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Evidence of Interaction Between INHBA and ACVR2A

The interaction score between INHBA and ACVR2A is 9.69E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between INHBA and ACVR2A = 0.04

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismINHBA OrthologueACVR2A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00297026 0.226 IPI00020431 0.091
human IPI00297026 0.226 IPI00437565 0.634
  • InVivo

Get References From PubMed
fly O61643 0.226 Q24229 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in INHBA and ACVR2A:
Domains in INHBADomains in ACVR2A
IPR002400 Growth factor, cystine knot
IPR001839 Transforming growth factor beta
IPR001111 Transforming growth factor beta (TGFb), N-terminal
IPR002405 Inhibin, alpha subunit
IPR001318 Inhibin, beta C subunit
IPR000491 Inhibin, beta A subunit
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor

The Chi square scores for co-occurrence of domains that are present in INHBA and ACVR2A are listed below.

Domain 1Domain 2Chi Square
IPR001839 Transforming growth factor beta IPR000472 TGF-beta receptor/activin receptor, type I/II 1864.47
IPR001839 Transforming growth factor beta IPR000333 Activin type II receptor 1635.59
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000472 TGF-beta receptor/activin receptor, type I/II 1502.1
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000333 Activin type II receptor 1405.74
IPR002405 Inhibin, alpha subunit IPR000472 TGF-beta receptor/activin receptor, type I/II 716.826
IPR002400 Growth factor, cystine knot IPR000472 TGF-beta receptor/activin receptor, type I/II 625.909
IPR002405 Inhibin, alpha subunit IPR000333 Activin type II receptor 492.756
IPR002400 Growth factor, cystine knot IPR000333 Activin type II receptor 428.465
IPR001318 Inhibin, beta C subunit IPR000472 TGF-beta receptor/activin receptor, type I/II 331.363
IPR001318 Inhibin, beta C subunit IPR000333 Activin type II receptor 179.464
IPR001839 Transforming growth factor beta IPR008271 Serine/threonine protein kinase, active site 113.519
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR008271 Serine/threonine protein kinase, active site 82.2948
IPR000491 Inhibin, beta A subunit IPR000472 TGF-beta receptor/activin receptor, type I/II 79.879
IPR001839 Transforming growth factor beta IPR000719 Protein kinase 46.8332
IPR002405 Inhibin, alpha subunit IPR008271 Serine/threonine protein kinase, active site 41.7425
IPR001839 Transforming growth factor beta IPR011009 Protein kinase-like 33.7075
IPR002400 Growth factor, cystine knot IPR008271 Serine/threonine protein kinase, active site 32.5032
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR000719 Protein kinase 26.4504
IPR001318 Inhibin, beta C subunit IPR008271 Serine/threonine protein kinase, active site 18.9084
IPR002400 Growth factor, cystine knot IPR000719 Protein kinase 15.838
IPR002405 Inhibin, alpha subunit IPR000719 Protein kinase 14.7429
IPR001111 Transforming growth factor beta (TGFb), N-terminal IPR011009 Protein kinase-like 13.6144
IPR002405 Inhibin, alpha subunit IPR011009 Protein kinase-like 6.8785
IPR001318 Inhibin, beta C subunit IPR000719 Protein kinase 6.47721
IPR002400 Growth factor, cystine knot IPR011009 Protein kinase-like 4.6692
IPR000491 Inhibin, beta A subunit IPR008271 Serine/threonine protein kinase, active site 3.24684
IPR000491 Inhibin, beta A subunit IPR000719 Protein kinase 0.573553
IPR001318 Inhibin, beta C subunit IPR011009 Protein kinase-like 0.236612

The background colour of the table refers to:

  • Blue Domain is only present in INHBA
  • Yellow Domain is only present in ACVR2A
  • Green Domain is present in both INHBA and ACVR2A

 0.217
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: INHBA

LocalisationReference
Secreted HPRD

Protein: ACVR2A

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between INHBA and ACVR2A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between INHBA andACVR2A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , INHBA has 102 interactors and ACVR2A has 176 interactors of which there are 13 common interactors.

Common InteractorName of Common InteractorScore for INHBA-Interactor (?)Score for ACVR2A-Interactor (?)
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 69.80 10.50
INHBB INHBB: Inhibin beta B chain precursor 6.81 62.40
ACVR1 ACVR1, ACVRLK2: Activin receptor type-1 precursor 0.361 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.195 3.52
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.083 0.143
BMP2 BMP2, BMP2A: Bone morphogenetic protein 2 precursor 0.060 0.128
BMP6 BMP6, VGR: Bone morphogenetic protein 6 precursor 0.044 61.50
TGFB2 TGFB2: Transforming growth factor beta-2 precursor 0.041 0.162
ARTN ARTN, EVN: Artemin precursor 0.0308 0.251
BMP5 BMP5: Bone morphogenetic protein 5 precursor 0.028 86.20
GDF7 gdf7: Growth differentiation factor 7 0.027 0.217
GDF1 GDF1: Embryonic growth/differentiation factor 1 precursor 0.027 0.217
GDNF GDNF: Glial cell line-derived neurotrophic factor precursor 0.027 0.217
0.347
Total Score 9.69E3