PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and NR5A1

The interaction score between TP53 and NR5A1 is 1.37.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and NR5A1 = 0.22

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3

Orthology

Organism	TP53 Orthologue		NR5A1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	Q8IH92	0.16	P33244	0.255

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in TP53 and NR5A1:

Domains in TP53

Domains in NR5A1

IPR008967	p53-like transcription factor, DNA-binding
IPR002117	p53 tumor antigen
IPR010991	p53, tetramerisation
IPR011615	P53_DNA_bd.
IPR012346	P53_RUNT_DNA_bd.

IPR000324	Vitamin D receptor
IPR000536	Ligand-binding domain of nuclear hormone receptor
IPR001628	Zn-finger, C4-type steroid receptor
IPR001723	Steroid hormone receptor
IPR008946	Steroid nuclear receptor, ligand-binding

The Chi square scores for co-occurrence of domains that are present in TP53 and NR5A1 are listed below.

Domain 1		Domain 2		Chi Square
IPR008967	p53-like transcription factor, DNA-binding	IPR001723	Steroid hormone receptor	0.930296
IPR008967	p53-like transcription factor, DNA-binding	IPR001628	Zn-finger, C4-type steroid receptor	0.881474
IPR008967	p53-like transcription factor, DNA-binding	IPR000536	Ligand-binding domain of nuclear hormone receptor	0.865601
IPR011615	P53_DNA_bd.	IPR001723	Steroid hormone receptor	0.0229703
IPR010991	p53, tetramerisation	IPR001723	Steroid hormone receptor	0.0229703
IPR002117	p53 tumor antigen	IPR001723	Steroid hormone receptor	0.0229703
IPR012346	P53_RUNT_DNA_bd.	IPR001723	Steroid hormone receptor	0.0229703
IPR010991	p53, tetramerisation	IPR001628	Zn-finger, C4-type steroid receptor	0.0176841
IPR011615	P53_DNA_bd.	IPR001628	Zn-finger, C4-type steroid receptor	0.0176841
IPR012346	P53_RUNT_DNA_bd.	IPR001628	Zn-finger, C4-type steroid receptor	0.0176841
IPR002117	p53 tumor antigen	IPR001628	Zn-finger, C4-type steroid receptor	0.0176841
IPR012346	P53_RUNT_DNA_bd.	IPR000536	Ligand-binding domain of nuclear hormone receptor	0.0160854
IPR011615	P53_DNA_bd.	IPR000536	Ligand-binding domain of nuclear hormone receptor	0.0160854
IPR010991	p53, tetramerisation	IPR000536	Ligand-binding domain of nuclear hormone receptor	0.0160854
IPR002117	p53 tumor antigen	IPR000536	Ligand-binding domain of nuclear hormone receptor	0.0160854

The background colour of the table refers to:

Blue Domain is only present in TP53
Yellow Domain is only present in NR5A1
Green Domain is present in both TP53 and NR5A1

