PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between CHMP4C and CHMP4B

The interaction score between CHMP4C and CHMP4B is 4.43E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	CHMP4C Orthologue		CHMP4B Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00025974	0.157	IPI00023068	0.349	Y2H Get References From PubMed
human	IPI00023068	0.279	IPI00023068	0.349	Y2H Get References From PubMed
bakers yeast	YLR025W	0.279	YLR025W	0.349	Y2H Other Get References From PubMed
worm	Q18886	0.157	Q18886	1
worm	Q18886	0.157	Q22916	0.392
fly	Q8T0Q4	0.246	Q8T0Q4	1	Y2H Other Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01

Domains

No domains were used in calculating likelihood of interaction

0.265

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

Protein: CHMP4C

Localisation	Reference
Cytosol	HPRD
Cytoplasm	HPRD

Protein: CHMP4B

Localisation	Reference
Cytosol	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between CHMP4C and CHMP4B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CHMP4C andCHMP4B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CHMP4C has 25 interactors and CHMP4B has 23 interactors of which there are 22 common interactors.

Common Interactor	Name of Common Interactor	Score for CHMP4C-Interactor (?)	Score for CHMP4B-Interactor (?)
CHMP4A	N/A	319.00	319.00
CHMP6	CHMP6, VPS20: Charged multivesicular body protein 6	319.00	319.00
VPS4B	VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B	169.00	169.00
VPS24	VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3	169.00	169.00
CHMP2A	CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a	12.60	12.60
VPS4A	VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A	3.58	3.58
SYT6	SYT6: Synaptotagmin-6	1.07	1.07
CHMP1B	CHMP1B, C18orf2: Charged multivesicular body protein 1b	0.265	0.265
CHMP7	CHMP7: Charged multivesicular body protein 7	0.265	0.265
CHMP5	CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul	0.237	0.237
CHMP2B	CHMP2B, CGI-84: Charged multivesicular body protein 2b	0.237	0.237
PDCD6IP	PDCD6IP, AIP1, ALIX, KIAA1375: Programmed cell death 6-interacting protein	0.143	0.143
SNX15	SNX15: Sorting nexin-15	0.141	0.141
CAPN7	CAPN7, PALBH: Calpain-7	0.126	0.126
STAMBP	STAMBP, AMSH: STAM-binding protein	0.117	0.177
STAMBPL1	N/A	0.0718	0.117
LOC283683	N/A	0.064	0.064
ATP6V0D2	ATP6V0D2: Vacuolar ATP synthase subunit d 2	0.064	0.064
PCOLN3	CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a	0.0288	0.0288
SPG20	N/A	0.0288	0.0288
FBXO34	CGI-301: Protein CGI-301	0.0288	0.0288
SRPR	SRPR: Uncharacterized protein SRPR	0.027	0.027

0.347

Total Score

4.43E4