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Evidence of Interaction Between PSMA7 and PSMA2

The interaction score between PSMA7 and PSMA2 is 3.76E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA7 and PSMA2 = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPSMA7 OrthologuePSMA2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YOL038W 1 YML092C 1
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q95005 1 Q27488 1
  • Other

Get References From PubMed
fly P22769 0.424 P40301 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in PSMA7 and PSMA2:
Domains in PSMA7Domains in PSMA2
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMA7 and PSMA2 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000426 Proteasome alpha-subunit IPR000426 Proteasome alpha-subunit 78.5459

The background colour of the table refers to:

  • Blue Domain is only present in PSMA7
  • Yellow Domain is only present in PSMA2
  • Green Domain is present in both PSMA7 and PSMA2

 0.265
Post-translational Modifications

Protein: PSMA7

PTMResidueReference

Protein: PSMA2

PTMResidueReference
Phosphotyrosine 23 HPRD
Phosphotyrosine 97 HPRD
Localisation

Protein: PSMA7

LocalisationReference
Cytoplasm HPRD

Protein: PSMA2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA7 and PSMA2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA7 andPSMA2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA7 has 222 interactors and PSMA2 has 927 interactors of which there are 175 common interactors.

Common InteractorName of Common InteractorScore for PSMA7-Interactor (?)Score for PSMA2-Interactor (?)
PSMA5 PSMA5: Proteasome subunit alpha type-5 1.64E3 1.02E4
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 691.00 1.59E3
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 691.00 195.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 691.00 323.00
PSMB3 PSMB3: Proteasome subunit beta type-3 691.00 195.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 323.00 2.07E3
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 323.00 3.41E3
PSMB2 PSMB2: Proteasome subunit beta type-2 323.00 691.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 319.00
PSMB4 N/A 3.89 1.82
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 2.15 10.50
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 1.82 5.97
NULL RcPSMB3 (Fragment) 1.37 1.37
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 1.36 0.666
THUMPD1 N/A 1.29 0.770
CD2AP CD2AP: CD2-associated protein 1.10 0.078
RANBP5 0.890 1.82
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.890 0.129
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.596
PSME4 PSME4, KIAA0077: Proteasome activator complex subunit 4 0.593 0.593
KIAA0368 ECM29, KIAA0368: Proteasome-associated protein ECM29 homolog 0.593 0.218
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 3.01
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.376 0.046
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.366 5.60
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.354 0.025
PSMA1 N/A 0.354 1.79
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.263 0.461
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.263 0.763
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.263 0.763
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.36
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.221 0.048
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 69.20
LOC391276 N/A 0.191 0.191
NSF NSF: Vesicle-fusing ATPase 0.147 0.147
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.179
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.132 3.35
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.123 0.074
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.123 1.62
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.123 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.123 0.225
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.123 0.461
NULL N/A 0.119 0.119
RANBP6 N/A 0.119 0.119
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.0968 0.035
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.083
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.083
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.074 0.372
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.074 0.372
RPS6KB1 N/A 0.074 0.372
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.074 0.275
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.074 0.372
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.074 0.060
CSNK1D CSNK1D: Casein kinase I isoform delta 0.074 0.036
CDK4 CDK4: Cell division protein kinase 4 0.074 0.763
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.074 0.275
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.074 0.372
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.067 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.515
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.103
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.067 0.191
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.060 0.036
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.060 0.275
CDK7 CDK7, MO15: Cell division protein kinase 7 0.060 0.763
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.060 0.225
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.060 0.044
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.060 0.058
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.060 0.461
CDK2 CDK2: Cell division protein kinase 2 0.060 0.461
STK10 STK10: Uncharacterized protein STK10 0.060 0.225
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.060 0.123
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.060 0.275
CLK3 CLK3: Dual specificity protein kinase CLK3 0.060 0.044
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.044
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.060 0.225
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.060 0.275
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.060 0.225
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.372
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.060 0.171
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.060 0.123
GAK GAK: Cyclin G-associated kinase 0.059 0.029
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.059 0.304
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.050 0.064
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.050 0.852
EIF2AK1 N/A 0.050 0.041
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.050 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.050 0.251
VRK3 N/A 0.050 0.0308
ROCK1 ROCK1: Rho-associated protein kinase 1 0.050 0.416
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.047 0.0968
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.044 0.372
BUB1 0.044 0.074
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.044 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.044 0.225
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.044 0.126
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.044 0.074
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.044
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.044 0.171
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.275
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.044
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.044 0.036
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.044 0.036
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.044 0.275
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.044
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.044 0.372
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.191
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.041 0.191
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.191
STK16 N/A 0.041 0.307
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.041 0.152
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.041 0.0308
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.038 0.188
CSK CSK: Tyrosine-protein kinase CSK 0.038 0.233
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.036 0.372
WEE1 WEE1: Wee1-like protein kinase 0.036 0.372
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.036 0.171
PIM1 N/A 0.036 0.028
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.036 0.372
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.058
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.036 0.136
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.036 0.275
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.036 0.036
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.036 0.136
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.225
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.036 0.093
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.036 0.111
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.036 0.058
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.035 0.047
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.035
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.166
LIMK2 LIMK2: LIM domain kinase 2 0.0308 0.085
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.0308 0.152
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.191
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.028 0.225
CDK6 CDK6: Cell division protein kinase 6 0.028 0.136
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.028 0.136
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.028 0.044
CDK5 CDK5: Cell division protein kinase 5 0.028 0.136
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.028
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.028 0.372
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.028 0.275
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.025
DGUOK N/A 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.053
EIF2AK3 EIF2AK3, PEK, PERK: Eukaryotic translation initiation factor 2-alpha kinase 3 pr 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
CDC2L2 N/A 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
MAP2K5 N/A 0.027 0.056
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.056
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
MAPK15 N/A 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
MAPKAPK5 N/A 0.027 0.165
0.572
Total Score 3.76E5