1.53

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: NR5A1

PTM	Residue	Reference
Acetylation	34	PubMed, HPRD
Acetylation	38	PubMed, HPRD
Acetylation	72	PubMed, HPRD
Phosphorylation	203	PubMed, HPRD
Sumoylation	119	PubMed, HPRD
Sumoylation	194	PubMed, HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: NR5A1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between TP53 and NR5A1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andNR5A1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and NR5A1 has 876 interactors of which there are 673 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for NR5A1-Interactor (?)
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	4.77	0.026
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	1.58	0.069
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	1.26	0.102
PGR	PGR, NR3C3: Progesterone receptor	1.00	0.123
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.158
NR4A2	NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2	0.902	0.171
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	0.171
PCNA	PCNA: Proliferating cell nuclear antigen	0.704	0.029
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.704	0.158
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.114
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.191
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.541	0.057
SP100	N/A	0.525	0.152
MCM3	MCM3: DNA replication licensing factor MCM3	0.515	0.038
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.503	0.051
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.503	0.041
SREBF2	N/A	0.475	0.026
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.471	0.086
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.191
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.077
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.096
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.096
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.191
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.430	0.029
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.127
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.096
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.152
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.425	0.126
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.086
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.171
CCNB1	Cyclin B1	0.385	0.086
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.171
SP3	SP3: Transcription factor Sp3	0.347	0.069
SRF	SRF: Serum response factor	0.344	0.069
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.029
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.304	0.051
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.304	0.041
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.290	0.029
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.276	0.071
POLA2	POLA2: DNA polymerase subunit alpha B	0.276	0.029
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.276	0.029
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.276	0.038
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.276	0.071
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.276	0.054
CENPA	CENPA: Histone H3-like centromeric protein A	0.269	0.026
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.096
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.260	0.038
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.191
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.251
EP300	N/A	0.254	0.158
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.253	0.057
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.245	0.051
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.241	0.038
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.029
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.029
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.046
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.233	0.086
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.069
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.225
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.086
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.227	0.051
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.216	0.127
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.026
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.096
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.152
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.136
RB1	RB1: Retinoblastoma-associated protein	0.210	0.077
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.208	0.111
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.086
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.188	0.171
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.111
CXorf9	N/A	0.188	0.029
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.188	0.086
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.188	0.056
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.114
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.086
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.114
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.188	0.038
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.188	0.056
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.047
MYB	MYB: Myb proto-oncogene protein	0.176	0.191
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.056
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.172	0.049
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.156	0.055
TP73	TP73, P73: Tumor protein p73	0.156	0.032
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.026
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.077
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.026
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.096
MITF	MITF: Microphthalmia-associated transcription factor	0.152	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.152	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.152	0.165
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.152
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.086
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.146	0.029
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.146	0.086
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.029
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.032
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.032
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.080
ESPL1	N/A	0.144	0.026
PTMA	N/A	0.144	0.032
ABCF1	N/A	0.144	0.032
MKI67	MKI67: Antigen KI-67	0.144	0.032
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.032
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.141	0.067
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.140	0.136
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.139	0.069
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.139	0.069
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	0.136
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.139	0.086
COPE	COPE: Coatomer subunit epsilon	0.139	0.049
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.056
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.139	0.086
KIAA1012	KIAA1012: Protein TRS85 homolog	0.139	0.086
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.139	0.086
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.029
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.139	0.225
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.139	0.086
CDC23	CDC23: Cell division cycle protein 23 homolog	0.137	0.051
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.137	0.051
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.137	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	1.37
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	1.37
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.137	0.148
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.132	0.032
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.077
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.032
CBX3	CBX3: Chromobox protein homolog 3	0.129	0.038
