Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to EFNA1

Evidence of Interaction Between EFNA1 and EPHA2

The interaction score between EFNA1 and EPHA2 is 566.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismEFNA1 OrthologueEPHA2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00005123 0.219 IPI00008315 0.315
human IPI00005125 0.17 IPI00008315 0.315
human IPI00005517 0.23 IPI00008315 0.315
  • InVitro
  • InVivo

Get References From PubMed
human IPI00005123 0.219 IPI00016645 0.312
  • Other
  • InVivo

Get References From PubMed
human IPI00005125 0.17 IPI00016645 0.312
  • Other

Get References From PubMed
human IPI00005517 0.23 IPI00016645 0.312
  • Other
  • InVitro

Get References From PubMed
worm O44516 1 O61460 0.312
  • pullDown

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in EFNA1 and EPHA2:
Domains in EFNA1Domains in EPHA2
IPR001799 Ephrin
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR008979 Galactose-binding like
IPR013032 IPR006209.
IPR013761 Sterile alpha motif-type

The Chi square scores for co-occurrence of domains that are present in EFNA1 and EPHA2 are listed below.

Domain 1Domain 2Chi Square
IPR001799 Ephrin IPR001426 Receptor tyrosine kinase, class V 1988.46
IPR001799 Ephrin IPR001090 Ephrin receptor, ligand binding 1988.46
IPR001799 Ephrin IPR001660 Sterile alpha motif SAM 683.581
IPR001799 Ephrin IPR013761 Sterile alpha motif-type 387.685
IPR001799 Ephrin IPR008979 Galactose-binding like 246.01
IPR001799 Ephrin IPR003961 Fibronectin, type III 147.446
IPR001799 Ephrin IPR008957 Fibronectin, type III-like fold 99.447
IPR001799 Ephrin IPR008266 Tyrosine protein kinase, active site 73.3233
IPR001799 Ephrin IPR001245 Tyrosine protein kinase 64.1366
IPR001799 Ephrin IPR006209 EGF-like domain 50.0861
IPR001799 Ephrin IPR000719 Protein kinase 30.3648
IPR001799 Ephrin IPR013032 IPR006209. 15.905
IPR001799 Ephrin IPR011009 Protein kinase-like 1.52758

The background colour of the table refers to:

  • Blue Domain is only present in EFNA1
  • Yellow Domain is only present in EPHA2
  • Green Domain is present in both EFNA1 and EPHA2

 0.543
Post-translational Modifications

Protein: EFNA1

PTMResidueReference
Glycosyl phosphatidyl inositol GPI 186 PubMed, HPRD

Protein: EPHA2

PTMResidueReference
Phosphorylation 588 PubMed, HPRD
Phosphorylation 594 PubMed, HPRD
Phosphorylation 772 PubMed, HPRD
Phosphotyrosine 588 PubMed, HPRD
Phosphotyrosine 594 PubMed, HPRD
Phosphotyrosine 772 PubMed, HPRD
Phosphotyrosine 921 PubMed, HPRD
Localisation

Protein: EFNA1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD

Protein: EPHA2

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between EFNA1 and EPHA2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EFNA1 andEPHA2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EFNA1 has 323 interactors and EPHA2 has 1476 interactors of which there are 192 common interactors.

