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Evidence of Interaction Between PSMA6 and PSMA3

The interaction score between PSMA6 and PSMA3 is 3.76E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA6 and PSMA3 = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPSMA6 OrthologuePSMA3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YGL011C 1 YOR362C 1
  • Y2H
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm O17586 1 Q09583 1
  • Y2H

Get References From PubMed
fly Q9XZJ4 1 Q9V5C6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in PSMA6 and PSMA3:
Domains in PSMA6Domains in PSMA3
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMA6 and PSMA3 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000426 Proteasome alpha-subunit IPR000426 Proteasome alpha-subunit 78.5459

The background colour of the table refers to:

  • Blue Domain is only present in PSMA6
  • Yellow Domain is only present in PSMA3
  • Green Domain is present in both PSMA6 and PSMA3

 0.265
Post-translational Modifications

Protein: PSMA6

PTMResidueReference

Protein: PSMA3

PTMResidueReference
Acetylation 2 PubMed, HPRD
N-acetylserine 1 HPRD
Phosphorylation 243 PubMed, HPRD
Phosphorylation 250 PubMed, HPRD
Phosphoserine 249 HPRD
Phosphotyrosine 160 HPRD
Localisation

Protein: PSMA6

LocalisationReference
Nucleus HPRD
Mitochondrion HPRD
Cytoplasm HPRD
Ribosome HPRD

Protein: PSMA3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA6 and PSMA3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA6 andPSMA3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA6 has 188 interactors and PSMA3 has 1068 interactors of which there are 165 common interactors.

Common InteractorName of Common InteractorScore for PSMA6-Interactor (?)Score for PSMA3-Interactor (?)
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 691.00 1.59E3
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 691.00 323.00
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 323.00 691.00
PSMA5 PSMA5: Proteasome subunit alpha type-5 323.00 3.41E3
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 195.00 195.00
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 195.00 3.41E3
PSMB3 PSMB3: Proteasome subunit beta type-3 195.00 195.00
PSMB2 PSMB2: Proteasome subunit beta type-2 195.00 691.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 23.40 31.70
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 2.15 0.040
PSMB4 N/A 1.82 1.82
PSMA1 N/A 1.79 1.79
NULL RcPSMB3 (Fragment) 1.37 1.37
RANBP5 1.10 1.82
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.890 0.078
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.824 0.824
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.739 0.739
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
PSME4 PSME4, KIAA0077: Proteasome activator complex subunit 4 0.593 0.593
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.263 0.763
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 1.62
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.36
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.221 0.366
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.878
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.145
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.132 3.35
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.123 0.461
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.123 0.461
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.123 0.060
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.123 0.461
RANBP6 N/A 0.119 0.119
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.082 0.027
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.074 0.074
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.074 0.372
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.074 0.763
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.074 0.372
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.074 0.044
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.074 0.763
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.074 0.123
RPS6KB1 N/A 0.074 0.461
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.074 0.372
CDK4 CDK4: Cell division protein kinase 4 0.074 0.763
CDK2 CDK2: Cell division protein kinase 2 0.074 0.763
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.060
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.074 0.275
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.372
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.074 0.123
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.067 1.81
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.067 0.083
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.852
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.515
VRK3 N/A 0.067 0.0308
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.060 0.275
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.060 0.275
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.060 0.225
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.060 0.275
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.060 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.060 0.275
BUB1 0.060 0.123
CDK7 CDK7, MO15: Cell division protein kinase 7 0.060 0.763
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.060 0.263
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.060 0.372
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.060 0.372
CSNK1D CSNK1D: Casein kinase I isoform delta 0.060 0.044
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.059 0.059
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.059 0.047
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.059 0.503
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.050 0.251
ROCK1 ROCK1: Rho-associated protein kinase 1 0.050 0.416
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.050 0.067
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.067
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.050 0.251
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.050 0.251
GAK GAK: Cyclin G-associated kinase 0.047 0.035
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.047 0.059
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.047 0.035
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.044 0.372
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.044 0.044
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
CDK6 CDK6: Cell division protein kinase 6 0.044 0.136
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.044 0.372
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.044 0.225
STK10 STK10: Uncharacterized protein STK10 0.044 0.225
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.044 0.275
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.074
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.044 0.171
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.044 0.461
WEE1 WEE1: Wee1-like protein kinase 0.044 0.372
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.044 0.171
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.275
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.044 0.036
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.036
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.044 0.275
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.036
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.044 0.044
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.225
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.275
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.044 0.036
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.251
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.041 0.041
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.251
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.041 0.152
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.041 0.191
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.038 0.233
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.038 0.385
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.225
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.036 0.028
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.036 0.275
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.171
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.036 0.275
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.036 0.171
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.036
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.036 0.275
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.036 0.028
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.166
EIF2AK1 N/A 0.0308 0.0308
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.0308
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.0308 0.152
LIMK2 LIMK2: LIM domain kinase 2 0.0308 0.191
PRKAA1 N/A 0.0308 0.152
STK16 N/A 0.0308 0.307
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.191
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
CDK5 CDK5: Cell division protein kinase 5 0.028 0.171
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.028 0.225
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.028 0.036
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.028 0.136
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.028
PIM1 N/A 0.028 0.028
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.028 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.028 0.171
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.028 0.225
DYRK3 N/A 0.028 0.111
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.028 0.136
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.028 0.111
HNRPD N/A 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
CDC2L2 N/A 0.027 0.027
MAPK15 N/A 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
MAPKAPK5 N/A 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
MAP2K5 N/A 0.027 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
0.572
Total Score 3.76E5