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.129	0.029
NPM1	NPM1, NPM: Nucleophosmin	0.129	0.029
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.038
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.129	0.054
NUP153	N/A	0.129	0.038
SSB	SSB: Lupus La protein	0.129	0.054
KIF11	N/A	0.129	0.038
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.129	0.029
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.129	0.054
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.038
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.029
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	0.029
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.038
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.071
CDK4	CDK4: Cell division protein kinase 4	0.129	0.038
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.038
MAD2L1	MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A	0.129	0.029
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.029
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.129	0.054
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.129	0.029
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.129	0.086
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.086
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.096
HIVEP1	N/A	0.127	0.077
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.127	0.026
ZNF335	ZNF335: Zinc finger protein 335	0.127	0.086
SALL1	SALL1, SAL1: Sal-like protein 1	0.125	0.049
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.090
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.029
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.118	0.086
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.118	0.038
CCNH	CCNH: Cyclin-H	0.114	0.056
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.086
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.114	0.029
MTF1	MTF1: Metal regulatory transcription factor 1	0.114	0.096
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.054
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.069
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.114	0.111
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.054
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.114	0.096
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.114	0.086
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.114	0.069
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.114	0.171
FKBP4	FKBP4: FK506-binding protein 4	0.114	0.056
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.114	0.069
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.029
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.114	0.056
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.114	0.049
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.069
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.111	0.049
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.111	0.033
HSP90AA1	Hsp89-alpha-delta-N	0.111	0.051
STAT6	STAT6: Signal transducer and activator of transcription 6	0.111	0.033
HDAC4	HDAC4, KIAA0288: Histone deacetylase 4	0.102	0.056
GTF2F2	N/A	0.0971	0.026
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.096	0.069
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.096	0.032
NFATC1	N/A	0.096	0.096
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.080
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.096	0.096
PDK1	PDK1: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precu	0.094	0.035
TFAP2B	TFAP2B: Transcription factor AP-2 beta	0.090	0.026
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.090	0.097
DNMT1	DNMT1, AIM, DNMT: DNA	0.087	0.032
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.191
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	0.096
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.032
UNG	N/A	0.087	0.225
SET	SET: Protein SET	0.087	0.032
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.060
TCOF1	N/A	0.087	0.032
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.026
GNB2L1	Lung cancer oncogene 7	0.087	0.026
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.060
NCOA3	N/A	0.087	0.026
KIF23	N/A	0.087	0.032
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.048
IFI16	N/A	0.087	0.032
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.087	0.056
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.069
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.086	0.171
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.086	0.136
BRPF1	BRPF1, BR140: Peregrin	0.086	0.111
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.069
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.086	0.086
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.086	0.044
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.086	0.069
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	0.111
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.086	0.056
ATM	ATM: Serine-protein kinase ATM	0.086	0.029
SOX4	SOX4: Transcription factor SOX-4	0.086	0.136
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.069
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.028
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.083
UHRF1		0.083	0.165
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.165
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.075
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.165
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.165
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.083
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.083
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.083
PPEF1	N/A	0.083	0.028
MAPK15	N/A	0.083	0.083
C20orf18	N/A	0.083	0.165
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
KIAA0664	KIAA0664: Putative eukaryotic translation initiation factor 3 subunit	0.0818	0.041
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.0818	0.041
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.073
NAPG	NAPG, SNAPG: Gamma-soluble NSF attachment protein	0.0818	0.051
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.071
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.078	0.029
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.225
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.054
LIG1	LIG1: DNA ligase 1	0.078	0.029
NOL1	N/A	0.078	0.038
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.029
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	0.029
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.078	0.043
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.029
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.038
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.029
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.038
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.136
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.029
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.086
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.054
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.071
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.054
FNBP1	N/A	0.078	0.171
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.043
CDK2	CDK2: Cell division protein kinase 2	0.078	0.029
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.029
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.078	0.035
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.043
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.078	0.029
ERG	ERG: Transcriptional regulator ERG	0.077	0.026
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.026
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.077	0.056
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.127
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.077
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.077	0.069
CCNT2	CCNT2: Cyclin-T2	0.075	0.047
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.025
GIT2	N/A	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.075
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.047
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.148
