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Evidence of Interaction Between PSMB3 and PSMB7

The interaction score between PSMB3 and PSMB7 is 1.49E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMB3 and PSMB7 = 0.79

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPSMB3 OrthologuePSMB7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER094C 1 YOR157C 1
  • Y2H
  • Other

Get References From PubMed
worm Q23237 1 O62102 1
  • Y2H

Get References From PubMed
fly Q9XYN7 1 Q9VUJ1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in PSMB3 and PSMB7:
Domains in PSMB3Domains in PSMB7
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits

The Chi square scores for co-occurrence of domains that are present in PSMB3 and PSMB7 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMB3
  • Yellow Domain is only present in PSMB7
  • Green Domain is present in both PSMB3 and PSMB7

 0.265
Post-translational Modifications

Protein: PSMB3

PTMResidueReference

Protein: PSMB7

PTMResidueReference
Phosphotyrosine 154 HPRD
Localisation

Protein: PSMB3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMB7

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMB3 and PSMB7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMB3 andPSMB7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMB3 has 165 interactors and PSMB7 has 911 interactors of which there are 156 common interactors.

Common InteractorName of Common InteractorScore for PSMB3-Interactor (?)Score for PSMB7-Interactor (?)
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 691.00 691.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 691.00 691.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 2.07E3
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 323.00 691.00
PSMB2 PSMB2: Proteasome subunit beta type-2 323.00 691.00
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 195.00 691.00
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 195.00 1.59E3
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 195.00 1.59E3
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 39.30 23.40
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
PSMB4 N/A 3.89 19.70
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 1.36 2.91
PSMA5 PSMA5: Proteasome subunit alpha type-5 1.22 3.41E3
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 1.01 0.141
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.824 0.666
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.440 0.596
EEF2 EEF2, EF2: Elongation factor 2 0.265 0.078
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.95
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.179
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.221 0.221
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.878
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.179
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.123 0.275
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.123 0.763
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.123 1.62
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.082 2.47
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.123
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.074 0.372
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.074 0.763
CDK4 CDK4: Cell division protein kinase 4 0.074 0.461
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.461
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.074 0.372
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.074 0.372
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.074 0.275
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.074 0.763
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.074 0.461
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.074 0.044
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.074 0.275
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.067 0.515
STK16 N/A 0.067 0.251
CDK7 CDK7, MO15: Cell division protein kinase 7 0.060 0.461
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.372
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.060 0.060
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.060 0.074
CSNK1D CSNK1D: Casein kinase I isoform delta 0.060 0.060
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.060 0.074
CDK2 CDK2: Cell division protein kinase 2 0.060 0.461
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.060 0.461
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.060 0.060
CLK3 CLK3: Dual specificity protein kinase CLK3 0.060 0.044
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.060 0.074
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.060 0.225
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.060 0.461
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.050 0.085
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.050 0.307
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.050 0.083
VRK3 N/A 0.050 0.050
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.050 0.067
LIMK2 LIMK2: LIM domain kinase 2 0.050 0.085
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.047 0.047
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.047 0.059
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.047 0.304
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.044 0.171
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.060
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.044 0.372
STK10 STK10: Uncharacterized protein STK10 0.044 0.225
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
RPS6KB1 N/A 0.044 0.372
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.044 0.275
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.225
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.044 0.275
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.044 0.126
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.044 0.372
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.044 0.093
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.044 0.372
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.044 0.275
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.044 0.275
BUB1 0.044 0.060
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.191
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.041 0.251
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.041 0.251
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.251
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.041 0.140
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.041 0.067
EIF2AK1 N/A 0.041 0.041
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.041 0.0308
ROCK1 ROCK1: Rho-associated protein kinase 1 0.041 0.307
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.041 0.191
PIM1 N/A 0.036 0.028
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.036 0.275
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.036 0.036
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.036 0.275
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.076
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.036 0.036
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.036 0.036
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.036 0.275
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.036 0.076
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.036 0.060
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.036 0.372
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.044
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.036 0.372
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.036
WEE1 WEE1: Wee1-like protein kinase 0.036 0.275
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.036 0.225
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.036 0.093
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.035 0.059
GAK GAK: Cyclin G-associated kinase 0.035 0.035
IRAK3 IRAK3: Interleukin-1 receptor-associated kinase 3 0.032 0.032
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.166
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.0308 0.0308
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0308 0.191
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.029 0.047
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.028 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.028 0.136
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.028 0.171
ULK1 ULK1, KIAA0722: Serine/threonine-protein kinase ULK1 0.028 0.028
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.028 0.036
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.028 0.044
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.028 0.171
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.028 0.171
PHKG2 PHKG2: Phosphorylase b kinase gamma catalytic chain, testis/liver isoform 0.028 0.036
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.028 0.275
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.028 0.171
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.028 0.136
CDK6 CDK6: Cell division protein kinase 6 0.028 0.225
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.028 0.036
NDUFA1 NDUFA1: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 0.027 0.027
UBE2V1 N/A 0.027 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
MAP2K5 N/A 0.027 0.056
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.056
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
CDC2L2 N/A 0.027 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
MAPKAPK5 N/A 0.027 0.165
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
MAPK15 N/A 0.027 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
NULL RcPSMB3 (Fragment) 0.0258 34.70
0.228
Total Score 1.49E5