 0.071
LOC653122 N/A 1.49 0.593
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 1.10 0.354
CNOT3 CNOT3, KIAA0691, LENG2, NOT3: CCR4-NOT transcription complex subunit 3 1.10 0.593
TAF2 TAF2, CIF150, TAF2B: Transcription initiation factor TFIID subunit 2 0.730 3.01
ASF1B ASF1B: Histone chaperone ASF1B 0.657 0.354
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.408 0.354
TAF7L TAF7L, GHc-521F8.1-003: Transcription initiation factor TFIID subunit 7-like pro 0.408 0.354
SUPT3H N/A 0.354 0.354
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.179 0.071
TAF7 TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7 0.179 0.071
ASF1A ASF1A, CGI-98, HSPC146: Histone chaperone ASF1A 0.132 0.071
NULL N/A 0.119 0.119
BRDT N/A 0.119 0.119
BRD4 N/A 0.071 0.071
TBPL2 0.071 0.071
TAF4 TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor 0.060 0.070
0.347
Total Score 249.00