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.075	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.075
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.075
RNF20		0.075	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.075	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.047
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.075
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.148
BRD4	N/A	0.075	0.148
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.075
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.148
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.083
SOX8	SOX8: Transcription factor SOX-8	0.075	0.148
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.025
API5	N/A	0.070	0.0425
UBAP2	N/A	0.070	0.032
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.026
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.032
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.070	0.026
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.032
PLEK	PLEK, P47: Pleckstrin	0.070	0.026
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.032
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.032
KIAA0853	N/A	0.070	0.0425
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.048
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.069	0.136
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.069	0.069
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.069	0.056
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.069	0.069
ZNF551	N/A	0.069	0.069
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.069	0.136
LIG4	LIG4: DNA ligase 4	0.069	0.029
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.069	0.096
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.067	0.041
SUMO2	SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor	0.0668	0.035
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.066	0.041
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.043
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.029
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.063	0.043
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.063	0.038
HDAC2	HDAC2: Histone deacetylase 2	0.063	0.086
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.225
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.038
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.063	0.038
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.029
PPP1R8	N/A	0.063	0.029
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.136
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.029
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.029
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.054
RBM7		0.063	0.043
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.029
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.086
RPS6KB1	N/A	0.063	0.038
PHF10	N/A	0.063	0.225
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.038
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.029
WBSCR20A	N/A	0.063	0.029
SH3BP3		0.062	0.062
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.062
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.062	0.127
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.123
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.060	0.069
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.060	0.077
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.056	0.071
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.056	0.069
SP1	SP1, TSFP1: Transcription factor Sp1	0.056	0.069
PCAF	PCAF: Histone acetyltransferase PCAF	0.056	0.111
HCC-1	HCC1, HSPC316: Nuclear protein Hcc-1	0.055	0.051
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.054
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.055	0.152
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.029
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.054	0.136
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.052	0.083
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.052	0.028
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.032
EMD	EMD, EDMD, STA: Emerin	0.052	0.032
ARFGAP1	N/A	0.052	0.032
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.191
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.251
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.0425
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.060
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.026
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.032
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.048
CHUK	N/A	0.052	0.032
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.048
AFF1	N/A	0.052	0.026
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.191
TOP2B	N/A	0.052	0.032
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.032
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.037
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.051	0.051
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.050	0.097
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.049	0.109
SF3A3	SF3A3, SAP61: Splicing factor 3A subunit 3	0.049	0.030
STAT3		0.049	0.036
NASP	NASP: Nuclear autoantigenic sperm protein	0.049	0.049
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.049
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.049
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.049	0.109
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	0.049
SPAG1	SPAG1: Sperm-associated antigen 1	0.049	0.056
SOX11	SOX11: Transcription factor SOX-11	0.049	0.097
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.049
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.049	0.049
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.048	0.123
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.048	0.123
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.026
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.047	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.047	0.075
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.025
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.047	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.047	0.025
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.046	0.043
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.171
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.029
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.056
KLHDC4	N/A	0.046	0.029
CRSP2	MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol	0.046	0.029
CUL4B	N/A	0.046	0.029
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.029
CUL5	CUL5, VACM1: Cullin-5	0.046	0.029
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.071
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.043
SAPS3	N/A	0.046	0.029
MDN1	MDN1, KIAA0301: Midasin	0.046	0.029
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.029
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.038
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.046	0.071
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.046	0.069
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.038
LMAN1	LMAN1, ERGIC53, F5F8D: Protein ERGIC-53 precursor	0.046	0.028
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.0446	0.126
KLC2	KLC2: Kinesin light chain 2	0.044	0.049
EGR1	EGR1, ZNF225: Early growth response protein 1	0.044	0.069
VDR	VDR, NR1I1: Vitamin D3 receptor	0.043	0.171
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.043	0.056
SMARCC2	N/A	0.0425	0.026
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.026
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.0425
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.096
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.191
RGS14	N/A	0.0425	0.032
MARK2	N/A	0.0425	0.026
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.060
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.032
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.032
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.191
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.032
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.152