Common InteractorName of Common InteractorScore for EFNA1-Interactor (?)Score for EPHA2-Interactor (?)
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 1.27E3 46.90
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 654.00 82.20
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 654.00 65.60
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 654.00 46.80
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 654.00 108.00
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 654.00 71.20
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 654.00 46.80
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 654.00 53.10
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 654.00 65.60
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 1.53 0.051
LCP2 LCP2: Lymphocyte cytosolic protein 2 1.53 0.355
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 1.53 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 1.53 0.051
FN1 FN1, FN: Fibronectin precursor 1.53 0.051
SCML2 SCML2: Sex comb on midleg-like protein 2 1.53 0.045
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 1.53 0.051
TP73 TP73, P73: Tumor protein p73 1.53 0.041
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 1.37 0.062
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 1.37 0.098
CASKIN2 CASKIN2, KIAA1139: Caskin-2 1.37 0.073
CXorf9 N/A 1.37 0.064
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 1.37 0.058
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 1.37 0.046
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 1.37 0.090
FN1 N/A 1.30 0.165
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.944 0.088
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.543 0.152
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.543 0.165
ITGB4 N/A 0.543 0.515
NEO1 NEO1, NGN: Neogenin precursor 0.486 0.111
DCC DCC: Netrin receptor DCC precursor 0.486 0.097
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.486 0.148
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.265 0.027
PTPRS PTPRS: Protein tyrosine phosphatase, receptor type, S 0.217 0.0308
PTPRD PTPRD: PTPRD protein 0.217 0.027
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.165 0.072
C8A C8A: Complement component C8 alpha chain precursor 0.165 0.081
C6 C6: Complement component C6 precursor 0.165 0.073
C8B C8B: Complement component C8 beta chain precursor 0.148 0.073
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.148 0.064
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.148 0.148
C7 C7: Complement component C7 precursor 0.148 0.064
F7 F7: Coagulation factor VII precursor 0.056 0.098
C1R C1R: Complement C1r subcomponent precursor 0.056 0.081
UMOD UMOD: Uromodulin precursor 0.056 0.109
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.056 0.152
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.056 0.109
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.056 0.100
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.056 0.165
C1S C1S: Complement C1s subcomponent precursor 0.056 0.072
F12 F12: Coagulation factor XII precursor 0.056 0.100
THBD THBD, THRM: Thrombomodulin precursor 0.056 0.064
F5 F5: Coagulation factor V precursor 0.056 0.731
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.056 0.165
PLAT PLAT: Tissue-type plasminogen activator precursor 0.056 0.098
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.056 0.072
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.056 0.274
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.056 0.123
PROC PROC: Vitamin K-dependent protein C precursor 0.056 0.090
CRLF3 N/A 0.056 0.109
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.056 0.081
MUC2 MUC2, SMUC: Mucin-2 precursor 0.056 0.072
CSPG2 N/A 0.056 0.072
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.050 0.136
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.050 0.090
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.050 0.073
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.050 0.073
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.050 0.098
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.050 0.040
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.050 0.111
ALK ALK: ALK tyrosine kinase receptor precursor 0.050 0.073
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.050 0.097
F9 F9: Coagulation factor IX precursor 0.050 0.073
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.050 0.090
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.050 0.064
F10 F10: Coagulation factor X precursor 0.050 0.136
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.050 0.090
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.050 0.111
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.050 0.064
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.050 0.064
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.050 0.040
BMP1 N/A 0.050 0.098
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.050 0.097
TNC TNC, HXB: Tenascin precursor 0.050 0.171
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.050 0.073
DLG2 DLG2: Disks large homolog 2 0.050 0.058
CNTN1 CNTN1: Contactin-1 precursor 0.050 0.148
CNTN4 CNTN4: Contactin-4 precursor 0.050 0.148
NOTCH4 N/A 0.050 0.136
EGF EGF: Pro-epidermal growth factor precursor 0.044 0.109
DLK1 DLK1, DLK: Delta-like protein precursor 0.044 0.165
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.044 0.098
F3 F3: Tissue factor precursor 0.044 0.416
PRLR PRLR: Prolactin receptor precursor 0.044 0.098
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.044 0.123
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.044 0.251
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.044 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.044 0.165
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.044 0.109
GHR GHR: Growth hormone receptor precursor 0.044 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.044 0.123
SELE SELE, ELAM1: E-selectin precursor 0.044 0.123
PTPRZ1 N/A 0.044 0.088
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.148
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.044 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.044 0.109
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.044 0.123
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.044 0.165
IL9R IL9R: Interleukin-9 receptor precursor 0.044 0.123
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.044 0.165
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.044 0.123
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.044 0.191
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.044 0.165
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.044 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.044 0.098
AREG AREG, SDGF: Amphiregulin precursor 0.044 0.416
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.044 0.088
EPOR EPOR: Erythropoietin receptor precursor 0.044 0.098
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.044 0.152
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.044 0.109
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.044 0.191
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.044 0.251
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.044 0.123
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.044 0.123
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.044 0.098
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.044 0.123
MET MET: Hepatocyte growth factor receptor precursor 0.044 0.307
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.044 0.098
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.044 0.191
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.044 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.165
SORL1 SORL1: Sortilin-related receptor precursor 0.044 0.109
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.040 0.097
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.040 0.035
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.040 0.025
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.040 0.148
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.040 0.225
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.040 0.136
KIT KIT: Mast/stem cell growth factor receptor precursor 0.040 0.097
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.097
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.040 0.044
ATRN N/A 0.040 0.148
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.040 0.097
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.040 0.025
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.040 0.148
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.097
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.040 0.275
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.040 0.097
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.040 0.111
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.040 0.111
INSR INSR: Insulin receptor precursor 0.040 0.088
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.040 0.097
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.040 0.097
MEP1A MEP1A: Meprin A subunit alpha precursor 0.040 0.111
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.040 0.111
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.040 0.111
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.040 0.111
MEP1B MEP1B: Meprin A subunit beta precursor 0.040 0.136
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 0.148
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.040 0.225
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.040 0.148
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.040 0.097
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.040 0.111
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.040 53.10
JAG2 JAG2: Jagged-2 precursor 0.040 0.148
LDLR LDLR: Low-density lipoprotein receptor precursor 0.040 0.225
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.040 0.136
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.040 0.097
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.040 0.136
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.097
CFP CFP, PFC: Properdin precursor 0.028 0.072
APOE APOE: Apolipoprotein E precursor 0.028 0.037
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.028 0.126
CFB CFB, BF, BFD: Complement factor B precursor 0.028 0.081
SERPINF2 SERPINF2, AAP, PLI: Alpha-2-antiplasmin precursor 0.028 0.100
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
LAMB3 LAMB3, LAMNB1: Laminin subunit beta-3 precursor 0.027 0.065
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
IL5RA N/A 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
FLRT3 FLRT3, KIAA1469, UNQ856/PRO1865: Leucine-rich repeat transmembrane protein FLRT3 0.027 0.0308
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
RTEL1 TNFRSF6B, DCR3, UNQ186/PRO212, TR6: Tumor necrosis factor receptor superfamily m 0.027 0.032
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
LAMA3 0.027 0.053
INPPL1 INPPL1, SHIP2: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 0.0258 0.0258
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.025 0.065
VWF VWF, F8VWF: von Willebrand factor precursor 0.025 0.073
2.15E-3
Total Score 566.00