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Evidence of Interaction Between TBP and TAF12

The interaction score between TBP and TAF12 is 5.84E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TBP and TAF12 = 0.39

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismTBP OrthologueTAF12 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER148W 1 YDR145W 1
  • Immunoprecipitation
  • AffinityCaptureMS
  • ReconstitutedComplex

Get References From PubMed
worm P32085 1 Q9U226 1
fly P20227 1 P49905 1
  • Other

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: TBP

LocalisationReference
Nucleus HPRD

Protein: TAF12

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TBP and TAF12 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TBP andTAF12. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TBP has 180 interactors and TAF12 has 254 interactors of which there are 50 common interactors.

Common InteractorName of Common InteractorScore for TBP-Interactor (?)Score for TAF12-Interactor (?)
TAF9 TAF9, TAF2G, TAFII31: Transcription initiation factor TFIID subunit 9 100.00 80.90
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 80.90 7.31
TAF9B TAF9B, TAF9L: Transcription initiation factor TFIID subunit 9B 32.20 32.20
H2AFZ H2AFZ, H2AZ: Histone H2A.Z 15.90 0.044
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 11.70 0.890
H2AFX H2AFX, H2AX: Histone H2A.x 9.63 0.036
HIST1H2BG HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B 5.83 0.028
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 4.88 0.890
TAF13 TAF13, TAF2K, TAFII18: Transcription initiation factor TFIID subunit 13 4.72 5.83
TADA2L TADA2L, KL04P: Transcriptional adapter 2-like 2.95 0.326
TAF1 N/A 1.79 0.354
TAF1L TAF1L: Transcription initiation factor TFIID 210 kDa subunit 1.79 0.390
HIST1H2BK HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K 1.46 0.036
H2BFS H2BFS: Histone H2B type F-S 1.46 0.028
HIST1H2AB N/A 1.46 0.028
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 1.10 15.90
BRD7 BRD7, BP75, CELTIX1: Bromodomain-containing protein 7 1.10 0.890
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.890 0.060
TAF2 TAF2, CIF150, TAF2B: Transcription initiation factor TFIID subunit 2 0.730 0.593
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.408 2.24
TAF7L TAF7L, GHc-521F8.1-003: Transcription initiation factor TFIID subunit 7-like pro 0.408 0.233
SUPT3H N/A 0.354 0.354
NOLA2 NOLA2, NHP2, HSPC286: H/ACA ribonucleoprotein complex subunit 2 0.298 0.029
PCAF PCAF: Histone acetyltransferase PCAF 0.264 1.79
TAF7 TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7 0.179 3.20
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.179 0.982
TRRAP TRRAP, PAF400: Transformation/transcription domain-associated protein 0.143 0.593
NULL N/A 0.119 0.119
BRDT N/A 0.119 0.029
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
BP75 N/A 0.119 0.119
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.082 0.291
BRD9 N/A 0.071 0.071
TBPL2 0.071 0.071
BRD4 N/A 0.071 0.390
POLE3 POLE3, CHRAC17: DNA polymerase epsilon subunit 3 0.060 0.060
TAF11 TAF11, TAF2I, PRO2134: Transcription initiation factor TFIID subunit 11 0.060 0.036
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.060 0.060
TAF4 TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor 0.060 1.89
DR1 DR1: TATA-binding protein-associated phosphoprotein 0.060 0.060
SOS1 SOS1: Son of sevenless homolog 1 0.044 0.036
SOS2 SOS2: Son of sevenless homolog 2 0.044 0.044
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.044 0.074
CENPA CENPA: Histone H3-like centromeric protein A 0.041 0.0308
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.028 0.036
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.028 0.036
NFYB NFYB, HAP3: Nuclear transcription factor Y subunit beta 0.028 0.028
HIST1H2AD HIST1H2AD, H2AFG: Histone H2A type 1-D 0.027 0.027
H2AFY2 H2AFY2, MACROH2A2: Core histone macro-H2A.2 0.027 0.027
0.299
Total Score 5.84E3