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.0425	0.026
EXOC2	N/A	0.041	0.041
STUB1	STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1	0.041	0.033
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.040	0.090
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.040	0.041
ETF1	ETF1, ERF1, RF1, SUP45L1: Eukaryotic peptide chain release factor subunit 1	0.040	0.046
XPO1	XPO1, CRM1: Exportin-1	0.040	0.054
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.040	0.041
PPARG	CREB3L2-PPARgamma	0.039	0.088
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.026
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.054
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.171
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.035
MAFG	MAFG: Transcription factor MafG	0.038	0.069
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.029
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.049
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.038
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.038	0.054
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.038	0.029
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.029
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.038	0.054
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.038	0.111
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.038	0.054
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.069
TFAM	TFAM, TCF6L2: Transcription factor A, mitochondrial precursor	0.038	0.036
SAFB2	SAFB2, KIAA0138: Scaffold attachment factor B2	0.036	0.053
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.126
HD	HD, IT15: Huntingtin	0.036	0.126
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.136
SCML2	SCML2: Sex comb on midleg-like protein 2	0.034	0.026
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.034	0.049
FOXL2	FOXL2: Forkhead box protein L2	0.034	0.069
RAD18	RAD18, RNF73: E3 ubiquitin-protein ligase RAD18	0.034	0.0688
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.033	0.090
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.077
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.032
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.0971
GTF3C1	N/A	0.032	0.026
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.152
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.032	0.055
AHR	AHR: Aryl hydrocarbon receptor precursor	0.032	0.097
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.026
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.055
CASP3	CASP3, CPP32: Caspase-3 precursor	0.032	0.033
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.041
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.032	0.033
NR1D1	NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1	0.031	0.111
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.031	0.152
NFIB	N/A	0.031	0.049
PTPRF	PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor	0.030	0.062
FKBP8	DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment)	0.029	0.029
RUNX1	N/A	0.029	0.038
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.029
TOP3A	TOP3A, TOP3: DNA topoisomerase 3-alpha	0.029	0.029
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.029	0.029
JUNB	JUNB: Transcription factor jun-B	0.029	0.069
HTATSF1	HTATSF1: HIV Tat-specific factor 1	0.029	0.054
METTL1	METTL1, C12orf1: tRNA	0.029	0.171
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.029	0.056
JUND	JUND: Transcription factor jun-D	0.029	0.069
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.029	0.086
RCP9	CRCP: DNA-directed RNA polymerase III subunit RPC9	0.029	0.038
SMCX	JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C	0.029	0.111
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.029	0.029
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.056
COL1A2	COL1A2: Collagen alpha-2(I) chain precursor	0.029	0.029
COL5A2	COL5A2: Collagen alpha-2(V) chain precursor	0.029	0.029
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.165
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.148
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.052
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.052
IRF7	N/A	0.028	0.028
WDR54	N/A	0.028	0.028
DUSP15	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
KIF1B	N/A	0.028	0.028
HDAC8	N/A	0.028	0.083
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.165
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.075
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.025
CORO6	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.025
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
NES	N/A	0.028	0.028
SNRPB	N/A	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.025
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
CABLES1	N/A	0.028	0.028
HDAC7A	N/A	0.028	0.075
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
FLJ23436	N/A	0.028	0.025
DSP	DSP: Desmoplakin	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
BID	BID: BH3-interacting domain death agonist	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.083
ZNF265	N/A	0.028	0.028
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.028
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.165
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.052
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.165
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.025
NR4A1	CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor	0.028	0.136
FABP5	FABP5: Fatty acid-binding protein, epidermal	0.027	0.033
MECP2	MECP2: Methyl-CpG-binding protein 2	0.026	0.026
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.026
TRIM16	TRIM16, EBBP: Tripartite motif-containing protein 16	0.026	0.123
KRT18	KRT18: Uncharacterized protein KRT18	0.026	0.098
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.026	0.0425
MEF2A	N/A	0.026	0.062
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.026	0.026
ATXN7	ATXN7, SCA7: Ataxin-7	0.0253	0.0253
CIC	CIC, KIAA0306: Protein capicua homolog	0.025	0.045
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.148
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.148
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.025
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.075
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.075
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.047
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.148
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
GRK6	N/A	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NUP98	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
SEC13L1	N/A	0.025	0.025
NIPBL	N/A	0.025	0.047
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.047
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.047
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.148
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.047
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.075
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.047
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
HTATIP	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.148
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.075
DIDO1	N/A	0.025	0.148
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.047
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.047
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.047
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.148
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.148
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.075
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.047
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.047
SON		0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.148
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.025
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.148
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
KCTD1		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MAX	MAX: Protein max	0.025	0.075
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.148
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.025	0.059

2.15E-3

Total Score

1.37